{"id":"https://openalex.org/W2089587495","doi":"https://doi.org/10.1111/j.1365-2125.1982.tb01394.x","title":"On the role of alpha 1\u2010acid glycoprotein in lignocaine accumulation following myocardial infarction.","display_name":"On the role of alpha 1\u2010acid glycoprotein in lignocaine accumulation following myocardial infarction.","publication_year":1982,"publication_date":"1982-03-01","ids":{"openalex":"https://openalex.org/W2089587495","doi":"https://doi.org/10.1111/j.1365-2125.1982.tb01394.x","mag":"2089587495","pmid":"https://pubmed.ncbi.nlm.nih.gov/7059443","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1402123"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2125.1982.tb01394.x","doi":"https://doi.org/10.1111/j.1365-2125.1982.tb01394.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1982.tb01394.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1982.tb01394.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1982.tb01394.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041655739","display_name":"Aaron Barchowsky","orcid":"https://orcid.org/0000-0003-1268-8159","observed_orcids":["https://orcid.org/0000-0003-1268-8159"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Barchowsky","raw_affiliation_strings":["Departments of Pharmacology and Medicine , Duke University Medical Center , Durham , NC 27710 , U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Medicine , Duke University Medical Center , Durham , NC 27710 , U.S.A","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111845214","display_name":"DG Shand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DG Shand","raw_affiliation_strings":["Departments of Pharmacology and Medicine , Duke University Medical Center , Durham , NC 27710 , U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Medicine , Duke University Medical Center , Durham , NC 27710 , U.S.A","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051163030","display_name":"W. Wayne Stargel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WW Stargel","raw_affiliation_strings":["Departments of Pharmacology and Medicine , Duke University Medical Center , Durham , NC 27710 , U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Medicine , Duke University Medical Center , Durham , NC 27710 , U.S.A","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007512560","display_name":"Galen S. Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GS Wagner","raw_affiliation_strings":["Departments of Pharmacology and Medicine , Duke University Medical Center , Durham , NC 27710 , U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Medicine , Duke University Medical Center , Durham , NC 27710 , U.S.A","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109173140","display_name":"PA Routledge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PA Routledge","raw_affiliation_strings":["Departments of Pharmacology and Medicine , Duke University Medical Center , Durham , NC 27710 , U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Medicine , Duke University Medical Center , Durham , NC 27710 , U.S.A","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.1294,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.87983467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"13","issue":"3","first_page":"411","last_page":"415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.375,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.375,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.24950000643730164,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.22830000519752502,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.8709999918937683},{"id":"https://openalex.org/keywords/alpha-1-acid-glycoprotein","display_name":"alpha-1-acid glycoprotein","score":0.9580000042915344},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-accumulation","display_name":"drug accumulation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"plasma protein binding","score":0.8999999761581421},{"id":"https://openalex.org/keywords/drug-redistribution","display_name":"drug redistribution","score":0.49399998784065247},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.7549999952316284},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.6320000290870667},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7480000257492065},{"id":"https://openalex.org/keywords/mexiletine","display_name":"mexiletine","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6596387624740601},{"id":"https://openalex.org/C2781233306","wikidata":"https://www.wikidata.org/wiki/Q5500236","display_name":"Free