{"id":"https://openalex.org/W2090185016","doi":"https://doi.org/10.1161/01.atv.4.3.276","title":"Specific sorbent of apolipoprotein B-containing lipoproteins for plasmapheresis. Characterization and experimental use in hypercholesterolemic rabbits.","display_name":"Specific sorbent of apolipoprotein B-containing lipoproteins for plasmapheresis. Characterization and experimental use in hypercholesterolemic rabbits.","publication_year":1984,"publication_date":"1984-05-01","ids":{"openalex":"https://openalex.org/W2090185016","doi":"https://doi.org/10.1161/01.atv.4.3.276","mag":"2090185016","pmid":"https://pubmed.ncbi.nlm.nih.gov/6712541"},"language":"en","primary_location":{"id":"doi:10.1161/01.atv.4.3.276","doi":"https://doi.org/10.1161/01.atv.4.3.276","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.4.3.276","pdf_url":null,"source":{"id":"https://openalex.org/S4210182225","display_name":"Arteriosclerosis An Official Journal of the American Heart Association Inc","issn_l":"0276-5047","issn":["0276-5047","2330-9180"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis: An Official Journal of the American Heart Association, Inc.","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101897882","display_name":"Shinji Yokoyama","orcid":"https://orcid.org/0000-0003-0552-9168","observed_orcids":["https://orcid.org/0000-0003-0552-9168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Yokoyama","raw_affiliation_strings":["S Yokoyama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S Yokoyama","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073602201","display_name":"Rikuro HAYASHI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Hayashi","raw_affiliation_strings":["R Hayashi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R Hayashi","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034922501","display_name":"Toshiro Kikkawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kikkawa","raw_affiliation_strings":["T Kikkawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"T Kikkawa","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056129781","display_name":"Nobutaka Tani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Tani","raw_affiliation_strings":["N Tani"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N Tani","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102706910","display_name":"Satoshi Takada","orcid":"https://orcid.org/0000-0002-0070-0379","observed_orcids":["https://orcid.org/0000-0002-0070-0379","https://orcid.org/0009-0003-4508-0868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Takada","raw_affiliation_strings":["S Takada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S Takada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109843996","display_name":"K. Hatanaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Hatanaka","raw_affiliation_strings":["K Hatanaka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K Hatanaka","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022444323","display_name":"Akira Yamamoto","orcid":"https://orcid.org/0000-0002-1058-4762","observed_orcids":["https://orcid.org/0000-0002-1058-4762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Yamamoto","raw_affiliation_strings":["A Yamamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A Yamamoto","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5204,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.96116455,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"4","issue":"3","first_page":"276","last_page":"282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-b-containing-lipoproteins","display_name":"apolipoprotein B-containing lipoproteins","score":0.9549999833106995},{"id":"https://openalex.org/keywords/plasmapheresis","display_name":"plasmapheresis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/dextran-sulfate","display_name":"dextran sulfate","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cellulose-beads","display_name":"cellulose beads","score":0.7289999723434448},{"id":"https://openalex.org/keywords/very-low-density-lipoprotein","display_name":"VLDL","score":0.8920000195503235},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/high-density-lipoprotein","display_name":"high-density lipoprotein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/langmuir-isotherm","display_name":"Langmuir isotherm","score":0.8730000257492065},{"id":"https://openalex.org/keywords/extracorporeal-circulation","display_name":"extracorporeal circulation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/whhl-rabbits","display_name":"WHHL rabbits","score":0.6959999799728394},{"id":"https://openalex.org/keywords/plasma-cholesterol-reduction","display_name":"plasma cholesterol