{"id":"https://openalex.org/W2089174726","doi":"https://doi.org/10.1074/jbc.m212013200","title":"Evidence for CD4-enchanced Signaling through the Chemokine Receptor CCR5","display_name":"Evidence for CD4-enchanced Signaling through the Chemokine Receptor CCR5","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W2089174726","doi":"https://doi.org/10.1074/jbc.m212013200","mag":"2089174726","pmid":"https://pubmed.ncbi.nlm.nih.gov/12531905"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m212013200","doi":"https://doi.org/10.1074/jbc.m212013200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m212013200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m212013200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036616774","display_name":"Robert Staudinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800015068","display_name":"VA NY Harbor Healthcare System","ror":"https://ror.org/03s5r4e84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2800015068","https://openalex.org/I4210094901"]},{"id":"https://openalex.org/I4210147155","display_name":"Pediatrics and Genetics","ror":"https://ror.org/03t432d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Staudinger","raw_affiliation_strings":["Veterans Affairs New York Harbor Healthcare System, New York, New York 10016, USA. robert.staudinger@med.nyu.edu","Departments of Neurology and","Veterans Affairs New York Harbor Healthcare System and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs New York Harbor Healthcare System, New York, New York 10016, USA. robert.staudinger@med.nyu.edu","institution_ids":["https://openalex.org/I2800015068"]},{"raw_affiliation_string":"Departments of Neurology and","institution_ids":["https://openalex.org/I4210147155"]},{"raw_affiliation_string":"Veterans Affairs New York Harbor Healthcare System and","institution_ids":["https://openalex.org/I2800015068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111924024","display_name":"Sanjay Kumar Phogat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay K. Phogat","raw_affiliation_strings":["Laboratory of Experimental and Computational Biology, Frederick Cancer Research and Development Center, NCI, National Institutes of Health, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental and Computational Biology, Frederick Cancer Research and Development Center, NCI, National Institutes of Health, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064642149","display_name":"Xiaodong Xiao","orcid":"https://orcid.org/0009-0007-2676-450X","observed_orcids":["https://orcid.org/0009-0007-2676-450X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaodong Xiao","raw_affiliation_strings":["Laboratory of Experimental and Computational Biology, Frederick Cancer Research and Development Center, NCI, National Institutes of Health, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental and Computational Biology, Frederick Cancer Research and Development Center, NCI, National Institutes of Health, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005444460","display_name":"Xiahong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800015068","display_name":"VA NY Harbor Healthcare System","ror":"https://ror.org/03s5r4e84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2800015068","https://openalex.org/I4210094901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiahong Wang","raw_affiliation_strings":["Veterans Affairs New York Harbor Healthcare System and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs New York Harbor Healthcare System and","institution_ids":["https://openalex.org/I2800015068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089862290","display_name":"Dimiter Stanchev Dimitrov","orcid":"https://orcid.org/0000-0002-2258-1024","observed_orcids":["https://orcid.org/0000-0002-2258-1024"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dimiter S. Dimitrov","raw_affiliation_strings":["Laboratory of Experimental and Computational Biology, Frederick Cancer Research and Development Center, NCI, National Institutes of Health, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental and Computational Biology, Frederick Cancer Research and Development Center, NCI, National Institutes of Health, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041332295","display_name":"Susan Zolla\u2010Pazner","orcid":"https://orcid.org/0000-0002-0750-2666","observed_orcids":["https://orcid.org/0000-0002-0750-2666"]},"institutions":[{"id":"https://openalex.org/I2800015068","display_name":"VA NY Harbor Healthcare System","ror":"https://ror.org/03s5r4e84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2800015068","https://openalex.org/I4210094901"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Zolla-Pazner","raw_affiliation_strings":["Departments of Pathology, New York University School of Medicine, New York, New York 10016 and the","Veterans Affairs New York Harbor Healthcare System and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, New York University School of Medicine, New York, New York 10016 and the","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Veterans Affairs New York Harbor Healthcare System and","institution_ids":["https://openalex.org/I2800015068"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5036616774"],"corresponding_institution_ids":["https://openalex.org/I2800015068","https://openalex.org/I4210147155"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.5411,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.88924603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"278","issue":"12","first_page":"10389","last_page":"10392"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cd4","display_name":"CD4","score":0.9459999799728394},{"id":"https://openalex.org/keywords/chemokine-receptor-signaling","display_name":"chemokine receptor signaling","score":0.8410000205039978},{"id":"https://openalex.org/keywords/receptor-complex","display_name":"receptor complex","score":0.5529999732971191},{"id":"https://openalex.org/keywords/mip-1beta","display_name":"MIP-1\u03b2","score":0.871999979019165},{"id":"https://openalex.org/keywords/g-protein-activation","display_name":"G protein activation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/interleukin-16","display_name":"interleukin-16","score":0.925000011920929},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/receptor-crosstalk","display_name":"receptor cross-talk","score":0.8579999804496765},{"id":"https://openalex.org/keywords/t-cell-co-receptors","display_name":"T cell