{"id":"https://openalex.org/W2090260786","doi":"https://doi.org/10.1016/j.jphs.2015.02.006","title":"Novel 5-HT5A receptor antagonists ameliorate scopolamine-induced working memory deficit in mice and reference memory impairment in aged rats","display_name":"Novel 5-HT5A receptor antagonists ameliorate scopolamine-induced working memory deficit in mice and reference memory impairment in aged rats","publication_year":2015,"publication_date":"2015-02-18","ids":{"openalex":"https://openalex.org/W2090260786","doi":"https://doi.org/10.1016/j.jphs.2015.02.006","mag":"2090260786","pmid":"https://pubmed.ncbi.nlm.nih.gov/25837935"},"language":"en","primary_location":{"id":"doi:10.1016/j.jphs.2015.02.006","doi":"https://doi.org/10.1016/j.jphs.2015.02.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jphs.2015.02.006","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1347861315000328/pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1347861315000328/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089779113","display_name":"Mayako Yamazaki","orcid":"https://orcid.org/0000-0002-1654-1851","observed_orcids":["https://orcid.org/0000-0002-1654-1851"]},"institutions":[{"id":"https://openalex.org/I142395110","display_name":"Astellas Pharma (Japan)","ror":"https://ror.org/01cjash87","country_code":"JP","type":"company","lineage":["https://openalex.org/I142395110"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mayako Yamazaki","raw_affiliation_strings":["Neuroscience Research Unit, Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan. Electronic address: mayako.yamazaki@astellas.com","Neuroscience Research Unit, Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Unit, Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan. Electronic address: mayako.yamazaki@astellas.com","institution_ids":["https://openalex.org/I142395110"]},{"raw_affiliation_string":"Neuroscience Research Unit, Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan","institution_ids":["https://openalex.org/I142395110"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mayuko Okabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142395110","display_name":"Astellas Pharma (Japan)","ror":"https://ror.org/01cjash87","country_code":"JP","type":"company","lineage":["https://openalex.org/I142395110"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayuko Okabe","raw_affiliation_strings":["Neuroscience Research Unit, Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Unit, Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan","institution_ids":["https://openalex.org/I142395110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101617575","display_name":"Noriyuki Yamamoto","orcid":"https://orcid.org/0000-0002-7654-6718","observed_orcids":["https://orcid.org/0000-0002-7654-6718"]},"institutions":[{"id":"https://openalex.org/I142395110","display_name":"Astellas Pharma (Japan)","ror":"https://ror.org/01cjash87","country_code":"JP","type":"company","lineage":["https://openalex.org/I142395110"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriyuki Yamamoto","raw_affiliation_strings":["Neuroscience Research Unit, Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Unit, Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan","institution_ids":["https://openalex.org/I142395110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066493166","display_name":"Junko Yarimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142395110","display_name":"Astellas Pharma (Japan)","ror":"https://ror.org/01cjash87","country_code":"JP","type":"company","lineage":["https://openalex.org/I142395110"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junko Yarimizu","raw_affiliation_strings":["Neuroscience Research Unit, Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Unit, Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan","institution_ids":["https://openalex.org/I142395110"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103102769","display_name":"Katsuya Harada","orcid":"https://orcid.org/0000-0002-0449-7574","observed_orcids":["https://orcid.org/0000-0002-0449-7574"]},"institutions":[{"id":"https://openalex.org/I142395110","display_name":"Astellas Pharma (Japan)","ror":"https://ror.org/01cjash87","country_code":"JP","type":"company","lineage":["https://openalex.org/I142395110"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuya Harada","raw_affiliation_strings":["Neuroscience Research Unit, Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Unit, Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan","institution_ids":["https://openalex.org/I142395110"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089779113"],"corresponding_institution_ids":["https://openalex.org/I142395110"],"apc_list":{"value":2070,"currency":"USD","value_usd":2070},"apc_paid":{"value":2070,"currency":"USD","value_usd":2070},"fwci":1.6262,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.80152257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"127","issue":"3","first_page":"362","last_page":"369"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-ht5a-receptor","display_name":"5-HT5A receptor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/serotonin-receptor-antagonists","display_name":"serotonin antagonists","score":0.8289999961853027},{"id":"https://openalex.org/keywords/scopolamine-induced-amnesia","display_name":"scopolamine-induced amnesia","score":0.8870000243186951},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.9629999995231628},{"id":"https://openalex.org/keywords/reference-memory","display_name":"reference memory","score":0.9860000014305115},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6380000114440918},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7509999871253967},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9449999928474426},{"id":"https://openalex.org/keywords/olfactory-bulb","display_name":"olfactory bulb","score":0.7670000195503235},{"id":"https://openalex.org/keywords/receptor-occupancy","display_name":"receptor