{"id":"https://openalex.org/W2090281148","doi":"https://doi.org/10.1074/jbc.m500469200","title":"Probing the Mechanism of the Archaeoglobus fulgidus Inositol-1-phosphate Synthase","display_name":"Probing the Mechanism of the Archaeoglobus fulgidus Inositol-1-phosphate Synthase","publication_year":2005,"publication_date":"2005-01-15","ids":{"openalex":"https://openalex.org/W2090281148","doi":"https://doi.org/10.1074/jbc.m500469200","mag":"2090281148","pmid":"https://pubmed.ncbi.nlm.nih.gov/15653679"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m500469200","doi":"https://doi.org/10.1074/jbc.m500469200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m500469200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m500469200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055769623","display_name":"Kelly Neelon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly Neelon","raw_affiliation_strings":["Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA","institution_ids":["https://openalex.org/I103531236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322939","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0003-2565-1515","observed_orcids":["https://orcid.org/0000-0003-2565-1515"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":["Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467","institution_ids":["https://openalex.org/I103531236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084942532","display_name":"Boguslaw Stec","orcid":"https://orcid.org/0000-0002-8696-0349","observed_orcids":["https://orcid.org/0000-0002-8696-0349"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boguslaw Stec","raw_affiliation_strings":["Department of Chemistry, University of Texas, El Paso, Texas 79968"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas, El Paso, Texas 79968","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047196423","display_name":"Mary Fedarko Roberts","orcid":"https://orcid.org/0000-0003-3547-951X","observed_orcids":["https://orcid.org/0000-0003-3547-951X"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary F. Roberts","raw_affiliation_strings":["Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467","institution_ids":["https://openalex.org/I103531236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047196423"],"corresponding_institution_ids":["https://openalex.org/I103531236"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.406,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.62297523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"280","issue":"12","first_page":"11475","last_page":"11482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.26460000872612,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.04670000076293945,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myo-inositol-1-phosphate-synthase","display_name":"myo-inositol-1-phosphate synthase","score":0.972000002861023},{"id":"https://openalex.org/keywords/archaeoglobus-fulgidus","display_name":"Archaeoglobus fulgidus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/catalytic-mechanism","display_name":"catalytic mechanism","score":0.7480000257492065},{"id":"https://openalex.org/keywords/site-directed-mutants","display_name":"site-directed mutants","score":0.8299999833106995},{"id":"https://openalex.org/keywords/active-site-residues","display_name":"active site residues","score":0.6309999823570251},{"id":"https://openalex.org/keywords/nad-reduction","display_name":"NAD+ reduction","score":0.8289999961853027},{"id":"https://openalex.org/keywords/osmolyte-biosynthesis","display_name":"osmolyte biosynthesis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/thermophilic-enzymes","display_name":"thermophilic enzymes","score":0.7139999866485596},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.6646873950958252},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.622211217880249},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5023303031921387},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.49595150351524353},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.47304767370224},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37889328598976135},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1931965947151184},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13425153493881226},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007296","descriptor_name":"Myo-Inositol-1-Phosphate Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007296","descriptor_name":"Myo-Inositol-1-Phosphate