{"id":"https://openalex.org/W2089172276","doi":"https://doi.org/10.1097/00000478-200312000-00001","title":"p16 Inactivation in Pancreatic Intraepithelial Neoplasias (PanINs) Arising in Patients With Chronic Pancreatitis","display_name":"p16 Inactivation in Pancreatic Intraepithelial Neoplasias (PanINs) Arising in Patients With Chronic Pancreatitis","publication_year":2003,"publication_date":"2003-11-21","ids":{"openalex":"https://openalex.org/W2089172276","doi":"https://doi.org/10.1097/00000478-200312000-00001","mag":"2089172276","pmid":"https://pubmed.ncbi.nlm.nih.gov/14657708"},"language":"en","primary_location":{"id":"doi:10.1097/00000478-200312000-00001","doi":"https://doi.org/10.1097/00000478-200312000-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000478-200312000-00001","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Surgical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053217861","display_name":"Christophe Rosty","orcid":"https://orcid.org/0000-0001-7671-2651","observed_orcids":["https://orcid.org/0000-0001-7671-2651"]},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christophe Rosty","raw_affiliation_strings":["Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA","institution_ids":["https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002353139","display_name":"Joseph Geradts","orcid":"https://orcid.org/0009-0002-3817-8499","observed_orcids":["https://orcid.org/0009-0002-3817-8499"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Geradts","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York","Roswell Park Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Roswell Park Cancer Institute","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078000437","display_name":"Norihiro Sato","orcid":"https://orcid.org/0000-0001-8940-8923","observed_orcids":["https://orcid.org/0000-0001-8940-8923"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Norihiro Sato","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109962295","display_name":"Robb E. Wilentz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robb E. Wilentz","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Helen Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR","GB"],"is_corresponding":false,"raw_author_name":"Helen Roberts","raw_affiliation_strings":["Nuffield Department of Clinical Laboratory Sciences, University of Oxford, United Kingdom. The current affiliation of Dr. Rosty is Institut Curie, Departement de Pathologie, Paris, France","University of Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Clinical Laboratory Sciences, University of Oxford, United Kingdom. The current affiliation of Dr. Rosty is Institut Curie, Departement de Pathologie, Paris, France","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I80043"]},{"raw_affiliation_string":"University of Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027685888","display_name":"Taylor Sohn Riall","orcid":"https://orcid.org/0000-0001-5917-8784","observed_orcids":["https://orcid.org/0000-0001-5917-8784"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taylor Sohn","raw_affiliation_strings":["From the Departments of *Pathology, \u2020Oncology, \u2021Surgery, and \u00a7Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland","Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of *Pathology, \u2020Oncology, \u2021Surgery, and \u00a7Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Maryland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103804691","display_name":"John L. Cameron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L. Cameron","raw_affiliation_strings":["From the Departments of *Pathology, \u2020Oncology, \u2021Surgery, and \u00a7Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of *Pathology, \u2020Oncology, \u2021Surgery, and \u00a7Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025415933","display_name":"Charles J. Yeo","orcid":"https://orcid.org/0000-0001-8097-0071","observed_orcids":["https://orcid.org/0000-0001-8097-0071"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles J. Yeo","raw_affiliation_strings":["From the Departments of *Pathology, \u2020Oncology, \u2021Surgery, and \u00a7Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of *Pathology, \u2020Oncology, \u2021Surgery, and \u00a7Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001682484","display_name":"Ralph H. Hruban","orcid":"https://orcid.org/0000-0003-4554-5672","observed_orcids":["https://orcid.org/0000-0003-4554-5672"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph H. Hruban","raw_affiliation_strings":["From the Departments of *Pathology, \u2020Oncology, \u2021Surgery, and \u00a7Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of *Pathology, \u2020Oncology, \u2021Surgery, and \u00a7Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090286753","display_name":"Michael Goggins","orcid":"https://orcid.org/0000-0002-4286-2296","observed_orcids":["https://orcid.org/0000-0002-4286-2296"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Goggins","raw_affiliation_strings":["From the Departments of *Pathology, \u2020Oncology, \u2021Surgery, and \u00a7Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of *Pathology, \u2020Oncology, \u2021Surgery, and \u00a7Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5053217861","https://openalex.org/A5078000437","https://openalex.org/A5109962295"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":null,"apc_paid":null,"fwci":2.6906,"has_fulltext":false,"cited_by_count":118,"citation_normalized_percentile":{"value":0.89746533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"27","issue":"12","first_page":"1495","last_page":"1501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-intraepithelial-neoplasia","display_name":"pancreatic intraepithelial neoplasia","score":0.9359999895095825},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/smad4","display_name":"SMAD4","score":0.9279999732971191},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pancreatic-neuroendocrine-tumors","display_name":"pancreatic neuroendocrine tumors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8569999933242798},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.8989999890327454},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.8479999899864197},{"id":"https://openalex.org/keywords/pancreatic-cancer-risk","display_name":"pancreatic cancer risk","score":0.4090000092983246},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.839389443397522},{"id":"https://openalex.org/C2909925829","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic Intraepithelial Neoplasia","level":5,"score":0.8283669948577881},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7058256268501282},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.608870267868042},{"id":"https://openalex.org/C2779960720","wikidata":"https://www.wikidata.org/wiki/Q668063","display_name":"Pancreatic duct","level":3,"score":0.5975328683853149},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5896443724632263},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5065187215805054},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.48929497599601746},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.48658287525177},{"id":"https://openalex.org/C2781397275","wikidata":"https://www.wikidata.org/wiki/Q1996053","display_name":"Pancreatitis, chronic","level":3,"score":0.4824238717556},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.46099594235420227},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.44884052872657776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42705345153808594},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.22002053260803223},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20758405327796936},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.10546422004699707}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019942","descriptor_name":"Genes, p16","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051901","descriptor_name":"Smad4 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00000478-200312000-00001","doi":"https://doi.org/10.1097/00000478-200312000-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000478-200312000-00001","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Surgical Pathology","raw_type":"journal-article"},{"id":"pmid:14657708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14657708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of surgical pathology","raw_type":"Comparative Study"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006739791","doi":null,"is_oa":false,"landing_page_url":"https://teikyo-u.repo.nii.ac.jp/records/2024699","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Surgical Pathology","raw_type":"journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6724689502","display_name":null,"funder_award_id":"R0391968","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G7609822642","display_name":null,"funder_award_id":"P50-CA69294","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W27728188","https://openalex.org/W156926268","https://openalex.org/W1511729470","https://openalex.org/W1565005755","https://openalex.org/W1964064067","https://openalex.org/W1970082669","https://openalex.org/W1972818536","https://openalex.org/W1977467011","https://openalex.org/W1992928961","https://openalex.org/W2001868613","https://openalex.org/W2011334018","https://openalex.org/W2013970540","https://openalex.org/W2022195700