{"id":"https://openalex.org/W2089162191","doi":"https://doi.org/10.1016/j.bmcl.2012.05.031","title":"Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of \u03b2-1,3-glucan synthase","display_name":"Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of \u03b2-1,3-glucan synthase","publication_year":2012,"publication_date":"2012-05-16","ids":{"openalex":"https://openalex.org/W2089162191","doi":"https://doi.org/10.1016/j.bmcl.2012.05.031","mag":"2089162191","pmid":"https://pubmed.ncbi.nlm.nih.gov/22672801"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2012.05.031","doi":"https://doi.org/10.1016/j.bmcl.2012.05.031","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2012.05.031","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085870272","display_name":"Brian H. Heasley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144816","display_name":"Scynexis (United States)","ror":"https://ror.org/03drnt809","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144816"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian H. Heasley","raw_affiliation_strings":["Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA. brian.heasley@scynexis.com","SCYNEXIS, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA. brian.heasley@scynexis.com","institution_ids":["https://openalex.org/I4210144816"]},{"raw_affiliation_string":"SCYNEXIS, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA","institution_ids":["https://openalex.org/I4210144816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030946254","display_name":"Gregory J. Pacofsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144816","display_name":"Scynexis (United States)","ror":"https://ror.org/03drnt809","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory J. Pacofsky","raw_affiliation_strings":["Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA","institution_ids":["https://openalex.org/I4210144816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048920806","display_name":"Ahmed Mamai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144816","display_name":"Scynexis (United States)","ror":"https://ror.org/03drnt809","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed Mamai","raw_affiliation_strings":["Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA","institution_ids":["https://openalex.org/I4210144816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100458883","display_name":"Hao Liu","orcid":"https://orcid.org/0000-0003-2343-4998","observed_orcids":["https://orcid.org/0000-0003-2343-4998"]},"institutions":[{"id":"https://openalex.org/I4210144816","display_name":"Scynexis (United States)","ror":"https://ror.org/03drnt809","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Liu","raw_affiliation_strings":["Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA","institution_ids":["https://openalex.org/I4210144816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068101634","display_name":"Kingsley H. Nelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144816","display_name":"Scynexis (United States)","ror":"https://ror.org/03drnt809","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kingsley Nelson","raw_affiliation_strings":["Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA","institution_ids":["https://openalex.org/I4210144816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071008040","display_name":"Ghjuvanni Coti","orcid":"https://orcid.org/0000-0001-5694-704X","observed_orcids":["https://orcid.org/0000-0001-5694-704X"]},"institutions":[{"id":"https://openalex.org/I4210144816","display_name":"Scynexis (United States)","ror":"https://ror.org/03drnt809","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ghjuvanni Coti","raw_affiliation_strings":["Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA","institution_ids":["https://openalex.org/I4210144816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065456947","display_name":"Michael R. Peel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144816","display_name":"Scynexis (United States)","ror":"https://ror.org/03drnt809","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Peel","raw_affiliation_strings":["Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scynexis, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA","institution_ids":["https://openalex.org/I4210144816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010189871","display_name":"James M. Balkovec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Balkovec","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064167706","display_name":"Mark L. Greenlee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark L. Greenlee","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012518704","display_name":"Paul Liberator","orcid":"https://orcid.org/0000-0001-8298-5779","observed_orcids":["https://orcid.org/0000-0001-8298-5779"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Liberator","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082125258","display_name":"Dong\u2010Fang Meng","orcid":"https://orcid.org/0000-0001-9840-1133","observed_orcids":["https://orcid.org/0000-0001-9840-1133"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongfang Meng","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077495456","display_name":"Dann L. Parker","orcid":"https://orcid.org/0000-0002-2338-4540","observed_orcids":["https://orcid.org/0000-0002-2338-4540"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dann L. Parker","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086657296","display_name":"Robert R. Wilkening","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert R. Wilkening","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045870438","display_name":"James M. Apgar","orcid":"https://orcid.org/0000-0002-9817-9568","observed_orcids":["https://orcid.org/0000-0002-9817-9568"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Apgar","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035358542","display_name":"Fred Racine","orcid":"https://orcid.org/0000-0002-4451-7517","observed_orcids":["https://orcid.org/0000-0002-4451-7517"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Racine","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112444256","display_name":"Ming Jo Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Jo Hsu","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080664093","display_name":"ROBERT A. GIACOBBE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Giacobbe","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028745761","display_name":"Jennifer Nielsen Kahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Nielsen Kahn","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085870272"],"corresponding_institution_ids":["https://openalex.org/I4210144816"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":2.0118,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.85711771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"22","first_page":"6811","last_page":"6816"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.062199998646974564,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.9110000133514404},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8320000171661377},{"id":"https://openalex.org/keywords/triterpenoid-saponins","display_name":"triterpenoid saponins","score":0.9350000023841858},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.824999988079071},{"id":"https://openalex.org/keywords/antifungal-drug-development","display_name":"antifungal drug development","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8856188058853149},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7770287990570068},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.592010498046875},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5808387994766235},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.539291501045227},{"id":"https://openalex.org/C202199734","wikidata":"https://www.wikidata.org/wiki/Q900386","display_name":"Demethylation","level":5,"score":0.5197451114654541},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5154205560684204},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5124488472938538},{"id":"https://openalex.org/C2777130413","wikidata":"https://www.wikidata.org/wiki/Q425702","display_name":"Silibinin","level":2,"score":0.5097665190696716},{"id":"https://openalex.org/C2776923573","wikidata":"https://www.wikidata.org/wiki/Q2294884","display_name":"Derivatization","level":3,"score":0.49193617701530457},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.45811551809310913},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3711230754852295},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3611273169517517},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24870112538337708},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.22654929757118225},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.10234394669532776},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005964","descriptor_name":"Glucosyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D005964","descriptor_name":"Glucosyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2012.05.031","doi":"https://doi.org/10.1016/j.bmcl.2012.05.031","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2012.05.031","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:22672801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22672801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W91615639","https://openalex.org/W1756263303","https://openalex.org/W1936457751","https://openalex.org/W1979633410","https://openalex.org/W1986924167","https://openalex.org/W2004503571","https://openalex.org/W2024843373","https://openalex.org/W2052941480","https://openalex.org/W2054587932","https://openalex.org/W2067924010","https://openalex.org/W2083313602","https://openalex.org/W2108491966","https://openalex.org/W2144149632","https://openalex.org/W2172101723","https://openalex.org/W2950336273"],"related_works":["https://openalex.org/W2106818151","https://openalex.org/W2324747321","https://openalex.org/W2108491966","https://openalex.org/W3036197820","https://openalex.org/W2169870952","https://openalex.org/W4251661125","https://openalex.org/W2012840629","https://openalex.org/W7213324531","https://openalex.org/W4387765350","https://openalex.org/W4404473960"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}