{"id":"https://openalex.org/W2089340273","doi":"https://doi.org/10.1073/pnas.0900122106","title":"Fibroblast growth factor\u20132 regulates the stability of nuclear bodies","display_name":"Fibroblast growth factor\u20132 regulates the stability of nuclear bodies","publication_year":2009,"publication_date":"2009-07-17","ids":{"openalex":"https://openalex.org/W2089340273","doi":"https://doi.org/10.1073/pnas.0900122106","mag":"2089340273","pmid":"https://pubmed.ncbi.nlm.nih.gov/19617559"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0900122106","doi":"https://doi.org/10.1073/pnas.0900122106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0900122106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2722362","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023975975","display_name":"Alexander-Francisco Bruns","orcid":"https://orcid.org/0000-0002-6970-4036","observed_orcids":["https://orcid.org/0000-0002-6970-4036"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander-Francisco Bruns","raw_affiliation_strings":["Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jeroen van Bergeijk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jeroen van Bergeijk","raw_affiliation_strings":["Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002199326","display_name":"Christina Lorbeer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christina Lorbeer","raw_affiliation_strings":["Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044053571","display_name":"Anna N\u00f6lle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna N\u00f6lle","raw_affiliation_strings":["Center for Systems Neuroscience Hannover, Hannover, Germany","Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and","Center for Systems Neuroscience Hannover, Hannover, Germany; Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Neuroscience Hannover, Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Center for Systems Neuroscience Hannover, Hannover, Germany; Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034126101","display_name":"Julia Jungnickel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Jungnickel","raw_affiliation_strings":["Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041646967","display_name":"Claudia Grothe","orcid":"https://orcid.org/0000-0002-4683-0769","observed_orcids":["https://orcid.org/0000-0002-4683-0769"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia Grothe","raw_affiliation_strings":["Center for Systems Neuroscience Hannover, Hannover, Germany","Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and","Center for Systems Neuroscience Hannover, Hannover, Germany; Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Neuroscience Hannover, Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Center for Systems Neuroscience Hannover, Hannover, Germany; Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102463970","display_name":"Peter Claus","orcid":"https://orcid.org/0000-0003-3824-9445","observed_orcids":["https://orcid.org/0000-0003-3824-9445"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Claus","raw_affiliation_strings":["Center for Systems Neuroscience Hannover, Hannover, Germany","Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and","Center for Systems Neuroscience Hannover, Hannover, Germany; Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Neuroscience Hannover, Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Center for Systems Neuroscience Hannover, Hannover, Germany; Hannover Medical School, Department of Neuroanatomy, Hannover, Germany; and","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I34809795"],"apc_list":null,"apc_paid":null,"fwci":1.3021,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.80478056,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"106","issue":"31","first_page":"12747","last_page":"12752"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0364999994635582,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibroblast-growth-factor-2","display_name":"fibroblast growth factor 2","score":0.9240000247955322},{"id":"https://openalex.org/keywords/survival-motor-neuron","display_name":"SMN","score":0.5400000214576721},{"id":"https://openalex.org/keywords/gemin2","display_name":"Gemin2","score":0.9309999942779541},{"id":"https://openalex.org/keywords/spinal-muscular-atrophy","display_name":"spinal muscular atrophy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cajal-bodies","display_name":"Cajal bodies","score":0.9129999876022339},{"id":"https://openalex.org/keywords/smn-complex","display_name":"SMN complex","score":0.699999988079071},{"id":"https://openalex.org/keywords/motor-neurons","display_name":"motor neurons","score":0.7929999828338623},{"id":"https://openalex.org/keywords/subnuclear-structures","display_name":"subnuclear structures","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.6922739744186401},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6453390717506409},{"id":"https://openalex.org/C2778558090","wikidata":"https://www.wikidata.org/wiki/Q580290","display_name":"Spinal muscular atrophy","level":3,"score":0.6035918593406677},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.5841975212097168},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5782684087753296},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5534482598304749},{"id":"https://openalex.org/C105686024","wikidata":"https://www.wikidata.org/wiki/Q906755","display_name":"Nuclear matrix","level":4,"score":0.5090131759643555},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.47724270820617676},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.4286544919013977},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35943663120269775},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2988901138305664},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29224228858947754},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20303499698638916},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020541","descriptor_name":"Coiled Bodies","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020541","descriptor_name":"Coiled Bodies","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020541","descriptor_name":"Coiled