{"id":"https://openalex.org/W2089923904","doi":"https://doi.org/10.1126/science.2163544","title":"Mediation of Wound-Related Rous Sarcoma Virus Tumorigenesis by TGF-\u03b2","display_name":"Mediation of Wound-Related Rous Sarcoma Virus Tumorigenesis by TGF-\u03b2","publication_year":1990,"publication_date":"1990-06-29","ids":{"openalex":"https://openalex.org/W2089923904","doi":"https://doi.org/10.1126/science.2163544","mag":"2089923904","pmid":"https://pubmed.ncbi.nlm.nih.gov/2163544"},"language":"en","primary_location":{"id":"doi:10.1126/science.2163544","doi":"https://doi.org/10.1126/science.2163544","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.2163544","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022397653","display_name":"Michael H. Sieweke","orcid":"https://orcid.org/0000-0002-3228-9537","observed_orcids":["https://orcid.org/0000-0002-3228-9537"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H. Sieweke","raw_affiliation_strings":["Cell and Molecular Biology Division, Lawrence Berkeley Laboratory, University of California, Berkeley, CA 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Molecular Biology Division, Lawrence Berkeley Laboratory, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nancy L. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy L. Thompson","raw_affiliation_strings":["Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108192090","display_name":"Michael B. Sporn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Sporn","raw_affiliation_strings":["Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072917052","display_name":"Mina J. Bissell","orcid":"https://orcid.org/0000-0001-5841-4423","observed_orcids":["https://orcid.org/0000-0001-5841-4423"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mina J. Bissell","raw_affiliation_strings":["Cell and Molecular Biology Division, Lawrence Berkeley Laboratory, University of California, Berkeley, CA 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Molecular Biology Division, Lawrence Berkeley Laboratory, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.1762,"has_fulltext":false,"cited_by_count":205,"citation_normalized_percentile":{"value":0.97379515,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"248","issue":"4963","first_page":"1656","last_page":"1660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rous-sarcoma-virus","display_name":"Rous sarcoma virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.6779999732971191},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.5210000276565552},{"id":"https://openalex.org/keywords/tumor-induction","display_name":"tumor induction","score":0.6629999876022339},{"id":"https://openalex.org/keywords/chickens","display_name":"chickens","score":0.3569999933242798},{"id":"https://openalex.org/keywords/v-src-oncogene","display_name":"v-src oncogene","score":0.7260000109672546},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.5730000138282776},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.8579999804496765},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9079999923706055},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8899999856948853},{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7849330902099609},{"id":"https://openalex.org/C2777441520","wikidata":"https://www.wikidata.org/wiki/Q1444330","display_name":"Rous sarcoma virus","level":3,"score":0.775720477104187},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.6812599897384644},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.58920818567276},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.5594567060470581},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5090303421020508},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.49250468611717224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4920949339866638},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.49201127886772156},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.4659403860569},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3543410003185272},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3338526487350464},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32138118147850037},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23227819800376892},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22290724515914917},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19288191199302673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18718314170837402},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09324648976325989}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001357","descriptor_name":"Sarcoma, Avian","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001357","descriptor_name":"Sarcoma, Avian","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.2163544","doi":"https://doi.org/10.1126/science.2163544","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.2163544","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:2163544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2163544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W79720118","https://openalex.org/W1542358602","https://openalex.org/W1583155141","https://openalex.org/W1593177203","https://openalex.org/W1936384492","https://openalex.org/W1980035932","https://openalex.org/W1983031935","https://openalex.org/W1997419670","https://openalex.org/W2031468048","https://openalex.org/W2042965746","https://openalex.org/W2043366026","https://openalex.org/W2050973237","https://openalex.org/W2053131178","https://openalex.org/W2062565240","https://openalex.org/W2068769994","https://openalex.org/W2074585769","https://openalex.org/W2087272945","https://openalex.org/W2090851364","https://openalex.org/W2099941826","https://openalex.org/W2106480106","https://openalex.org/W2107718611","https://openalex.org/W2108104357","https://openalex.org/W2168476587","https://openalex.org/W2314203153","https://openalex.org/W2414738336","https://openalex.org/W2421141831","https://openalex.org/W2895451238"],"related_works":["https://openalex.org/W1775141903","https://openalex.org/W2043366026","https://openalex.org/W1936384492","https://openalex.org/W2067323580","https://openalex.org/W2107718611","https://openalex.org/W2093013756","https://openalex.org/W2002344491","https://openalex.org/W2062565240","https://openalex.org/W1968324730","https://openalex.org/W2411526628"],"abstract_inverted_index":{"In":[0,54],"Rous":[1],"sarcoma":[2],"virus":[3],"(RSV)-infected":[4],"chickens,":[5],"wounding":[6,70],"leads":[7],"to":[8,32,100],"tumor":[9,72,101],"formation":[10,102],"with":[11,89,116],"nearly":[12],"100%":[13,90],"frequency":[14],"in":[15,36,71,86,103,119,182],"tissues":[16],"that":[17,42,166],"would":[18],"otherwise":[19],"remain":[20],"tumor-free.":[21],"Identifying":[22],"molecular":[23],"mediators":[24],"of":[25,58,77,80,83,94,105],"this":[26,183],"phenomenon":[27],"should":[28],"yield":[29],"important":[30],"clues":[31],"the":[33,106,125,157],"mechanisms":[34],"involved":[35],"RSV":[37,172],"tumorigenesis.":[38],"Immunohistochemical":[39],"staining":[40],"showed":[41],"TGF-beta":[43,84,154],"is":[44],"present":[45],"locally":[46],"shortly":[47],"after":[48,151],"wounding,":[49],"but":[50],"not":[51,123],"unwounded":[52],"controls.":[53],"addition,":[55],"subcutaneous":[56],"administration":[57],"recombinant":[59],"transforming":[60],"growth":[61,114,129,139,144],"factor-beta":[62],"1":[63],"(TGF-beta":[64],"1)":[65],"could":[66],"substitute":[67],"completely":[68],"for":[69,171,180],"induction.":[73],"A":[74],"treatment":[75],"protocol":[76],"four":[78,92],"doses":[79,93],"800":[81],"nanograms":[82,97],"resulted":[85],"v-src-expressing":[87],"tumors":[88,150],"frequency;":[91],"only":[95,148],"10":[96],"still":[98],"led":[99],"80%":[104],"animals.":[107],"This":[108],"effect":[109],"was":[110],"specific,":[111],"as":[112,177],"other":[113],"factors":[115],"suggested":[117],"roles":[118],"wound":[120],"healing":[121],"did":[122],"elicit":[124],"same":[126],"response.":[127],"Epidermal":[128],"factor":[130,140],"(EGF)":[131],"or":[132,142],"TGF-alpha":[133],"had":[134],"no":[135],"effect,":[136],"and":[137,174],"platelet-derived":[138],"(PDGF)":[141],"insulin-like":[143],"factor-1":[145],"(IGF-1)":[146],"yielded":[147],"occasional":[149],"longer":[152],"latency.":[153],"release":[155],"during":[156],"wound-healing":[158],"response":[159],"may":[160,175],"thus":[161],"be":[162],"a":[163,168,178],"critical":[164],"event":[165],"creates":[167],"conducive":[169],"environment":[170],"tumorigenesis":[173],"act":[176],"cofactor":[179],"transformation":[181],"system.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
