{"id":"https://openalex.org/W2089695993","doi":"https://doi.org/10.1016/s0140-6736(00)02388-6","title":"Hit HIV-1 hard, but only when necessary","display_name":"Hit HIV-1 hard, but only when necessary","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W2089695993","doi":"https://doi.org/10.1016/s0140-6736(00)02388-6","mag":"2089695993","pmid":"https://pubmed.ncbi.nlm.nih.gov/10902643"},"language":"en","primary_location":{"id":"doi:10.1016/s0140-6736(00)02388-6","doi":"https://doi.org/10.1016/s0140-6736(00)02388-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(00)02388-6","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mark Harrington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801662763","display_name":"Treatment Action Group","ror":"https://ror.org/03w4sj937","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2801662763"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Harrington","raw_affiliation_strings":["Treatment Action Group, New York, NY 10001, USA. markharrington@aol.com","Treatment Action Group New York NY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Treatment Action Group, New York, NY 10001, USA. markharrington@aol.com","institution_ids":["https://openalex.org/I2801662763"]},{"raw_affiliation_string":"Treatment Action Group New York NY USA","institution_ids":["https://openalex.org/I2801662763"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071465373","display_name":"Charles C. J. Carpenter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles CJ Carpenter","raw_affiliation_strings":["Brown University School of Medicine, Miriam Hospital, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown University School of Medicine, Miriam Hospital, Providence, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800640726"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":7890,"currency":"USD","value_usd":7890},"apc_paid":null,"fwci":3.3978,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.95151515,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"355","issue":"9221","first_page":"2147","last_page":"2152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.31619998812675476,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.9290000200271606},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.8510000109672546},{"id":"https://openalex.org/keywords/treatment-initiation-timing","display_name":"treatment initiation timing","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.777999997138977},{"id":"https://openalex.org/keywords/viral-load-monitoring","display_name":"viral load monitoring","score":0.7639999985694885},{"id":"https://openalex.org/keywords/aids-progression","display_name":"AIDS progression","score":0.671999990940094},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.460999995470047},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6320000290870667},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9449999928474426},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.5640000104904175},{"id":"https://openalex.org/keywords/risk-benefit-assessment","display_name":"risk-benefit assessment","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.755954384803772},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.7279250025749207},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.557064414024353},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5359969735145569},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5224876999855042},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.5051410794258118},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.49715474247932434},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.43584901094436646},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42729613184928894},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4218120574951172},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4106025695800781},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.3289608657360077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26636216044425964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09079033136367798},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014943","descriptor_name":"Global Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017408","descriptor_name":"Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0140-6736(00)02388-6","doi":"https://doi.org/10.1016/s0140-6736(00)02388-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(00)02388-6","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},{"id":"pmid:10902643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10902643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:repository.library.georgetown.edu:10822/936369","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10822/936369","pdf_url":null,"source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eweb:219501","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1499001487","https://openalex.org/W1574561647","https://openalex.org/W1580217007","https://openalex.org/W1973685135","https://openalex.org/W1977705956","https://openalex.org/W1980574993","https://openalex.org/W1982448824","https://openalex.org/W1985376961","https://openalex.org/W2000239378","https://openalex.org/W2027821510","https://openalex.org/W2037343680","https://openalex.org/W2063205690","https://openalex.org/W2072327362","https://openalex.org/W2078978810","https://openalex.org/W2109075498","https://openalex.org/W2110799375","https://openalex.org/W2117261241","https://openalex.org/W2127591384","https://openalex.org/W2133315239","https://openalex.org/W2133556476","https://openalex.org/W2138619917","https://openalex.org/W2139185068","https://openalex.org/W2139250164","https://openalex.org/W2158035002","https://openalex.org/W2167644155","https://openalex.org/W2183940924","https://openalex.org/W2318289184","https://openalex.org/W2324473093","https://openalex.org/W2324816636","https://openalex.org/W2329397111","https://openalex.org/W2339219218","https://openalex.org/W4244919073","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2103323649","https://openalex.org/W1853541919","https://openalex.org/W1979931968","https://openalex.org/W2081208367","https://openalex.org/W2098571076","https://openalex.org/W6987168123","https://openalex.org/W2156253991","https://openalex.org/W2041214835","https://openalex.org/W2165872600","https://openalex.org/W3029933080"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
