{"id":"https://openalex.org/W2090430216","doi":"https://doi.org/10.1016/j.febslet.2005.12.016","title":"On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P4 is not a physiologic substrate","display_name":"On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P4 is not a physiologic substrate","publication_year":2005,"publication_date":"2005-12-19","ids":{"openalex":"https://openalex.org/W2090430216","doi":"https://doi.org/10.1016/j.febslet.2005.12.016","mag":"2090430216","pmid":"https://pubmed.ncbi.nlm.nih.gov/16376887"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2005.12.016","doi":"https://doi.org/10.1016/j.febslet.2005.12.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2005.12.016","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023315844","display_name":"Andrew M. Riley","orcid":"https://orcid.org/0000-0001-9003-3540","observed_orcids":["https://orcid.org/0000-0001-9003-3540"]},"institutions":[{"id":"https://openalex.org/I51601045","display_name":"University of Bath","ror":"https://ror.org/002h8g185","country_code":"GB","type":"education","lineage":["https://openalex.org/I51601045"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew M. Riley","raw_affiliation_strings":["Wolfson Laboratory for Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wolfson Laboratory for Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK","institution_ids":["https://openalex.org/I51601045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005072964","display_name":"Sandrine Deleu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandrine Deleu","raw_affiliation_strings":["Inositide Signaling Group, Laboratory of Signal Transduction, and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositide Signaling Group, Laboratory of Signal Transduction, and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xun Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xun Qian","raw_affiliation_strings":["Inositide Signaling Group, Laboratory of Signal Transduction, and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositide Signaling Group, Laboratory of Signal Transduction, and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109254189","display_name":"Jennifer L. Mitchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Mitchell","raw_affiliation_strings":["Inositide Signaling Group, Laboratory of Signal Transduction, and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositide Signaling Group, Laboratory of Signal Transduction, and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111817221","display_name":"Sung\u2010Kee Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung-Kee Chung","raw_affiliation_strings":["Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang 790-784, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang 790-784, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036355801","display_name":"Stephan Adelt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I167360494","display_name":"University of Wuppertal","ror":"https://ror.org/00613ak93","country_code":"DE","type":"education","lineage":["https://openalex.org/I167360494"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Adelt","raw_affiliation_strings":["Bergische Universita\u0308t Wuppertal, Fachbereich Mathematik und Naturwissenschaften \u2013 Biochemie, Gaussstrasse 20, 42097 Wuppertal, FRG","Bergische Universit\u00e4t Wuppertal, Fachbereich Mathematik und Naturwissenschaften \u2013 Biochemie, Gaussstrasse 20, 42097 Wuppertal, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bergische Universita\u0308t Wuppertal, Fachbereich Mathematik und Naturwissenschaften \u2013 Biochemie, Gaussstrasse 20, 42097 Wuppertal, FRG","institution_ids":["https://openalex.org/I167360494"]},{"raw_affiliation_string":"Bergische Universit\u00e4t Wuppertal, Fachbereich Mathematik und Naturwissenschaften \u2013 Biochemie, Gaussstrasse 20, 42097 Wuppertal, FRG","institution_ids":["https://openalex.org/I167360494"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113510528","display_name":"G\u00fcnter Vogel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I167360494","display_name":"University of Wuppertal","ror":"https://ror.org/00613ak93","country_code":"DE","type":"education","lineage":["https://openalex.org/I167360494"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G\u00fcnter Vogel","raw_affiliation_strings":["Bergische Universita\u0308t Wuppertal, Fachbereich Mathematik und Naturwissenschaften \u2013 Biochemie, Gaussstrasse 20, 42097 Wuppertal, FRG","Bergische Universit\u00e4t Wuppertal, Fachbereich Mathematik und Naturwissenschaften \u2013 Biochemie, Gaussstrasse 20, 42097 Wuppertal, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bergische Universita\u0308t Wuppertal, Fachbereich Mathematik und Naturwissenschaften \u2013 Biochemie, Gaussstrasse 20, 42097 Wuppertal, FRG","institution_ids":["https://openalex.org/I167360494"]},{"raw_affiliation_string":"Bergische Universit\u00e4t Wuppertal, Fachbereich Mathematik und Naturwissenschaften \u2013 Biochemie, Gaussstrasse 20, 42097 Wuppertal, FRG","institution_ids":["https://openalex.org/I167360494"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113898464","display_name":"Barry V. L. Potter","orcid":"https://orcid.org/0000-0003-3255-9135","observed_orcids":["https://orcid.org/0000-0003-3255-9135"]},"institutions":[{"id":"https://openalex.org/I51601045","display_name":"University of Bath","ror":"https://ror.org/002h8g185","country_code":"GB","type":"education","lineage":["https://openalex.org/I51601045"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Barry V.L. Potter","raw_affiliation_strings":["Wolfson Laboratory for Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wolfson Laboratory for Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK","institution_ids":["https://openalex.org/I51601045"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013107971","display_name":"Stephen