{"id":"https://openalex.org/W2089938014","doi":"https://doi.org/10.1167/iovs.12-10938","title":"TREM-2 Promotes Host Resistance Against Pseudomonas aeruginosa Infection by Suppressing Corneal Inflammation via a PI3K/Akt Signaling Pathway","display_name":"TREM-2 Promotes Host Resistance Against Pseudomonas aeruginosa Infection by Suppressing Corneal Inflammation via a PI3K/Akt Signaling Pathway","publication_year":2013,"publication_date":"2013-04-23","ids":{"openalex":"https://openalex.org/W2089938014","doi":"https://doi.org/10.1167/iovs.12-10938","mag":"2089938014","pmid":"https://pubmed.ncbi.nlm.nih.gov/23611998","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3658264"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.12-10938","doi":"https://doi.org/10.1167/iovs.12-10938","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.12-10938","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/933469/i1552-5783-54-5-3451.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/933469/i1552-5783-54-5-3451.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012872535","display_name":"Mingxia Sun","orcid":"https://orcid.org/0000-0002-3937-390X","observed_orcids":["https://orcid.org/0000-0002-3937-390X","https://orcid.org/0009-0007-7616-8052"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingxia Sun","raw_affiliation_strings":["Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035218462","display_name":"Min Zhu","orcid":"https://orcid.org/0000-0003-0023-3747","observed_orcids":["https://orcid.org/0000-0003-0023-3747"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Zhu","raw_affiliation_strings":["Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 2State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of","Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 2State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]},{"raw_affiliation_string":"Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447198","display_name":"Kang Chen","orcid":"https://orcid.org/0000-0003-0276-2474","observed_orcids":["https://orcid.org/0000-0003-0276-2474"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kang Chen","raw_affiliation_strings":["Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023613693","display_name":"Xinxin Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinxin Nie","raw_affiliation_strings":["Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051716075","display_name":"Qiuchan Deng","orcid":"https://orcid.org/0000-0002-3562-6324","observed_orcids":["https://orcid.org/0000-0002-3562-6324"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiuchan Deng","raw_affiliation_strings":["Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053675854","display_name":"Linda D. Hazlett","orcid":"https://orcid.org/0000-0003-1530-3242","observed_orcids":["https://orcid.org/0000-0003-1530-3242"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda D. Hazlett","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080445750","display_name":"Yongjian Wu","orcid":"https://orcid.org/0000-0003-1234-8760","observed_orcids":["https://orcid.org/0000-0003-1234-8760"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongjian Wu","raw_affiliation_strings":["Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009423959","display_name":"Meiyu Li","orcid":"https://orcid.org/0000-0002-2707-9615","observed_orcids":["https://orcid.org/0000-0002-2707-9615"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiyu Li","raw_affiliation_strings":["Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004681952","display_name":"Minhao Wu","orcid":"https://orcid.org/0000-0002-8711-868X","observed_orcids":["https://orcid.org/0000-0002-8711-868X"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minhao Wu","raw_affiliation_strings":["Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087787304","display_name":"Xi Huang","orcid":"https://orcid.org/0000-0002-4829-8390","observed_orcids":["https://orcid.org/0000-0002-4829-8390"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xi Huang","raw_affiliation_strings":["Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087787304"],"corresponding_institution_ids":["https://openalex.org/I157773358"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":5.9093,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.96119504,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"54","issue":"5","first_page":"3451","last_page":"3451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.24320000410079956,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trem2","display_name":"TREM2","score":1.0},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9509999752044678},{"id":"https://openalex.org/keywords/bacterial-keratitis","display_name":"bacterial keratitis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/keratitis","display_name":"keratitis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9589999914169312},{"id":"https://openalex.org/keywords/host-resistance","display_name":"host