fraction","level":3,"score":0.6254671216011047},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5906352996826172},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.5097441077232361},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.508633017539978},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49669843912124634},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.456330269575119},{"id":"https://openalex.org/C30787643","wikidata":"https://www.wikidata.org/wiki/Q24779782","display_name":"Orosomucoid","level":3,"score":0.41444331407546997},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4086284041404724},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34751075506210327},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3459407687187195},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.21009176969528198},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11774134635925293}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009961","descriptor_name":"Orosomucoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2125.1982.tb01394.x","doi":"https://doi.org/10.1111/j.1365-2125.1982.tb01394.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1982.tb01394.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1982.tb01394.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1402123","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1402123","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmid:7059443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7059443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2125.1982.tb01394.x","doi":"https://doi.org/10.1111/j.1365-2125.1982.tb01394.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1982.tb01394.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1982.tb01394.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2089587495.pdf","grobid_xml":"https://content.openalex.org/works/W2089587495.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W74649421","https://openalex.org/W1531062229","https://openalex.org/W1939694363","https://openalex.org/W1967367712","https://openalex.org/W1985401155","https://openalex.org/W1995496792","https://openalex.org/W2002983094","https://openalex.org/W2004180639","https://openalex.org/W2014884767","https://openalex.org/W2023447830","https://openalex.org/W2028573860","https://openalex.org/W2052432072","https://openalex.org/W2063206639","https://openalex.org/W2063660488"],"related_works":["https://openalex.org/W2010687472","https://openalex.org/W2052432072","https://openalex.org/W2068613645","https://openalex.org/W2032719074","https://openalex.org/W2034799743","https://openalex.org/W2084326462","https://openalex.org/W1994525860","https://openalex.org/W2138373908","https://openalex.org/W1997032653","https://openalex.org/W2512182227"],"abstract_inverted_index":{"1":[0,74],"Blood":[1],"plasma":[2,56,78,100,122,128,187,203],"and":[3,20,37,63,127,143,205],"free":[4,83],"lignocaine":[5,177,217,226],"concentrations":[6,123,140,155],"have":[7],"been":[8],"measured":[9],"12":[10,61],"h":[11,62],"after":[12],"beginning":[13],"a":[14,102,214],"constant":[15],"infusion":[16,27],"of":[17,25,49,66,69,104,108,141,153,172,222,225],"2":[18,51],"mg/min":[19],"again":[21],"at":[22,169],"the":[23,26,64,151,173,193,223],"end":[24,65],"(36-72":[28],"h)":[29],"in":[30,72,91,99,147,157,161,175,195,216,228],"five":[31,40],"patients":[32,42],"with":[33,39,125,213],"myocardial":[34],"infarction":[35],"(MI)":[36],"compared":[38],"control":[41,117],"who":[43],"did":[44,86],"not":[45,87],"develop":[46],"objective":[47],"evidence":[48],"MI.":[50,229],"In":[52,116],"MI":[53,162,198],"patients,":[54,118,149],"total":[55],"concentration":[57,85,94,178],"rose":[58,136,160],"significantly":[59],"between":[60],"infusion.":[67],"Because":[68],"an":[70],"increase":[71],"alpha":[73],"acid":[75],"glycoprotein":[76],"(AAG)":[77],"binding":[79,129,204],"increased,":[80],"so":[81],"that":[82,98,168,192],"drug":[84,105,133,206],"change.":[88],"The":[89,139],"rise":[90,174,194],"whole":[92],"blood":[93,120,176],"was":[95,179],"less":[96],"than":[97],"as":[101],"result":[103],"redistribution":[106,207],"out":[107],"red":[109],"cells":[110],"due":[111,180],"to":[112,181],"enhanced":[113,186],"binding.":[114,188],"3":[115],"neither":[119],"nor":[121],"changed":[124],"time":[126],"remained":[130,145],"constant.":[131],"Free":[132],"concentrations,":[134],"however,":[135],"slightly.":[137],"4":[138],"GX":[142],"MEGX":[144],"unchanged":[146],"all":[148],"but":[150,159],"ratio":[152],"lignocaine/MEGX":[154],"fell":[156],"controls":[158],"patients.":[163],"5":[164],"Pharmacokinetic":[165],"modelling":[166],"suggested":[167],"least":[170],"some":[171],"reduced":[182],"clearance":[183],"resulting":[184],"from":[185],"6":[189],"We":[190],"conclude":[191],"AAG":[196],"following":[197],"is":[199],"responsible":[200],"for":[201],"increased":[202],"within":[208],"blood.":[209],"These":[210],"changes,":[211],"together":[212],"reduction":[215],"clearance,":[218],"can":[219],"explain":[220],"much":[221],"phenomenon":[224],"accumulation":[227]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}