{"id":"https://openalex.org/W2089570388","doi":"https://doi.org/10.1111/dme.12579","title":"Dorothy Hodgkin Lecture 2014 Understanding genes identified by genome\u2010wide association studies for Type 2 diabetes","display_name":"Dorothy Hodgkin Lecture 2014 Understanding genes identified by genome\u2010wide association studies for Type 2 diabetes","publication_year":2014,"publication_date":"2014-09-03","ids":{"openalex":"https://openalex.org/W2089570388","doi":"https://doi.org/10.1111/dme.12579","mag":"2089570388","pmid":"https://pubmed.ncbi.nlm.nih.gov/25186316"},"language":"en","primary_location":{"id":"doi:10.1111/dme.12579","doi":"https://doi.org/10.1111/dme.12579","is_oa":false,"landing_page_url":"https://doi.org/10.1111/dme.12579","pdf_url":null,"source":{"id":"https://openalex.org/S72944096","display_name":"Diabetic Medicine","issn_l":"0742-3071","issn":["0742-3071","1096-9136","1464-5491"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetic Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015737554","display_name":"Guy A. Rutter","orcid":"https://orcid.org/0000-0001-6360-0343","observed_orcids":["https://orcid.org/0000-0001-6360-0343"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"G. A. Rutter","raw_affiliation_strings":["Department of Medicine, Section of Cell Biology, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Cell Biology, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015737554"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":4870,"currency":"USD","value_usd":4870},"apc_paid":null,"fwci":0.9754,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.69347582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"31","issue":"12","first_page":"1480","last_page":"1487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.053700000047683716,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9580000042915344},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6290000081062317},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.8460000157356262},{"id":"https://openalex.org/keywords/tcf7l2","display_name":"TCF7L2","score":0.9509999752044678},{"id":"https://openalex.org/keywords/slc30a8","display_name":"SLC30A8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adcy5","display_name":"ADCY5","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mtnr1b","display_name":"MTNR1B","score":1.0},{"id":"https://openalex.org/keywords/cdkal1","display_name":"CDKAL1","score":1.0},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.6079999804496765},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.6480000019073486},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7269999980926514},{"id":"https://openalex.org/keywords/animal-models-of-diabetes","display_name":"animal models of diabetes","score":0.6710000038146973},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.668565034866333},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6422802209854126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6387270092964172},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5970486402511597},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5778136253356934},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.5756928324699402},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5170046091079712},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4513690173625946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44321417808532715},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.4192204475402832},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3791080713272095},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3395724296569824},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.22951123118400574},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.21787497401237488},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08405858278274536}],"mesh":[{"descriptor_ui":"D000075703","descriptor_name":"Zinc Transporter 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012359","descriptor_name":"tRNA Methyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044123","descriptor_name":"Receptor, Melatonin, MT2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051360","descriptor_name":"Cyclin-Dependent Kinase 5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058118","descriptor_name":"Transcription Factor 7-Like 2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/dme.12579","doi":"https://doi.org/10.1111/dme.12579","is_oa":false,"landing_page_url":"https://doi.org/10.1111/dme.12579","pdf_url":null,"source":{"id":"https://openalex.org/S72944096","display_name":"Diabetic Medicine","issn_l":"0742-3071","issn":["0742-3071","1096-9136","1464-5491"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetic Medicine","raw_type":"journal-article"},{"id":"pmid:25186316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25186316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetic medicine : a journal of the British Diabetic Association","raw_type":"Review"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1832852638","display_name":"Understanding pancreatic beta cell dysfunction in diabetes.","funder_award_id":"098424","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2021752256","display_name":"Roles of GWA genes in controlling pancreatic beta cell function and mass.","funder_award_id":"MR/K001981/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3545490237","display_name":"Role