B. Shears","orcid":"https://orcid.org/0000-0001-7309-8916","observed_orcids":["https://orcid.org/0000-0001-7309-8916"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen B. Shears","raw_affiliation_strings":["Inositide Signaling Group, Laboratory of Signal Transduction, and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositide Signaling Group, Laboratory of Signal Transduction, and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5013107971"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.251,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.53345657,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"580","issue":"1","first_page":"324","last_page":"330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stereospecificity","display_name":"stereospecificity","score":0.800000011920929},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.8169999718666077},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C187921627","wikidata":"https://www.wikidata.org/wiki/Q2469470","display_name":"Stereospecificity","level":3,"score":0.8671904802322388},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6769793033599854},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.6244831681251526},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.5718609094619751},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.571185290813446},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5243085622787476},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.43101412057876587},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3462004065513611},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23652401566505432},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16531577706336975},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.febslet.2005.12.016","doi":"https://doi.org/10.1016/j.febslet.2005.12.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2005.12.016","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:16376887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16376887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/229471","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/229471","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"FEBS letters, 580 (1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:oasis.postech.ac.kr:2014.oak/24239","doi":null,"is_oa":false,"landing_page_url":"https://oasis.postech.ac.kr/handle/2014.oak/24239","pdf_url":null,"source":{"id":"https://openalex.org/S4306401965","display_name":"Open Access System for Information Sharing (Pohang University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123900574","host_organization_name":"Pohang University of Science and Technology","host_organization_lineage":["https://openalex.org/I123900574"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W302838846","https://openalex.org/W324477760","https://openalex.org/W429458206","https://openalex.org/W1508325619","https://openalex.org/W1512142615","https://openalex.org/W1543925548","https://openalex.org/W1558610458","https://openalex.org/W1561094053","https://openalex.org/W1965726948","https://openalex.org/W1971517152","https://openalex.org/W1977870999","https://openalex.org/W1981906878","https://openalex.org/W1983536335","https://openalex.org/W1992625839","https://openalex.org/W1994071091","https://openalex.org/W2022163354","https://openalex.org/W2023543654","https://openalex.org/W2023959712","https://openalex.org/W2029268837","https://openalex.org/W2037950101","https://openalex.org/W2059141024","https://openalex.org/W2066465046","https://openalex.org/W2069031972","https://openalex.org/W2069789229","https://openalex.org/W2071503618","https://openalex.org/W2080209900","https://openalex.org/W2080351019","https://openalex.org/W2087358641","https://openalex.org/W2109890918","https://openalex.org/W2111780853","https://openalex.org/W2143680734","https://openalex.org/W2146718650","https://openalex.org/W2276140391","https://openalex.org/W2336512389"],"related_works":["https://openalex.org/W1481652408","https://openalex.org/W6987315921","https://openalex.org/W1977870999","https://openalex.org/W1999584710","https://openalex.org/W2752132413","https://openalex.org/W2083104582","https://openalex.org/W2162807269","https://openalex.org/W1979509750","https://openalex.org/W4390228384","https://openalex.org/W4323812458"],"abstract_inverted_index":{"Ins(1,4,5,6)P4,":[0,94],"a":[1,10],"biologically":[2],"active":[3],"cell":[4],"constituent,":[5],"was":[6],"recently":[7],"advocated":[8],"as":[9],"substrate":[11],"of":[12,44,57,65,86],"human":[13],"Ins(3,4,5,6)P4":[14,78],"1-kinase":[15],"(hITPK1),":[16],"because":[17],"stereochemical":[18],"factors":[19],"were":[20],"believed":[21],"relatively":[22],"unimportant":[23],"to":[24],"specificity":[25],"[Miller,":[26],"G.J.,":[27],"Wilson,":[28],"M.P.,":[29],"Majerus,":[30],"P.W.":[31],"and":[32,68,90],"Hurley,":[33],"J.H.":[34],"(2005)":[35],"Specificity":[36],"determinants":[37],"in":[38],"inositol":[39,45],"polyphosphate":[40],"synthesis:":[41],"crystal":[42],"structure":[43],"1,3,4-triphosphate":[46],"5/6-kinase.":[47],"Mol.":[48],"Cell.":[49],"18,":[50],"201-212].":[51],"Contrarily,":[52],"we":[53],"provide":[54],"three":[55],"examples":[56],"hITPK1":[58,60,73,87],"stereospecificity.":[59],"phosphorylates":[61],"only":[62],"the":[63,69],"1-hydroxyl":[64],"both":[66],"Ins(3,5,6)P3":[67],"meso-compound,":[70],"Ins(4,5,6)P3.":[71],"Moreover,":[72],"has":[74],">13,000-fold":[75],"preference":[76],"for":[77],"over":[79],"its":[80],"enantiomer,":[81],"Ins(1,4,5,6)P4.":[82],"The":[83],"biological":[84],"significance":[85],"being":[88],"stereospecific,":[89],"not":[91],"physiologically":[92],"phosphorylating":[93],"is":[95,102],"reinforced":[96],"by":[97,108],"our":[98],"demonstrating":[99],"that":[100],"Ins(1,4,5,6)P4":[101],"phosphorylated":[103],"(K(m)":[104],"=":[105],"0.18":[106],"microM)":[107],"inositolphosphate-multikinase.":[109]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
