{"id":"https://openalex.org/W2090717137","doi":"https://doi.org/10.1182/blood-2006-10-052522","title":"Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A","display_name":"Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A","publication_year":2007,"publication_date":"2007-03-29","ids":{"openalex":"https://openalex.org/W2090717137","doi":"https://doi.org/10.1182/blood-2006-10-052522","mag":"2090717137","pmid":"https://pubmed.ncbi.nlm.nih.gov/17392505","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1975837"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2006-10-052522","doi":"https://doi.org/10.1182/blood-2006-10-052522","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2006-10-052522","pdf_url":"https://ashpublications.org/blood/article-pdf/110/5/1475/1293311/zh801707001475.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/110/5/1475/1293311/zh801707001475.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Colman","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.912,"has_fulltext":true,"cited_by_count":84,"citation_normalized_percentile":{"value":0.9152822,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"110","issue":"5","first_page":"1475","last_page":"1482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7260000109672546},{"id":"https://openalex.org/keywords/phosphodiesterase-3a","display_name":"PDE3A","score":0.9010000228881836},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9300000071525574},{"id":"https://openalex.org/keywords/protein-phosphatase-1","display_name":"protein phosphatase 1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/p2y12-receptor","display_name":"P2Y12 receptor","score":0.9259999990463257},{"id":"https://openalex.org/keywords/camp-hydrolysis","display_name":"cAMP hydrolysis","score":0.800000011920929},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.8650000095367432},{"id":"https://openalex.org/keywords/3-isobutyl-1-methylxanthine","display_name":"3-isobutyl-1-methylxanthine","score":0.8820000290870667},{"id":"https://openalex.org/keywords/milrinone","display_name":"milrinone","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cilostazol","display_name":"cilostazol","score":0.9319999814033508}],"concepts":[{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.8471584320068359},{"id":"https://openalex.org/C58141971","wikidata":"https://www.wikidata.org/wiki/Q906688","display_name":"Phosphodiesterase 3","level":4,"score":0.7062956690788269},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5589143633842468},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.5428739190101624},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.5337657928466797},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4758607745170593},{"id":"https://openalex.org/C79418042","wikidata":"https://www.wikidata.org/wiki/Q5864325","display_name":"PDE10A","level":4,"score":0.46290314197540283},{"id":"https://openalex.org/C2781298581","wikidata":"https://www.wikidata.org/wiki/Q223093","display_name":"IBMX","level":4,"score":0.4483696520328522},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.4233500063419342},{"id":"https://openalex.org/C2776645727","wikidata":"https://www.wikidata.org/wiki/Q847399","display_name":"Milrinone","level":3,"score":0.4211384057998657},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3803133964538574},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.36752739548683167},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.35263970494270325},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3440017104148865},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32719704508781433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32639914751052856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3115757703781128},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.29502421617507935},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.25989240407943726},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1732766032218933},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10010036826133728},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0795314610004425},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067956","descriptor_name":"Adenylyl Cyclase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077407","descriptor_name":"Cilostazol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006490","descriptor_name":"Hemostatics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015056","descriptor_name":"1-Methyl-3-isobutylxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015105","descriptor_name":"3',5'-Cyclic-AMP Phosphodiesterases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018048","descriptor_name":"Receptors, Purinergic P2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020105","descriptor_name":"Milrinone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054645","descriptor_name":"Protein Phosphatase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054684","descriptor_name":"Cyclic Nucleotide Phosphodiesterases, Type 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058919","descriptor_name":"Purinergic P2 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058925","descriptor_name":"Receptors, Purinergic P2Y12","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2006-10-052522","doi":"https://doi.org/10.1182/blood-2006-10-052522","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2006-10-052522","pdf_url":"https://ashpublications.org/blood/article-pdf/110/5/1475/1293311/zh801707001475.