{"id":"https://openalex.org/W2090380901","doi":"https://doi.org/10.1556/aphysiol.95.2008.2.5","title":"Kinetic assay for the determination of the oxidative stress biomarker, advanced oxidation protein products (AOPP) in the human blood plasma","display_name":"Kinetic assay for the determination of the oxidative stress biomarker, advanced oxidation protein products (AOPP) in the human blood plasma","publication_year":2008,"publication_date":"2008-06-01","ids":{"openalex":"https://openalex.org/W2090380901","doi":"https://doi.org/10.1556/aphysiol.95.2008.2.5","mag":"2090380901","pmid":"https://pubmed.ncbi.nlm.nih.gov/18642760"},"language":"en","primary_location":{"id":"doi:10.1556/aphysiol.95.2008.2.5","doi":"https://doi.org/10.1556/aphysiol.95.2008.2.5","is_oa":false,"landing_page_url":"https://doi.org/10.1556/aphysiol.95.2008.2.5","pdf_url":null,"source":{"id":"https://openalex.org/S71935151","display_name":"Acta Physiologica Hungarica","issn_l":"0231-424X","issn":["0231-424X","1588-2682","1588-2683"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320364","host_organization_name":"Akad\u00e9miai Kiad\u00f3","host_organization_lineage":["https://openalex.org/P4310320364","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Akad\u00e9miai Kiad\u00f3","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiologica Hungarica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111605707","display_name":"L. Selmeci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"L\u00e1szl\u00f3 Selmeci","raw_affiliation_strings":["Department of Cardiovascular Surgery, Faculty of Medicine, Semmelweis University, V\u00e1rosmajor u. 68, H-1122 Budapest, Hungary. laszlo.selmeci@excite.com","Department of Cardiovascular Surgery, Faculty of Medicine, Semmelweis University, V\u00e1rosmajor u. 68, H-1122 Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Faculty of Medicine, Semmelweis University, V\u00e1rosmajor u. 68, H-1122 Budapest, Hungary. laszlo.selmeci@excite.com","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"Department of Cardiovascular Surgery, Faculty of Medicine, Semmelweis University, V\u00e1rosmajor u. 68, H-1122 Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Seres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019392618","display_name":"Gottsegen National Cardiovascular Center","ror":"https://ror.org/04r60ve96","country_code":"HU","type":"facility","lineage":["https://openalex.org/I3019392618"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"L. Seres","raw_affiliation_strings":["Gottsegen Gy\u00f6rgy National Institute of Cardiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gottsegen Gy\u00f6rgy National Institute of Cardiology","institution_ids":["https://openalex.org/I3019392618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056794059","display_name":"P\u00e1l So\u00f3s","orcid":"https://orcid.org/0000-0002-3708-483X","observed_orcids":["https://orcid.org/0000-0002-3708-483X"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"P. So\u00f3s","raw_affiliation_strings":["Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Sz\u00e9kely","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"M. Sz\u00e9kely","raw_affiliation_strings":["Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111910941","display_name":"G Acs\u00e1dy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Gy. Acs\u00e1dy","raw_affiliation_strings":["Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5314,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.63353438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"95","issue":"2","first_page":"209","last_page":"218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-oxidation-protein-products","display_name":"advanced oxidation protein products","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress-biomarkers","display_name":"oxidative stress biomarkers","score":0.8019999861717224},{"id":"https://openalex.org/keywords/kinetic-assay","display_name":"kinetic assay","score":0.9850000143051147},{"id":"https://openalex.org/keywords/blood-plasma","display_name":"blood plasma","score":0.828000009059906},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.972000002861023},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8550000190734863},{"id":"https://openalex.org/keywords/peripheral-vascular-disease","display_name":"peripheral vascular disease","score":0.8360000252723694},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7917265892028809},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.7840104103088379},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7573151588439941},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.6333544254302979},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5923036932945251},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.5024149417877197},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.5017008781433105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48160621523857117},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4390681982040405},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4320318102836609},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3830673396587372},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2948276400566101}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002700","descriptor_name":"Chloramines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014105","descriptor_name":"Tosyl