{"id":"https://openalex.org/W2089784154","doi":"https://doi.org/10.1128/aac.00359-08","title":"Inhibition of Herpes Simplex Virus Types 1 and 2 In Vitro Infection by Sulfated Derivatives of Escherichia coli K5 Polysaccharide","display_name":"Inhibition of Herpes Simplex Virus Types 1 and 2 In Vitro Infection by Sulfated Derivatives of Escherichia coli K5 Polysaccharide","publication_year":2008,"publication_date":"2008-06-24","ids":{"openalex":"https://openalex.org/W2089784154","doi":"https://doi.org/10.1128/aac.00359-08","mag":"2089784154","pmid":"https://pubmed.ncbi.nlm.nih.gov/18573926","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2533499"},"language":"en","primary_location":{"id":"doi:10.1128/aac.00359-08","doi":"https://doi.org/10.1128/aac.00359-08","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.00359-08","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2533499/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009919822","display_name":"Debora Pinna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debora Pinna","raw_affiliation_strings":["Viral Pathogens and Biosafety Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Viral Pathogens and Biosafety Unit","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019992897","display_name":"Pasqua Oreste","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pasqua Oreste","raw_affiliation_strings":["Glycores 2000 S.r.l"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glycores 2000 S.r.l","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041368161","display_name":"Tiziana Coradin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tiziana Coradin","raw_affiliation_strings":["Viral Pathogens and Biosafety Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Viral Pathogens and Biosafety Unit","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013633344","display_name":"Anna Kajaste\u2010Rudnitski","orcid":"https://orcid.org/0000-0003-1549-2426","observed_orcids":["https://orcid.org/0000-0003-1549-2426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Kajaste-Rudnitski","raw_affiliation_strings":["Viral Pathogens and Biosafety Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Viral Pathogens and Biosafety Unit","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002836937","display_name":"Silvia Ghezzi","orcid":"https://orcid.org/0000-0002-7586-663X","observed_orcids":["https://orcid.org/0000-0002-7586-663X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvia Ghezzi","raw_affiliation_strings":["Viral Pathogens and Biosafety Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Viral Pathogens and Biosafety Unit","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000563099","display_name":"Giorgio Zoppetti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgio Zoppetti","raw_affiliation_strings":["Glycores 2000 S.r.l"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glycores 2000 S.r.l","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089008457","display_name":"Antonella Rotola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella Rotola","raw_affiliation_strings":["Department of Experimental and Diagnostic Medicine, Section of Microbiology, University of Ferrara, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Diagnostic Medicine, Section of Microbiology, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031712590","display_name":"Rafaela Argnani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rafaela Argnani","raw_affiliation_strings":["Department of Experimental and Diagnostic Medicine, Section of Microbiology, University of Ferrara, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Diagnostic Medicine, Section of Microbiology, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019228154","display_name":"Guido Poli","orcid":"https://orcid.org/0000-0001-7241-4526","observed_orcids":["https://orcid.org/0000-0001-7241-4526"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Guido Poli","raw_affiliation_strings":["AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute","Vita-Salute San Raffaele University, School of Medicine, Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"Vita-Salute San Raffaele University, School of Medicine, Milan","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067484713","display_name":"Roberto Manservigi","orcid":"https://orcid.org/0000-0002-2827-229X","observed_orcids":["https://orcid.org/0000-0002-2827-229X"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Manservigi","raw_affiliation_strings":["Department of Experimental and Diagnostic Medicine, Section of Microbiology, University of Ferrara, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Diagnostic Medicine, Section of Microbiology, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062067515","display_name":"Elisa Vicenzi","orcid":"https://orcid.org/0000-0003-0051-3968","observed_orcids":["https://orcid.org/0000-0003-0051-3968"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elisa Vicenzi","raw_affiliation_strings":["Viral Pathogens and Biosafety Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Viral Pathogens and Biosafety Unit","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062067515"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9978,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.85954202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"52","issue":"9","first_page":"3078","last_page":"3084"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-2","display_name":"herpes simplex virus type 2","score":1.0},{"id":"https://openalex.org/keywords/sulfated-polysaccharides","display_name":"sulfated polysaccharides","score":0.9229999780654907},{"id":"https://openalex.org/keywords/microbicides","display_name":"microbicides","score":0.8330000042915344},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/virus-entry-inhibition","display_name":"viral entry inhibition","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cell-to-cell-spread","display_name":"cell-to-cell transmission","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hiv-1-transmission","display_name":"HIV-1 transmission","score":0.7509999871253967},{"id":"https://openalex.org/keywords/genital-herpes","display_name":"genital herpes","score":0.8009999990463257},{"id":"https://openalex.org/keywords/heparin-like-glycosaminoglycans","display_name":"heparin-like