{"id":"https://openalex.org/W2089413807","doi":"https://doi.org/10.1111/j.1600-0781.2006.00246.x","title":"Photodynamic therapy with methylaminolevulinate as a valuable treatment option for unilesional cutaneous T\u2010cell lymphoma","display_name":"Photodynamic therapy with methylaminolevulinate as a valuable treatment option for unilesional cutaneous T\u2010cell lymphoma","publication_year":2006,"publication_date":"2006-08-31","ids":{"openalex":"https://openalex.org/W2089413807","doi":"https://doi.org/10.1111/j.1600-0781.2006.00246.x","mag":"2089413807","pmid":"https://pubmed.ncbi.nlm.nih.gov/16948827"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0781.2006.00246.x","doi":"https://doi.org/10.1111/j.1600-0781.2006.00246.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0781.2006.00246.x","pdf_url":null,"source":{"id":"https://openalex.org/S197087632","display_name":"Photodermatology Photoimmunology & Photomedicine","issn_l":"0905-4383","issn":["0905-4383","1600-0781"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photodermatology, Photoimmunology &amp; Photomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047500191","display_name":"Cristina Zane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103289","display_name":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","ror":"https://ror.org/015rhss58","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210103289"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Zane","raw_affiliation_strings":["Department of Dermatology, Spedali Civili, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Spedali Civili, Brescia, Italy","institution_ids":["https://openalex.org/I4210103289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043253957","display_name":"Maria do Carmo Venturini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103289","display_name":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","ror":"https://ror.org/015rhss58","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210103289"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Venturini","raw_affiliation_strings":["Department of Dermatology, Spedali Civili, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Spedali Civili, Brescia, Italy","institution_ids":["https://openalex.org/I4210103289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110541149","display_name":"Raffaella Sala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103289","display_name":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","ror":"https://ror.org/015rhss58","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210103289"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaella Sala","raw_affiliation_strings":["Department of Dermatology, Spedali Civili, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Spedali Civili, Brescia, Italy","institution_ids":["https://openalex.org/I4210103289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061835780","display_name":"Piergiacomo Calzavara\u2010Pinton","orcid":"https://orcid.org/0000-0002-0935-7204","observed_orcids":["https://orcid.org/0000-0002-0935-7204"]},"institutions":[{"id":"https://openalex.org/I4210103289","display_name":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","ror":"https://ror.org/015rhss58","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210103289"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Piergiacomo Calzavara\u2010Pinton","raw_affiliation_strings":["Department of Dermatology, Spedali Civili, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Spedali Civili, Brescia, Italy","institution_ids":["https://openalex.org/I4210103289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061835780"],"corresponding_institution_ids":["https://openalex.org/I4210103289"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":6.5215,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.97004177,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"5","first_page":"254","last_page":"258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/methyl-aminolevulinate","display_name":"methyl aminolevulinate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mycosis-fungoides","display_name":"mycosis fungoides","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cutaneous-t-cell-lymphoma","display_name":"cutaneous T-cell lymphoma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/topical-chemotherapy","display_name":"topical chemotherapy","score":0.48500001430511475},{"id":"https://openalex.org/keywords/red-light-irradiation","display_name":"red light irradiation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.6769999861717224},{"id":"https://openalex.org/keywords/treatment-tolerance","display_name":"treatment tolerance","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9091918468475342},{"id":"https://openalex.org/C2777756187","wikidata":"https://www.wikidata.org/wiki/Q1891209","display_name":"Mycosis fungoides","level":3,"score":0.876460075378418},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.6912252902984619},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6627751588821411},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6401012539863586},{"id":"https://openalex.org/C2780439664","wikidata":"https://www.wikidata.org/wiki/Q7535376","display_name":"Skin biopsy","level":3,"score":0.4883231818675995},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4756188690662384},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.46389058232307434},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.46264636516571045},{"id":"https://openalex.org/C2776780870","wikidata":"https://www.wikidata.org/wiki/Q5196687","display_name":"Cutaneous T-cell lymphoma","level":4,"score":0.45542991161346436},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4127582907676697},{"id":"https://openalex.org/C2777891184","wikidata":"https://www.wikidata.org/wiki/Q7168693","display_name":"Peripheral T-cell lymphoma","level":4,"score":0.411668598651886},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.40738704800605774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19427165389060974},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000622","descriptor_name":"Aminolevulinic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000622","descriptor_name":"Aminolevulinic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016410","descriptor_name":"Lymphoma, T-Cell, Cutaneous","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016410","descriptor_name":"Lymphoma, T-Cell, Cutaneous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1600-0781.2006.00246.x","doi":"https://doi.org/10.1111/j.1600-0781.2006.00246.