{"id":"https://openalex.org/W2089560141","doi":"https://doi.org/10.2174/1573395510666140304235916","title":"Type 2 Innate Lymphoid Cells in Allergic Disease","display_name":"Type 2 Innate Lymphoid Cells in Allergic Disease","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W2089560141","doi":"https://doi.org/10.2174/1573395510666140304235916","mag":"2089560141","pmid":"https://pubmed.ncbi.nlm.nih.gov/24876829","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4033554"},"language":"en","primary_location":{"id":"doi:10.2174/1573395510666140304235916","doi":"https://doi.org/10.2174/1573395510666140304235916","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1573395510666140304235916","pdf_url":"http://www.eurekaselect.com/article/59478","source":{"id":"https://openalex.org/S175109673","display_name":"Current Immunology Reviews","issn_l":"1573-3955","issn":["1573-3955","1875-631X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Immunology Reviews","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.eurekaselect.com/article/59478","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062447612","display_name":"Sean J. Lund","orcid":"https://orcid.org/0000-0002-9807-6585","observed_orcids":["https://orcid.org/0000-0002-9807-6585"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean Lund","raw_affiliation_strings":["Department of Medicine, University of California, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, La Jolla, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hannah Walford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Walford","raw_affiliation_strings":["Rady's Children's Hospital of San Diego, Division of Rheumatology, Allergy and Immunology, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rady's Children's Hospital of San Diego, Division of Rheumatology, Allergy and Immunology, San Diego, CA, USA","institution_ids":["https://openalex.org/I4210087384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033296532","display_name":"Taylor Alan Doherty","orcid":"https://orcid.org/0000-0003-3256-0398","observed_orcids":["https://orcid.org/0000-0003-3256-0398"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Taylor Doherty","raw_affiliation_strings":["Department of Medicine, University of California, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, La Jolla, CA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033296532"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8058,"has_fulltext":true,"cited_by_count":98,"citation_normalized_percentile":{"value":0.96097247,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"9","issue":"4","first_page":"214","last_page":"221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/group-2-innate-lymphoid-cells","display_name":"ILC2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/allergic-inflammation","display_name":"allergic inflammation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.925000011920929},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":1.0},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9380000233650208},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":1.0},{"id":"https://openalex.org/keywords/il-25","display_name":"IL-25","score":0.8339999914169312},{"id":"https://openalex.org/keywords/il-33","display_name":"IL-33","score":1.0},{"id":"https://openalex.org/keywords/thymic-stromal-lymphopoietin","display_name":"thymic stromal lymphopoietin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/leukotriene-d4","display_name":"leukotriene D4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epithelial-cytokines","display_name":"epithelial cytokines","score":0.9359999895095825},{"id":"https://openalex.org/keywords/ilc2-activation","display_name":"ILC2 activation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.9664343595504761},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7197375297546387},{"id":"https://openalex.org/C2779675166","wikidata":"https://www.wikidata.org/wiki/Q4732119","display_name":"Allergic inflammation","level":3,"score":0.6720244288444519},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5896215438842773},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5136556029319763},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.49218693375587463},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4645378887653351},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.45380499958992004},{"id":"https://openalex.org/C122862929","wikidata":"https://www.wikidata.org/wiki/Q18048437","display_name":"Interleukin 33","level":4,"score":0.43503737449645996},{"id":"https://openalex.org/C50345908","wikidata":"https://www.wikidata.org/wiki/Q14907275","display_name":"Interleukin 22","level":4,"score":0.42423728108406067},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.25579527020454407},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.18693807721138},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.16209188103675842}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.2174/1573395510666140304235916","doi":"https://doi.org/10.2174/1573395510666140304235916","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1573395510666140304235916","pdf_url":"http://www.eurekaselect.com/article/59478","source":{"id":"https://openalex.org/S175109673","display_name":"Current Immunology Reviews","issn_l":"1573-3955","issn":["1573-3955","1875-631X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Immunology Reviews","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3007945","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4033554","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4033554","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4033554","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Immunol Rev","raw_type":"Text"},{"id":"pmid:24876829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24876829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current immunology reviews","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7q66s65z","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7q66s65z","pdf_url":"https://escholarship.org/content/qt7q66s65z/qt7q66s65z.