{"id":"https://openalex.org/W2089313271","doi":"https://doi.org/10.1074/jbc.m104521200","title":"Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation","display_name":"Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W2089313271","doi":"https://doi.org/10.1074/jbc.m104521200","mag":"2089313271","pmid":"https://pubmed.ncbi.nlm.nih.gov/11483607"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m104521200","doi":"https://doi.org/10.1074/jbc.m104521200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m104521200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2089313271"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m104521200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111636033","display_name":"Lisa A. Schubert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa A. Schubert","raw_affiliation_strings":["Immunology Program, Virginia Mason Research Center, Seattle, Washington 98101, USA","\u2021Immunology Program, Virginia Mason Research Center, Seattle, Washington 98101 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Program, Virginia Mason Research Center, Seattle, Washington 98101, USA","institution_ids":[]},{"raw_affiliation_string":"\u2021Immunology Program, Virginia Mason Research Center, Seattle, Washington 98101 and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003337295","display_name":"Eric W. Jeffery","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Jeffery","raw_affiliation_strings":["\u00a7Celltech-Chiroscience R&D, Bothell, Washington 98021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Celltech-Chiroscience R&D, Bothell, Washington 98021","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388089","display_name":"Yi Zhang","orcid":"https://orcid.org/0000-0001-9861-4681","observed_orcids":["https://orcid.org/0000-0001-9861-4681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["\u00a7Celltech-Chiroscience R&D, Bothell, Washington 98021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Celltech-Chiroscience R&D, Bothell, Washington 98021","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050752577","display_name":"Fred Ramsdell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fred Ramsdell","raw_affiliation_strings":["\u00a7Celltech-Chiroscience R&D, Bothell, Washington 98021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Celltech-Chiroscience R&D, Bothell, Washington 98021","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050390918","display_name":"Steven F. Ziegler","orcid":"https://orcid.org/0000-0003-0657-5529","observed_orcids":["https://orcid.org/0000-0003-0657-5529","https://orcid.org/0000-0002-9043-9273"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Steven F. Ziegler","raw_affiliation_strings":["\u2021Immunology Program, Virginia Mason Research Center, Seattle, Washington 98101 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Immunology Program, Virginia Mason Research Center, Seattle, Washington 98101 and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5050390918"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.5422,"has_fulltext":false,"cited_by_count":549,"citation_normalized_percentile":{"value":0.96758764,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"276","issue":"40","first_page":"37672","last_page":"37679"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.906000018119812},{"id":"https://openalex.org/keywords/forkhead-box-transcription-factors","display_name":"forkhead transcription factor","score":0.8019999861717224},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.9700000286102295},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.968999981880188},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cytokine-gene-expression","display_name":"cytokine gene expression","score":0.777999997138977},{"id":"https://openalex.org/keywords/t-cell-homeostasis","display_name":"T cell homeostasis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.531000018119812},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6480116248130798},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.6178722977638245},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6059265732765198},{"id":"https://openalex.org/C189938988","wikidata":"https://www.wikidata.org/wiki/Q24744925","display_name":"NFAT","level":4,"score":0.6009865403175354},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.5488118529319763},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4809095859527588},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4487723410129547},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4483623504638672},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4415639042854309},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.4283524751663208},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4002309739589691},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3392564058303833},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3285088539123535},