{"id":"https://openalex.org/W2090309653","doi":"https://doi.org/10.1016/s0168-9525(97)81398-4","title":"Anti-gene therapy: the use of ribozymes to inhibit gene function","display_name":"Anti-gene therapy: the use of ribozymes to inhibit gene function","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W2090309653","doi":"https://doi.org/10.1016/s0168-9525(97)81398-4","mag":"2090309653","pmid":"https://pubmed.ncbi.nlm.nih.gov/9257533"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-9525(97)81398-4","doi":"https://doi.org/10.1016/s0168-9525(97)81398-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-9525(97)81398-4","pdf_url":null,"source":{"id":"https://openalex.org/S139283865","display_name":"Trends in Genetics","issn_l":"0168-9525","issn":["0168-9525","1362-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Genetics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081343739","display_name":"Larry A. Couture","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Larry A. Couture","raw_affiliation_strings":["Ribozyme Pharmaceuticals, Inc, Bouldar, CO 80301, USA","L.A. Couture and D.T. Stinchcomb are in the Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, CO 80301, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ribozyme Pharmaceuticals, Inc, Bouldar, CO 80301, USA","institution_ids":[]},{"raw_affiliation_string":"L.A. Couture and D.T. Stinchcomb are in the Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, CO 80301, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028413988","display_name":"Dan T. Stinchcomb","orcid":"https://orcid.org/0000-0002-3634-7503","observed_orcids":["https://orcid.org/0000-0002-3634-7503"]},"institutions":[{"id":"https://openalex.org/I4210093778","display_name":"Heska (United States)","ror":"https://ror.org/00kpnax84","country_code":"US","type":"company","lineage":["https://openalex.org/I4210093778"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dan T. Stinchcomb","raw_affiliation_strings":["D.T. Stinchcomb is also in the Heska Corporation, 1825 Sharp Point Drive, Fort Collins, CO 80525, USA","L.A. Couture and D.T. Stinchcomb are in the Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, CO 80301, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D.T. Stinchcomb is also in the Heska Corporation, 1825 Sharp Point Drive, Fort Collins, CO 80525, USA","institution_ids":["https://openalex.org/I4210093778"]},{"raw_affiliation_string":"L.A. Couture and D.T. Stinchcomb are in the Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, CO 80301, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028413988","https://openalex.org/A5081343739"],"corresponding_institution_ids":["https://openalex.org/I4210093778"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":0.7078,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.62150838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"12","first_page":"510","last_page":"515"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribozymes","display_name":"ribozymes","score":0.9879999756813049},{"id":"https://openalex.org/keywords/rna-cleavage","display_name":"RNA cleavage","score":0.7319999933242798},{"id":"https://openalex.org/keywords/mrna-targeting","display_name":"mRNA targeting","score":0.5929999947547913},{"id":"https://openalex.org/keywords/protein-expression-inhibition","display_name":"protein expression inhibition","score":0.8209999799728394},{"id":"https://openalex.org/keywords/ribozyme-design","display_name":"ribozyme design","score":0.9049999713897705},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.9930678009986877},{"id":"https://openalex.org/C1342335","wikidata":"https://www.wikidata.org/wiki/Q6545871","display_name":"Ligase ribozyme","level":5,"score":0.8176982402801514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7728940844535828},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6327283978462219},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.6249685883522034},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5859718322753906},{"id":"https://openalex.org/C19014433","wikidata":"https://www.wikidata.org/wiki/Q5130995","display_name":"Cleave","level":3,"score":0.5859028697013855},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5263227820396423},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49613651633262634},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4456753730773926},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.43530622124671936},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3679433763027191},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.18178731203079224},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0168-9525(97)81398-4","doi":"https://doi.org/10.1016/s0168-9525(97)81398-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-9525(97)81398-4","pdf_url":null,"source":{"id":"https://openalex.org/S139283865","display_name":"Trends in Genetics","issn_l":"0168-9525","issn":["0168-9525","1362-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Genetics","raw_type":"journal-article"},{"id":"pmid:9257533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9257533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in genetics : TIG","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1524880457","https://openalex.org/W1565134347","https://openalex.org/W1570375907","https://openalex.org/W1595347306","https://openalex.org/W1676925074","https://openalex.org/W1905106889","https://openalex.org/W1968282235","https://openalex.org/W1969707875","https://openalex.org/W1980527259","https://openalex.org/W1997533384","https://openalex.org/W1999391211","https://openalex.org/W2006162544","https://openalex.org/W2009899276","https://openalex.org/W2015243129","https://openalex.org/W2017304478","https://openalex.org/W2018304763","https://openalex.org/W2033282111","https://openalex.org/W2038036667","https://openalex.org/W2042841971","https://openalex.org/W2050992506","https://openalex.org/W2051585221","https://openalex.org/W2055887493","https://openalex.org/W2066962402","https://openalex.org/W2071601231","https://openalex.org/W2084208256","https://openalex.org/W2084299659","https://openalex.org/W2089461960","https://openalex.org/W2101518561","https://openalex.org/W2102128719","https://openalex.org/W2108276123","https://openalex.org/W2115066994","https://openalex.org/W2124860623","https://openalex.org/W2130251705","https://openalex.org/W2131095976","https://openalex.org/W2148879761","https://openalex.org/W2169138906","https://openalex.org/W2179465481","https://openalex.org/W2338145704","https://openalex.org/W2401693875","https://openalex.org/W2409753504","https://openalex.org/W2417182618","https://openalex.org/W3023609138","https://openalex.org/W4230164139"],"related_works":["https://openalex.org/W2367312430","https://openalex.org/W1993325450","https://openalex.org/W2382418680","https://openalex.org/W1966053598","https://openalex.org/W1996962471","https://openalex.org/W2081901407","https://openalex.org/W2392568458","https://openalex.org/W2413202751","https://openalex.org/W3110677770","https://openalex.org/W2056076369"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