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Immunology Reviews, vol 9, iss 4","raw_type":"article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.986.9618","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.986.9618","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC4033554%26blobtype%3Dpdf","raw_type":"text"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt7q66s65z","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7q66s65z","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current immunology reviews, vol 9, iss 4","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2174/1573395510666140304235916","doi":"https://doi.org/10.2174/1573395510666140304235916","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1573395510666140304235916","pdf_url":"http://www.eurekaselect.com/article/59478","source":{"id":"https://openalex.org/S175109673","display_name":"Current Immunology Reviews","issn_l":"1573-3955","issn":["1573-3955","1875-631X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Immunology Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5053102451","display_name":"OX40/OX40L interactions in allergen-induced airway inflammation and remodeling","funder_award_id":"K08AI080938","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2089560141.pdf","grobid_xml":"https://content.openalex.org/works/W2089560141.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1575966267","https://openalex.org/W1579102917","https://openalex.org/W1592394199","https://openalex.org/W1885435857","https://openalex.org/W1929917332","https://openalex.org/W1968204922","https://openalex.org/W1975438745","https://openalex.org/W1978530217","https://openalex.org/W1978596588","https://openalex.org/W1978824927","https://openalex.org/W1981650730","https://openalex.org/W1984337354","https://openalex.org/W1988035869","https://openalex.org/W1994569436","https://openalex.org/W1995939269","https://openalex.org/W1997535189","https://openalex.org/W1997745506","https://openalex.org/W1998846885","https://openalex.org/W2007940860","https://openalex.org/W2008996473","https://openalex.org/W2015234837","https://openalex.org/W2019710737","https://openalex.org/W2022678975","https://openalex.org/W2029771203","https://openalex.org/W2033050749","https://openalex.org/W2033289727","https://openalex.org/W2036163316","https://openalex.org/W2036867429","https://openalex.org/W2038846887","https://openalex.org/W2038960406","https://openalex.org/W2047882259","https://openalex.org/W2050604953","https://openalex.org/W2061847435","https://openalex.org/W2061882872","https://openalex.org/W2062783549","https://openalex.org/W2068044260","https://openalex.org/W2076155302","https://openalex.org/W2083665488","https://openalex.org/W2085187432","https://openalex.org/W2086914849","https://openalex.org/W2088102919","https://openalex.org/W2089685608","https://openalex.org/W2091437077","https://openalex.org/W2092520647","https://openalex.org/W2096349085","https://openalex.org/W2096545973","https://openalex.org/W2100908574","https://openalex.org/W2101500685","https://openalex.org/W2106790228","https://openalex.org/W2107023210","https://openalex.org/W2126612550","https://openalex.org/W2127180104","https://openalex.org/W2129161823","https://openalex.org/W2130604431","https://openalex.org/W2132130088","https://openalex.org/W2135675677","https://openalex.org/W2135790224","https://openalex.org/W2140083164","https://openalex.org/W2140206763","https://openalex.org/W2143761993","https://openalex.org/W2145818079","https://openalex.org/W2150464681","https://openalex.org/W2152222824","https://openalex.org/W2152893906","https://openalex.org/W2155432151","https://openalex.org/W2158243297","https://openalex.org/W2162490282","https://openalex.org/W2163465379","https://openalex.org/W2165235005","https://openalex.org/W2165638693","https://openalex.org/W2170948066","https://openalex.org/W2993259418","https://openalex.org/W4319308391","https://openalex.org/W6665978104","https://openalex.org/W6836311171"],"related_works":["https://openalex.org/W7095730440","https://openalex.org/W1984337354","https://openalex.org/W2022678975","https://openalex.org/W2754140340","https://openalex.org/W2294037042","https://openalex.org/W2900916646","https://openalex.org/W2100120771","https://openalex.org/W2009357776","https://openalex.org/W2116139675","https://openalex.org/W2941488122"],"abstract_inverted_index":{"Type":[0],"II":[1],"innate":[2],"lymphoid":[3],"cells":[4,12,124],"(ILC2)":[5],"are":[6,24,99],"a":[7,47],"novel":[8],"population":[9],"of":[10,17,41,95,107,158,165],"lineage-negative":[11],"that":[13,84],"produce":[14],"high":[15],"levels":[16],"Th2":[18],"cytokines":[19,57],"IL-5":[20],"and":[21,29,43,60,80,129,155,160],"IL-13.":[22],"ILC2":[23,50,76,108,126,137,166],"found":[25],"in":[26,35,51,88,93,109,142,167],"human":[27],"respiratory":[28],"gastrointestinal":[30],"tissue":[31],"as":[32,34,62,64,112,114],"well":[33,63,113],"skin.":[36],"Studies":[37],"from":[38],"mouse":[39],"models":[40],"asthma":[42],"atopic":[44],"dermatitis":[45],"suggest":[46],"role":[48,164],"for":[49],"promoting":[52],"allergic":[53,89,110,140,169],"inflammation.":[54],"The":[55],"epithelial":[56],"IL-25,":[58],"IL-33,":[59],"TSLP,":[61],"the":[65,82,104,148,163],"lipid":[66],"mediator":[67],"leukotriene":[68],"D4,":[69],"have":[70],"been":[71],"shown":[72],"to":[73,101,135],"potently":[74],"activate":[75],"under":[77],"specific":[78],"conditions":[79],"supporting":[81],"notion":[83],"many":[85],"separate":[86],"pathways":[87],"disease":[90],"may":[91,138],"result":[92],"stimulation":[94],"ILC2.":[96],"Ongoing":[97],"investigations":[98],"required":[100],"better":[102],"characterize":[103],"relative":[105],"contribution":[106],"inflammation":[111,141],"mechanisms":[115],"by":[116],"which":[117],"other":[118],"cell":[119],"types":[120],"including":[121],"conventional":[122],"T":[123],"regulate":[125],"survival,":[127],"proliferation,":[128],"cytokine":[130,153],"production.":[131],"Importantly,":[132],"therapeutic":[133],"strategies":[134],"target":[136],"reduce":[139],"afflicted":[143],"individuals.":[144],"This":[145],"review":[146],"summarizes":[147],"development,":[149],"surface":[150],"marker":[151],"profile,":[152],"production,":[154],"upstream":[156],"regulation":[157],"ILC2,":[159],"focuses":[161],"on":[162],"common":[168],"diseases.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