Bodies","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051496","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051496","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051496","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055531","descriptor_name":"Gemini of Coiled Bodies","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055531","descriptor_name":"Gemini of Coiled Bodies","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055531","descriptor_name":"Gemini of Coiled Bodies","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055532","descriptor_name":"SMN Complex Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D055532","descriptor_name":"SMN Complex Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D055532","descriptor_name":"SMN Complex Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D055532","descriptor_name":"SMN Complex Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055532","descriptor_name":"SMN Complex Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055532","descriptor_name":"SMN Complex Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0900122106","doi":"https://doi.org/10.1073/pnas.0900122106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0900122106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:19617559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19617559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2722362","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2722362","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2722362","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2722362","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1904553979","https://openalex.org/W1973840148","https://openalex.org/W1979488144","https://openalex.org/W1980477780","https://openalex.org/W1991772727","https://openalex.org/W1996412713","https://openalex.org/W1999877750","https://openalex.org/W2004824571","https://openalex.org/W2008297395","https://openalex.org/W2012172513","https://openalex.org/W2013121282","https://openalex.org/W2023546332","https://openalex.org/W2025187013","https://openalex.org/W2026245681","https://openalex.org/W2035326552","https://openalex.org/W2036328920","https://openalex.org/W2037179118","https://openalex.org/W2041634189","https://openalex.org/W2041912154","https://openalex.org/W2046593551","https://openalex.org/W2052064222","https://openalex.org/W2067574987","https://openalex.org/W2082468024","https://openalex.org/W2086259312","https://openalex.org/W2091521382","https://openalex.org/W2096650232","https://openalex.org/W2097568302","https://openalex.org/W2099624163","https://openalex.org/W2106830069","https://openalex.org/W2107252117","https://openalex.org/W2113768195","https://openalex.org/W2115122189","https://openalex.org/W2116949627","https://openalex.org/W2119098947","https://openalex.org/W2121930828","https://openalex.org/W2122329067","https://openalex.org/W2126848848","https://openalex.org/W2128595951","https://openalex.org/W2133421983","https://openalex.org/W2138165292","https://openalex.org/W2138482402","https://openalex.org/W2139189662","https://openalex.org/W2140099557","https://openalex.org/W2142871524","https://openalex.org/W2143079500","https://openalex.org/W2149865900","https://openalex.org/W2151093888","https://openalex.org/W2161748099","https://openalex.org/W2162279304","https://openalex.org/W2162831628","https://openalex.org/W2171807068"],"related_works":["https://openalex.org/W2414898915","https://openalex.org/W2322182184","https://openalex.org/W2404707484","https://openalex.org/W6734000","https://openalex.org/W4245782041","https://openalex.org/W2010928807","https://openalex.org/W2021588766","https://openalex.org/W2085351745","https://openalex.org/W1511578149","https://openalex.org/W2090685521"],"abstract_inverted_index":{"Nuclear":[0],"bodies":[1,39],"are":[2],"distinct":[3],"subnuclear":[4],"structures.":[5],"The":[6,26,188],"survival":[7],"of":[8,37,67,75,89,106,130,145,151,171,184,196,206,213,216],"motoneuron":[9],"(SMN)":[10],"gene":[11,27],"is":[12,30,70,135,157],"mutated":[13],"or":[14],"deleted":[15],"in":[16,49,56,159,163,173,177,194,210],"patients":[17,62],"with":[18,54,111,126],"the":[19,73,90,104,131,182,203,211,217],"neurodegenerative":[20],"disease":[21],"spinal":[22],"muscular":[23],"atrophy":[24],"(SMA).":[25],"product":[28],"SMN":[29,44,110,132],"a":[31,64,86,118,167,207],"marker":[32],"protein":[33],"for":[34,137,140],"one":[35],"class":[36],"nuclear":[38,42,76,87,114,153,174,186],"denoted":[40],"as":[41],"gems.":[43,68],"has":[45],"also":[46],"been":[47],"found":[48],"Cajal":[50],"bodies,":[51],"which":[52],"co-localize":[53],"gems":[55],"many":[57],"cell":[58],"types.":[59],"Interestingly,":[60],"SMA":[61],"display":[63],"reduced":[65],"number":[66,183],"Little":[69],"known":[71],"about":[72],"regulation":[74,212],"body":[77,115,175],"formation":[78],"and":[79,162],"stabilization.":[80],"We":[81],"have":[82],"previously":[83],"shown":[84],"that":[85,123,134],"isoform":[88],"fibroblast":[91],"growth":[92,208],"factor-2":[93],"(FGF-2(23))":[94],"binds":[95],"directly":[96],"to":[97,109,113,142],"SMN.":[98,143],"In":[99],"this":[100],"study,":[101],"we":[102,121],"analyzed":[103],"consequences":[105],"FGF-2(23)":[107,124,180],"binding":[108,141],"regard":[112],"formation.":[116],"On":[117],"molecular":[119],"level,":[120],"showed":[122],"competed":[125],"Gemin2":[127,146],"(a":[128],"component":[129],"complex":[133],"necessary":[136],"gem":[138],"stabilization)":[139],"Down-regulation":[144],"by":[147,166],"siRNA":[148],"caused":[149],"destabilization":[150],"SMN-positive":[152,185],"bodies.":[154,187],"This":[155,200],"process":[156],"reflected":[158],"both":[160],"cellular":[161],"vivo":[164],"systems":[165],"negative":[168],"regulatory":[169],"function":[170],"FGF-2":[172,197],"formation:":[176],"HEK293":[178],"cells,":[179],"decreased":[181],"same":[189],"effect":[190],"could":[191],"be":[192],"observed":[193],"motoneurons":[195],"transgenic":[198],"mice.":[199],"study":[201],"demonstrates":[202],"functional":[204],"role":[205],"factor":[209],"structural":[214],"entities":[215],"nucleus.":[218]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}