resistance","score":0.7900000214576721},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8050000071525574},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.8209999799728394},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.8700000047683716},{"id":"https://openalex.org/keywords/wortmannin","display_name":"wortmannin","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8087906241416931},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5264164805412292},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5045286417007446},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47788894176483154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4561334252357483},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4519096612930298},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41713306307792664},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4107973873615265},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.23565798997879028},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14408251643180847}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015169","descriptor_name":"Colony Count, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015818","descriptor_name":"Eye Infections, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015818","descriptor_name":"Eye Infections, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015818","descriptor_name":"Eye Infections, Bacterial","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1167/iovs.12-10938","doi":"https://doi.org/10.1167/iovs.12-10938","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.12-10938","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/933469/i1552-5783-54-5-3451.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2802960","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3658264","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23611998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23611998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3658264","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3658264/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Invest Ophthalmol Vis Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1167/iovs.12-10938","doi":"https://doi.org/10.1167/iovs.12-10938","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.12-10938","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/933469/i1552-5783-54-5-3451.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1022687494","display_name":null,"funder_award_id":"2011Y035","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G1479137238","display_name":null,"funder_award_id":"20100171110047","funder_id":"https://openalex.org/F4320336024","funder_display_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China"},{"id":"https://openalex.org/G156324800","display_name":null,"funder_award_id":"81261160323","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1757385683","display_name":"Attacking the Global Problem of Antimicrobial Resistance","funder_award_id":"R01EY016058","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G2037558836","display_name":null,"funder_award_id":"U0832006","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2072431842","display_name":null,"funder_award_id":"10251008901000013","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G2104499215","display_name":null,"funder_award_id":"2011Y035","funder_id":"https://openalex.org/F4320333334","funder_display_name":"Guangdong Province Introduction of Innovative R&D Team"},{"id":"https://openalex.org/G421110680","display_name":null,"funder_award_id":"81172811","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4224273064","display_name":null,"funder_award_id":"2009010058","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4708718232","display_name":null,"funder_award_id":"2009010058","funder_id":"https://openalex.org/F4320333334","funder_display_name":"Guangdong Province Introduction of Innovative R&D Team"},{"id":"https://openalex.org/G5381977887","display_name":null,"funder_award_id":"2009010058","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5401515598","display_name":null,"funder_award_id":"No. 2009010058","funder_id":"https://openalex.org/F4320333334","funder_display_name":"Guangdong Province Introduction of Innovative R&D Team"},{"id":"https://openalex.org/G5751125607","display_name":null,"funder_award_id":"31200662","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6589828840","display_name":null,"funder_award_id":"S2012040006680","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G7442726885","display_name":"Role of Triggering Receptors Expressed on Myeloid Cells in Bacterial Keratitis","funder_award_id":"R01EY019021","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G841709106","display_name":null,"funder_award_id":"2009010058","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G9000863115","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY004068","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320329903","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333334","display_name":"Guangdong Province Introduction of Innovative R&D Team","ror":null},{"id":"https://openalex.org/F4320336024","display_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","ror":null},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2089938014.pdf","grobid_xml":"https://content.openalex.org/works/W2089938014.