{"id":"https://openalex.org/W2090081036","doi":"https://doi.org/10.1111/j.1600-0609.1996.tb01384.x","title":"Salvage chemotherapy for relapsed or refractory non\u2010Hodgkin's lymphoma with a combination of ACES (high\u2010dose Ara C, carboplatin, etoposide and steroids) therapy","display_name":"Salvage chemotherapy for relapsed or refractory non\u2010Hodgkin's lymphoma with a combination of ACES (high\u2010dose Ara C, carboplatin, etoposide and steroids) therapy","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W2090081036","doi":"https://doi.org/10.1111/j.1600-0609.1996.tb01384.x","mag":"2090081036","pmid":"https://pubmed.ncbi.nlm.nih.gov/8982296"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0609.1996.tb01384.x","doi":"https://doi.org/10.1111/j.1600-0609.1996.tb01384.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0609.1996.tb01384.x","pdf_url":null,"source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051372277","display_name":"Nozomi Niitsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"N. Niitsu","raw_affiliation_strings":["First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078749313","display_name":"Masanori Umeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Umeda","raw_affiliation_strings":["The First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051372277"],"corresponding_institution_ids":["https://openalex.org/I129634264"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":0.2965,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.5626054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"57","issue":"4","first_page":"320","last_page":"324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salvage-chemotherapy","display_name":"salvage chemotherapy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/relapsed-non-hodgkin-s-lymphoma","display_name":"relapsed non-Hodgkin's lymphoma","score":0.968999981880188},{"id":"https://openalex.org/keywords/high-dose-cytarabine","display_name":"high-dose cytarabine","score":0.9459999799728394},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":1.0},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.8759999871253967},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9290000200271606},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.7860000133514404},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8830000162124634},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.4909999966621399},{"id":"https://openalex.org/keywords/granulocytopenia","display_name":"granulocytopenia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.8406555652618408},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8056036233901978},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.7884055376052856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6525511145591736},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.5963459014892578},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.589057207107544},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5726242661476135},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.546440839767456},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5101342797279358},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.4868273138999939},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4479408860206604},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4417176842689514},{"id":"https://openalex.org/C2778476748","wikidata":"https://www.wikidata.org/wiki/Q1138590","display_name":"Non-Hodgkin's lymphoma","level":3,"score":0.4361022710800171},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.05162978172302246},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008775","descriptor_name":"Methylprednisolone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0609.1996.tb01384.x","doi":"https://doi.org/10.1111/j.1600-0609.1996.tb01384.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0609.1996.tb01384.x","pdf_url":null,"source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:8982296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8982296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of haematology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1605164920","https://openalex.org/W1827669382","https://openalex.org/W1874309326","https://openalex.org/W1881397173","https://openalex.org/W1911976151","https://openalex.org/W1979300931","https://openalex.org/W1994351520","https://openalex.org/W2005541439","https://openalex.org/W2055147379","https://openalex.org/W2117964879","https://openalex.org/W2167805334","https://openalex.org/W2273109191","https://openalex.org/W2395495313","https://openalex.org/W2410954598","https://openalex.org/W2441783071","https://openalex.org/W2473507984"],"related_works":["https://openalex.org/W2082670418","https://openalex.org/W2782058498","https://openalex.org/W1980104261","https://openalex.org/W21319454","https://openalex.org/W2064460484","https://openalex.org/W347035928","https://openalex.org/W2077126828","https://openalex.org/W1543339576","https://openalex.org/W2029346234","https://openalex.org/W1836056413"],"abstract_inverted_index":{"ACES":[0,50],"(Ara-C,":[1],"carboplatin,":[2],"etoposide,":[3],"steroids)":[4],"therapy":[5,51,99],"using":[6,45],"granulocyte-colony":[7],"stimulating":[8],"factor":[9],"(G-CSF)":[10],"was":[11,100,131,152,161,183,205],"designed":[12],"for":[13,63,82,117,143,200],"relapsed":[14,36,208],"or":[15,122,168],"refractory":[16,40],"non-Hodgkin's":[17],"lymphoma":[18],"(NHL),":[19],"and":[20,24,38,58,89,136,155,177,197,210],"the":[21,67,75,86,95,114,125,156],"therapeutic":[22],"effects":[23],"adverse":[25,217],"reactions":[26,164],"were":[27,31,109],"studied.":[28],"The":[29,49,107,148],"subjects":[30],"40":[32,126],"patients,":[33,127],"including":[34],"19":[35],"cases":[37],"21":[39],"cases,":[41],"subjected":[42],"to":[43,111,187],"chemotherapy":[44],"anthracycline":[46],"type":[47],"agents.":[48],"consisted":[52],"of":[53,113,146,165,193],"carboplatin":[54],"at":[55,60,71,79,91],"100":[56],"mg/m2":[57,62],"etoposide":[59],"80":[61],"4":[64],"d":[65,84],"from":[66,85,94],"first":[68,87],"day,":[69,77],"Ara-C":[70],"2":[72,92],"g/m2":[73],"on":[74],"fifth":[76],"solumedrol":[78],"500":[80],"mg":[81],"5":[83],"day":[88],"G-CSF":[90],"micrograms/kg":[93],"seventh":[96],"day.":[97],"This":[98,203],"performed":[101,213],"every":[102],"3":[103,167],"weeks,":[104],"in":[105,133,140,172,175,179],"principle.":[106],"doses":[108],"reduced":[110],"70%":[112],"above":[115],"values":[116],"patients":[118,190],"aged":[119],"70":[120],"yr":[121],"older.":[123],"Among":[124],"complete":[128],"remission":[129,138],"(CR)":[130],"achieved":[132],"14":[134,141],"(35%)":[135,142],"partial":[137],"(PR)":[139],"a":[144],"response":[145],"70%.":[147],"50%":[149],"survival":[150,159],"period":[151],"526":[153],"d,":[154],"2-yr":[157],"disease-free":[158],"rate":[160],"58.3%.":[162],"Adverse":[163],"grade":[166],"higher":[169],"included":[170],"granulocytopenia":[171],"62.5%,":[173],"anemia":[174],"17.5%":[176],"thrombocytopenia":[178],"50%,":[180],"but":[181],"there":[182],"no":[184],"death":[185],"related":[186],"treatment.":[188],"Four":[189],"underwent":[191],"transplantation":[192],"hematopoietic":[194],"stem":[195],"cells":[196],"have":[198],"survived":[199],"long":[201],"periods.":[202],"treatment":[204],"effective":[206],"against":[207],"NHL":[209],"could":[211],"be":[212],"safely":[214],"with":[215],"few":[216],"reactions.":[218]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
