{"id":"https://openalex.org/W2089734036","doi":"https://doi.org/10.1152/ajpgi.00038.2004","title":"Participation of prostaglandin E receptor EP4 subtype in duodenal bicarbonate secretion in rats","display_name":"Participation of prostaglandin E receptor EP4 subtype in duodenal bicarbonate secretion in rats","publication_year":2004,"publication_date":"2004-06-11","ids":{"openalex":"https://openalex.org/W2089734036","doi":"https://doi.org/10.1152/ajpgi.00038.2004","mag":"2089734036","pmid":"https://pubmed.ncbi.nlm.nih.gov/15194560"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00038.2004","doi":"https://doi.org/10.1152/ajpgi.00038.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00038.2004","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040501411","display_name":"Masako Aoi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masako Aoi","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086552382","display_name":"Eitaro Aihara","orcid":"https://orcid.org/0000-0003-1160-4929","observed_orcids":["https://orcid.org/0000-0003-1160-4929"]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eitaro Aihara","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110478618","display_name":"Masato Nakashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Nakashima","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090713682","display_name":"Koji Takeuchi","orcid":"https://orcid.org/0000-0002-9668-6021","observed_orcids":["https://orcid.org/0000-0002-9668-6021","https://orcid.org/0009-0008-3293-2730"]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Takeuchi","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan","institution_ids":["https://openalex.org/I25998863"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I25998863"],"apc_list":null,"apc_paid":null,"fwci":3.9805,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.93193158,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"287","issue":"1","first_page":"G96","last_page":"G103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ep4-receptor","display_name":"EP4 receptor","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ep3-receptor","display_name":"EP3 receptor","score":0.8899999856948853},{"id":"https://openalex.org/keywords/duodenal-bicarbonate-secretion","display_name":"duodenal bicarbonate secretion","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sulprostone","display_name":"sulprostone","score":0.7049999833106995},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8970000147819519},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.9490000009536743},{"id":"https://openalex.org/keywords/capsaicin-sensitive-afferent-neurons","display_name":"capsaicin-sensitive afferent neurons","score":0.8339999914169312},{"id":"https://openalex.org/keywords/duodenal-secretion","display_name":"duodenal secretion","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.7307835817337036},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6252360939979553},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5985704660415649},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5736252069473267},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5043493509292603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5035540461540222},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4601946175098419},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3084031641483307}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006851","descriptor_name":"Hydrochloric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008738","descriptor_name":"Methyl Ethers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010654","descriptor_name":"Phenylbutyrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014700","descriptor_name":"Verapamil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015056","descriptor_name":"1-Methyl-3-isobutylxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058309","descriptor_name":"Receptors, Prostaglandin E, EP4 Subtype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpgi.00038.2004","doi":"https://doi.org/10.1152/ajpgi.00038.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00038.2004","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:15194560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15194560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327845","display_name":"Ono Pharmaceutical","ror":"https://ror.org/022jefx64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W222299101","https://openalex.org/W1607540395","https://openalex.org/W1652980032","https://openalex.org/W1803247695","https://openalex.org/W1913770988","https://openalex.org/W1971434151","https://openalex.org/W1981092443","https://openalex.org/W1985427009","https://openalex.org/W2009342363","https://openalex.org/W2013930024","https://openalex.org/W2039291690","https://openalex.org/W2056635601","https://openalex.org/W2081477898","https://openalex.org/W2081688069","https://openalex.org/W2083256905","https://openalex.org/W2091040980","https://openalex.org/W2135166720","https://openalex.org/W2147347457","https://openalex.org/W2148407975","https://openalex.org/W2164890520","https://openalex.org/W2176125519","https://openalex.org/W2258579859","https://openalex.org/W2292069179","https://openalex.org/W2300593783","https://openalex.org/W2419023971","https://openalex.org/W4243630079"],"related_works":["https://openalex.org/W2085947237","https://openalex.org/W2056635601","https://openalex.org/W2128690195","https://openalex.org/W2312917927","https://openalex.org/W2110560266","https://openalex.org/W2083256905","https://openalex.org/W2056381178","https://openalex.org/W2127471132","https://openalex.org/W2044517853","https://openalex.org/W2104451403"],"abstract_inverted_index":{"We":[0,161],"examined,":[1],"by":[2,23,34,64,76,94,174,185,203,212,225],"using":[3],"a":[4,36,96,115],"specific":[5,97],"PGE":[6],"receptor":[7],"subtype":[8],"EP4":[9,16,98,164,199],"agonist":[10],"and":[11,25,46,87,112,131,215],"antagonist,":[12],"the":[13,56,68,105,125,136,152,157,169,222],"involvement":[14],"of":[15,59,85,110,128,138,145,156,239],"receptors":[17,165,192,200,209],"in":[18,28,168,178,236],"duodenal":[19,37,170],"HCO(3)(-)":[20,60,107,171,187],"secretion":[21],"induced":[22,75,173],"PGE(2)":[24,88,175],"mucosal":[26],"acidification":[27,31,177],"rats.":[29],"Mucosal":[30],"was":[32,61,92],"achieved":[33],"exposing":[35],"loop":[38],"to":[39,73,154,180],"10":[40,44,53],"mM":[41],"HCl":[42],"for":[43],"min,":[45],"various":[47],"EP":[48,158],"agonists":[49,159],"were":[50],"given":[51],"intravenously":[52],"min":[54],"before":[55],"acidification.":[57],"Secretion":[58],"dose-dependently":[62],"stimulated":[63],"AE1-329":[65,86,113],"(EP4":[66],"agonist),":[67],"maximal":[69],"response":[70,118,153,172],"being":[71],"equivalent":[72],"that":[74,163,206],"sulprostone":[77,91,111,130,139],"(EP1/EP3":[78],"agonist)":[79],"or":[80,176],"PGE(2).":[81],"The":[82,183,229],"stimulatory":[83,126,237],"action":[84,127],"but":[89,140],"not":[90,141,150,234],"attenuated":[93],"AE3-208,":[95],"antagonist.":[99],"This":[100],"antagonist":[101],"also":[102],"significantly":[103],"mitigated":[104,135],"acid-induced":[106],"secretion.":[108],"Coadministration":[109],"caused":[114],"greater":[116],"secretory":[117],"than":[119],"either":[120],"agent":[121],"alone.":[122],"IBMX":[123],"potentiated":[124],"both":[129,213],"AE1-329,":[132],"whereas":[133,205],"verapamil":[134],"effect":[137],"AE1-329.":[142],"Chemical":[143],"ablation":[144],"capsaicin-sensitive":[146],"afferent":[147],"neurons":[148],"did":[149],"affect":[151],"any":[155],"used.":[160],"conclude":[162],"are":[166],"involved":[167,235],"addition":[179],"EP3":[181,208],"receptors.":[182,228],"process":[184],"which":[186],"is":[188,201,210,219,233],"secreted":[189],"through":[190,198,207],"these":[191,226,240],"differs":[193],"regarding":[194],"second-messenger":[195],"coupling.":[196],"Stimulation":[197],"mediated":[202,224],"cAMP,":[204],"regulated":[211],"cAMP":[214],"Ca(2+);":[216],"yet":[217],"there":[218],"cooperation":[220],"between":[221],"actions":[223,238],"two":[227],"neuronal":[230],"reflex":[231],"pathway":[232],"prostanoids.":[241]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}