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W122165383","https://openalex.org/W1536674483","https://openalex.org/W1575242432","https://openalex.org/W1594774706","https://openalex.org/W1615829672","https://openalex.org/W1643888758","https://openalex.org/W1712936277","https://openalex.org/W1805681402","https://openalex.org/W1840611749","https://openalex.org/W1917677571","https://openalex.org/W1938273074","https://openalex.org/W1965225193","https://openalex.org/W1966416481","https://openalex.org/W1969548666","https://openalex.org/W1986564074","https://openalex.org/W1986899130","https://openalex.org/W1993216157","https://openalex.org/W2000349011","https://openalex.org/W2009242793","https://openalex.org/W2009886463","https://openalex.org/W2010817360","https://openalex.org/W2011719826","https://openalex.org/W2014926360","https://openalex.org/W2024306318","https://openalex.org/W2033579947","https://openalex.org/W2034452980","https://openalex.org/W2037605075","https://openalex.org/W2039862342","https://openalex.org/W2043799115","https://openalex.org/W2045628444","https://openalex.org/W2051731334","https://openalex.org/W2058177423","https://openalex.org/W2063603929","https://openalex.org/W2065737885","https://openalex.org/W2068666775","https://openalex.org/W2074800088","https://openalex.org/W2078900016","https://openalex.org/W2079111811","https://openalex.org/W2079537922","https://openalex.org/W2080204807","https://openalex.org/W2080503511","https://openalex.org/W2083746808","https://openalex.org/W2086964969","https://openalex.org/W2090134990","https://openalex.org/W2106141541","https://openalex.org/W2112425640","https://openalex.org/W2116858503","https://openalex.org/W2118751252","https://openalex.org/W2121590561","https://openalex.org/W2123646630","https://openalex.org/W2124881273","https://openalex.org/W2139075966","https://openalex.org/W2141710755","https://openalex.org/W2163175900","https://openalex.org/W2170107264","https://openalex.org/W2758601031","https://openalex.org/W4312808386","https://openalex.org/W6684172825","https://openalex.org/W7126786685"],"related_works":["https://openalex.org/W2106141541","https://openalex.org/W1035119604","https://openalex.org/W7095287012","https://openalex.org/W2802625088","https://openalex.org/W2083674522","https://openalex.org/W2944241989","https://openalex.org/W2083746808","https://openalex.org/W2563595758","https://openalex.org/W3205453216","https://openalex.org/W2806271954"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"explore":[2],"the":[3,64,181,219,250],"role":[4,65],"of":[5,37,66,104,126,192,206,225,249],"triggering":[6],"receptor":[7],"expressed":[8],"on":[9],"myeloid":[10],"cells":[11],"2":[12],"(TREM-2)":[13],"in":[14,68,98,101,115,131,154,180,218,228],"Pseudomonas":[15],"aeruginosa":[16],"(PA)":[17],"keratitis.":[18,70,213],"METHODS:":[19],"BALB/c":[20,48,160,183],"mice":[21,51,161],"were":[22,52,76,90,110,129,162],"routinely":[23],"infected":[24,182],"with":[25,55,120,142,164],"PA":[26,69,212,232,241],"and":[27,44,49,73,81,86,95,100,137,166,171,201,223],"evaluated":[28],"at":[29,185],"various":[30],"postinfection":[31],"time":[32],"points":[33],"for":[34,144,168],"corneal":[35,202,233,245],"expression":[36,89,177],"TREM-2,":[38],"by":[39,78,92,112,197,243],"real-time":[40,93],"PCR,":[41],"Western":[42,113],"blot,":[43],"flow":[45],"cytometry.":[46],"Next,":[47],"C57BL/6":[50],"respectively":[53],"treated":[54,163],"TREM-2":[56,67,135,176,193,207,236],"siRNA":[57],"or":[58,146,187],"agonistic":[59,121],"anti-TREM-2":[60,122],"antibody,":[61],"to":[62,148,211,240],"determine":[63,149],"Bacterial":[71],"load":[72,170,200],"neutrophil":[74],"infiltration":[75],"tested":[77,91,111],"plate":[79],"count":[80],"myeloperoxidase":[82],"assay,":[83],"respectively.":[84],"Th1-/Th2-type":[85],"proinflammatory":[87,127,172],"cytokine":[88,173],"PCR":[94],"ELISA":[96],"after":[97,118,134,231],"vivo":[99],"vitro":[102],"silencing":[103],"TREM-2.":[105],"Moreover,":[106],"phosphorylated":[107],"Akt":[108],"levels":[109,125],"blot":[114],"murine":[116,132],"macrophages":[117,133],"treatment":[119],"antibody.":[123],"mRNA":[124],"cytokines":[128],"examined":[130],"activation":[136,205,248],"lipopolysaccharide":[138],"stimulation,":[139],"following":[140],"pretreatment":[141],"inhibitors":[143],"PI3K":[145,226],"Akt,":[147],"whether":[150],"PI3K/Akt":[151,214,251],"is":[152,216],"required":[153,217],"TREM-2-mediated":[155,220],"immune":[156,221],"modulation.":[157],"In":[158],"addition,":[159],"wortmannin":[165],"analyzed":[167],"bacterial":[169,199],"expression.":[174],"RESULTS:":[175],"was":[178],"elevated":[179],"corneas":[184],"3":[186],"5":[188],"days":[189],"postinfection.":[190],"Silencing":[191],"accelerated":[194],"disease":[195,230],"progression":[196],"enhancing":[198],"inflammation,":[203],"whereas":[204],"promoted":[208,237],"host":[209,238],"resistance":[210,239],"signaling":[215],"modulation,":[222],"inhibition":[224],"resulted":[227],"worsened":[229],"infection.":[234],"CONCLUSIONS:":[235],"infection":[242],"suppressing":[244],"inflammation":[246],"via":[247],"pathway.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