Synthase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019611","descriptor_name":"Archaeoglobus fulgidus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m500469200","doi":"https://doi.org/10.1074/jbc.m500469200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m500469200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15653679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15653679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m500469200","doi":"https://doi.org/10.1074/jbc.m500469200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m500469200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5135375845","display_name":"Structural study of enzymes of inositol biosynthesis","funder_award_id":"R01GM064481","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1501831169","https://openalex.org/W1695129589","https://openalex.org/W1967674805","https://openalex.org/W1969734146","https://openalex.org/W1971682510","https://openalex.org/W1975033426","https://openalex.org/W2001262372","https://openalex.org/W2027875846","https://openalex.org/W2034307843","https://openalex.org/W2044395778","https://openalex.org/W2051655070","https://openalex.org/W2095147391","https://openalex.org/W2123860660","https://openalex.org/W2125094371","https://openalex.org/W2140597554","https://openalex.org/W2144553803","https://openalex.org/W2169594103","https://openalex.org/W2320915119","https://openalex.org/W2397220833"],"related_works":["https://openalex.org/W2044395778","https://openalex.org/W2080497585","https://openalex.org/W1970778929","https://openalex.org/W2049114729","https://openalex.org/W2031693021","https://openalex.org/W2054944053","https://openalex.org/W2001262372","https://openalex.org/W4401610262","https://openalex.org/W172934802","https://openalex.org/W4224437476"],"abstract_inverted_index":{"myo-Inositol-1-phosphate":[0],"synthase":[1],"(mIPS)":[2],"catalyzes":[3,23],"the":[4,12,24,28,32,40,49,52,59,66,69,76,104,129,151,165,177,189,199,211],"conversion":[5],"of":[6,31,39,51,128,154,158,164,173,181,191,204],"glucose-6-phosphate":[7],"(G-6-P)":[8],"to":[9,47,68,96,110,122,160],"inositol-1-phosphate.":[10],"In":[11],"sulfate-reducing":[13],"archaeon":[14],"Archaeoglobus":[15],"fulgidus":[16],"it":[17],"is":[18,186],"a":[19],"metal-dependent":[20],"thermozyme":[21],"that":[22,55,134],"first":[25],"step":[26],"in":[27,75,125,171,188,198],"biosynthetic":[29],"pathway":[30],"unusual":[33],"osmolyte":[34],"di-myo-inositol-1,1'-phosphate.":[35],"Several":[36],"site-specific":[37],"mutants":[38,206],"archaeal":[41],"mIPS":[42],"were":[43,108],"prepared":[44],"and":[45,64,84,86,91,107,146,156],"characterized":[46],"probe":[48],"details":[50],"catalytic":[53,115,212],"mechanism":[54,213],"was":[56],"suggested":[57],"by":[58,65,176],"recently":[60],"solved":[61],"crystal":[62],"structure":[63],"comparison":[67],"yeast":[70],"mIPS.":[71],"Six":[72],"charged":[73,99],"residues":[74,89,100,119],"active":[77,105],"site":[78,106],"(Asp225,":[79],"Lys274,":[80],"Lys278,":[81],"Lys306,":[82],"Asp332,":[83],"Lys367)":[85],"two":[87,142],"noncharged":[88,118],"(Asn255":[90],"Leu257)":[92],"have":[93],"been":[94],"changed":[95],"alanine.":[97],"The":[98,162],"are":[101,120],"located":[102],"at":[103],"proposed":[109,215],"play":[111],"binding":[112,127,172],"and/or":[113],"direct":[114],"roles,":[116],"whereas":[117,141],"likely":[121],"be":[123],"involved":[124],"proper":[126],"substrate.":[130],"Kinetic":[131],"studies":[132],"showed":[133],"only":[135],"N255A":[136],"retains":[137],"any":[138],"measurable":[139],"activity,":[140],"other":[143],"mutants,":[144],"K306A":[145],"D332A,":[147],"can":[148],"carry":[149],"out":[150],"initial":[152],"oxidation":[153],"G-6-P":[155,174,185],"reduction":[157],"NAD+":[159,194],"NADH.":[161],"rest":[163],"mutant":[166],"enzymes":[167],"show":[168],"major":[169],"changes":[170,197],"(monitored":[175],"31P":[178],"line":[179],"width":[180],"inorganic":[182],"phosphate":[183],"when":[184],"added":[187],"presence":[190],"EDTA)":[192],"or":[193],"(detected":[195],"via":[196],"protein":[200],"intrinsic":[201],"fluorescence).":[202],"Characterization":[203],"these":[205],"provides":[207],"new":[208],"twists":[209],"on":[210],"previously":[214],"for":[216],"this":[217],"enzyme.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
