{"id":"https://openalex.org/W2089900699","doi":"https://doi.org/10.1038/oby.2010.13","title":"Lack of Association Between PCK1 Polymorphisms and Obesity, Physical Activity, and Fitness in European Youth Heart Study (EYHS)","display_name":"Lack of Association Between PCK1 Polymorphisms and Obesity, Physical Activity, and Fitness in European Youth Heart Study (EYHS)","publication_year":2010,"publication_date":"2010-02-04","ids":{"openalex":"https://openalex.org/W2089900699","doi":"https://doi.org/10.1038/oby.2010.13","mag":"2089900699","pmid":"https://pubmed.ncbi.nlm.nih.gov/20134411"},"language":"en","primary_location":{"id":"doi:10.1038/oby.2010.13","doi":"https://doi.org/10.1038/oby.2010.13","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2010.13","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2010.13","source":{"id":"https://openalex.org/S29918858","display_name":"Obesity","issn_l":"1930-7381","issn":["1930-7381","1930-739X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2010.13","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047095747","display_name":"Karani Santhanakrishnan Vimaleswaran","orcid":"https://orcid.org/0000-0002-8485-8930","observed_orcids":["https://orcid.org/0000-0002-8485-8930"]},"institutions":[{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karani S. Vimaleswaran","raw_affiliation_strings":["Institute of Metabolic Science, MRC Epidemiology Unit, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Metabolic Science, MRC Epidemiology Unit, Cambridge, UK","institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I4210158597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024645589","display_name":"Paul W. Franks","orcid":"https://orcid.org/0000-0002-0520-7604","observed_orcids":["https://orcid.org/0000-0002-0520-7604"]},"institutions":[{"id":"https://openalex.org/I4210099621","display_name":"University Hospital of Ume\u00e5","ror":"https://ror.org/012k96e85","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210099621"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"Paul W. Franks","raw_affiliation_strings":["Genetic Epidemiology and Clinical Research Group, Division of Medicine, Department of Public Health and Clinical Medicine, Umea\u030a University Hospital, Umea\u030a, Sweden","Institute of Metabolic Science, MRC Epidemiology Unit, Cambridge, UK","Genetic Epidemiology and Clinical Research Group, Division of Medicine, Department of Public Health and Clinical Medicine, Ume\u00e5 University Hospital, Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Epidemiology and Clinical Research Group, Division of Medicine, Department of Public Health and Clinical Medicine, Umea\u030a University Hospital, Umea\u030a, Sweden","institution_ids":["https://openalex.org/I4210099621"]},{"raw_affiliation_string":"Institute of Metabolic Science, MRC Epidemiology Unit, Cambridge, UK","institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I4210158597"]},{"raw_affiliation_string":"Genetic Epidemiology and Clinical Research Group, Division of Medicine, Department of Public Health and Clinical Medicine, Ume\u00e5 University Hospital, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I4210099621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005269147","display_name":"S\u00f8ren Brage","orcid":"https://orcid.org/0000-0002-1265-7355","observed_orcids":["https://orcid.org/0000-0002-1265-7355"]},"institutions":[{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Soren Brage","raw_affiliation_strings":["Institute of Metabolic Science, MRC Epidemiology Unit, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Metabolic Science, MRC Epidemiology Unit, Cambridge, UK","institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I4210158597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046830376","display_name":"Anders Gr\u00f8ntved","orcid":"https://orcid.org/0000-0003-1584-679X","observed_orcids":["https://orcid.org/0000-0003-1584-679X"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anders Grontved","raw_affiliation_strings":["Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100717719","display_name":"Nicholas J. Wareham","orcid":"https://orcid.org/0000-0003-1422-2993","observed_orcids":["https://orcid.org/0000-0003-1422-2993"]},"institutions":[{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas J. Wareham","raw_affiliation_strings":["Institute of Metabolic Science, MRC Epidemiology Unit, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Metabolic Science, MRC Epidemiology Unit, Cambridge, UK","institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I4210158597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064338533","display_name":"Ulf Ekelund","orcid":"https://orcid.org/0000-0003-2115-9267","observed_orcids":["https://orcid.org/0000-0003-2115-9267"]},"institutions":[{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ulf Ekelund","raw_affiliation_strings":["Institute of Metabolic Science, MRC Epidemiology Unit, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Metabolic Science, MRC Epidemiology Unit, Cambridge, UK","institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I4210158597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016233543","display_name":"Ruth J. F. Loos","orcid":"https://orcid.org/0000-0002-8532-5087","observed_orcids":["https://orcid.org/0000-0002-8532-5087"]},"institutions":[{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ruth