occupancy","score":0.5379999876022339},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2778576352","wikidata":"https://www.wikidata.org/wiki/Q337188","display_name":"Scopolamine","level":2,"score":0.741732656955719},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.6176993250846863},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.5993800163269043},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4682009816169739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4531266689300537},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44776850938796997},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36991703510284424},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.17707204818725586}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008238","descriptor_name":"Lysergic Acid Diethylamide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009830","descriptor_name":"Olfactory Bulb","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jphs.2015.02.006","doi":"https://doi.org/10.1016/j.jphs.2015.02.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jphs.2015.02.006","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1347861315000328/pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},{"id":"pmid:25837935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25837935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b01a7889f4fd426698797771c050b807","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b01a7889f4fd426698797771c050b807","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 362-369 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jphs.2015.02.006","doi":"https://doi.org/10.1016/j.jphs.2015.02.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jphs.2015.02.006","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1347861315000328/pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320324271","display_name":"Astellas Foundation for Research on Metabolic Disorders","ror":"https://ror.org/01cjash87"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2090260786.pdf","grobid_xml":"https://content.openalex.org/works/W2090260786.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W339951692","https://openalex.org/W1555054303","https://openalex.org/W1790958593","https://openalex.org/W1975351746","https://openalex.org/W1976698562","https://openalex.org/W1983235123","https://openalex.org/W1990388039","https://openalex.org/W2001336216","https://openalex.org/W2009615669","https://openalex.org/W2012945651","https://openalex.org/W2019808522","https://openalex.org/W2027399928","https://openalex.org/W2039998766","https://openalex.org/W2041341404","https://openalex.org/W2048510539","https://openalex.org/W2053418873","https://openalex.org/W2058424007","https://openalex.org/W2061833498","https://openalex.org/W2064111465","https://openalex.org/W2067218568","https://openalex.org/W2071200330","https://openalex.org/W2091855875","https://openalex.org/W2110902221","https://openalex.org/W2117805673","https://openalex.org/W2124982452","https://openalex.org/W2273040927","https://openalex.org/W2318039445"],"related_works":["https://openalex.org/W1975351746","https://openalex.org/W2790818339","https://openalex.org/W1995888208","https://openalex.org/W2069849212","https://openalex.org/W2011835802","https://openalex.org/W2044030876","https://openalex.org/W2131605048","https://openalex.org/W2044321262","https://openalex.org/W2275861028","https://openalex.org/W2019562435"],"abstract_inverted_index":{"Despite":[0],"the":[1,9,31,50,61,75,115,137,151,175,183,207],"human":[2],"5-HT5A":[3,33,56,81,107,135,180,197,208,220],"receptor":[4,14,34,57,82,139,209,221],"being":[5],"cloned":[6],"in":[7,40,69,88,159,166,182,188,212],"1994,":[8],"biological":[10],"function":[11],"of":[12,24,44,49,55,91,98,114,118,150,177,186,195],"this":[13,119],"has":[15],"not":[16,232],"been":[17],"extensively":[18],"characterized":[19],"due":[20],"to":[21,112,179],"a":[22,102,129,146,189],"lack":[23],"specific":[25],"ligands.":[26],"We":[27],"recently":[28],"reported":[29],"that":[30,47,109,113,206,217],"selective":[32],"antagonist":[35],"ASP5736":[36,173],"ameliorated":[37,154],"cognitive":[38,92,228],"impairment":[39,165,229],"several":[41],"animal":[42],"models":[43,90],"schizophrenia.":[45],"Given":[46],"areas":[48],"brain":[51,196],"with":[52,95,219,231],"high":[53,103,147],"levels":[54],"expression,":[58],"such":[59],"as":[60],"hippocampus":[62],"and":[63,71,79,86,161,192,214,216],"cerebral":[64],"cortex,":[65],"have":[66],"important":[67],"functions":[68],"cognition":[70],"memory,":[72],"we":[73],"evaluated":[74],"chemically":[76],"diverse,":[77],"potent":[78],"brain-penetrating":[80],"antagonists":[83,222],"ASP5736,":[84],"AS2030680,":[85],"AS2674723":[87],"rodent":[89],"dysfunction":[93],"associated":[94,230],"dementia.":[96,237],"Each":[97,149],"these":[99],"compounds":[100,144,153],"exhibited":[101],"affinity":[104,131],"for":[105,132,140,227],"recombinant":[106],"receptors":[108,181,198],"was":[110,136],"comparable":[111],"non-selective":[116],"ligand":[117],"receptor,":[120],"lysergic":[121],"acid":[122],"diethylamide":[123],"(LSD).":[124],"Although":[125],"each":[126],"compound":[127],"had":[128,145],"low":[130],"other":[133],"receptors,":[134],"only":[138,233],"which":[141],"all":[142],"three":[143,152],"affinity.":[148],"scopolamine-induced":[155],"working":[156],"memory":[157,164,215],"deficit":[158],"mice":[160],"improved":[162],"reference":[163],"aged":[167],"rats":[168,187],"at":[169,199],"similar":[170],"doses.":[171,202],"Further,":[172],"decreased":[174],"binding":[176],"LSD":[178],"olfactory":[184],"bulb":[185],"dose-dependent":[190],"manner":[191],"occupied":[193],"15%-50%":[194],"behaviorally":[200],"effective":[201,226],"These":[203],"results":[204],"indicate":[205],"is":[210],"involved":[211],"learning":[213],"treatment":[218],"might":[223],"be":[224],"broadly":[225],"schizophrenia":[234],"but":[235],"also":[236]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}