{"id":"https://openalex.org/W2089754759","doi":"https://doi.org/10.1111/j.1749-6632.1958.tb54619.x","title":"CHLOROTHIAZIDE IN HYPERTENSIVE AND NORMOTENSIVE PATIENTS","display_name":"CHLOROTHIAZIDE IN HYPERTENSIVE AND NORMOTENSIVE PATIENTS","publication_year":1958,"publication_date":"1958-02-01","ids":{"openalex":"https://openalex.org/W2089754759","doi":"https://doi.org/10.1111/j.1749-6632.1958.tb54619.x","mag":"2089754759","pmid":"https://pubmed.ncbi.nlm.nih.gov/13583800"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.1958.tb54619.x","doi":"https://doi.org/10.1111/j.1749-6632.1958.tb54619.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1958.tb54619.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://profiles.nlm.nih.gov/ps/retrieve/ResourceMetadata/XFBBCY","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110333605","display_name":"Edward D. Freis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4405285767","display_name":"Veterans Administration","ror":"https://ror.org/006ym5897","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I4405285767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward D. Freis","raw_affiliation_strings":["Veterans Administration and Georgetown University Hospitals, Washington, D. C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Administration and Georgetown University Hospitals, Washington, D. C","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4405285767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009497724","display_name":"Annemarie Wanko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4405285767","display_name":"Veterans Administration","ror":"https://ror.org/006ym5897","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I4405285767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annemarie Wanko","raw_affiliation_strings":["Veterans Administration and Georgetown University Hospitals, Washington, D. C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Administration and Georgetown University Hospitals, Washington, D. C","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4405285767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077691453","display_name":"Ilse M. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4405285767","display_name":"Veterans Administration","ror":"https://ror.org/006ym5897","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I4405285767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilse M. Wilson","raw_affiliation_strings":["Veterans Administration and Georgetown University Hospitals, Washington, D. C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Administration and Georgetown University Hospitals, Washington, D. C","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4405285767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108363402","display_name":"Alvin E. Parrish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4405285767","display_name":"Veterans Administration","ror":"https://ror.org/006ym5897","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I4405285767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alvin E. Parrish","raw_affiliation_strings":["Veterans Administration and Georgetown University Hospitals, Washington, D. C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Administration and Georgetown University Hospitals, Washington, D. C","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4405285767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":21.4401,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.99791558,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"71","issue":"4 Chlorothiazid","first_page":"450","last_page":"455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlorothiazide","display_name":"chlorothiazide","score":1.0},{"id":"https://openalex.org/keywords/diuretics","display_name":"diuretics","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7409999966621399},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.9100000262260437},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.781000018119812},{"id":"https://openalex.org/keywords/blood-volume","display_name":"blood volume","score":0.6330000162124634},{"id":"https://openalex.org/keywords/normotensive-subjects","display_name":"normotensive subjects","score":0.6660000085830688},{"id":"https://openalex.org/keywords/history-of-hypertension-treatment","display_name":"history of hypertension treatment","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2779660313","wikidata":"https://www.wikidata.org/wiki/Q2603363","display_name":"Chlorothiazide","level":3,"score":0.988963782787323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5726991891860962},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41834738850593567},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.38642966747283936},{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.1868838667869568}],"mesh":[{"descriptor_ui":"D000086","descriptor_name":"Acetazolamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002740","descriptor_name":"Chlorothiazide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1749-6632.1958.tb54619.x","doi":"https://doi.org/10.1111/j.1749-6632.1958.tb54619.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1958.tb54619.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"doi:10.1111/j.1749-6632.1958.tb46773.x","doi":"https://doi.org/10.1111/j.1749-6632.1958.tb46773.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1958.tb46773.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:13583800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13583800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"},{"id":"pmh:oai:profiles.nlm.nih.gov:XFBBCY","doi":null,"is_oa":true,"landing_page_url":"https://profiles.nlm.nih.gov/ps/retrieve/ResourceMetadata/XFBBCY","pdf_url":null,"source":{"id":"https://openalex.org/S7407064262","display_name":"Profiles in Science","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Freis, Edward D., Annemarie Wanko, Ilse M. Wilson, and Alvin E. Parrish. \"Chlorothiazide in Hypertensive and Normotensive Patients.\" Annals of the New York Academy of Sciences 71, 4 (3 February 1958): 450-455. Article. 6 Images.","raw_type":"Articles"}],"best_oa_location":{"id":"pmh:oai:profiles.nlm.nih.gov:XFBBCY","doi":null,"is_oa":true,"landing_page_url":"https://profiles.nlm.nih.gov/ps/retrieve/ResourceMetadata/XFBBCY","pdf_url":null,"source":{"id":"https://openalex.org/S7407064262","display_name":"Profiles in Science","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Freis, Edward D., Annemarie Wanko, Ilse M. Wilson, and Alvin E. Parrish. \"Chlorothiazide in Hypertensive and Normotensive Patients.\" Annals of the New York Academy of Sciences 71, 4 (3 February 1958): 450-455. Article. 6 Images.","raw_type":"Articles"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2065794843","https://openalex.org/W2320727160"],"related_works":["https://openalex.org/W2399922585","https://openalex.org/W7074107256","https://openalex.org/W7056013519","https://openalex.org/W2411666445","https://openalex.org/W2421618198","https://openalex.org/W2092928056","https://openalex.org/W2398351712","https://openalex.org/W2235262432","https://openalex.org/W2408797719","https://openalex.org/W2397848845"],"abstract_inverted_index":{"This":[0],"was":[1,58],"one":[2],"of":[3,19],"Freis's":[4],"first":[5],"attempts":[6],"to":[7,15],"evaluate":[8],"chlorothiazide,":[9],"a":[10],"new":[11],"diuretic":[12],"that":[13,50,56],"acted":[14],"increase":[16],"the":[17,40,48],"excretion":[18],"water":[20],"and":[21,23,30,43,61],"salt,":[22],"therefore":[24],"reduced":[25],"fluid":[26],"in":[27],"blood":[28,32],"volume":[29],"decreased":[31],"pressure.":[33],"Here,":[34],"along":[35],"with":[36],"several":[37],"colleagues":[38],"from":[39],"Veterans":[41],"Administration":[42],"Georgetown":[44],"University,":[45],"he":[46],"recognized":[47],"promise":[49],"this":[51],"antihypertensive":[52],"agent":[53],"held,":[54],"noting":[55],"chlorothiazide":[57],"an":[59],"\"effective":[60],"well-tolerated\"":[62],"treatment.":[63]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}