co-receptors","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C45635710","wikidata":"https://www.wikidata.org/wiki/Q418404","display_name":"Chemokine receptor CCR5","level":5,"score":0.6457423567771912},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6021561622619629},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5370724201202393},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.5368360280990601},{"id":"https://openalex.org/C125590012","wikidata":"https://www.wikidata.org/wiki/Q2086231","display_name":"Co-receptor","level":3,"score":0.533069908618927},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5173053741455078},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.49584588408470154},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4514457583427429},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4483385384082794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4375634491443634},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4341728687286377},{"id":"https://openalex.org/C17971392","wikidata":"https://www.wikidata.org/wiki/Q18027445","display_name":"5-HT5A receptor","level":3,"score":0.4323257505893707},{"id":"https://openalex.org/C128879288","wikidata":"https://www.wikidata.org/wiki/Q5009764","display_name":"CC chemokine receptors","level":5,"score":0.4199076294898987},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38682791590690613},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3150247633457184}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019402","descriptor_name":"Macrophage Inflammatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019410","descriptor_name":"Interleukin-16","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054407","descriptor_name":"Chemokine CCL4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m212013200","doi":"https://doi.org/10.1074/jbc.m212013200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m212013200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12531905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12531905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m212013200","doi":"https://doi.org/10.1074/jbc.m212013200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m212013200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1407162629","display_name":"Design and Use of HIV V3 Mimetic Immunogens","funder_award_id":"R01AI036085","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2212129905","display_name":"Center for AIDS Research","funder_award_id":"P30AI027742","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3060362913","display_name":null,"funder_award_id":"HL59725","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3135156904","display_name":null,"funder_award_id":"AI27742","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4013958739","display_name":null,"funder_award_id":"AI-36085","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G857020472","display_name":"Protective Human Monoclonal Antibodies to HIV-1","funder_award_id":"R01HL059725","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W135521365","https://openalex.org/W1481198769","https://openalex.org/W1527292242","https://openalex.org/W1531473167","https://openalex.org/W1595449036","https://openalex.org/W1852077611","https://openalex.org/W1964093851","https://openalex.org/W1965019797","https://openalex.org/W1969802279","https://openalex.org/W1971777539","https://openalex.org/W1981164507","https://openalex.org/W1981440980","https://openalex.org/W1981644527","https://openalex.org/W1988395319","https://openalex.org/W1990056722","https://openalex.org/W1996183144","https://openalex.org/W2007243487","https://openalex.org/W2017551575","https://openalex.org/W2038670239","https://openalex.org/W2051109968","https://openalex.org/W2058124227","https://openalex.org/W2070758048","https://openalex.org/W2113282092","https://openalex.org/W2116935908","https://openalex.org/W2119745827","https://openalex.org/W2131376910","https://openalex.org/W2137162710","https://openalex.org/W2144935474","https://openalex.org/W2158152148","https://openalex.org/W4313347773"],"related_works":["https://openalex.org/W1989622725","https://openalex.org/W2153776586","https://openalex.org/W1969802279","https://openalex.org/W1914256230","https://openalex.org/W2073244735","https://openalex.org/W2079470893","https://openalex.org/W2109648693","https://openalex.org/W7100319187","https://openalex.org/W7099110341","https://openalex.org/W2058124227"],"abstract_inverted_index":{"The":[0,84],"chemokine":[1],"receptor":[2,68,108,146],"CCR5":[3,34,56,104,118,143],"is":[4,180],"constitutively":[5],"associated":[6],"with":[7,38,117,131,148],"the":[8,18,43,52,64,87,99,137,153,161,166,178,187],"T":[9],"cell":[10,15,193],"co-receptor":[11],"CD4":[12,58,102,130,141,167],"in":[13,59,63,106,145,186],"plasma":[14],"membranes,":[16],"but":[17,98],"physiological":[19,163],"role":[20,164],"of":[21,42,46,55,66,86,101,129,140,152,158,165,183,190],"this":[22],"interaction":[23,100],"has":[24],"not":[25],"been":[26],"elucidated.":[27],"Here":[28],"we":[29],"show":[30],"that":[31,51,70,79,110,177],"detergent-solubilized,":[32],"purified":[33,39],"can":[35,175],"directly":[36],"associate":[37],"soluble":[40],"fragments":[41],"extracellular":[44],"portion":[45],"CD4.":[47],"We":[48],"further":[49,124],"demonstrate":[50],"physical":[53,138],"association":[54,139],"and":[57,103,142,155],"membrane":[60],"vesicles":[61],"results":[62,144],"formation":[65],"a":[67,107,181],"complex":[69,89,109],"exhibits":[71],"macrophage":[72],"inflammatory":[73],"protein":[74],"1beta":[75],"(MIP-1beta)":[76],"binding":[77,154],"properties":[78,157],"are":[80],"distinct":[81],"from":[82],"CCR5.":[83,159],"affinity":[85],"CD4-CCR5":[88],"for":[90,96],"MIP-1beta":[91],"was":[92,123],"3.5-fold":[93],"lower":[94],"than":[95],"CCR5,":[97],"resulted":[105],"exhibited":[111],"enhanced":[112],"G-protein":[113,121],"signaling":[114,156,171],"as":[115],"compared":[116],"alone.":[119],"MIP-1beta-induced":[120],"activation":[122],"increased":[125],"by":[126],"simultaneous":[127],"stimulation":[128],"its":[132],"natural":[133],"agonist,":[134],"interleukin-16.":[135],"Thus,":[136],"cross-talk":[147,179],"allosteric":[149],"CD4-dependent":[150],"regulation":[151],"Although":[160],"precise":[162],"effects":[168],"on":[169],"CCR5-mediated":[170],"remains":[172],"unknown,":[173],"one":[174],"speculate":[176],"component":[182],"mechanisms":[184],"involved":[185],"fine":[188],"tuning":[189],"immune":[191],"system":[192],"responses.":[194]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}