{"id":"https://openalex.org/W2089177065","doi":"https://doi.org/10.1016/0006-2944(77)90026-6","title":"Synthetic substrates for vertebrate collagenase","display_name":"Synthetic substrates for vertebrate collagenase","publication_year":1977,"publication_date":"1977-04-01","ids":{"openalex":"https://openalex.org/W2089177065","doi":"https://doi.org/10.1016/0006-2944(77)90026-6","mag":"2089177065","pmid":"https://pubmed.ncbi.nlm.nih.gov/193489"},"language":"en","primary_location":{"id":"doi:10.1016/0006-2944(77)90026-6","doi":"https://doi.org/10.1016/0006-2944(77)90026-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2944(77)90026-6","pdf_url":null,"source":{"id":"https://openalex.org/S110816294","display_name":"Biochemical Medicine","issn_l":"0006-2944","issn":["0006-2944","1557-7996"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052016150","display_name":"Yoshihiro Masui","orcid":"https://orcid.org/0000-0001-7883-3297","observed_orcids":["https://orcid.org/0000-0001-7883-3297"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4210151276","display_name":"Peptide Institute (Japan)","ror":"https://ror.org/055bszj51","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210151276"]},{"id":"https://openalex.org/I4210152009","display_name":"Protein Research Foundation","ror":"https://ror.org/03yzv7g36","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210152009"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Masui","raw_affiliation_strings":["Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University, Kanda-surugadai, Chiyoda-ku, Tokyo 101 Japan","Protein Research Foundation, Peptide Institute, Ina, Minoh, Osaka 562 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University, Kanda-surugadai, Chiyoda-ku, Tokyo 101 Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Protein Research Foundation, Peptide Institute, Ina, Minoh, Osaka 562 Japan","institution_ids":["https://openalex.org/I4210151276","https://openalex.org/I4210152009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111681484","display_name":"Tadashi Takemoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4210151276","display_name":"Peptide Institute (Japan)","ror":"https://ror.org/055bszj51","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210151276"]},{"id":"https://openalex.org/I4210152009","display_name":"Protein Research Foundation","ror":"https://ror.org/03yzv7g36","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210152009"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Takemoto","raw_affiliation_strings":["Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University, Kanda-surugadai, Chiyoda-ku, Tokyo 101 Japan","Protein Research Foundation, Peptide Institute, Ina, Minoh, Osaka 562 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University, Kanda-surugadai, Chiyoda-ku, Tokyo 101 Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Protein Research Foundation, Peptide Institute, Ina, Minoh, Osaka 562 Japan","institution_ids":["https://openalex.org/I4210151276","https://openalex.org/I4210152009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069474155","display_name":"Shumpei Sakakibara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4210151276","display_name":"Peptide Institute (Japan)","ror":"https://ror.org/055bszj51","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210151276"]},{"id":"https://openalex.org/I4210152009","display_name":"Protein Research Foundation","ror":"https://ror.org/03yzv7g36","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210152009"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shumpei Sakakibara","raw_affiliation_strings":["Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University, Kanda-surugadai, Chiyoda-ku, Tokyo 101 Japan","Protein Research Foundation, Peptide Institute, Ina, Minoh, Osaka 562 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University, Kanda-surugadai, Chiyoda-ku, Tokyo 101 Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Protein Research Foundation, Peptide Institute, Ina, Minoh, Osaka 562 Japan","institution_ids":["https://openalex.org/I4210151276","https://openalex.org/I4210152009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046809901","display_name":"Hisae Hori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4210151276","display_name":"Peptide Institute (Japan)","ror":"https://ror.org/055bszj51","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210151276"]},{"id":"https://openalex.org/I4210152009","display_name":"Protein Research Foundation","ror":"https://ror.org/03yzv7g36","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210152009"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisae Hori","raw_affiliation_strings":["Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University, Kanda-surugadai, Chiyoda-ku, Tokyo 101 Japan","Protein Research Foundation, Peptide Institute, Ina, Minoh, Osaka 562 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University, Kanda-surugadai, Chiyoda-ku, Tokyo 101 Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Protein Research Foundation, Peptide Institute, Ina, Minoh, Osaka 562 Japan","institution_ids":["https://openalex.org/I4210151276","https://openalex.org/I4210152009"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048907152","display_name":"Yutaka Nagai","orcid":"https://orcid.org/0000-0002-1962-2614","observed_orcids":["https://orcid.org/0000-0002-1962-2614"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4210151276","display_name":"Peptide Institute (Japan)","ror":"https://ror.org/055bszj51","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210151276"]},{"id":"https://openalex.org/I4210152009","display_name":"Protein Research Foundation","ror":"https://ror.org/03yzv7g36","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210152009"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yutaka Nagai","raw_affiliation_strings":["Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University, Kanda-surugadai, Chiyoda-ku, Tokyo 101 Japan","Protein Research Foundation, Peptide Institute, Ina, Minoh, Osaka 562 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University, Kanda-surugadai, Chiyoda-ku, Tokyo 101 Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Protein Research Foundation, Peptide Institute, Ina, Minoh, Osaka 562 Japan","institution_ids":["https://openalex.org/I4210151276","https://openalex.org/I4210152009"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048907152"],"corresponding_institution_ids":["https://openalex.org/I125602781","https://openalex.org/I4210151276","https://openalex.org/I4210152009"],"apc_list":null,"apc_paid":null,"fwci":2.7128,"has_fulltext":false,"cited_by_count":143,"citation_normalized_percentile":{"value":0.89425982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"17","issue":"2","first_page":"215","last_page":"221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagenase","display_name":"collagenase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/artificial-substrates","display_name":"artificial substrates","score":0.828000009059906},{"id":"https://openalex.org/keywords/peptide-hydrolysis","display_name":"peptide hydrolysis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/synovial-fluid","display_name":"synovial fluid","score":0.9890000224113464},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0}],"concepts":[{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.9264180660247803},{"id":"https://openalex.org/C2778177356","wikidata":"https://www.wikidata.org/wiki/Q19903955","display_name":"Dinitrophenyl","level":3,"score":0.613345742225647},{"id":"https://openalex.org/C129527566","wikidata":"https://www.wikidata.org/wiki/Q18029185","display_name":"MMP1","level":4,"score":0.5889567732810974},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5402488708496094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5295630097389221},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5137633085250854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41793322563171387},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.33751991391181946},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31982386112213135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23256534337997437},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19909259676933289},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001001","descriptor_name":"Anura","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003012","descriptor_name":"Microbial Collagenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004140","descriptor_name":"Dinitrophenols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-2944(77)90026-6","doi":"https://doi.org/10.1016/0006-2944(77)90026-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2944(77)90026-6","pdf_url":null,"source":{"id":"https://openalex.org/S110816294","display_name":"Biochemical Medicine","issn_l":"0006-2944","issn":["0006-2944","1557-7996"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Medicine","raw_type":"journal-article"},{"id":"pmid:193489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/193489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W1584531376","https://openalex.org/W1971792197","https://openalex.org/W1987869017","https://openalex.org/W1992653023"],"related_works":["https://openalex.org/W1971792197","https://openalex.org/W1966603682","https://openalex.org/W2769906099","https://openalex.org/W2029318035","https://openalex.org/W2075889252","https://openalex.org/W2077113770","https://openalex.org/W2088399964","https://openalex.org/W4239658534","https://openalex.org/W1970097594","https://openalex.org/W2409469634"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}