{"id":"https://openalex.org/W2089968858","doi":"https://doi.org/10.1016/s0304-4165(01)00211-2","title":"Kinetic parameters for small-molecule drug delivery by covalent cell surface targeting","display_name":"Kinetic parameters for small-molecule drug delivery by covalent cell surface targeting","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2089968858","doi":"https://doi.org/10.1016/s0304-4165(01)00211-2","mag":"2089968858","pmid":"https://pubmed.ncbi.nlm.nih.gov/11750762"},"language":"en","primary_location":{"id":"doi:10.1016/s0304-4165(01)00211-2","doi":"https://doi.org/10.1016/s0304-4165(01)00211-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-4165(01)00211-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210238601","display_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","issn_l":"0304-4165","issn":["0304-4165","1872-8006"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060054638","display_name":"David A. Nauman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Nauman","raw_affiliation_strings":["Department of Chemistry, University of California-Berkeley, Berkeley, CA 94720, USA","Department of Chemistry, University of California, Berkeley, CA 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California-Berkeley, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Chemistry, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088409133","display_name":"Carolyn Ruth Bertozzi","orcid":"https://orcid.org/0000-0003-4482-2754","observed_orcids":["https://orcid.org/0000-0003-4482-2754"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carolyn R. Bertozzi","raw_affiliation_strings":["Department of Chemistry, University of California, Berkeley, CA 94720, USA","Department of Molecular Cell Biology, University of California, Berkeley, CA 94720, USA","Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088409133"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I95457486"],"apc_list":{"value":3310,"currency":"USD","value_usd":3310},"apc_paid":null,"fwci":0.5819,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.64050332,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1568","issue":"2","first_page":"147","last_page":"154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.5512999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.5512999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.3181000053882599,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.04740000143647194,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-molecule-drug-delivery","display_name":"small molecule drug delivery","score":0.8809999823570251},{"id":"https://openalex.org/keywords/chemoselective-ligation","display_name":"chemoselective ligation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cell-surface-glycoconjugates","display_name":"cell surface glycoconjugates","score":0.9269999861717224},{"id":"https://openalex.org/keywords/kinetic-parameters","display_name":"kinetic parameters","score":0.5580000281333923},{"id":"https://openalex.org/keywords/hydrolysis-rate-constants","display_name":"hydrolysis rate constants","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.7238450646400452},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6262284517288208},{"id":"https://openalex.org/C2777738585","wikidata":"https://www.wikidata.org/wiki/Q170744","display_name":"Ketone","level":2,"score":0.6043530702590942},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.591440737247467},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4738747775554657},{"id":"https://openalex.org/C2780115458","wikidata":"https://www.wikidata.org/wiki/Q419311","display_name":"Sialic acid","level":2,"score":0.46889203786849976},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.45487579703330994},{"id":"https://openalex.org/C93391505","wikidata":"https://www.wikidata.org/wiki/Q658700","display_name":"Reaction rate constant","level":3,"score":0.41063833236694336},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.37767672538757324},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3637475371360779},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2475777268409729},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21780964732170105},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.15644589066505432},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006595","descriptor_name":"Hexosamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006595","descriptor_name":"Hexosamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007659","descriptor_name":"Ketones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012794","descriptor_name":"Sialic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0304-4165(01)00211-2","doi":"https://doi.org/10.1016/s0304-4165(01)00211-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-4165(01)00211-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210238601","display_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","issn_l":"0304-4165","issn":["0304-4165","1872-8006"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","raw_type":"journal-article"},{"id":"pmid:11750762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11750762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1199060901","display_name":null,"funder_award_id":"R01 GM 58867-01","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000880016","display_name":"Chemical glycobiology tool development: Proximity-based modalities","funder_award_id":"R01GM058867","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1490688374","https://openalex.org/W1520029826","https://openalex.org/W1574498833","https://openalex.org/W1647383865","https://openalex.org/W1886907949","https://openalex.org/W1965381942","https://openalex.org/W1966954785","https://openalex.org/W1979260134","https://openalex.org/W1981520090","https://openalex.org/W1987966136","https://openalex.org/W1989104087","https://openalex.org/W1994349020","https://openalex.org/W1997692114","https://openalex.org/W2011495830","https://openalex.org/W2020737596","https://openalex.org/W2023423234","https://openalex.org/W2035194423","https://openalex.org/W2044582684","https://openalex.org/W2044708833","https://openalex.org/W2054922338","https://openalex.org/W2055642315","https://openalex.org/W2055713782","https://openalex.org/W2057153919","https://openalex.org/W2072590705","https://openalex.org/W2077924138","https://openalex.org/W2087774895","https://openalex.org/W2106595936","https://openalex.org/W2108514136","https://openalex.org/W2113471132","https://openalex.org/W2117052700","https://openalex.org/W2182561260","https://openalex.org/W2330907418","https://openalex.org/W2896860430","https://openalex.org/W4388243180"],"related_works":["https://openalex.org/W2072590705","https://openalex.org/W1987966136","https://openalex.org/W1595841096","https://openalex.org/W7214623367","https://openalex.org/W2412667829","https://openalex.org/W2129106319","https://openalex.org/W35816609","https://openalex.org/W2399660201","https://openalex.org/W2118939320","https://openalex.org/W2104644534"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
