{"id":"https://openalex.org/W2089087003","doi":"https://doi.org/10.1371/journal.pone.0037178","title":"Mechanics Regulates Fate Decisions of Human Embryonic Stem Cells","display_name":"Mechanics Regulates Fate Decisions of Human Embryonic Stem Cells","publication_year":2012,"publication_date":"2012-05-16","ids":{"openalex":"https://openalex.org/W2089087003","doi":"https://doi.org/10.1371/journal.pone.0037178","mag":"2089087003","pmid":"https://pubmed.ncbi.nlm.nih.gov/22615930","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3353896"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0037178","doi":"https://doi.org/10.1371/journal.pone.0037178","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0037178","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0037178&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0037178&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021469738","display_name":"Yubing Sun","orcid":"https://orcid.org/0000-0002-6831-3383","observed_orcids":["https://orcid.org/0000-0002-6831-3383"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yubing Sun","raw_affiliation_strings":["Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan, United States of America","Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026973519","display_name":"Luis Gerardo Villa-Diaz","orcid":"https://orcid.org/0000-0001-5709-9054","observed_orcids":["https://orcid.org/0000-0001-5709-9054"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis G. Villa-Diaz","raw_affiliation_strings":["Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058078911","display_name":"Raymond H. W. Lam","orcid":"https://orcid.org/0000-0002-5188-3830","observed_orcids":["https://orcid.org/0000-0002-5188-3830"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond H. W. Lam","raw_affiliation_strings":["Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America","Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100739315","display_name":"Weiqiang Chen","orcid":"https://orcid.org/0000-0002-9469-8328","observed_orcids":["https://orcid.org/0000-0002-9469-8328"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiqiang Chen","raw_affiliation_strings":["Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America","Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019484706","display_name":"Paul H. Krebsbach","orcid":"https://orcid.org/0000-0001-9062-4981","observed_orcids":["https://orcid.org/0000-0001-9062-4981"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul H. Krebsbach","raw_affiliation_strings":["Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan, United States of America","Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063240874","display_name":"Jianping Fu","orcid":"https://orcid.org/0000-0001-9629-6739","observed_orcids":["https://orcid.org/0000-0001-9629-6739"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jianping Fu","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America","Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America","Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063240874"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":9.5346,"has_fulltext":true,"cited_by_count":118,"citation_normalized_percentile":{"value":0.98963248,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"7","issue":"5","first_page":"e37178","last_page":"e37178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":1.0},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"cell fate determination","score":0.6700000166893005},{"id":"https://openalex.org/keywords/matrix-rigidity","display_name":"matrix rigidity","score":0.828000009059906},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.8809999823570251},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.878000020980835},{"id":"https://openalex.org/keywords/cell-mechanics","display_name":"cell mechanics","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7732299566268921},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.7715706825256348},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7604312896728516},{"id":"https://openalex.org/C4001165","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Mechanosensitive channels","level":4,"score":0.6518424153327942},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5257514119148254},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.5007483959197998},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4827791750431061},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4700195789337158},{"id":"https://openalex.org/C2780021956","wikidata":"https://www.wikidata.org/wiki/Q21020749","display_name":"Cell mechanics","level":4,"score":0.44008103013038635},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.43261879682540894},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3111805021762848},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11908438801765442},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.09686097502708435},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004129","descriptor_name":"Dimethylpolysiloxanes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009757","descriptor_name":"Nylons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0037178","doi":"https://doi.org/10.1371/journal.pone.0037178","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0037178","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0037178&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2361359","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3353896","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3353896","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3353896","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22615930","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22615930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.810.2672","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.810.2672","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c0/f9/pone.0037178.PMC3353896.pdf","raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:publications/420315ce-03b2-45ef-b1f0-8f7b92a05400","doi":null,"is_oa":true,"landing_page_url":"https://scholars.cityu.edu.hk/en/publications/420315ce-03b2-45ef-b1f0-8f7b92a05400","pdf_url":null,"source":{"id":"https://openalex.org/S7407055387","display_name":"CityU