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0781.2006.00246.x","pdf_url":null,"source":{"id":"https://openalex.org/S197087632","display_name":"Photodermatology Photoimmunology & Photomedicine","issn_l":"0905-4383","issn":["0905-4383","1600-0781"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photodermatology, Photoimmunology &amp; Photomedicine","raw_type":"journal-article"},{"id":"pmid:16948827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16948827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photodermatology, photoimmunology & photomedicine","raw_type":"Clinical Trial"},{"id":"pmh:oai:iris.unibs.it:11379/23662","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11379/23662","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unibs.it:11379/85673","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11379/85673","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1993071149","https://openalex.org/W1994143652","https://openalex.org/W2001146803","https://openalex.org/W2001665037","https://openalex.org/W2005429148","https://openalex.org/W2017397752","https://openalex.org/W2025084317","https://openalex.org/W2031477667","https://openalex.org/W2042848759","https://openalex.org/W2051318514","https://openalex.org/W2065442550","https://openalex.org/W2071923848","https://openalex.org/W2075724486","https://openalex.org/W2077719169","https://openalex.org/W2096160655","https://openalex.org/W2121049651","https://openalex.org/W2131877980","https://openalex.org/W2132033669","https://openalex.org/W2151102241","https://openalex.org/W2170447022"],"related_works":["https://openalex.org/W1998044572","https://openalex.org/W2093003768","https://openalex.org/W2415573977","https://openalex.org/W4387797616","https://openalex.org/W2023704106","https://openalex.org/W2054032211","https://openalex.org/W2586422576","https://openalex.org/W2131877980","https://openalex.org/W7084088314","https://openalex.org/W2023698380"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mycosis":[1],"fungoides":[2],"(MF)":[3],"is":[4,15],"the":[5,22,78,89,173,179,184],"most":[6],"common":[7],"primary":[8],"cutaneous":[9],"T-cell":[10],"lymphoma":[11],"(CTCL).":[12],"Unilesional":[13],"MF":[14,102],"characterized":[16],"by":[17,148],"a":[18,25,199,216],"limited":[19],"involvement":[20],"of":[21,80,91,142,158,172,181,224],"skin":[23,136,162,200],"and":[24,43,52,55,61,114,203,215,248,265],"chronical,":[26],"though":[27],"indolent":[28],"course.":[29],"If":[30],"lesions":[31,174],"are":[32,45,65],"refractory":[33,68],"to":[34,67,76,107,241,261],"topical":[35,85,110],"steroids,":[36,111],"therapies":[37],"such":[38],"as":[39],"localized":[40,112],"chemotherapy,":[41],"photochemotherapy":[42],"radiotherapy":[44],"available.":[46],"However,":[47],"they":[48],"have":[49],"several":[50],"acute":[51],"chronic":[53],"side-effects":[54],"toxicity":[56],"may":[57],"accumulate":[58],"if":[59],"repeated":[60,166],"protracted":[62],"treatment":[63,90,108,267],"cycles":[64],"delivered":[66,147],"or":[69,117],"relapsing":[70],"lesions.":[71],"The":[72,221],"present":[73],"study":[74],"aims":[75],"assess":[77],"efficacy":[79],"photodynamic":[81],"therapy":[82,116,185],"(PDT)":[83],"with":[84,109,139,155],"methylaminolevulinate":[86],"(MAL)":[87],"in":[88,178,212,219],"unilesional":[92,101,270],"MF.":[93,271],"METHODS:":[94],"Five":[95],"patients":[96,197,214],"were":[97,245],"enrolled":[98],"who":[99],"had":[100],"that":[103],"did":[104],"not":[105],"respond":[106],"psoralen":[113],"UVA":[115],"UVA1":[118],"phototherapies.":[119],"A":[120,207],"20%":[121],"MAL":[122],"(Metvix":[123],"cream)":[124],"cream":[125],"was":[126,137,165,175,186,210,226,233,251,259],"applied":[127],"under":[128],"occlusive":[129],"dressing":[130],"for":[131,269],"3":[132],"h.":[133],"Soon":[134],"afterwards,":[135],"irradiated":[138],"37.5":[140],"J/cm(2)":[141],"red":[143],"light":[144],"(635+/-18":[145],"nm)":[146],"an":[149,156,263],"Aktilite":[150],"CL128":[151],"lamp":[152],"(PhotoCure":[153],"ASA)":[154],"irradiance":[157],"86":[159],"W/cm(2)":[160],"at":[161,236],"level.":[163],"PDT":[164,258],"once":[167],"weekly":[168],"until":[169],"complete":[170,208],"clearing":[171],"obtained,":[176],"or,":[177],"case":[180],"partial":[182,217],"clearing,":[183],"interupted":[187],"when":[188],"three":[189],"successive":[190],"treatments":[191,225],"provided":[192],"no":[193,231],"further":[194],"improvement.":[195],"All":[196],"underwent":[198],"biopsy":[201],"before":[202],"after":[204],"PDT.":[205],"RESULTS:":[206],"remission":[209],"observed":[211],"four":[213],"improvement":[218],"one.":[220],"median":[222],"number":[223],"six":[227],"(range":[228],"1-9).":[229],"In":[230,255],"cases":[232],"recurrence":[234],"seen":[235,260],"follow-up":[237],"(ranging":[238],"from":[239],"12":[240],"34":[242],"months).":[243],"Treatments":[244],"well":[246],"tolerated":[247],"local":[249],"anesthesia":[250],"never":[252],"requested.":[253],"CONCLUSION:":[254],"conclusion,":[256],"here,":[257],"be":[262],"effective":[264],"well-tolerated":[266],"option":[268]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