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2616383135318756}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050778","descriptor_name":"NFATC Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m104521200","doi":"https://doi.org/10.1074/jbc.m104521200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m104521200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11483607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11483607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m104521200","doi":"https://doi.org/10.1074/jbc.m104521200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m104521200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W11294627","https://openalex.org/W1486722793","https://openalex.org/W1498280191","https://openalex.org/W1499151513","https://openalex.org/W1524354116","https://openalex.org/W1575585006","https://openalex.org/W1585102022","https://openalex.org/W1618754640","https://openalex.org/W1780702984","https://openalex.org/W1786368438","https://openalex.org/W1836730957","https://openalex.org/W1836845228","https://openalex.org/W1969855284","https://openalex.org/W1972187865","https://openalex.org/W1972239225","https://openalex.org/W1978373343","https://openalex.org/W1993493268","https://openalex.org/W1998924554","https://openalex.org/W2015085911","https://openalex.org/W2035913301","https://openalex.org/W2037505364","https://openalex.org/W2038326211","https://openalex.org/W2043503174","https://openalex.org/W2047519730","https://openalex.org/W2048073154","https://openalex.org/W2053387942","https://openalex.org/W2054333952","https://openalex.org/W2056156489","https://openalex.org/W2056401234","https://openalex.org/W2060116181","https://openalex.org/W2060394892","https://openalex.org/W2068045085","https://openalex.org/W2072227251","https://openalex.org/W2076067786","https://openalex.org/W2082472137","https://openalex.org/W2084143461","https://openalex.org/W2086084335","https://openalex.org/W2093542451","https://openalex.org/W2113002082","https://openalex.org/W2122229386","https://openalex.org/W2140707292","https://openalex.org/W2146963242","https://openalex.org/W2148379368","https://openalex.org/W2152330273","https://openalex.org/W2161575486","https://openalex.org/W4377428108"],"related_works":["https://openalex.org/W1967351618","https://openalex.org/W2149527985","https://openalex.org/W1575585006","https://openalex.org/W2130133601","https://openalex.org/W2021603971","https://openalex.org/W1985406652","https://openalex.org/W2512885158","https://openalex.org/W2043848106","https://openalex.org/W2063865193","https://openalex.org/W2125761262"],"abstract_inverted_index":{"We":[0,142],"have":[1,143],"recently":[2],"identified":[3,144],"and":[4,23,48,109,140,181],"cloned":[5],"Foxp3,":[6],"the":[7,13,29,34,42,58,79,91,155,174,191,194],"gene":[8,31,36],"defective":[9],"in":[10,20,24,28,41,54,78,115,131,154,167,189],"mice":[11,22],"with":[12,26,57],"scurfy":[14],"mutation.":[15],"The":[16,50],"immune":[17,59],"dysregulation":[18,60,68],"documented":[19],"these":[21,55],"humans":[25],"mutations":[27],"orthologous":[30],"indicates":[32],"that":[33,100,173],"foxp3":[35],"product,":[37],"scurfin,":[38],"is":[39,104,163],"involved":[40],"regulation":[43,80],"of":[44,81,90,94,120,157,176,193,196],"T":[45,82,133,198],"cell":[46,83],"activation":[47],"differentiation.":[49],"autoimmune":[51],"state":[52],"observed":[53],"patients":[56],"polyendocrinopathy,":[61],"enteropathy,":[62],"X-linked":[63,66],"syndrome,":[64],"or":[65],"autoimmunity-allergic":[67],"syndrome":[69],"also":[70],"points":[71],"to":[72,149,165,178,200],"a":[73,87,121,124,186],"critical":[74,150],"role":[75,188],"for":[76,106],"scurfin":[77,135,177],"homeostasis.":[84],"FOXP3":[85],"encodes":[86],"novel":[88],"member":[89],"forkhead":[92,126],"family":[93],"transcription":[95,119],"factors.":[96],"Here":[97],"we":[98],"demonstrate":[99],"this":[101],"structural":[102],"domain":[103],"required":[105],"nuclear":[107],"localization":[108],"DNA":[110],"binding.":[111],"Scurfin,":[112],"transiently":[113],"expressed":[114],"heterologous":[116],"cells,":[117,134],"represses":[118],"reporter":[122],"containing":[123],"multimeric":[125],"binding":[127,146],"site.":[128],"Upon":[129],"overexpression":[130],"CD4":[132,197],"attenuates":[136],"activation-induced":[137],"cytokine":[138,159],"production":[139],"proliferation.":[141],"FKH":[145],"sequences":[147],"adjacent":[148],"NFAT":[151],"regulatory":[152],"sites":[153],"promoters":[156],"several":[158],"genes":[160],"whose":[161],"expression":[162],"sensitive":[164],"changes":[166],"SFN":[168],"abundance.":[169],"Our":[170],"findings":[171],"indicate":[172],"ability":[175],"bind":[179],"DNA,":[180],"presumably":[182],"repress":[183],"transcription,":[184],"plays":[185],"paramount":[187],"determining":[190],"amplitude":[192],"response":[195],"cells":[199],"activation.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":29},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}