Scholars","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sun, Y, Villa-Diaz, L G, Lam, R H W, Chen, W, Krebsbach, P H & Fu, J 2012, 'Mechanics regulates fate decisions of human embryonic stem cells', PLOS ONE, vol. 7, no. 5, e37178. https://doi.org/10.1371/journal.pone.0037178","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:a639c639d1a2406aa33f02304d4de327","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a639c639d1a2406aa33f02304d4de327","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 5, p e37178 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/125029","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Mechanics_Regulates_Fate_Decisions_of_Human_Embryonic_Stem_Cells/125029","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0037178","doi":"https://doi.org/10.1371/journal.pone.0037178","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0037178","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0037178&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4347545539","display_name":"Dissecting Self-renewal Mechanisms of iPS Cells on Defined Synthetic Substrates","funder_award_id":"R01DE016530","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5934578446","display_name":null,"funder_award_id":"DE016530","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G7636208478","display_name":"Mesenchymal Stem Cells and the Synthetic Microenvironment: An Integrated Approach","funder_award_id":"1129611","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8084298715","display_name":null,"funder_award_id":"CMMI 1129611","funder_id":"https://openalex.org/F4320337391","funder_display_name":"Division of Civil, Mechanical and Manufacturing Innovation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337391","display_name":"Division of Civil, Mechanical and Manufacturing Innovation","ror":"https://ror.org/028yd4c30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2089087003.pdf","grobid_xml":"https://content.openalex.org/works/W2089087003.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1974365381","https://openalex.org/W1980616032","https://openalex.org/W1983805504","https://openalex.org/W1986958075","https://openalex.org/W2020832610","https://openalex.org/W2040914220","https://openalex.org/W2054635074","https://openalex.org/W2055312969","https://openalex.org/W2060088854","https://openalex.org/W2068811666","https://openalex.org/W2083312275","https://openalex.org/W2093126111","https://openalex.org/W2096076159","https://openalex.org/W2106278040","https://openalex.org/W2110148884","https://openalex.org/W2111811045","https://openalex.org/W2114053889","https://openalex.org/W2117948786","https://openalex.org/W2126326508","https://openalex.org/W2134208433","https://openalex.org/W2150600914","https://openalex.org/W2152237832","https://openalex.org/W2156363980","https://openalex.org/W2169755701"],"related_works":["https://openalex.org/W2009760145","https://openalex.org/W2501380663","https://openalex.org/W4300102016","https://openalex.org/W2150600914","https://openalex.org/W2306120034","https://openalex.org/W2888165634","https://openalex.org/W2909341781","https://openalex.org/W3118678535","https://openalex.org/W2181599373","https://openalex.org/W2883924970"],"abstract_inverted_index":{"Research":[0],"on":[1],"human":[2],"embryonic":[3],"stem":[4],"cells":[5],"(hESCs)":[6],"has":[7],"attracted":[8],"much":[9],"attention":[10],"given":[11],"their":[12,42,69],"great":[13],"potential":[14],"for":[15],"tissue":[16],"regenerative":[17],"therapy":[18],"and":[19,65,98,118,122,129,132],"fundamental":[20],"developmental":[21],"biology":[22],"studies.":[23],"Yet,":[24],"there":[25],"is":[26],"still":[27],"limited":[28],"understanding":[29],"of":[30,39,57,80,82,104,120],"how":[31],"mechanical":[32],"signals":[33],"in":[34,95,101,135],"the":[35,54,109],"local":[36],"cellular":[37,116],"microenvironment":[38],"hESCs":[40,62,121],"regulate":[41],"fate":[43,102],"decisions.":[44],"Here,":[45],"we":[46],"applied":[47],"a":[48,124],"microfabricated":[49],"micromechanical":[50],"platform":[51],"to":[52,127],"investigate":[53],"mechanoresponsive":[55],"behaviors":[56],"hESCs.":[58,83,105],"We":[59],"demonstrated":[60],"that":[61],"are":[63],"mechanosensitive,":[64],"they":[66],"could":[67],"increase":[68],"cytoskeleton":[70,86],"contractility":[71,87],"with":[72,92],"matrix":[73,114],"rigidity.":[74],"Furthermore,":[75],"rigid":[76],"substrates":[77],"supported":[78],"maintenance":[79],"pluripotency":[81,119],"Matrix":[84],"mechanics-mediated":[85],"might":[88],"be":[89],"functionally":[90],"correlated":[91],"E-cadherin":[93],"expressions":[94],"cell-cell":[96],"contacts":[97],"thus":[99],"involved":[100],"decisions":[103],"Our":[106],"results":[107],"highlighted":[108],"important":[110],"functional":[111],"link":[112],"between":[113],"rigidity,":[115],"mechanics,":[117],"provided":[123],"novel":[125],"approach":[126],"characterize":[128],"understand":[130],"mechanotransduction":[131],"its":[133],"involvement":[134],"hESC":[136],"function.":[137]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}