{"id":"https://openalex.org/W2089618186","doi":"https://doi.org/10.1126/science.144.3623.1228","title":"Heparinic Acids: Determination of Equivalent Weights and Sulfate to Carboxyl Ratios","display_name":"Heparinic Acids: Determination of Equivalent Weights and Sulfate to Carboxyl Ratios","publication_year":1964,"publication_date":"1964-06-05","ids":{"openalex":"https://openalex.org/W2089618186","doi":"https://doi.org/10.1126/science.144.3623.1228","mag":"2089618186","pmid":"https://pubmed.ncbi.nlm.nih.gov/14150327"},"language":"en","primary_location":{"id":"doi:10.1126/science.144.3623.1228","doi":"https://doi.org/10.1126/science.144.3623.1228","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.144.3623.1228","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108810478","display_name":"Klaus E. Kuettner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Klaus E. Kuettner","raw_affiliation_strings":["Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049815739","display_name":"A. Lindenbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur Lindenbaum","raw_affiliation_strings":["Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois","institution_ids":["https://openalex.org/I1282105669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1282105669"],"apc_list":null,"apc_paid":null,"fwci":1.4496,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.82587719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"3623","first_page":"1228","last_page":"1229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.07850000262260437,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/equivalent-weight","display_name":"equivalent weight","score":0.8709999918937683},{"id":"https://openalex.org/keywords/sulfate-content","display_name":"sulfate content","score":0.8410000205039978},{"id":"https://openalex.org/keywords/polyelectrolytes","display_name":"polyelectrolytes","score":0.9350000023841858},{"id":"https://openalex.org/keywords/automated-titration","display_name":"automatic titration","score":0.75},{"id":"https://openalex.org/keywords/animal-sources","display_name":"animal sources","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C2778343803","wikidata":"https://www.wikidata.org/wiki/Q172290","display_name":"Sulfate","level":2,"score":0.8923372626304626},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6340718865394592},{"id":"https://openalex.org/C153356533","wikidata":"https://www.wikidata.org/wiki/Q901016","display_name":"Polyelectrolyte","level":3,"score":0.5989599823951721},{"id":"https://openalex.org/C184866935","wikidata":"https://www.wikidata.org/wiki/Q191010","display_name":"Titration","level":2,"score":0.5976681709289551},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5713506937026978},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5251367092132568},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.18908408284187317},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17768430709838867},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.15154486894607544},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14354491233825684}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.144.3623.1228","doi":"https://doi.org/10.1126/science.144.3623.1228","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.144.3623.1228","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:14150327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14150327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.550000011920929,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W60613942","https://openalex.org/W195901728","https://openalex.org/W1512675648","https://openalex.org/W1965378682","https://openalex.org/W1985781899","https://openalex.org/W1989251486","https://openalex.org/W2017172145","https://openalex.org/W2054140794","https://openalex.org/W2072600252","https://openalex.org/W2079787393","https://openalex.org/W2326699044","https://openalex.org/W2415153270","https://openalex.org/W2744168154","https://openalex.org/W4236613565"],"related_works":["https://openalex.org/W375366585","https://openalex.org/W2374572882","https://openalex.org/W2156998789","https://openalex.org/W2417536804","https://openalex.org/W2048343647","https://openalex.org/W2418585939","https://openalex.org/W2218112272","https://openalex.org/W2024805270","https://openalex.org/W1984799718","https://openalex.org/W2403287172"],"abstract_inverted_index":{"By":[0],"means":[1],"of":[2,9,25,30,39],"an":[3,21],"automatic":[4],"titration":[5],"apparatus,":[6],"a":[7,27,34],"polyelectrolyte":[8],"biological":[10],"origin,":[11],"heparin,":[12],"from":[13],"two":[14],"animal":[15],"sources,":[16],"was":[17],"found":[18],"to":[19,36],"have":[20],"average":[22],"equivalent":[23],"weight":[24],"170.0,":[26],"sulfate":[28,35],"content":[29],"34.44":[31],"percent,":[32],"and":[33],"carboxyl":[37],"ratio":[38],"2.59.":[40]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}