{"id":"https://openalex.org/W2090163793","doi":"https://doi.org/10.1177/1758834011423540","title":"Future directions in the evaluation of c-MET-driven malignancies","display_name":"Future directions in the evaluation of c-MET-driven malignancies","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2090163793","doi":"https://doi.org/10.1177/1758834011423540","mag":"2090163793","pmid":"https://pubmed.ncbi.nlm.nih.gov/22128288","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3225021"},"language":"en","primary_location":{"id":"doi:10.1177/1758834011423540","doi":"https://doi.org/10.1177/1758834011423540","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1758834011423540","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1758834011423540","source":{"id":"https://openalex.org/S41085503","display_name":"Therapeutic Advances in Medical Oncology","issn_l":"1758-8340","issn":["1758-8340","1758-8359"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Medical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/1758834011423540","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072378199","display_name":"Johann Sebastian De Bono","orcid":"https://orcid.org/0000-0002-2034-595X","observed_orcids":["https://orcid.org/0000-0002-2034-595X"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Johann S. de Bono","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Downs Road, Sutton, Surrey, SM2 5PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Downs Road, Sutton, Surrey, SM2 5PT, UK","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068368047","display_name":"Timothy Anthony Yap","orcid":"https://orcid.org/0000-0002-2154-3309","observed_orcids":["https://orcid.org/0000-0002-2154-3309"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timothy A. Yap","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":0.2251,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62086605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"3","issue":"1_suppl","first_page":"S51","last_page":"S60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hgf-c-met-signaling","display_name":"HGF/MET signaling","score":0.7940000295639038},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.871999979019165},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9589999914169312},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/anticancer-drug-development","display_name":"anticancer drug development","score":0.800000011920929},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7996386289596558},{"id":"https://openalex.org/C2781064419","wikidata":"https://www.wikidata.org/wiki/Q795057","display_name":"Cabozantinib","level":3,"score":0.587685227394104},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.5741814374923706},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5654700398445129},{"id":"https://openalex.org/C2780467284","wikidata":"https://www.wikidata.org/wiki/Q5005897","display_name":"C-Met","level":4,"score":0.5065172910690308},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.48034894466400146},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.47939085960388184},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4781673550605774},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.47670453786849976},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4673958718776703},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43603378534317017},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4148849844932556},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4132225513458252},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3996780216693878},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34007886052131653},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3093492388725281},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24134302139282227},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11475187540054321},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07989639043807983},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1177/1758834011423540","doi":"https://doi.org/10.1177/1758834011423540","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1758834011423540","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1758834011423540","source":{"id":"https://openalex.org/S41085503","display_name":"Therapeutic Advances in Medical Oncology","issn_l":"1758-8340","issn":["1758-8340","1758-8359"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Medical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3225021","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3225021","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Adv Med Oncol","raw_type":"Text"},{"id":"pmid:22128288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22128288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic advances in medical oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5b1fd7bac1f54676ad05d24570b03e62","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5b1fd7bac1f54676ad05d24570b03e62","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Therapeutic Advances in Medical Oncology, Vol 3 