{"id":"https://openalex.org/W2089159206","doi":"https://doi.org/10.1021/bi9529420","title":"Raman Signature of the Four-Stranded Intercalated Cytosine Motif in Crystal and Solution Structures of DNA Deoxycytidylates d(CCCT) and d(C 8 )","display_name":"Raman Signature of the Four-Stranded Intercalated Cytosine Motif in Crystal and Solution Structures of DNA Deoxycytidylates d(CCCT) and d(C 8 )","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2089159206","doi":"https://doi.org/10.1021/bi9529420","mag":"2089159206","pmid":"https://pubmed.ncbi.nlm.nih.gov/8639535"},"language":"en","primary_location":{"id":"doi:10.1021/bi9529420","doi":"https://doi.org/10.1021/bi9529420","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi9529420","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023823920","display_name":"James M. Benevides","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]},{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Benevides","raw_affiliation_strings":["Division of Cell Biology and Biophysics, School of Biological Sciences, University of MissouriKansas City, Kansas City, Missouri 64110-2499, and Department of Biochemistry and Biophysics, Washington State University, Pullman, Washington 99164-4660"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology and Biophysics, School of Biological Sciences, University of MissouriKansas City, Kansas City, Missouri 64110-2499, and Department of Biochemistry and Biophysics, Washington State University, Pullman, Washington 99164-4660","institution_ids":["https://openalex.org/I72951846","https://openalex.org/I75421653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071667418","display_name":"ChulHee Kang","orcid":"https://orcid.org/0000-0002-0693-7860","observed_orcids":["https://orcid.org/0000-0002-0693-7860"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]},{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ChulHee Kang","raw_affiliation_strings":["Division of Cell Biology and Biophysics, School of Biological Sciences, University of MissouriKansas City, Kansas City, Missouri 64110-2499, and Department of Biochemistry and Biophysics, Washington State University, Pullman, Washington 99164-4660"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology and Biophysics, School of Biological Sciences, University of MissouriKansas City, Kansas City, Missouri 64110-2499, and Department of Biochemistry and Biophysics, Washington State University, Pullman, Washington 99164-4660","institution_ids":["https://openalex.org/I72951846","https://openalex.org/I75421653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109136389","display_name":"George J. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]},{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George J. Thomas","raw_affiliation_strings":["Division of Cell Biology and Biophysics, School of Biological Sciences, University of MissouriKansas City, Kansas City, Missouri 64110-2499, and Department of Biochemistry and Biophysics, Washington State University, Pullman, Washington 99164-4660"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology and Biophysics, School of Biological Sciences, University of MissouriKansas City, Kansas City, Missouri 64110-2499, and Department of Biochemistry and Biophysics, Washington State University, Pullman, Washington 99164-4660","institution_ids":["https://openalex.org/I72951846","https://openalex.org/I75421653"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6311,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.66554313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"35","issue":"18","first_page":"5747","last_page":"5755"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/i-motif","display_name":"i-motif","score":0.902999997138977},{"id":"https://openalex.org/keywords/raman-spectroscopy","display_name":"Raman spectroscopy","score":0.7139999866485596},{"id":"https://openalex.org/keywords/ph-titration","display_name":"pH titration","score":0.8199999928474426},{"id":"https://openalex.org/keywords/solution-conformation","display_name":"solution conformation","score":0.4819999933242798},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7639999985694885},{"id":"https://openalex.org/keywords/telomeric-dna","display_name":"telomeric DNA","score":0.9070000052452087},{"id":"https://openalex.org/keywords/dna-intercalation","display_name":"DNA