J.F. Loos","raw_affiliation_strings":["Institute of Metabolic Science, MRC Epidemiology Unit, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Metabolic Science, MRC Epidemiology Unit, Cambridge, UK","institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I4210158597"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016233543"],"corresponding_institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I4210158597"],"apc_list":{"value":4980,"currency":"USD","value_usd":4980},"apc_paid":null,"fwci":0.1797,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.57592324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"18","issue":"10","first_page":"1975","last_page":"1980"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.15610000491142273,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10010","display_name":"Obesity, Physical Activity, Diet","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pck1","display_name":"PCK1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9169999957084656},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/physical-fitness","display_name":"physical fitness","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hepatic-gluconeogenesis","display_name":"hepatic gluconeogenesis","score":0.921999990940094},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.7480000257492065},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8970000147819519},{"id":"https://openalex.org/keywords/waist-circumference","display_name":"waist circumference","score":0.9789999723434448},{"id":"https://openalex.org/keywords/skinfold-thickness","display_name":"skinfold thickness","score":0.9340000152587891},{"id":"https://openalex.org/keywords/overweight","display_name":"overweight","score":0.39399999380111694},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.680281937122345},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.6551158428192139},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.5876228213310242},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.5865107774734497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5557231903076172},{"id":"https://openalex.org/C171687745","wikidata":"https://www.wikidata.org/wiki/Q309252","display_name":"Physical fitness","level":2,"score":0.45108893513679504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3035728931427002},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.12916868925094604},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001837","descriptor_name":"Body Weights and Measures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003718","descriptor_name":"Denmark","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004957","descriptor_name":"Estonia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010729","descriptor_name":"Phosphoenolpyruvate Carboxykinase (GTP)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010809","descriptor_name":"Physical Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/oby.2010.13","doi":"https://doi.org/10.1038/oby.2010.13","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2010.13","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2010.13","source":{"id":"https://openalex.org/S29918858","display_name":"Obesity","issn_l":"1930-7381","issn":["1930-7381","1930-739X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity","raw_type":"journal-article"},{"id":"pmid:20134411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20134411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity (Silver Spring, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:sdu.dk:openaire_cris_publications/89da1f43-68bc-4476-98d5-8ab8980abc8c","doi":null,"is_oa":false,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/89da1f43-68bc-4476-98d5-8ab8980abc8c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vimaleswaran, K S, Franks, P W, Brage, S, Gr\u00f8ntved, A, Wareham, N J, Ekelund, U & Loos, R J F 2010, 'Lack of association between PCK1 polymorphisms and obesity, physical activity, and fitness in European Youth Heart Study (EYHS)', Obesity, vol. 18, no. 10, pp. 1975-80. https://doi.org/10.1038/oby.2010.13","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:centaur.reading.ac.uk:34656","doi":null,"is_oa":true,"landing_page_url":"https://centaur.reading.ac.uk/view/creators/90005601.html>","pdf_url":"https://centaur.reading.ac.uk/34656/1/oby.2010.13.pdf","source":{"id":"https://openalex.org/S4306402273","display_name":"CentAUR (University of Reading)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71052956","host_organization_name":"University of Reading","host_organization_lineage":["https://openalex.org/I71052956"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1385222","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1385222/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Obesity (Silver Spring) , 18 (10) pp. 1975-1980. (2010)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/oby.2010.13","doi":"https://doi.org/10.1038/oby.2010.13","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2010.13","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2010.13","source":{"id":"https://openalex.org/S29918858","display_name":"Obesity","issn_l":"1930-7381","issn":["1930-7381","1930-739X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5899999737739563}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309763","display_name":"Hjerteforeningen","ror":"https://ror.org/0375vv569"},{"id":"https://openalex.org/F4320310483","display_name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","ror":"https://ror.org/03ge1nb22"},{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320321018","display_name":"Eesti Teadusfondi","ror":"https://ror.org/00jjeja18"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320323799","display_name":"Syddansk Universitet","ror":"https://ror.org/03yrrjy16"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2089900699.pdf","grobid_xml":"https://content.openalex.org/works/W2089900699.