{"id":"https://openalex.org/W2090115932","doi":"https://doi.org/10.1152/ajpcell.00151.2007","title":"Distinct pathways of ERK activation by the muscarinic agonists pilocarpine and carbachol in a human salivary cell line","display_name":"Distinct pathways of ERK activation by the muscarinic agonists pilocarpine and carbachol in a human salivary cell line","publication_year":2008,"publication_date":"2008-04-03","ids":{"openalex":"https://openalex.org/W2090115932","doi":"https://doi.org/10.1152/ajpcell.00151.2007","mag":"2090115932","pmid":"https://pubmed.ncbi.nlm.nih.gov/18385290"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.00151.2007","doi":"https://doi.org/10.1152/ajpcell.00151.2007","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00151.2007","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102105898","display_name":"Alan L. Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan L. Lin","raw_affiliation_strings":["Department of Dental Diagnostic Science, University of Texas Health Science Center, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Diagnostic Science, University of Texas Health Science Center, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bing Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bing Zhu","raw_affiliation_strings":["","University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":null,"display_name":"WanKe Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WanKe Zhang","raw_affiliation_strings":["","University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110076980","display_name":"Howard Dang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard Dang","raw_affiliation_strings":["","Developmental Dentistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Developmental Dentistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113618924","display_name":"Bin-Xian Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin-Xian Zhang","raw_affiliation_strings":["","Comprehensive Dentistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Comprehensive Dentistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael S. Katz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael S. Katz","raw_affiliation_strings":["","Comprehensive Dentistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Comprehensive Dentistry","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043757062","display_name":"Chih\u2010Ko Yeh","orcid":"https://orcid.org/0000-0001-6611-9942","observed_orcids":["https://orcid.org/0000-0001-6611-9942"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chih-Ko Yeh","raw_affiliation_strings":["","Comprehensive Dentistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Comprehensive Dentistry","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7598,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.68228875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"294","issue":"6","first_page":"C1454","last_page":"C1464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.7445999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.7445999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.11800000071525574,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.09629999846220016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erk1-2-activation","display_name":"ERK1/2 activation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pilocarpine","display_name":"pilocarpine","score":0.878000020980835},{"id":"https://openalex.org/keywords/carbachol","display_name":"carbachol","score":1.0},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.8650000095367432},{"id":"https://openalex.org/keywords/muscarinic-m3-receptor","display_name":"M3 muscarinic receptor","score":0.7599999904632568},{"id":"https://openalex.org/keywords/m1-receptor","display_name":"M1 receptor","score":0.9819999933242798},{"id":"https://openalex.org/keywords/salivary-glands","display_name":"salivary glands","score":0.6420000195503235},{"id":"https://openalex.org/keywords/salivary-cells","display_name":"salivary cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/egf-receptor-transactivation","display_name":"EGF receptor transactivation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.718999981880188},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8820000290870667},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.6970000267028809},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.5690000057220459},{"id":"https://openalex.org/keywords/xerostomia","display_name":"xerostomia","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C2778988552","wikidata":"https://www.wikidata.org/wiki/Q419401","display_name":"Carbachol","level":3,"score":0.9229030609130859},{"id":"https://openalex.org/C2777204577","wikidata":"https://www.wikidata.org/wiki/Q411461","display_name":"Pilocarpine","level":3,"score":0.8487389087677002},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.7252736687660217},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5891296863555908},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5725507736206055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5635989308357239},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5520791411399841},{"id":"https://openalex.org/C116289061","wikidata":"https://www.wikidata.org/wiki/Q17861955","display_name":"Muscarinic acetylcholine receptor M3","level":4,"score":0.528296709060669},{"id":"https://openalex.org/C207723603","wikidata":"https://www.wikidata.org/wiki/Q17861926","display_name":"Muscarinic acetylcholine receptor M1","level":4,"score":0.4970104992389679},{"id":"https://openalex.org/C2778616617","wikidata":"https://www.wikidata.org/wiki/Q419550","display_name":"Pirenzepine","level":4,"score":0.48916104435920715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2848300337791443},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2778553366661072},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.20918729901313782},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.18752846121788025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13311511278152466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09946450591087341},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.06598770618438721},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002217","descriptor_name":"Carbachol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010306","descriptor_name":"Parotid Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010306","descriptor_name":"Parotid