{"id":"https://openalex.org/W20905478","doi":null,"title":"Correlation of aPKC-iota and E-cadherin expression with invasion and prognosis of cholangiocarcinoma.","display_name":"Correlation of aPKC-iota and E-cadherin expression with invasion and prognosis of cholangiocarcinoma.","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W20905478","mag":"20905478","pmid":"https://pubmed.ncbi.nlm.nih.gov/18234642"},"language":"en","primary_location":{"id":"pmid:18234642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18234642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100430044","display_name":"Qiang Li","orcid":"https://orcid.org/0000-0003-1466-4580","observed_orcids":["https://orcid.org/0000-0003-1466-4580"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Li","raw_affiliation_strings":["Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100707507","display_name":"Jianming Wang","orcid":"https://orcid.org/0000-0002-9151-284X","observed_orcids":["https://orcid.org/0000-0002-9151-284X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-Ming Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100331538","display_name":"Cong Liu","orcid":"https://orcid.org/0000-0001-6432-0511","observed_orcids":["https://orcid.org/0000-0001-6432-0511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cong Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026551288","display_name":"Xiao Bao-lai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bao-Lai Xiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002700565","display_name":"Jinxi Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin-Xi Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112158960","display_name":"Shengquan Zou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheng-Quan Zou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6509,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.91607275,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"70","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9819999933242798},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.847000002861023},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8130000233650208},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.8040000200271606},{"id":"https://openalex.org/keywords/protein-expression-correlation","display_name":"protein expression correlation","score":0.5770000219345093},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5199999809265137},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.6209999918937683},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.7353255152702332},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6929121017456055},{"id":"https://openalex.org/C2779777945","wikidata":"https://www.wikidata.org/wiki/Q851111","display_name":"Bile duct","level":2,"score":0.6075927019119263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5989141464233398},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5436761379241943},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5032393336296082},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.4754464328289032},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4543123245239258},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4352300465106964},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.41146695613861084},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3642116189002991},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3530120849609375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33964282274246216},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24855434894561768},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.21345865726470947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20216631889343262},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.09479114413261414},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099293","descriptor_name":"Protein Kinase C-lambda","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001653","descriptor_name":"Bile Ducts, Intrahepatic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001653","descriptor_name":"Bile Ducts, Intrahepatic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18234642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18234642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},{"id":"mag:20905478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18234642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W143691525","https://openalex.org/W150586073","https://openalex.org/W1896219833","https://openalex.org/W1966265295","https://openalex.org/W1972419229","https://openalex.org/W1973104659","https://openalex.org/W1987473368","https://openalex.org/W1993579677","https://openalex.org/W2040139767","https://openalex.org/W2079464218","https://openalex.org/W2108713158","https://openalex.org/W2115899458","https://openalex.org/W2122264749","https://openalex.org/W2154122181","https://openalex.org/W2277312268","https://openalex.org/W2283386288","https://openalex.org/W2317277689","https://openalex.org/W2411825002"],"related_works":["https://openalex.org/W3029052884","https://openalex.org/W2028170508","https://openalex.org/W2148233444","https://openalex.org/W248231881","https://openalex.org/W2144838596","https://openalex.org/W7100095275","https://openalex.org/W2365694868","https://openalex.org/W2082331213","https://openalex.org/W2371003127","https://openalex.org/W2377712920"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,87,118,251],"abnormal":[2],"expression":[3,30,64,91,120,142,165,192,215,231],"of":[4,29,31,41,49,53,65,72,79,84,89,98,108,122,144,166,178,193,197,209,216,225,239,253,264,290,311],"atypical":[5],"protein":[6],"kinase":[7],"C-iota":[8],"(aPKC-iota)":[9],"subtype":[10],"and":[11,19,33,39,43,51,67,81,96,174,195,241,255,261,267,309],"E-cadherin":[12,34,68,145,179,198,242,256,268],"play":[13,302],"important":[14,244,304],"roles":[15],"in":[16,69,124,131,148,151,218,277,286,306],"tumor":[17,172],"occurrence":[18],"progression.":[20],"This":[21],"study":[22],"was":[23,59,100,106,126,146,168,180,186,220],"designed":[24],"to":[25,44,61,171],"investigate":[26],"the":[27,36,46,54,63,90,112,141,164,182,191,205,210,226,237,259,284,288,307],"correlation":[28],"aPKC-iota":[32,66,123,167,194,217,240,254,266,300],"with":[35,92,212,228,279,292],"clinicopathological":[37,93,280],"characteristics":[38],"prognosis":[40,97,289],"cholangiocarcinoma,":[42],"analyze":[45],"molecular":[47],"mechanisms":[48],"invasion":[50,95,308],"metastasis":[52,310],"tumor.":[55],"METHODS:":[56],"EnVision":[57],"immunohistochemistry":[58],"used":[60,276],"detect":[62],"9":[70],"specimens":[71,78,83],"benign":[73,132,152],"bile":[74,133,153],"duct":[75,134,154],"tissues,":[76],"35":[77],"cholangiocarcinoma":[80,99,125,149,219,248],"6":[82],"metastatic":[85],"cholangiocarcinoma.":[86,265,293,312],"relationship":[88,189],"characteristics,":[94,281],"analyzed.":[101],"A":[102],"multivariate":[103,233],"regression":[104],"analysis":[105,161,202,234],"made":[107],"these":[109],"data":[110],"by":[111],"Cox":[113],"proportional":[114],"hazard":[115],"model.":[116],"RESULTS:":[117],"positive":[119],"level":[121,143],"remarkably":[127,221],"higher":[128,214],"than":[129,150,223],"that":[130,163,177,196,204,224,236],"tissues":[135,155],"(68.6%":[136],"vs.":[137,157],"11.1%,":[138],"P=0.006),":[139],"but":[140],"lower":[147,222,230],"(37.1%":[156],"88.9%,":[158],"P=0.016).":[159],"Correlation":[160],"revealed":[162,235],"positively":[169],"related":[170],"differentiation":[173,260],"invasion,":[175],"whereas":[176],"entirely":[181],"contrary.":[183],"Moreover,":[184],"there":[185],"a":[187,213,229,295],"negative":[188],"between":[190],"(r=-0.287,":[199],"P<0.05).":[200],"Univariate":[201],"showed":[203],"overall":[206],"survival":[207],"rate":[208],"group":[211,227],"(P<0.01);":[232],"expressions":[238,252],"are":[243],"prognostic":[245,272],"factors":[246,273],"for":[247],"(P<0.05).":[249],"CONCLUSIONS:":[250],"may":[257,269,282,301],"reflect":[258],"invasive":[262],"potential":[263],"be":[270],"independent":[271],"and,":[274],"when":[275],"combination":[278],"increase":[283],"accuracy":[285],"predicting":[287],"patients":[291],"As":[294],"polar":[296],"regulative":[297],"associated":[298],"protein,":[299],"an":[303],"role":[305]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
