{"id":"https://openalex.org/W2090559569","doi":"https://doi.org/10.1021/tx00042a008","title":"Metabolism and Disposition of O6-Benzyl-2'-deoxyguanosine in Sprague-Dawley Rats","display_name":"Metabolism and Disposition of O6-Benzyl-2'-deoxyguanosine in Sprague-Dawley Rats","publication_year":1994,"publication_date":"1994-11-01","ids":{"openalex":"https://openalex.org/W2090559569","doi":"https://doi.org/10.1021/tx00042a008","mag":"2090559569","pmid":"https://pubmed.ncbi.nlm.nih.gov/7696530"},"language":"en","primary_location":{"id":"doi:10.1021/tx00042a008","doi":"https://doi.org/10.1021/tx00042a008","is_oa":false,"landing_page_url":"https://doi.org/10.1021/tx00042a008","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110227196","display_name":"Demetrius M. Kokkinakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Demetrius M. Kokkinakis","raw_affiliation_strings":["Department of Neurology, University of Texas, Southwestern Medical Center, Dallas 75235-9036"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Texas, Southwestern Medical Center, Dallas 75235-9036","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054533021","display_name":"Robert C. Moschel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Moschel","raw_affiliation_strings":["University of Texas Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110184049","display_name":"Anthony E. Pegg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony E. Pegg","raw_affiliation_strings":["Department of Cellular and Molecular Physiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Physiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057135590","display_name":"M. Eileen Dolan","orcid":"https://orcid.org/0000-0003-1613-097X","observed_orcids":["https://orcid.org/0000-0003-1613-097X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Eileen Dolan","raw_affiliation_strings":["University of Texas Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002449505","display_name":"S. Clifford Schold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Clifford Schold","raw_affiliation_strings":["University of Texas Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.2534,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.49280576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"6","first_page":"762","last_page":"769"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/o6-benzylguanine","display_name":"O6-benzylguanine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/o6-methylguanine-dna-methyltransferase","display_name":"O6-methylguanine-DNA methyltransferase","score":0.890999972820282},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.7910000085830688},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8299999833106995},{"id":"https://openalex.org/keywords/glucuronidation","display_name":"glucuronidation","score":0.890999972820282},{"id":"https://openalex.org/keywords/biliary-excretion","display_name":"biliary excretion","score":0.7670000195503235},{"id":"https://openalex.org/keywords/hepatic-clearance","display_name":"hepatic clearance","score":0.41499999165534973},{"id":"https://openalex.org/keywords/c6-glioma-cells","display_name":"C6 glioma cells","score":0.703000009059906},{"id":"https://openalex.org/keywords/nucleoside-transport","display_name":"nucleoside transport","score":0.7379999756813049},{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.645851194858551},{"id":"https://openalex.org/C38022665","wikidata":"https://www.wikidata.org/wiki/Q1149305","display_name":"Disposition","level":2,"score":0.5645329356193542},{"id":"https://openalex.org/C2780441211","wikidata":"https://www.wikidata.org/wiki/Q422488","display_name":"Deoxyguanosine","level":3,"score":0.5512689352035522},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.522392749786377},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5190730690956116},{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.4699034094810486},{"id":"https://openalex.org/C2778407487","wikidata":"https://www.wikidata.org/wiki/Q14565201","display_name":"Altmetrics","level":2,"score":0.4296719431877136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30579712986946106},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.28675132989883423},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2563544809818268},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16984134912490845},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.12209486961364746},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003849","descriptor_name":"Deoxyguanosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003849","descriptor_name":"Deoxyguanosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/tx00042a008","doi":"https://doi.org/10.1021/tx00042a008","is_oa":false,"landing_page_url":"https://doi.org/10.1021/tx00042a008","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},{"id":"pmid:7696530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7696530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical