{"id":"https://openalex.org/W2089409909","doi":"https://doi.org/10.1074/jbc.m707316200","title":"Interaction between ERK and GSK3\u03b2 Mediates Basic Fibroblast Growth Factor-induced Apoptosis in SK-N-MC Neuroblastoma Cells","display_name":"Interaction between ERK and GSK3\u03b2 Mediates Basic Fibroblast Growth Factor-induced Apoptosis in SK-N-MC Neuroblastoma Cells","publication_year":2008,"publication_date":"2008-02-09","ids":{"openalex":"https://openalex.org/W2089409909","doi":"https://doi.org/10.1074/jbc.m707316200","mag":"2089409909","pmid":"https://pubmed.ncbi.nlm.nih.gov/18263590","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2431019"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m707316200","doi":"https://doi.org/10.1074/jbc.m707316200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m707316200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m707316200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110127017","display_name":"Cuiling Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Cuiling Ma","raw_affiliation_strings":["Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, WV 26506, USA","Department of Dermatology, Xijing Hospital, Xi'an 710032, China","Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia 26506"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, WV 26506, USA","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Department of Dermatology, Xijing Hospital, Xi'an 710032, China","institution_ids":["https://openalex.org/I4210158926"]},{"raw_affiliation_string":"Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia 26506","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020033545","display_name":"Kimberly A. Bower","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly A. Bower","raw_affiliation_strings":["Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia 26506"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia 26506","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389245","display_name":"Gang Chen","orcid":"https://orcid.org/0000-0002-0839-8477","observed_orcids":["https://orcid.org/0000-0002-0839-8477"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gang Chen","raw_affiliation_strings":["Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia 26506"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia 26506","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088517899","display_name":"Xianglin Shi","orcid":"https://orcid.org/0000-0001-9512-7570","observed_orcids":["https://orcid.org/0000-0001-9512-7570"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianglin Shi","raw_affiliation_strings":["Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052936351","display_name":"Zunji Ke","orcid":"https://orcid.org/0000-0003-4038-2456","observed_orcids":["https://orcid.org/0000-0003-4038-2456"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zun-Ji Ke","raw_affiliation_strings":["Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041424398","display_name":"Jia Luo","orcid":"https://orcid.org/0000-0002-6968-3618","observed_orcids":["https://orcid.org/0000-0002-6968-3618"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Jia Luo","raw_affiliation_strings":["Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia 26506","Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia 26506","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5041424398"],"corresponding_institution_ids":["https://openalex.org/I12097938","https://openalex.org/I19820366","https://openalex.org/I4210106477"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.6755,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.92635532,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"283","issue":"14","first_page":"9248","last_page":"9256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.4309000074863434,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.4309000074863434,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.07670000195503235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.04769999906420708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.6639999747276306},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.9290000200271606},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.972000002861023},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/erk-nuclear-translocation","display_name":"ERK nuclear translocation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/peripheral-primitive-neuroectodermal-tumor","display_name":"peripheral primitive neuroectodermal tumor","score":0.9259999990463257},{"id":"https://openalex.org/keywords/sk-n-mc-cells","display_name":"SK-N-MC cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/ewing-sarcoma-family-of-tumors","display_name":"Ewing sarcoma family of tumors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.7289999723434448},{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.9350000023841858},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7449808120727539},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5847223401069641},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5261991620063782},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5219259262084961},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.5180944800376892},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49118348956108093},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.4895089864730835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4583965241909027},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4355345666408539},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42706581950187683},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.416507363319397},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3837594985961914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3777868151664734},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3605176508426666},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17370763421058655},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.1690007746219