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1570013080","https://openalex.org/W1604537227","https://openalex.org/W1607418727","https://openalex.org/W1915172443","https://openalex.org/W1971729606","https://openalex.org/W1987476157","https://openalex.org/W1989165206","https://openalex.org/W1991042824","https://openalex.org/W2025980820","https://openalex.org/W2026653395","https://openalex.org/W2029412665","https://openalex.org/W2033893422","https://openalex.org/W2037202398","https://openalex.org/W2059746178","https://openalex.org/W2062042168","https://openalex.org/W2065967041","https://openalex.org/W2066826642","https://openalex.org/W2073582448","https://openalex.org/W2073875251","https://openalex.org/W2077097398","https://openalex.org/W2077918092","https://openalex.org/W2089255385","https://openalex.org/W2090157020","https://openalex.org/W2092966600","https://openalex.org/W2094785612","https://openalex.org/W2096413829","https://openalex.org/W2096589896","https://openalex.org/W2099352432","https://openalex.org/W2099711963","https://openalex.org/W2104129218","https://openalex.org/W2106571787","https://openalex.org/W2120181458","https://openalex.org/W2126583131","https://openalex.org/W2129150286","https://openalex.org/W2145915583","https://openalex.org/W2157037423","https://openalex.org/W2158963518","https://openalex.org/W2163144326","https://openalex.org/W2166431807","https://openalex.org/W2167192842","https://openalex.org/W2171952619","https://openalex.org/W3204901048","https://openalex.org/W4249306982"],"related_works":["https://openalex.org/W4389069942","https://openalex.org/W2766937430","https://openalex.org/W2062042168","https://openalex.org/W4308890817","https://openalex.org/W2129604539","https://openalex.org/W2075444104","https://openalex.org/W4388622312","https://openalex.org/W1968691125","https://openalex.org/W2469698613","https://openalex.org/W1983885209"],"abstract_inverted_index":{"Phosphoenolpyruvate":[0],"carboxykinase-1":[1],"(PCK1)":[2],"is":[3,214],"the":[4,8,43,60,63,86,118,123,129,166,170,188,201,215,221,240],"rate-limiting":[5],"enzyme":[6],"in":[7,19,22,42,68,122,165,239],"hepatic":[9],"gluconeogenic":[10],"pathway.":[11],"Studies":[12],"have":[13],"shown":[14],"that":[15,116],"overexpression":[16],"of":[17,28,62,96,138,169,179,190,223,248],"Pck1":[18],"mice":[20],"results":[21],"obesity-related":[23,47],"traits":[24],"and":[25,50,52,57,77,82,106,132,142,156,183,185,203,207,229,254],"higher":[26],"levels":[27],"physical":[29],"activity":[30],"(PA).":[31],"Therefore,":[32],"our":[33,237],"aims":[34],"were":[35,71,159,172,209],"to":[36,53,218,244],"investigate":[37],"whether":[38,55],"common":[39,119],"genetic":[40,120],"variation":[41],"PCK1":[44,64,124,130,224,249],"gene":[45],"influences":[46],"traits,":[48],"PA,":[49,141,182,206,228,253],"fitness,":[51,184],"examine":[54,220],"PA":[56],"fitness":[58,143,208],"attenuate":[59],"influence":[61],"polymorphisms":[65,115,131,171,202,225,250],"on":[66,73],"obesity":[67],"children.":[69],"Analyses":[70],"undertaken":[72],"data":[74],"from":[75,85,234],"Danish":[76],"Estonian":[78],"children":[79,97],"(958":[80],"boys":[81],"1,104":[83],"girls)":[84],"European":[87],"Youth":[88],"Heart":[89],"Study":[90],"(EYHS),":[91],"a":[92],"school-based,":[93],"cross-sectional":[94],"study":[95,217,238],"(mean":[98],"\u00b1":[99,103,109],"s.d.":[100],"age:":[101],"9.6":[102],"0.4":[104],"years)":[105],"adolescents":[107],"(15.5":[108],"0.5":[110],"years).":[111],"We":[112],"genotyped":[113],"eight":[114],"captured":[117],"variations":[121],"gene.":[125],"The":[126,198],"association":[127,222,247],"between":[128,200],"BMI,":[133,176],"waist":[134],"circumference":[135],"(WC),":[136],"sum":[137,178],"four":[139,180],"skinfolds,":[140,181],"was":[144],"tested":[145,160],"using":[146],"an":[147,246],"additive":[148],"model":[149],"adjusted":[150],"for":[151],"age,":[152],"age-group,":[153,204],"gender,":[154,205],"maturity,":[155],"country.":[157],"Interactions":[158],"by":[161],"including":[162],"interaction":[163],"terms":[164],"model.":[167],"None":[168],"significantly":[173],"associated":[174],"with":[175,187,226,251],"WC,":[177],"also":[186],"risk":[189],"being":[191],"overweight":[192],"or":[193],"obese":[194],"(P":[195],">":[196],"0.05).":[197],"interactions":[199],"not":[210],"statistically":[211],"significant.":[212],"This":[213],"first":[216],"comprehensively":[219],"obesity,":[227,252],"fitness.":[230,255],"Despite":[231],"strong":[232],"evidence":[233],"animal":[235],"studies,":[236],"EYHS":[241],"cohort":[242],"failed":[243],"identify":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}