{"id":"https://openalex.org/W2089140477","doi":"https://doi.org/10.1097/00005373-199407000-00004","title":"LIPOPOLYSACCHARIDE-INDUCED CD11B-MEDIATED NEUTROPHIL-ENDOTHELIAL ADHESION IS NOT REQUIRED FOR POLYMORPHONUCLEAR CELL PRIMING","display_name":"LIPOPOLYSACCHARIDE-INDUCED CD11B-MEDIATED NEUTROPHIL-ENDOTHELIAL ADHESION IS NOT REQUIRED FOR POLYMORPHONUCLEAR CELL PRIMING","publication_year":1994,"publication_date":"1994-07-01","ids":{"openalex":"https://openalex.org/W2089140477","doi":"https://doi.org/10.1097/00005373-199407000-00004","mag":"2089140477","pmid":"https://pubmed.ncbi.nlm.nih.gov/8028050"},"language":"en","primary_location":{"id":"doi:10.1097/00005373-199407000-00004","doi":"https://doi.org/10.1097/00005373-199407000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005373-199407000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S2312674","display_name":"The Journal of Trauma: Injury, Infection, and Critical Care","issn_l":"0022-5282","issn":["0022-5282","1529-8809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Trauma: Injury, Infection, and Critical Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Robert A. Read","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801983979","display_name":"Denver Health Medical Center","ror":"https://ror.org/01fbz6h17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801983979"]},{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Read","raw_affiliation_strings":["Department of Surgery, Denver General Hospital, CO 80204-4507","Denver General Hospital, and the; University of Colorado Health Sciences Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Denver General Hospital, CO 80204-4507","institution_ids":["https://openalex.org/I2801983979"]},{"raw_affiliation_string":"Denver General Hospital, and the; University of Colorado Health Sciences Center","institution_ids":["https://openalex.org/I2801983979","https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112087820","display_name":"Ernest E. Moore","orcid":"https://orcid.org/0000-0002-0419-4848","observed_orcids":["https://orcid.org/0000-0002-0419-4848"]},"institutions":[{"id":"https://openalex.org/I2801983979","display_name":"Denver Health Medical Center","ror":"https://ror.org/01fbz6h17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801983979"]},{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernest E. Moore","raw_affiliation_strings":["Denver General Hospital, and the","University of Colorado Health Sciences Center","Denver General Hospital, and the; University of Colorado Health Sciences Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Denver General Hospital, and the","institution_ids":["https://openalex.org/I2801983979"]},{"raw_affiliation_string":"University of Colorado Health Sciences Center","institution_ids":[]},{"raw_affiliation_string":"Denver General Hospital, and the; University of Colorado Health Sciences Center","institution_ids":["https://openalex.org/I2801983979","https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111808176","display_name":"Frederick Alan Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801983979","display_name":"Denver Health Medical Center","ror":"https://ror.org/01fbz6h17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801983979"]},{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick A. Moore","raw_affiliation_strings":["Denver General Hospital, and the","University of Colorado Health Sciences Center","Denver General Hospital, and the; University of Colorado Health Sciences Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Denver General Hospital, and the","institution_ids":["https://openalex.org/I2801983979"]},{"raw_affiliation_string":"University of Colorado Health Sciences Center","institution_ids":[]},{"raw_affiliation_string":"Denver General Hospital, and the; University of Colorado Health Sciences Center","institution_ids":["https://openalex.org/I2801983979","https://openalex.org/I4210087413"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038412137","display_name":"Virginia S. Carl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801983979","display_name":"Denver Health Medical Center","ror":"https://ror.org/01fbz6h17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801983979"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia Carl","raw_affiliation_strings":["Denver General Hospital, and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Denver General Hospital, and the","institution_ids":["https://openalex.org/I2801983979"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1252,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47323136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"1","first_page":"13","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.5067999958992004,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.5067999958992004,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.4625999927520752,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd11b","display_name":"CD11b","score":0.7459999918937683},{"id":"https://openalex.org/keywords/neutrophil-endothelial-adhesion","display_name":"neutrophil-endothelial adhesion","score":0.8830000162124634},{"id":"https://openalex.org/keywords/neutrophil-priming","display_name":"neutrophil