635},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07722160220146179},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06389886140823364}],"mesh":[{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m707316200","doi":"https://doi.org/10.1074/jbc.m707316200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m707316200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2431019","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2431019","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:18263590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18263590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m707316200","doi":"https://doi.org/10.1074/jbc.m707316200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m707316200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7400000095367432,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2572184644","display_name":"Endoplasmic Reticulum Stress and Alcohol Neurotoxicity","funder_award_id":"2r01aa015407-18a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2978868897","display_name":null,"funder_award_id":"R01\u00a0AA015407","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G7633784009","display_name":null,"funder_award_id":"AA015407","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W81226474","https://openalex.org/W1575367484","https://openalex.org/W1821277660","https://openalex.org/W1952953777","https://openalex.org/W1969294711","https://openalex.org/W1972343960","https://openalex.org/W1982628692","https://openalex.org/W1988509015","https://openalex.org/W1990065094","https://openalex.org/W1990414934","https://openalex.org/W1991939194","https://openalex.org/W2000894432","https://openalex.org/W2001051671","https://openalex.org/W2001626986","https://openalex.org/W2003590186","https://openalex.org/W2006466204","https://openalex.org/W2012448969","https://openalex.org/W2014474720","https://openalex.org/W2021736277","https://openalex.org/W2024004416","https://openalex.org/W2024055311","https://openalex.org/W2025297620","https://openalex.org/W2038582574","https://openalex.org/W2042545863","https://openalex.org/W2051390434","https://openalex.org/W2054223500","https://openalex.org/W2056086258","https://openalex.org/W2056983875","https://openalex.org/W2057169129","https://openalex.org/W2064913654","https://openalex.org/W2076892771","https://openalex.org/W2078099913","https://openalex.org/W2078721711","https://openalex.org/W2081855695","https://openalex.org/W2081999467","https://openalex.org/W2083076387","https://openalex.org/W2085448417","https://openalex.org/W2085663173","https://openalex.org/W2087609448","https://openalex.org/W2093255506","https://openalex.org/W2111650249","https://openalex.org/W2121238995","https://openalex.org/W2122838322","https://openalex.org/W2135453228","https://openalex.org/W2137979644","https://openalex.org/W2153244109","https://openalex.org/W2163205710","https://openalex.org/W2166952635","https://openalex.org/W2170620326","https://openalex.org/W2396287578"],"related_works":["https://openalex.org/W2003590186","https://openalex.org/W2057169129","https://openalex.org/W2555786968","https://openalex.org/W4245479937","https://openalex.org/W1968234710","https://openalex.org/W2003271206","https://openalex.org/W1989645913","https://openalex.org/W2130625511","https://openalex.org/W2014957929","https://openalex.org/W2604377396"],"abstract_inverted_index":{"The":[0,37,201],"Ewing's":[1,8],"sarcoma":[2,9],"family":[3],"of":[4,13,30,57,66,101,114,118,153,173,191,203,215,223],"tumors":[5],"(ESFT)":[6],"includes":[7],"(ES),":[10],"Askin's":[11],"tumor":[12,48],"the":[14,28,72,76,97,135,194,210,216],"chest":[15],"wall,":[16],"and":[17,33,59,62,80,86,88,109,131,140,163,170,225],"peripheral":[18,45],"primitive":[19,46],"neuroectodermal":[20,47],"tumor.":[21],"Basic":[22],"fibroblast":[23],"growth":[24,29],"factor":[25],"(FGF2)":[26],"suppresses":[27],"ESFT":[31],"cells":[32,92,157],"causes":[34],"their":[35],"apoptosis.":[36,95],"underlying":[38],"mechanism":[39],"is":[40,196],"unclear.":[41],"Using":[42],"a":[43,111,119,176],"human":[44],"cell":[49,148,181],"line,":[50],"SK-N-MC,":[51],"we":[52],"demonstrated":[53],"FGF2":[54,74,159],"stimulated":[55],"phosphorylation":[56],"ERK1":[58],"ERK2":[60],"(pERK1/2)":[61],"GSK3beta":[63,84,122,139,155],"(pGSK3beta(Tyr-216)),":[64],"all":[65],"which":[67],"were":[68],"primarily":[69],"retained":[70,207],"in":[71,193,209,220],"cytoplasm.":[73,211],"promoted":[75],"association":[77,108,130],"between":[78],"ERK":[79,89],"pGSK3beta(Tyr-216).":[81],"Inhibitors":[82],"for":[83,198],"(TDZD":[85],"LiCl)":[87],"(PD98059)":[90],"protected":[91],"from":[93],"FGF2-induced":[94,147,180,189],"On":[96],"other":[98],"hand,":[99],"inhibitors":[100],"GSK3beta,":[102],"but":[103],"not":[104],"PD98059":[105],"decreased":[106],"ERK/pGSK3beta(Tyr-216)":[107,129,168],"caused":[110],"nuclear":[112,221],"translocation":[113,222],"pERK1/2.":[115,174],"Similarly,":[116],"expression":[117],"kinase-deficient":[120],"(K85R)":[121],"or":[123],"GSK3beta-small":[124],"interfering":[125,142],"RNA":[126,143],"inhibited":[127],"FGF2-regulated":[128],"translocated":[132],"pERK":[133],"to":[134,158],"nucleus.":[136],"Both":[137],"K85R":[138],"small":[141],"offered":[144,226],"protection":[145],"against":[146],"death.":[149,182],"In":[150,212],"contrast,":[151,213],"overexpression":[152],"wild-type":[154],"sensitized":[156],"cytotoxicity.":[160],"Hydrogen":[161],"peroxide":[162],"ethanol":[164],"enhanced":[165],"FGF2-stimulated":[166],"pGSK3beta(Tyr-216),":[167],"association,":[169],"cytoplasmic":[171],"retention":[172],"As":[175],"result,":[177],"they":[178],"potentiated":[179],"Taken":[183],"together,":[184],"our":[185],"results":[186],"suggested":[187],"that":[188],"accumulation":[190],"pERK1/2":[192,208,224],"cytoplasm":[195],"toxic":[197],"SK-N-MC":[199],"cells.":[200],"formation":[202],"an":[204],"ERK.GSK3beta":[205,217],"complex":[206,218],"disruption":[214],"resulted":[219],"protection.":[227]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}