research in toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1565972033","display_name":null,"funder_award_id":"CA57725","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G551830852","display_name":null,"funder_award_id":"N01-CA74101","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8361843806","display_name":"MODULATION OF ALKYLTRANSFERASES TO ENHANCE CHEMOTHERAPY","funder_award_id":"R29CA047228","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2115938423","https://openalex.org/W2118541260","https://openalex.org/W7099003270","https://openalex.org/W2174123365","https://openalex.org/W1969542807","https://openalex.org/W2396305583","https://openalex.org/W1752108534","https://openalex.org/W2109311906","https://openalex.org/W2166382251","https://openalex.org/W1563201163"],"abstract_inverted_index":{"O6-Benzyl-2'-deoxyguanosine":[0],"is":[1,8,48,279],"a":[2,88,115,181],"potential":[3,56],"antitumor":[4],"drug":[5,226,235],"modulator":[6],"that":[7,203,266],"intended":[9],"to":[10,20,86,107,114,169,194,228],"reduce":[11],"or":[12,103,276],"eliminate":[13],"O6-alkylguanine-DNA":[14],"alkyltransferase":[15,174],"activity":[16],"in":[17,52,66,96,135,144,172,214],"tumors":[18],"prior":[19],"treatment":[21],"with":[22,220],"genotoxic":[23],"chemotherapeutic":[24],"alkylating":[25],"agents.":[26],"The":[27],"rationale":[28],"for":[29,120,147,205,258,285],"using":[30],"this":[31,286],"compound":[32,82,243],"instead":[33],"of":[34,62,75,100,123,127,140,150,154,160,177,183,191,212,224,233,241,268],"the":[35,45,81,97,101,104,121,128,136,148,151,158,178,221,225,234,269],"more":[36,209],"active":[37],"O6-benzylguanine":[38,109,163,192],"and":[39,55,60,110,131,162,200,254],"its":[40,49],"substituted":[41],"benzyl":[42,46,105],"derivatives":[43],"at":[44,124,164,186,197,202,206,259],"ring":[47],"greater":[50],"solubility":[51],"aqueous":[53],"media":[54],"pharmacologic":[57],"advantage.":[58],"Metabolism":[59,118],"disposition":[61],"O6-benzyl-2'-deoxyguanosine":[63,161,213],"was":[64,83,93],"determined":[65],"adult":[67],"male":[68],"Sprague-Dawley":[69],"rats":[70],"following":[71],"an":[72,282],"ip":[73],"injection":[74],"100":[76],"mg/kg.":[77],"Under":[78],"these":[79],"conditions,":[80],"partially":[84],"metabolized":[85],"yield":[87,108],"glucuronic":[89],"acid":[90],"conjugate,":[91],"which":[92,166],"secreted":[94],"exclusively":[95],"bile.":[98],"Removal":[99],"2'-deoxyribose":[102],"group":[106],"2'-deoxyguanosine,":[111],"respectively,":[112],"occurred":[113],"lesser":[116],"extent.":[117],"accounted":[119,146],"clearance":[122],"least":[125,207,260],"58%":[126],"total":[129],"dose":[130],"took":[132],"place":[133],"primarily":[134],"liver.":[137],"Direct":[138],"excretion":[139],"unchanged":[141],"drug,":[142],"mainly":[143],"urine,":[145],"remainder":[149],"dose.":[152],"Analysis":[153],"venous":[155],"blood":[156],"showed":[157],"presence":[159],"concentrations":[165],"are":[167],"considered":[168],"be":[170],"effective":[171],"depleting":[173],"activity.":[175],"Levels":[176],"nucleoside":[179,270],"reached":[180,236],"maximum":[182],"45":[184],"microM":[185,196,240],"2":[187],"h,":[188],"while":[189],"those":[190],"peaked":[193],"20":[195],"4":[198,208],"h":[199],"remained":[201,255],"level":[204],"hours.":[210],"Transport":[211],"C6":[215],"glioma":[216],"cells":[217,246,272],"increased":[218],"linearly":[219],"extracellular":[222,242],"concentration":[223],"up":[227],"600":[229],"microM.":[230],"Intracellular":[231],"levels":[232,264],"1.2":[237],"pmol":[238],"per":[239,244],"10(6)":[245],"as":[247,249,256],"soon":[248],"30":[250],"s":[251],"after":[252],"exposure":[253],"high":[257],"1":[261],"h.":[262],"Such":[263],"indicate":[265],"entrapment":[267],"inside":[271],"by":[273],"either":[274],"phosphorylation":[275],"other":[277],"means":[278],"probably":[280],"not":[281],"important":[283],"feature":[284],"drug.(ABSTRACT":[287],"TRUNCATED":[288],"AT":[289],"250":[290],"WORDS)":[291]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}