of mitochondrial calcium transport in the regulation of insulin secretion","funder_award_id":"BB/J015873/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3555667338","display_name":null,"funder_award_id":"WT098424AIA","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1964738953","https://openalex.org/W1965141016","https://openalex.org/W1966650637","https://openalex.org/W1980089198","https://openalex.org/W1987002804","https://openalex.org/W1989257844","https://openalex.org/W1996018366","https://openalex.org/W2010174774","https://openalex.org/W2012515461","https://openalex.org/W2013253832","https://openalex.org/W2014489310","https://openalex.org/W2025143098","https://openalex.org/W2041152378","https://openalex.org/W2042362312","https://openalex.org/W2044413110","https://openalex.org/W2065285024","https://openalex.org/W2066399874","https://openalex.org/W2066752848","https://openalex.org/W2067387842","https://openalex.org/W2068201869","https://openalex.org/W2073312394","https://openalex.org/W2078591745","https://openalex.org/W2082793267","https://openalex.org/W2087104293","https://openalex.org/W2094943786","https://openalex.org/W2096656039","https://openalex.org/W2103338840","https://openalex.org/W2104740310","https://openalex.org/W2108147094","https://openalex.org/W2111824788","https://openalex.org/W2113544353","https://openalex.org/W2115883884","https://openalex.org/W2120041117","https://openalex.org/W2122929112","https://openalex.org/W2126776706","https://openalex.org/W2130595746","https://openalex.org/W2132484969","https://openalex.org/W2141642891","https://openalex.org/W2144472637","https://openalex.org/W2144576542","https://openalex.org/W2148749248","https://openalex.org/W2153554912","https://openalex.org/W2153956170","https://openalex.org/W2155078339","https://openalex.org/W2157044641","https://openalex.org/W2159422401","https://openalex.org/W2159570963","https://openalex.org/W2161556085","https://openalex.org/W2171874894","https://openalex.org/W2285296053","https://openalex.org/W2789732774"],"related_works":["https://openalex.org/W2016710377","https://openalex.org/W2025143098","https://openalex.org/W1994822807","https://openalex.org/W2186884189","https://openalex.org/W2315193278","https://openalex.org/W2143093961","https://openalex.org/W2075076459","https://openalex.org/W2384245259","https://openalex.org/W2019604587","https://openalex.org/W2074470899"],"abstract_inverted_index":{"Whilst":[0,43],"the":[1,16,35,39,44,53,60,62,84,87,95,108,126,145,157,197,210,224,236,239,249],"heritable":[2],"nature":[3],"of":[4,38,51,59,97,107,115,128,144,147,199,228,238,251],"Type":[5],"2":[6],"diabetes":[7],"has":[8],"been":[9,91],"recognized":[10],"for":[11,56,248],"many":[12],"years,":[13],"only":[14],"in":[15,23,29,41,153,182,184,191,193,223,230],"past":[17],"two":[18],"decades":[19],"have":[20,46,90],"linkage":[21],"analyses":[22,176],"families":[24],"and":[25,105,134,190,207,226],"genome-wide":[26,244],"association":[27,245],"studies":[28],"large":[30,66],"populations":[31],"begun":[32],"to":[33,77,93,137,163,242],"reveal":[34],"genetic":[36],"landscape":[37],"disease":[40,79,132],"detail.":[42],"former":[45],"provided":[47],"a":[48,99,171],"powerful":[49],"means":[50],"identifying":[52],"genes":[54,111,165],"responsible":[55],"monogenic":[57],"forms":[58],"disease,":[61],"latter":[63],"highlight":[64],"relatively":[65],"genomic":[67],"regions.":[68],"These":[69,120,233],"often":[70],"harbour":[71],"multiple":[72],"genes,":[73],"whose":[74,166],"relative":[75],"contribution":[76],"exaggerated":[78],"risk":[80],"is":[81,168],"uncertain.":[82],"In":[83],"present":[85],"study,":[86],"approaches":[88],"that":[89],"used":[92],"dissect":[94],"role":[96],"just":[98],"few":[100],"(TCF7L2,":[101],"SLC30A8,":[102],"ADCY5,":[103],"MTNR1B":[104],"CDKAL1)":[106],"~":[109],"500":[110],"identified":[112,148],"at":[113],"dozens":[114],"implicated":[116],"loci":[117],"are":[118,121,160],"described.":[119],"usually":[122],"selected":[123],"based":[124],"on":[125,131,150],"strength":[127],"their":[129,138],"effect":[130],"risk,":[133],"predictions":[135],"as":[136],"likely":[139],"biological":[140],"role.":[141],"Direct":[142],"determination":[143],"effects":[146,213],"polymorphisms":[149,200],"gene":[151,180],"expression":[152,167,181],"disease-relevant":[154],"tissues,":[155],"notably":[156],"pancreatic":[158],"islet,":[159],"then":[161,177],"performed":[162],"identify":[164],"affected":[169],"by":[170],"particular":[172],"polymorphism.":[173],"Subsequent":[174],"functional":[175],"involve":[178],"perturbing":[179],"vitro":[183],"\u03b2-cell":[185],"lines":[186],"or":[187],"isolated":[188],"islets":[189],"vivo":[192],"animal":[194],"models.":[195],"Although":[196],"majority":[198],"affect":[201,209],"insulin":[202],"production":[203],"rather":[204],"than":[205],"action,":[206],"mainly":[208],"\u03b2":[211],"cell,":[212],"via":[214],"other":[215],"tissues":[216],"may":[217],"also":[218],"contribute,":[219],"requiring":[220],"careful":[221],"consideration":[222],"design":[225],"interpretation":[227],"experiments":[229],"model":[231],"systems.":[232],"considerations":[234],"illustrate":[235],"scale":[237],"task":[240],"needed":[241],"exploit":[243],"study":[246],"data":[247],"development":[250],"new":[252],"therapeutic":[253],"strategies.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