Compounds","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016491","descriptor_name":"Peripheral Vascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1556/aphysiol.95.2008.2.5","doi":"https://doi.org/10.1556/aphysiol.95.2008.2.5","is_oa":false,"landing_page_url":"https://doi.org/10.1556/aphysiol.95.2008.2.5","pdf_url":null,"source":{"id":"https://openalex.org/S71935151","display_name":"Acta Physiologica Hungarica","issn_l":"0231-424X","issn":["0231-424X","1588-2682","1588-2683"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320364","host_organization_name":"Akad\u00e9miai Kiad\u00f3","host_organization_lineage":["https://openalex.org/P4310320364","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Akad\u00e9miai Kiad\u00f3","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiologica Hungarica","raw_type":"journal-article"},{"id":"pmid:18642760","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18642760","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta physiologica Hungarica","raw_type":"Journal Article"},{"id":"pmh:oai:real.mtak.hu:65742","doi":null,"is_oa":false,"landing_page_url":"http://real.mtak.hu/65742/1/aphysiol.95.2008.2.5.pdf","pdf_url":"http://real.mtak.hu/65742/1/aphysiol.95.2008.2.5.pdf","source":{"id":"https://openalex.org/S4306400081","display_name":"Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210140733","host_organization_name":"Library and Information Centre of the Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210140733"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1757677751","https://openalex.org/W2001283789","https://openalex.org/W2011683287","https://openalex.org/W2036354712","https://openalex.org/W2042641359","https://openalex.org/W2048005287","https://openalex.org/W2048294577","https://openalex.org/W2048470111","https://openalex.org/W2080529628","https://openalex.org/W2085777303","https://openalex.org/W2086476775","https://openalex.org/W2091837205","https://openalex.org/W2100322364","https://openalex.org/W2154477836","https://openalex.org/W2157682304"],"related_works":["https://openalex.org/W2036354712","https://openalex.org/W1975523151","https://openalex.org/W7120761271","https://openalex.org/W2035059690","https://openalex.org/W2042641359","https://openalex.org/W2512604987","https://openalex.org/W1980906599","https://openalex.org/W2162424354","https://openalex.org/W2430951780","https://openalex.org/W2020892461"],"abstract_inverted_index":{"UNLABELLED:":[0],"A":[1],"number":[2],"of":[3,28,33,63,99,203,210],"human":[4,75],"diseases":[5],"and":[6,101,126,163,171,217],"pathological":[7],"conditions":[8],"were":[9,109,116],"found":[10],"to":[11,44,92,141,199],"be":[12,222],"associated":[13],"with":[14,95,177],"increased":[15],"oxidative":[16,29,65,231],"stress.":[17],"In":[18],"the":[19,26,45,61,64,74,142,201,208],"literature":[20],"several":[21],"techniques":[22],"are":[23,35],"available":[24],"for":[25,38,60,111,238],"assessment":[27],"stress,":[30],"but":[31],"most":[32],"them":[34],"not":[36],"applicable":[37],"a":[39,55,96,128,148],"routine":[40,227],"medical":[41],"laboratory":[42,228],"due":[43],"complex":[46],"methodology":[47],"and/or":[48],"financial":[49],"reasons.":[50],"We":[51],"report":[52],"here":[53],"on":[54],"simple,":[56],"inexpensive,":[57],"kinetic":[58,129,219],"assay":[59,122,220],"determination":[62],"stress":[66,232],"biomarker,":[67],"advanced":[68],"oxidation":[69],"protein":[70],"products":[71],"(AOPP)":[72],"in":[73,132,207,225,230],"blood":[76],"plasma.":[77],"METHODS:":[78],"This":[79,215],"study":[80],"involved":[81],"70":[82],"patients":[83,108],"(47M/23F;":[84],"mean":[85],"age:":[86],"64.6":[87],"y;":[88],"range:":[89],"16-85)":[90],"admitted":[91],"our":[93,133,204],"Department":[94],"wide":[97],"range":[98],"cardiovascular":[100],"peripheral":[102],"vascular":[103],"diseases.":[104],"Three":[105],"critically":[106,211,240],"ill":[107,212,241],"assigned":[110],"monitoring":[112,209,239],"purposes.":[113],"Plasma":[114,135],"AOPP":[115,159,164,169,172],"simultaneously":[117],"determined":[118],"using":[119],"an":[120],"end-point":[121],"as":[123],"reference":[124],"method":[125,130,206],"by":[127],"developed":[131],"laboratory.":[134],"fibrinogen":[136,179],"concentration":[137,160,170,180],"was":[138,147],"measured":[139],"according":[140],"Clauss":[143],"method.":[144],"RESULTS:":[145],"There":[146],"highly":[149],"significant":[150],"correlation":[151],"(r2":[152,181],"=":[153,182,188],"0.588;":[154],"p":[155,184,190],"<":[156,185,191],"0.0001)":[157],"between":[158],"(reference":[161],"method)":[162],"reactivity":[165,173],"(kinetic":[166],"method).":[167],"Both":[168],"also":[174],"significantly":[175],"correlated":[176],"plasma":[178],"0.780;":[183],"0.0001;":[186],"r2":[187],"0.564;":[189],"0.0001).":[192],"The":[193],"three":[194],"representative":[195],"cases":[196],"presented":[197],"appear":[198],"support":[200],"relevance":[202],"novel":[205],"patients.":[213,244],"CONCLUSIONS:":[214],"simple":[216],"inexpensive":[218],"can":[221],"widely":[223],"used":[224],"any":[226],"interested":[229],"research.":[233],"It":[234],"is":[235],"especially":[236],"recommended":[237],"or":[242],"other":[243]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}