{"id":"https://openalex.org/W2089356927","doi":"https://doi.org/10.1093/carcin/3.8.841","title":"Identification of the mutagenic metabolites of fluoranthene, 2-methylfluoranthene, and 3-methylfluoranthene","display_name":"Identification of the mutagenic metabolites of fluoranthene, 2-methylfluoranthene, and 3-methylfluoranthene","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W2089356927","doi":"https://doi.org/10.1093/carcin/3.8.841","mag":"2089356927","pmid":"https://pubmed.ncbi.nlm.nih.gov/7127666"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/3.8.841","doi":"https://doi.org/10.1093/carcin/3.8.841","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/3.8.841","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032798692","display_name":"Edmond J. LaVoie","orcid":"https://orcid.org/0000-0001-9244-1249","observed_orcids":["https://orcid.org/0000-0001-9244-1249"]},"institutions":[{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edmond J. LaVoie","raw_affiliation_strings":["Division of Environmental Carcinogenesis, Naylor Dana Institute for Disease Prevention, American Health FoundationValhalla, NY 10595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Carcinogenesis, Naylor Dana Institute for Disease Prevention, American Health FoundationValhalla, NY 10595, USA","institution_ids":["https://openalex.org/I4210167017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033402104","display_name":"Stephen S. Hecht","orcid":"https://orcid.org/0000-0001-7228-1356","observed_orcids":["https://orcid.org/0000-0001-7228-1356"]},"institutions":[{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen S. Hecht","raw_affiliation_strings":["Division of Environmental Carcinogenesis, Naylor Dana Institute for Disease Prevention, American Health FoundationValhalla, NY 10595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Carcinogenesis, Naylor Dana Institute for Disease Prevention, American Health FoundationValhalla, NY 10595, USA","institution_ids":["https://openalex.org/I4210167017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016852086","display_name":"Victoria Bedenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Bedenko","raw_affiliation_strings":["Division of Environmental Carcinogenesis, Naylor Dana Institute for Disease Prevention, American Health FoundationValhalla, NY 10595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Carcinogenesis, Naylor Dana Institute for Disease Prevention, American Health FoundationValhalla, NY 10595, USA","institution_ids":["https://openalex.org/I4210167017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109995598","display_name":"Dietrich Hoffmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dietrich Hoffmann","raw_affiliation_strings":["Division of Environmental Carcinogenesis, Naylor Dana Institute for Disease Prevention, American Health FoundationValhalla, NY 10595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Carcinogenesis, Naylor Dana Institute for Disease Prevention, American Health FoundationValhalla, NY 10595, USA","institution_ids":["https://openalex.org/I4210167017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210167017"],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":0.8572,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.69350705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"8","first_page":"841","last_page":"846"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluoranthene","display_name":"fluoranthene","score":0.9909999966621399},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mutagenic-metabolites","display_name":"mutagenic metabolites","score":0.8709999918937683},{"id":"https://openalex.org/keywords/dihydrodiols","display_name":"dihydrodiols","score":0.765999972820282},{"id":"https://openalex.org/keywords/liver-homogenate","display_name":"liver homogenate","score":0.7039999961853027},{"id":"https://openalex.org/keywords/salmonella-typhimurium-ta100","display_name":"Salmonella typhimurium TA100","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.4659999907016754},{"id":"https://openalex.org/keywords/activation-pathways","display_name":"activation pathways","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C2780112459","wikidata":"https://www.wikidata.org/wiki/Q423462","display_name":"Fluoranthene","level":3,"score":0.9652564525604248},{"id":"https://openalex.org/C2776639595","wikidata":"https://www.wikidata.org/wiki/Q221696","display_name":"Mutagen","level":3,"score":0.9223766326904297},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.8121081590652466},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6293800473213196},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6209455728530884},{"id":"https://openalex.org/C117632636","wikidata":"https://www.wikidata.org/wiki/Q30912","display_name":"Ames test","level":4,"score":0.47504308819770813},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4417656660079956},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.43241727352142334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42902612686157227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3015598952770233},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.13503402471542358},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.1256466507911682},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.11774548888206482},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10975778102874756},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07445099949836731},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04987567663192749}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005449","descriptor_name":"Fluorenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/3.8.841","doi":"https://doi.org/10.1093/carcin/3.8.841","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/3.8.841","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:7127666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7127666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2075224414","https://openalex.org/W1547025256","https://openalex.org/W1581610694","https://openalex.org/W95684551","https://openalex.org/W2008700275","https://openalex.org/W2041753807","https://openalex.org/W2056850911","https://openalex.org/W3024986933","https://openalex.org/W2090499274","https://openalex.org/W2151822822"],"abstract_inverted_index":{"The":[0,25],"metabolites":[1,27,53,78,98],"of":[2,28,54,59,63,76,79,83,96,99,108],"fluoranthene,":[3,100],"2-methylfluoranthene,":[4,101],"and":[5,30,36,102,137],"3-methylfluoranthene":[6,55,103],"obtained":[7],"upon":[8],"incubation":[9],"with":[10,81],"liver":[11],"homogenate":[12],"from":[13],"Aroclor":[14],"pretreated":[15],"rats":[16],"were":[17,32,110],"assayed":[18],"for":[19,135],"mutagenicity":[20],"in":[21,51],"Salmonella":[22],"typhimurium":[23],"TA100.":[24],"mutagenic":[26,61,121],"fluoranthene":[29,80],"2-methylfluoranthene":[31],"identified":[33],"as":[34],"2,3-dihydro-2,3-dihydroxyfluoranthene":[35],"4,5-dihydro-4,5-dihydroxy-2-methylfluoranthene,":[37],"respectively.":[38],"In":[39],"contrast":[40],"to":[41,117,130],"these":[42],"results,":[43],"the":[44,50,60,67,77,87,97,127],"major":[45],"proximate":[46],"mutagen":[47],"detected":[48],"among":[49],"vitro":[52],"was":[56,69,89,114],"3-hydroxymethylfluoranthene.":[57],"Comparison":[58],"potential":[62],"2-hydroxymethylfluoranthene":[64],"demonstrated":[65,85],"that":[66,82,86,105,126],"latter":[68,88],"a":[70,90,119],"more":[71,91],"powerful":[72,92],"mutagen.":[73,93],"Quantitative":[74,94],"analyses":[75,95],"3-hydroxymethylfluoranthene":[84],"indicated":[104],"similar":[106],"amounts":[107],"dihydrodiols":[109],"formed.":[111],"4,5-Dihydro-4,5-dihydoxy-3-methylfluoranthene,":[112],"however,":[113],"not":[115],"found":[116],"be":[118],"potent":[120],"metabolite.":[122],"These":[123],"data":[124],"suggest":[125],"activation":[128],"pathway":[129],"ultimate":[131],"mutagens":[132],"may":[133],"differ":[134],"2-":[136],"3-methylfluoranthene.":[138]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