","https://openalex.org/W2036675056","https://openalex.org/W2045519549","https://openalex.org/W2047601328","https://openalex.org/W2050069911","https://openalex.org/W2050164769","https://openalex.org/W2058218248","https://openalex.org/W2059960890","https://openalex.org/W2087389479","https://openalex.org/W2129560190","https://openalex.org/W2137300622","https://openalex.org/W2157330585","https://openalex.org/W2162746063","https://openalex.org/W2318156113","https://openalex.org/W4243712609"],"related_works":["https://openalex.org/W2036675056","https://openalex.org/W2371638710","https://openalex.org/W2416552300","https://openalex.org/W2063477456","https://openalex.org/W2094645903","https://openalex.org/W1893799451","https://openalex.org/W2089231540","https://openalex.org/W2410220803","https://openalex.org/W2141542749","https://openalex.org/W2012509431"],"abstract_inverted_index":{"Patients":[0],"with":[1,49,54,63,72,81,111,138,144,159,173,230,236,250,280,350,365,383,405],"long-standing":[2],"chronic":[3,50,76,174,184,231,244,318,366,384,406],"pancreatitis":[4,51,77,175,185,232,245,319,367,385,407],"are":[5,61],"thought":[6],"to":[7,45,98,156,394,400,408],"be":[8],"at":[9,91],"increased":[10,22],"risk":[11,23],"of":[12,75,119,128,135,147,169,291,299,310,322,325,329,334,340,345,359,378,388,403],"developing":[13],"pancreatic":[14,34,39,65,84,89,160,206,237,352,395,410],"ductal":[15,35,66,411],"adenocarcinoma,":[16],"but":[17,285],"the":[18,30,92,133,148,170,183,205,228,243,247,256,317,326,330,335,346,360,401],"mechanism":[19],"for":[20],"this":[21],"is":[24],"unknown.":[25],"Since":[26],"increasing":[27],"evidence":[28],"supports":[29],"notion":[31],"that":[32,60,87,139,374],"infiltrating":[33,64,145],"adenocarcinomas":[36],"arise":[37],"from":[38,96,101,348,363],"intraepithelial":[40],"lesions":[41,164,180,337],"(PanINs),":[42],"we":[43],"sought":[44],"determine":[46],"if":[47],"patients":[48,71,80,249,258,286,349,364,382,404],"harbor":[52],"PanINs":[53,100,129,142,157,211,226,251,260,297,347,361,379],"alterations":[55],"in":[56,125,141,152,167,182,227,234,381],"tumor":[57,86,208,354],"suppressor":[58],"genes":[59],"associated":[62,143,158,279],"adenocarcinoma.":[67,412],"We":[68,372],"identified":[69,151,181],"122":[70,171],"a":[73,82,126,289,375],"diagnosis":[74],"and":[78,109,113,121,132,155,200,218,332],"29":[79],"well-differentiated":[83],"endocrine":[85,161,207,353],"underwent":[88],"surgery":[90],"Johns":[93],"Hopkins":[94],"Hospital":[95],"1985":[97],"1999.":[99],"each":[102],"resection":[103],"specimen":[104],"were":[105,123,165,188,192,195,198,202,212,222,252],"identified,":[106],"graded,":[107],"counted,":[108],"correlated":[110],"smoking":[112],"alcohol":[114,293],"history.":[115],"The":[116],"expression":[117],"patterns":[118],"p16":[120,341,356,389],"Smad4":[122,370],"determined":[124],"subset":[127],"by":[130],"immunohistochemistry,":[131],"pattern":[134],"labeling":[136],"compared":[137],"seen":[140],"adenocarcinoma":[146,238],"pancreas":[149],"as":[150],"prior":[153],"studies,":[154],"tumor.":[162],"Duct":[163],"present":[166],"80":[168,248],"pancreata":[172,229,235],"(66%).":[176],"Of":[177],"405":[178],"duct":[179],"group,":[186,209,246,320],"7.6%":[187],"reactive":[189],"changes,":[190],"65.5%":[191],"PanIN-1A,":[193,215,323],"18%":[194],"PanIN-1B,":[196,217,327],"7.4%":[197],"PanIN-2,":[199,331],"1.5%":[201],"PanIN-3.":[203],"Within":[204,242],"22":[210],"identified:":[213],"15":[214],"4":[216],"3":[219],"PanIN-2.":[220],"There":[221],"significantly":[223,253],"fewer":[224,296],"high-grade":[225],"than":[233,255,304],"(P":[239],"<":[240],"0.0001).":[241],"older":[254],"42":[257],"without":[259],"(mean":[261],"age":[262],"57.0":[263],"+/-":[264,269],"14.1":[265],"years":[266],"vs.":[267],"50.9":[268],"14.7":[270],"years,":[271],"P":[272,313],"=":[273,314],"0.01).":[274],"Smoking":[275],"history":[276,290],"was":[277],"not":[278,308],"PanIN":[281],"prevalence":[282],"or":[283],"grade,":[284],"who":[287,306],"reported":[288],"excessive":[292],"consumption":[294],"had":[295],"(25":[298],"44":[300],"harbored":[301],"PanINs,":[302,397],"57%)":[303],"those":[305],"did":[307],"(54":[309],"74,":[311],"73%,":[312],"0.07).":[315],"In":[316],"0%":[321],"11%":[324],"16%":[328],"40%":[333],"PanIN-3":[336],"showed":[338],"loss":[339,387],"expression,":[342],"whereas":[343],"all":[344],"an":[351],"retained":[355,368],"expression.":[357,371,390],"All":[358],"analyzed":[362],"normal":[369],"conclude":[373],"significant":[376],"minority":[377],"arising":[380],"show":[386],"This":[391],"alteration,":[392],"common":[393],"cancer-associated":[396],"may":[398],"contribute":[399],"predisposition":[402],"develop":[409]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