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/1758834011423540","doi":"https://doi.org/10.1177/1758834011423540","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1758834011423540","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1758834011423540","source":{"id":"https://openalex.org/S41085503","display_name":"Therapeutic Advances in Medical Oncology","issn_l":"1758-8340","issn":["1758-8340","1758-8359"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Medical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2090163793.pdf"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1539293283","https://openalex.org/W1549144603","https://openalex.org/W1556788203","https://openalex.org/W1966803171","https://openalex.org/W1967394241","https://openalex.org/W1972607682","https://openalex.org/W1985995844","https://openalex.org/W1986159749","https://openalex.org/W1989050480","https://openalex.org/W1990115557","https://openalex.org/W1994912526","https://openalex.org/W1998450601","https://openalex.org/W1998971866","https://openalex.org/W1999868376","https://openalex.org/W2002790722","https://openalex.org/W2018456517","https://openalex.org/W2020224707","https://openalex.org/W2022527563","https://openalex.org/W2025528595","https://openalex.org/W2026104033","https://openalex.org/W2029480581","https://openalex.org/W2037356096","https://openalex.org/W2051782283","https://openalex.org/W2052378862","https://openalex.org/W2054022422","https://openalex.org/W2060641884","https://openalex.org/W2074242691","https://openalex.org/W2093613683","https://openalex.org/W2096844786","https://openalex.org/W2103146352","https://openalex.org/W2105841693","https://openalex.org/W2114556798","https://openalex.org/W2120795894","https://openalex.org/W2121262970","https://openalex.org/W2123326378","https://openalex.org/W2125440931","https://openalex.org/W2125519805","https://openalex.org/W2125954956","https://openalex.org/W2136146667","https://openalex.org/W2136390065","https://openalex.org/W2138309116","https://openalex.org/W2138896702","https://openalex.org/W2142564546","https://openalex.org/W2147786790","https://openalex.org/W2148479145","https://openalex.org/W2148885898","https://openalex.org/W2148971037","https://openalex.org/W2154402764","https://openalex.org/W2157158866","https://openalex.org/W2160725767","https://openalex.org/W2163981356","https://openalex.org/W2167344440","https://openalex.org/W2219581640","https://openalex.org/W2247320956","https://openalex.org/W2279974145","https://openalex.org/W2318605753","https://openalex.org/W2563709161","https://openalex.org/W2564488107","https://openalex.org/W2588925404"],"related_works":["https://openalex.org/W4412713762","https://openalex.org/W4205502918","https://openalex.org/W2073597573","https://openalex.org/W2016579969","https://openalex.org/W2410553787","https://openalex.org/W3171106033","https://openalex.org/W4289530376","https://openalex.org/W2074904551","https://openalex.org/W7202139260","https://openalex.org/W1992031126"],"abstract_inverted_index":{"The":[0,55,128],"c-MET":[1,38],"(mesenchymal-epithelial":[2],"transition":[3,116],"factor)":[4],"receptor":[5],"tyrosine":[6],"kinase":[7],"is":[8,63,107],"an":[9,108],"exciting":[10],"novel":[11],"drug":[12],"target":[13],"in":[14,20,30,43,80,171],"view":[15],"of":[16,33,58,71,100,117,134,143,156,174],"its":[17,25],"key":[18],"role":[19],"oncogenesis,":[21],"as":[22,24,93,98,151,153],"well":[23,152],"association":[26],"with":[27,126,164],"disease":[28],"prognosis":[29],"a":[31,81,86,94,101,165],"number":[32],"malignancies.":[34,176],"Several":[35],"drugs":[36,147],"targeting":[37],"are":[39],"currently":[40],"showing":[41],"promise":[42],"clinical":[44],"trials":[45],"and":[46,113,148],"will":[47],"hopefully":[48],"validate":[49],"positive":[50],"observations":[51],"from":[52],"preclinical":[53,118],"studies.":[54],"potential":[56],"efficacy":[57],"these":[59,162],"different":[60],"therapeutic":[61,103,122],"agents":[62,136],"expected":[64],"to":[65,111],"be":[66],"influenced":[67],"by":[68],"the":[69,115,132,141,154,172],"mechanism":[70],"aberrant":[72],"hepatocyte":[73],"growth":[74],"factor":[75],"(HGF)/c-MET":[76],"signaling":[77],"pathway":[78],"activation":[79],"particular":[82,166],"cancer,":[83],"but":[84],"presents":[85],"promising":[87],"strategy":[88],"for":[89,124,137],"cancer":[90,138],"treatment":[91,139],"either":[92],"single":[95],"agent":[96],"or":[97],"part":[99],"combination":[102,149],"approach.":[104],"However,":[105],"there":[106],"ongoing":[109],"need":[110],"improve":[112],"accelerate":[114],"research":[119],"into":[120],"improved":[121],"strategies":[123],"patients":[125],"cancer.":[127],"main":[129],"challenges":[130],"facing":[131],"development":[133],"HGF/c-MET-targeted":[135],"include":[140],"discovery":[142],"rationally":[144],"designed":[145],"anticancer":[146],"strategies,":[150],"validation":[155],"predictive":[157],"biomarkers.":[158],"This":[159],"paper":[160],"discusses":[161],"issues,":[163],"focus":[167],"on":[168],"future":[169],"directions":[170],"evaluation":[173],"c-MET-driven":[175]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