reduction","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C2777899863","wikidata":"https://www.wikidata.org/wiki/Q4428995","display_name":"Sorbent","level":3,"score":0.9371322989463806},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7680497169494629},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7115477323532104},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.6090065240859985},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.5452826619148254},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.5268981456756592},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.48669368028640747},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.4368639290332794},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24617356061935425},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.22991523146629333},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10301271080970764}],"mesh":[{"descriptor_ui":"D000327","descriptor_name":"Adsorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001053","descriptor_name":"Apolipoproteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008079","descriptor_name":"Lipoproteins, VLDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010956","descriptor_name":"Plasmapheresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.atv.4.3.276","doi":"https://doi.org/10.1161/01.atv.4.3.276","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.4.3.276","pdf_url":null,"source":{"id":"https://openalex.org/S4210182225","display_name":"Arteriosclerosis An Official Journal of the American Heart Association Inc","issn_l":"0276-5047","issn":["0276-5047","2330-9180"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis: An Official Journal of the American Heart Association, Inc.","raw_type":"journal-article"},{"id":"pmid:6712541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6712541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis (Dallas, Tex.)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.603.755","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.603.755","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://atvb.ahajournals.org/content/4/3/276.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1512559452","https://openalex.org/W1775749144","https://openalex.org/W1964836458","https://openalex.org/W1973398390","https://openalex.org/W1986319425","https://openalex.org/W1989432650","https://openalex.org/W1997858206","https://openalex.org/W2017234187","https://openalex.org/W2029592237","https://openalex.org/W2035067938","https://openalex.org/W2035241127","https://openalex.org/W2037581676","https://openalex.org/W2072302631","https://openalex.org/W2082607114","https://openalex.org/W2092716180","https://openalex.org/W2163746841","https://openalex.org/W2321230622","https://openalex.org/W2410423649","https://openalex.org/W3034983005"],"related_works":["https://openalex.org/W2162604125","https://openalex.org/W2406714202","https://openalex.org/W624569613","https://openalex.org/W2006454585","https://openalex.org/W7098890077","https://openalex.org/W1999435485","https://openalex.org/W2091112588","https://openalex.org/W4210754079","https://openalex.org/W2993424477","https://openalex.org/W2019162665"],"abstract_inverted_index":{"Dextran":[0],"sulfate":[1],"was":[2,63,87,128],"covalently":[3],"bound":[4],"to":[5,32],"cellulose":[6],"beads":[7],"(LA01)":[8],"and":[9,28,71,77,95,137,148],"used":[10,129],"as":[11],"the":[12,33,43,49,54,105,112,116,131],"specific":[13],"sorbent":[14,50,91,127,144],"of":[15,22,45,80,133,162],"apolipoprotein":[16],"B-containing":[17],"lipoproteins.":[18],"The":[19],"binding":[20,62],"profiles":[21],"very":[23,69,93,146],"low":[24,26,70,72,94,96,147,149],"density,":[25,27],"high":[29,59,106],"density":[30,60,73,97,107,150],"lipoproteins":[31,47,74,98,108,151],"material":[34],"were":[35,51,99,109,152],"consistent":[36],"with":[37,115,125],"simple":[38],"Langmuir":[39],"adsorption":[40],"isotherms.":[41],"Although":[42],"affinities":[44],"all":[46,104],"for":[48,58,68,130],"roughly":[52],"similar,":[53],"surface":[55],"area":[56],"available":[57],"lipoprotein":[61],"much":[64],"smaller":[65],"than":[66],"that":[67],"(29,":[75],"927,":[76],"1934":[78],"m2/liter":[79],"swollen":[81],"beads,":[82],"respectively).":[83],"When":[84],"human":[85],"plasma":[86,119,163],"passed":[88],"through":[89],"a":[90,141,160],"column,":[92,145],"selectively":[100,153],"adsorbed,":[101],"while":[102],"almost":[103],"recovered":[110],"from":[111,155],"column":[113],"together":[114],"other":[117],"major":[118],"components.":[120],"An":[121],"extracorporeal":[122],"circulation":[123],"system":[124],"this":[126],"treatment":[132],"hypercholesterolemic":[134],"rabbits":[135],"(diet-induced":[136],"homozygous":[138],"WHHL).":[139],"With":[140],"25":[142],"ml":[143],"removed":[154],"rabbit":[156],"plasma,":[157],"resulting":[158],"in":[159],"reduction":[161],"cholesterol":[164],"concentration":[165],"by":[166],"300":[167],"mg/dl.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}