intercalation","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2776023528","wikidata":"https://www.wikidata.org/wiki/Q178425","display_name":"Cytosine","level":3,"score":0.8357545733451843},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.74574875831604},{"id":"https://openalex.org/C30095370","wikidata":"https://www.wikidata.org/wiki/Q899488","display_name":"Protonation","level":3,"score":0.7220323085784912},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6881040334701538},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.573033332824707},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5147650241851807},{"id":"https://openalex.org/C184866935","wikidata":"https://www.wikidata.org/wiki/Q191010","display_name":"Titration","level":2,"score":0.47524094581604004},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.4584578573703766},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.41390275955200195},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.18719682097434998},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16917482018470764},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.11484462022781372},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08981052041053772},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003843","descriptor_name":"Deoxycytidine Monophosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007364","descriptor_name":"Intercalating Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013059","descriptor_name":"Spectrum Analysis, Raman","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi9529420","doi":"https://doi.org/10.1021/bi9529420","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi9529420","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:8639535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8639535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1215193996","display_name":null,"funder_award_id":"GM54378","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8696897306","display_name":"Structures, Interactions and Dynamics of Nucleic Acids","funder_award_id":"R01GM054378","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W103796485","https://openalex.org/W1591993193","https://openalex.org/W1964379701","https://openalex.org/W1971469902","https://openalex.org/W1988786731","https://openalex.org/W2008183908","https://openalex.org/W2036263076","https://openalex.org/W2048035090","https://openalex.org/W2055671081","https://openalex.org/W2061497347","https://openalex.org/W2123017921","https://openalex.org/W2123242549","https://openalex.org/W2894198337"],"related_works":["https://openalex.org/W3212494411","https://openalex.org/W4387939875","https://openalex.org/W2073757979","https://openalex.org/W2024910055","https://openalex.org/W1968607088","https://openalex.org/W1991950561","https://openalex.org/W2027093438","https://openalex.org/W4388188869","https://openalex.org/W2079247859","https://openalex.org/W2049884513"],"abstract_inverted_index":{"The":[0,92,180,202,220],"Raman":[1,54,93,209],"spectral":[2,77],"signature":[3],"of":[4,12,29,53,57,70,83,89,106,113,135,151,155,195,208,222,229],"the":[5,26,58,76,104,111,127,145,171,185,206,216],"four-stranded":[6,128],"cytosine":[7,59,84,107,114,163],"structure":[8,28,130],"formed":[9,132],"by":[10,63,133],"intercalation":[11],"two":[13,186],"hemiprotonated":[14],"and":[15,110,123,144],"parallel-stranded":[16],"oligodeoxycytidylate":[17],"duplexes":[18],"(so-called":[19],"i":[20,218],"motif)":[21],"has":[22],"been":[23],"obtained":[24,65],"from":[25,87],"crystal":[27],"d(CCCT)":[30,122,146],"[Kang,":[31],"C.H.,":[32],"Berger,":[33],"I.,":[34],"Lockshin,":[35],"C.,":[36],"Ratliff,":[37],"R.,":[38,40],"Moyzis,":[39],"&":[41],"Rich,":[42],"A.":[43],"(1994)":[44],"Proc.":[45],"Natl.":[46],"Acad.":[47],"Sci.":[48],"U.S.A.":[49],"91,":[50],"11636-11640].":[51],"Identification":[52],"markers":[55,211],"diagnostic":[56],"quadruplex":[60,90,108,147],"is":[61,85,131,167,188,233],"complemented":[62],"results":[64,224],"in":[66,117,138,165,182,215],"a":[67,97,149,191],"pH":[68],"titration":[69,152],"2'-deoxycytosine-5'-monophosphate":[71],"(5'-dCMP)":[72],"to":[73,120,190,212],"show":[74],"that":[75,88,126],"fingerprint":[78],"associated":[79],"with":[80,174],"N3":[81,115],"protonation":[82,116,164],"distinct":[86],"formation.":[91],"spectrum":[94],"thus":[95],"provides":[96],"definitive":[98],"basis":[99],"for":[100,225],"evaluating":[101],"quantitatively":[102],"both":[103,134,142],"extent":[105],"formation":[109],"degree":[112],"DNA.":[118],"Application":[119],"aqueous":[121,139],"d(C8)":[124,166],"demonstrates":[125],"intercalated":[129],"these":[136,223],"oligodeoxycytidylates":[137],"solution.":[140],"Whereas":[141],"5'-dCMP":[143],"exhibit":[148],"midpoint":[150],"(apparent":[153],"pKc)":[154],"4.5":[156],"+/-":[157,178],"0.2":[158],"at":[159,198],"10":[160,199],"degrees":[161,200],"C,":[162],"shifted":[168],"significantly":[169],"toward":[170],"physiological":[172],"range,":[173],"pKc":[175,183],"=":[176],"5.8":[177],"0.2.":[179],"difference":[181,194],"between":[184],"quadruplexes":[187],"equivalent":[189],"free":[192],"energy":[193],"1.7":[196],"kcal/mol":[197],"C.":[201],"present":[203],"findings":[204],"extend":[205],"library":[207],"conformation":[210],"deoxycytidylate":[213],"residues":[214],"novel":[217],"quadruplex.":[219],"significance":[221],"probing":[226],"solution":[227],"conformations":[228],"telomeric":[230],"DNA":[231],"sequences":[232],"also":[234],"considered.":[235]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}