priming","score":0.890999972820282},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9449999928474426},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.8769999742507935},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.4410000145435333},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.7839999794960022},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/fmlp","display_name":"fMLP","score":0.5429999828338623},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.8069999814033508},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.5299999713897705},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.8258998394012451},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.562998354434967},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5423352122306824},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.5320360064506531},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5146775841712952},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.47550827264785767},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4446839392185211},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4437254071235657},{"id":"https://openalex.org/C53122370","wikidata":"https://www.wikidata.org/wiki/Q2458503","display_name":"CD18","level":4,"score":0.44332340359687805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34092605113983154},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32944774627685547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30555182695388794},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27173173427581787},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23766472935676575},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007205","descriptor_name":"Indium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016177","descriptor_name":"Macrophage-1 Antigen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005373-199407000-00004","doi":"https://doi.org/10.1097/00005373-199407000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005373-199407000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S2312674","display_name":"The Journal of Trauma: Injury, Infection, and Critical Care","issn_l":"0022-5282","issn":["0022-5282","1529-8809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Trauma: Injury, Infection, and Critical Care","raw_type":"journal-article"},{"id":"pmid:8028050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8028050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of trauma","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2066634317","https://openalex.org/W2416238034","https://openalex.org/W428060193","https://openalex.org/W2087820683","https://openalex.org/W2027214209","https://openalex.org/W2035211353","https://openalex.org/W1981200477","https://openalex.org/W1985963644","https://openalex.org/W2351397841","https://openalex.org/W4244359740"],"abstract_inverted_index":{"Previous":[0],"work":[1],"has":[2,43],"implicated":[3],"both":[4,265],"neutrophil-endothelial":[5],"cell":[6,133],"(PMN-EC)":[7],"adhesion":[8,70,123,148,190,229,250,263,316],"and":[9,27,107,137,165,230,249,253,267],"PMN":[10,40,76,126,201,231,301,321],"priming":[11,202,232,248,276],"(enhanced":[12],"superoxide":[13,98],"production":[14,115],"following":[15,99],"activation)":[16],"in":[17,51,178,189,198,227,311],"the":[18,36,59,65,186,275,284,298],"development":[19],"of":[20,35,39,58,110,171,207,213,220,225,246,256,277,286,300],"postinjury":[21],"adult":[22],"respiratory":[23],"distress":[24],"syndrome":[25],"(ARDS)":[26],"multiple":[28],"organ":[29],"failure":[30],"(MOF).":[31],"CD11B,":[32],"a":[33,48,160,195,205,211],"member":[34],"integrin":[37],"family":[38],"surface":[41],"receptors,":[42],"been":[44],"alleged":[45],"to":[46,63,87,128,210,280],"have":[47,307],"prominent":[49],"role":[50,224,310],"these":[52],"inflammatory":[53],"PMN-EC":[54,69,105,122,147,183,228,293,313],"processes.":[55],"The":[56,146,223],"purpose":[57],"present":[60],"study":[61],"was":[62,116,149,191,233],"test":[64],"hypothesis":[66],"that":[67],"CD11B-mediated":[68,315],"is":[71,317],"necessary":[72],"for":[73,320],"endotoxin":[74],"(LPS)-induced":[75],"priming.":[77,302,322],"Human":[78],"neutrophils,":[79],"isolated":[80],"by":[81,118,159],"Percoll":[82],"gradient":[83],"centrifugation,":[84],"were":[85,112],"exposed":[86,279],"LPS":[88,172,221,257],"(100":[89],"ng/mL).":[90],"At":[91],"fixed":[92],"times":[93,245],"over":[94],"120":[95,169],"minutes":[96,157,164,170,209,219,255],"(a)":[97],"fMLP":[100],"activation":[101],"(i.e.,":[102,251],"priming),":[103],"(b)":[104],"adhesion,":[106,184,294,314],"(c)":[108],"expression":[109,139,175,289],"CD11B":[111,138,174,199,226,237,259,288,305],"assayed.":[113],"Superoxide":[114],"measured":[117],"cytochrome":[119],"c":[120],"reduction,":[121],"with":[124,140,151,181,193,236,292,297],"indium-labelled":[125],"adherence":[127],"human":[129],"umbilical":[130],"vein":[131],"endothelial":[132],"(HUVEC)":[134],"monolayer":[135],"cultures,":[136],"fluorescent":[141],"labelled":[142],"anti-CD11B":[143,242],"(60.1)":[144],"antibodies.":[145],"biphasic,":[150],"an":[152,308],"early":[153,182],"maximum":[154,212,247],"at":[155,162,244,264],"15":[156,208,252,266],"followed":[158],"nadir":[161],"60":[163,218],"secondary":[166,187],"rise":[167,197],"through":[168],"exposure.":[173,222],"changed":[176],"dramatically":[177,261],"temporal":[179],"association":[180],"but":[185,270,295],"increase":[188],"associated":[192],"only":[194],"mild":[196],"expression.":[200],"increased":[203],"after":[204,217],"latency":[206],"800":[214],"nmol/106":[215],"cells/min":[216],"further":[234],"investigated":[235],"blockade":[238,260],"using":[239],"specific":[240],"monoclonal":[241],"antibodies":[243],"90":[254,268],"exposure).":[258],"reduced":[262],"minutes,":[269],"had":[271],"no":[272],"effect":[273],"on":[274],"PMNs":[278],"LPS.":[281],"In":[282],"summary,":[283],"kinetics":[285],"LPS-induced":[287,312],"correlate":[290],"temporally":[291],"not":[296,318],"induction":[299],"Thus,":[303],"although":[304],"may":[306],"important":[309],"required":[319]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