Gland","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010862","descriptor_name":"Pilocarpine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018721","descriptor_name":"Muscarinic Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043587","descriptor_name":"Receptor, Muscarinic M3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043587","descriptor_name":"Receptor, Muscarinic M3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043587","descriptor_name":"Receptor, Muscarinic M3","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D043643","descriptor_name":"Receptor, Muscarinic M1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.00151.2007","doi":"https://doi.org/10.1152/ajpcell.00151.2007","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00151.2007","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:18385290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18385290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Cell physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6421634986","display_name":"Endothelial cell Ca2+ homoestasis and fatty acid effects","funder_award_id":"R01HL075011","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G919008438","display_name":"Salivary Stem Cell Identification for Tissue Restoration","funder_award_id":"R21DE015381","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W46184420","https://openalex.org/W148785554","https://openalex.org/W1565099167","https://openalex.org/W1699577610","https://openalex.org/W1845953708","https://openalex.org/W1856204339","https://openalex.org/W1965188809","https://openalex.org/W1966090845","https://openalex.org/W1966717825","https://openalex.org/W1969900856","https://openalex.org/W1970676821","https://openalex.org/W1979828510","https://openalex.org/W1983297072","https://openalex.org/W1988511882","https://openalex.org/W1994042430","https://openalex.org/W1996228949","https://openalex.org/W1997320822","https://openalex.org/W1998883743","https://openalex.org/W2002803308","https://openalex.org/W2005822178","https://openalex.org/W2010897402","https://openalex.org/W2021909983","https://openalex.org/W2031789764","https://openalex.org/W2035202152","https://openalex.org/W2042631205","https://openalex.org/W2051379292","https://openalex.org/W2052438966","https://openalex.org/W2081640740","https://openalex.org/W2083858338","https://openalex.org/W2084176896","https://openalex.org/W2084974301","https://openalex.org/W2085886710","https://openalex.org/W2102042038","https://openalex.org/W2102455218","https://openalex.org/W2114864480","https://openalex.org/W2121518247","https://openalex.org/W2129783259","https://openalex.org/W2155547273","https://openalex.org/W2167108385","https://openalex.org/W2175224397","https://openalex.org/W2178317988","https://openalex.org/W2272457211","https://openalex.org/W2286318020","https://openalex.org/W2411059849","https://openalex.org/W2415290982","https://openalex.org/W2419577964","https://openalex.org/W2442174276","https://openalex.org/W3144853614","https://openalex.org/W4285719527","https://openalex.org/W7203499059"],"related_works":["https://openalex.org/W2089751376","https://openalex.org/W2129783259","https://openalex.org/W1856204339","https://openalex.org/W2031789764","https://openalex.org/W7208408800","https://openalex.org/W2107964872","https://openalex.org/W3177032305","https://openalex.org/W2756130218","https://openalex.org/W2186728214","https://openalex.org/W2147252913"],"abstract_inverted_index":{"Cholinergic-muscarinic":[0],"receptor":[1,84,145,183,197],"agonists":[2,51],"are":[3,218],"used":[4],"to":[5,128,155],"alleviate":[6],"mouth":[7],"dryness,":[8],"although":[9],"the":[10,14,28,62,82,96,143,159,167,209,243],"cellular":[11],"signals":[12],"mediating":[13],"actions":[15,210],"of":[16,30,55,61,88,93,112,140,171,211,232],"these":[17],"agents":[18],"on":[19,108,242],"salivary":[20,42,216],"glands":[21],"have":[22],"not":[23,77,119,132,181],"been":[24],"identified.":[25],"We":[26],"examined":[27],"activation":[29,54,73,122,194,202],"ERK1/2":[31],"by":[32,74,81,90,116,123,173,178,203],"two":[33,221],"muscarinic":[34,144],"agonists,":[35],"pilocarpine":[36,58,109,130,174,212],"and":[37,195,213,229,235,240],"carbachol,":[38,78,129],"in":[39,136,215],"a":[40],"human":[41],"cell":[43],"line":[44],"(HSY).":[45],"Immunoblot":[46],"analysis":[47],"revealed":[48],"that":[49,208],"both":[50,156],"induced":[52,59],"transient":[53],"ERK1/2.":[56],"Whereas":[57],"phosphorylation":[60,103],"epidermal":[63],"growth":[64],"factor":[65],"(EGF)":[66],"receptor,":[67],"carbachol":[68,168,214,236],"did":[69,118,131],"not.":[70],"Moreover,":[71],"ERK":[72,102,121,153,193,201,244],"pilocarpine,":[75],"but":[76,104,180],"was":[79,175],"abolished":[80],"EGF":[83,196,233],"inhibitor":[85,189],"AG-1478.":[86],"Downregulation":[87],"PKC":[89],"prolonged":[91],"treatment":[92],"cells":[94,141,217],"with":[95,142],"phorbol":[97],"ester":[98],"PMA":[99],"diminished":[100],"carbachol-induced":[101],"had":[105],"no":[106],"effect":[107],"responsiveness.":[110],"Depletion":[111],"intracellular":[113],"Ca2+":[114],"([Ca2+]i":[115],"EGTA":[117],"affect":[120],"either":[124],"agent.":[125],"In":[126],"contrast":[127],"elicit":[133],"[Ca2+]i":[134],"mobilization":[135],"HSY":[137],"cells.":[138],"Treatment":[139],"subtype":[146,160],"3":[147],"(M3)":[148],"antagonist":[149,163],"N-(3-chloropropyl)-4-piperidnyl":[150],"diphenylacetate":[151],"decreased":[152,177],"responsiveness":[154],"agents,":[157],"whereas":[158],"1":[161],"(M1)":[162],"pirenzepine":[164],"reduced":[165],"only":[166],"response.":[169],"Stimulation":[170],"ERKs":[172],"also":[176],"M3,":[179],"M1,":[182],"small":[184],"interfering":[185],"RNA.":[186],"The":[187],"Src":[188],"PP2":[190],"blocked":[191],"pilocarpine-induced":[192],"phosphorylation,":[198],"without":[199],"affecting":[200],"carbachol.":[204],"Our":[205],"results":[206],"demonstrate":[207],"mediated":[219],"through":[220],"distinct":[222],"signaling":[223],"mechanisms-pilocarpine":[224],"acting":[225],"via":[226,237],"M3":[227],"receptors":[228,239],"Src-dependent":[230],"transactivation":[231],"receptors,":[234],"M1/M3":[238],"PKC-converging":[241],"pathway.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}