glycosaminoglycans","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.8393037915229797},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.807545006275177},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6605145931243896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5775565505027771},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5294318199157715},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5175842046737671},{"id":"https://openalex.org/C155138218","wikidata":"https://www.wikidata.org/wiki/Q994559","display_name":"Sulfation","level":2,"score":0.5167340636253357},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.45886915922164917},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45048898458480835},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.44043588638305664},{"id":"https://openalex.org/C3019340110","wikidata":"https://www.wikidata.org/wiki/Q525512","display_name":"Sexual transmission","level":4,"score":0.4123748540878296},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.37518835067749023},{"id":"https://openalex.org/C197746943","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Microbicide","level":3,"score":0.287941038608551},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.21677610278129578},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10237160325050354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10132947564125061}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016667","descriptor_name":"Bacterial Capsules","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016667","descriptor_name":"Bacterial Capsules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018258","descriptor_name":"Herpesvirus 2, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018258","descriptor_name":"Herpesvirus 2, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018258","descriptor_name":"Herpesvirus 2, Human","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1128/aac.00359-08","doi":"https://doi.org/10.1128/aac.00359-08","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.00359-08","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmid:18573926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18573926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2533499","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2533499/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.552.6240","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.552.6240","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://aac.asm.org/content/early/2008/06/23/AAC.00359-08.full.pdf","raw_type":"text"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/11716","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11768/11716","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:sfera.unife.it:11392/529767","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11392/529767","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2533499","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2533499/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W169652639","https://openalex.org/W206917024","https://openalex.org/W1485135772","https://openalex.org/W1684170753","https://openalex.org/W1820383529","https://openalex.org/W1927596245","https://openalex.org/W1938067578","https://openalex.org/W1968321554","https://openalex.org/W1992677585","https://openalex.org/W1992912761","https://openalex.org/W2016239796","https://openalex.org/W2024559068","https://openalex.org/W2036479803","https://openalex.org/W2044285535","https://openalex.org/W2056895491","https://openalex.org/W2065945112","https://openalex.org/W2093485518","https://openalex.org/W2095830444","https://openalex.org/W2096039378","https://openalex.org/W2100837670","https://openalex.org/W2105723626","https://openalex.org/W2107117443","https://openalex.org/W2114563428","https://openalex.org/W2120078856","https://openalex.org/W2121138614","https://openalex.org/W2133298868","https://openalex.org/W2139561917","https://openalex.org/W2140464029","https://openalex.org/W2143331022","https://openalex.org/W2143627435","https://openalex.org/W2153163492","https://openalex.org/W2155016049","https://openalex.org/W2157266096","https://openalex.org/W2158981482","https://openalex.org/W2161493739","https://openalex.org/W2163866020","https://openalex.org/W2316892465","https://openalex.org/W2334917064","https://openalex.org/W2339651847","https://openalex.org/W4211123708"],"related_works":["https://openalex.org/W7096459239","https://openalex.org/W7215998829","https://openalex.org/W2410721528","https://openalex.org/W2089798738","https://openalex.org/W2105723626","https://openalex.org/W2095830444","https://openalex.org/W2032678907","https://openalex.org/W2079952432","https://openalex.org/W7217037701","https://openalex.org/W199470883"],"abstract_inverted_index":{"Herpes":[0],"simplex":[1],"virus":[2,38],"type":[3,39],"1":[4,40],"(HSV-1)":[5],"and":[6,11,33,49,86,93,104,112,125,136,141,163,167,172,181,203],"HSV-2":[7,50,105,164],"are":[8],"neurotropic":[9],"viruses":[10],"common":[12],"human":[13,36],"pathogens":[14],"causing":[15],"major":[16],"public":[17],"health":[18],"problems":[19],"such":[20],"as":[21,150,152,194],"genital":[22],"herpes,":[23],"a":[24,56],"sexually":[25],"transmitted":[26],"disease":[27],"also":[28,97,183],"correlated":[29],"with":[30,55,127],"increased":[31],"transmission":[32,51,199],"replication":[34,94],"of":[35,45,62,75,120,161,177,200],"immunodeficiency":[37],"(HIV-1).":[41],"Therefore,":[42],"compounds":[43,156],"capable":[44],"blocking":[46],"HIV-1,":[47,201],"HSV-1,":[48,202],"represent":[52,189],"candidate":[53],"microbicides":[54,196],"potential":[57],"added":[58],"value":[59],"over":[60],"that":[61,72],"molecules":[63],"acting":[64],"selectively":[65],"against":[66,101],"either":[67],"infection.":[68],"We":[69],"report":[70],"here":[71],"sulfated":[73],"derivatives":[74],"the":[76,109,118,146,158,174],"Escherichia":[77],"coli":[78],"K5":[79],"polysaccharide,":[80],"structurally":[81],"highly":[82],"similar":[83],"to":[84,89,145],"heparin":[85],"previously":[87],"shown":[88],"inhibit":[90,184],"HIV-1":[91,185],"entry":[92,168],"in":[95],"vitro,":[96],"exert":[98],"suppressive":[99],"activities":[100],"both":[102],"HSV-1":[103,124,162],"infections.":[106],"In":[107],"particular,":[108],"N,O-sulfated":[110],"[K5-N,OS(H)]":[111],"O-sulfated":[113],"epimerized":[114],"[Epi-K5-OS(H)]":[115],"forms":[116],"inhibited":[117],"infection":[119],"Vero":[121],"cells":[122,147,171],"by":[123],"-2,":[126],"50%":[128],"inhibitory":[129],"concentrations":[130,149],"(IC(50))":[131],"between":[132],"3":[133],"+/-":[134,138],"0.05":[135],"48":[137],"27":[139],"nM,":[140],"were":[142],"not":[143],"toxic":[144],"at":[148],"high":[151],"5":[153],"muM.":[154],"These":[155],"impaired":[157],"early":[159],"steps":[160],"virion":[165],"attachment":[166],"into":[169],"host":[170],"reduced":[173],"cell-to-cell":[175],"spread":[176],"HSV-2.":[178,204],"Since":[179],"K5-N,OS(H)":[180],"Epi-K5-OS(H)":[182],"infection,":[186],"they":[187],"may":[188],"valid":[190],"candidates":[191],"for":[192],"development":[193],"topical":[195],"preventing":[197],"sexual":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}