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1975837","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1975837","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:17392505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17392505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1182/blood-2006-10-052522","doi":"https://doi.org/10.1182/blood-2006-10-052522","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2006-10-052522","pdf_url":"https://ashpublications.org/blood/article-pdf/110/5/1475/1293311/zh801707001475.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8777941575","display_name":null,"funder_award_id":"P01-64943","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2090717137.pdf","grobid_xml":"https://content.openalex.org/works/W2090717137.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1486029121","https://openalex.org/W1520160117","https://openalex.org/W1553473199","https://openalex.org/W1623233150","https://openalex.org/W1757478802","https://openalex.org/W1818189176","https://openalex.org/W1963861627","https://openalex.org/W1965475055","https://openalex.org/W1970435627","https://openalex.org/W1990779663","https://openalex.org/W2003103378","https://openalex.org/W2008900021","https://openalex.org/W2013039234","https://openalex.org/W2019842236","https://openalex.org/W2025654952","https://openalex.org/W2030821610","https://openalex.org/W2053228115","https://openalex.org/W2065609360","https://openalex.org/W2072203210","https://openalex.org/W2085131924","https://openalex.org/W2092875899","https://openalex.org/W2104539000","https://openalex.org/W2111419555","https://openalex.org/W2117290383","https://openalex.org/W2119473385","https://openalex.org/W2414075848","https://openalex.org/W2418005070","https://openalex.org/W2424635345","https://openalex.org/W4231681260"],"related_works":["https://openalex.org/W2528344171","https://openalex.org/W2029690794","https://openalex.org/W2043151108","https://openalex.org/W7125002573","https://openalex.org/W2005253053","https://openalex.org/W1520160117","https://openalex.org/W2046764598","https://openalex.org/W2764637401","https://openalex.org/W2020798389","https://openalex.org/W2081358537"],"abstract_inverted_index":{"Thrombin-induced":[0,115],"cyclic":[1],"AMP":[2],"(cAMP)":[3],"reduction":[4],"potentates":[5],"several":[6],"steps":[7],"in":[8,84,200],"platelet":[9,34],"activation,":[10],"including":[11],"Ca(++)":[12],"mobilization,":[13],"cytoskeletal":[14],"reorganization,":[15],"and":[16,59,65,109,136,174],"fibrinogen":[17],"receptor":[18],"conformation.":[19],"We":[20,189],"now":[21],"reinvestigate":[22],"the":[23,60,112,186],"signaling":[24,197],"pathways":[25],"by":[26,36,102,125,156,163,167,176,183],"which":[27],"intracellular":[28],"cAMP":[29,88,107,113,139,147,154,202],"content":[30],"is":[31],"controlled":[32],"after":[33],"activation":[35,117,135,205],"thrombin.":[37,157],"When":[38],"washed":[39],"human":[40],"platelets":[41],"were":[42],"stimulated":[43],"with":[44,97,121],"thrombin,":[45,103],"cAMP-dependent":[46,70],"phosphodiesterase":[47],"(PDE3A)":[48],"activity":[49],"was":[50,118,161,185],"significantly":[51],"increased.":[52],"A":[53,141],"nonselective":[54],"PDE":[55,71],"inhibitor,":[56],"3-isobutyl-1-methylxanthine":[57],"(IBMX),":[58],"PDE3":[61],"selective":[62],"inhibitors":[63],"milrinone":[64],"cilostazol":[66],"each":[67],"suppressed":[68],"thrombin-induced":[69,87,138,146],"responses,":[72],"but":[73],"not":[74],"2":[75],"different":[76],"PDE2":[77],"inhibitors.":[78],"Selective":[79],"inhibition":[80,98],"of":[81,86,99,123,151,193,206],"PDE3A":[82,105,116,124,134,160,194],"resulted":[83],"reversal":[85],"reduction,":[89],"indicating":[90],"that":[91,191],"thrombin":[92,204],"activated":[93,104],"PDE3A.":[94],"In":[95],"synergy":[96],"adenylate":[100],"cyclase":[101],"accelerates":[106],"hydrolysis":[108],"maximally":[110],"reduces":[111],"content.":[114],"diminished":[119],"concomitantly":[120],"dephosphorylation":[122],"protein":[126],"phosphatase":[127],"1":[128],"(PP1).":[129],"An":[130],"Akt":[131,184,196],"inhibitor":[132,143],"blocked":[133],"constrained":[137],"reduction.":[140,148],"P2Y(12)":[142],"also":[144],"reduced":[145],"The":[149,179],"combination":[150],"both":[152],"reversed":[153],"decrease":[155],"Thrombin-mediated":[158],"phosphorylated":[159,182],"isolated":[162],"liquid":[164],"chromatography,":[165],"detected":[166],"a":[168],"monoclonal":[169],"antibody":[170],"against":[171],"Akt-phosphorylated":[172],"substrate,":[173],"verified":[175],"immunoprecipitation":[177],"study.":[178],"predominant":[180],"isoform":[181],"136-kDa":[187],"species.":[188],"suggest":[190],"activation/phosphorylation":[192],"via":[195],"pathway":[198],"participates":[199],"regulating":[201],"during":[203],"platelets.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}