{"id":"https://openalex.org/W2089083932","doi":"https://doi.org/10.1016/j.dnarep.2004.03.033","title":"The Chk2 protein kinase","display_name":"The Chk2 protein kinase","publication_year":2004,"publication_date":"2004-04-24","ids":{"openalex":"https://openalex.org/W2089083932","doi":"https://doi.org/10.1016/j.dnarep.2004.03.033","mag":"2089083932","pmid":"https://pubmed.ncbi.nlm.nih.gov/15279791"},"language":"en","primary_location":{"id":"doi:10.1016/j.dnarep.2004.03.033","doi":"https://doi.org/10.1016/j.dnarep.2004.03.033","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.dnarep.2004.03.033","pdf_url":null,"source":{"id":"https://openalex.org/S3892243","display_name":"DNA repair","issn_l":"1568-7856","issn":["1568-7856","1568-7864"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Repair","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jinwoo Ahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinwoo Ahn","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, NY 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042240617","display_name":"Marshall J. Urist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marshall Urist","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, NY 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080267048","display_name":"Carol L. Prives","orcid":"https://orcid.org/0000-0003-1846-5562","observed_orcids":["https://orcid.org/0000-0003-1846-5562"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carol Prives","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, NY 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080267048"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":null,"fwci":1.3788,"has_fulltext":false,"cited_by_count":240,"citation_normalized_percentile":{"value":0.78933543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"3","issue":"8-9","first_page":"1039","last_page":"1047"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chk2","display_name":"Chk2","score":0.8899999856948853},{"id":"https://openalex.org/keywords/checkpoint-kinase-2","display_name":"checkpoint kinase 2","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9580000042915344},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phosphorylation-regulation","display_name":"phosphorylation regulation","score":0.753000020980835},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2910325170","wikidata":"https://www.wikidata.org/wiki/Q14912280","display_name":"Checkpoint Kinase 2","level":5,"score":0.9543989300727844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8068172335624695},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.724248468875885},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.5510290265083313},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5288031101226807},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5195596218109131},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.504939615726471},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4668816924095154},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.4100755453109741},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4028990566730499},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3961377739906311},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37108612060546875},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3075907230377197},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.27187293767929077},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22936055064201355},{"id":"https://openalex.org/C2910050888","wikidata":"https://www.wikidata.org/wiki/Q4857068","display_name":"Protein-Serine-Threonine Kinases","level":4,"score":0.11636623740196228}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.dnarep.2004.03.033","doi":"https://doi.org/10.1016/j.dnarep.2004.03.033","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.dnarep.2004.03.033","pdf_url":null,"source":{"id":"https://openalex.org/S3892243","display_name":"DNA repair","issn_l":"1568-7856","issn":["1568-7856","1568-7864"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Repair","raw_type":"journal-article"},{"id":"pmid:15279791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15279791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA repair","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2768115383","display_name":"Roles and Regulation of wild-type and mutant forms of p53","funder_award_id":"P01CA087497","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W1480741751","https://openalex.org/W1491129208","https://openalex.org/W1501608509","https://openalex.org/W1506174877","https://openalex.org/W1668554361","https://openalex.org/W1752089945","https://openalex.org/W1914194999","https://openalex.org/W1923812684","https://openalex.org/W1950559180","https://openalex.org/W1963636909","https://openalex.org/W1968171472","https://openalex.org/W1969210627","https://openalex.org/W1970891016","https://openalex.org/W1971936302","https://openalex.org/W1974190379","https://openalex.org/W1975245003","https://openalex.org/W1979543776","https://openalex.org/W1980017984","https://openalex.org/W1982305402","https://openalex.org/W1986891733","https://openalex.org/W1988876917","https://openalex.org/W1992783176","https://openalex.org/W1995842427","https://openalex.org/W1997034002","https://openalex.org/W1998939489","https://openalex.org/W2000285763","https://openalex.org/W2001627329","https://openalex.org/W2003842525","https://openalex.org/W2004896474","https://openalex.org/W2006389323","https://openalex.org/W2006705796","https://openalex.org/W2010255232","https://openalex.org/W2010378709","https://openalex.org/W2011139344","https://openalex.org/W2014156638","https://openalex.org/W2017718483","https://openalex.org/W2018198094","https://openalex.org/W2019392060","https://openalex.org/W2023937915","https://openalex.org/W2023961264","https://openalex.org/W2024414745","https://openalex.org/W2028044172","https://openalex.org/W2029304297","https://openalex.org/W2031365072","https://openalex.org/W2031414445","https://openalex.org/W2034195376","https://openalex.org/W2034317592","https://openalex.org/W2035983301","https://openalex.org/W2038612913","https://openalex.org/W2043136696","https://openalex.org/W2044366106","https://openalex.org/W2045526190","https://openalex.org/W2046083330","https://openalex.org/W2047660841","https://openalex.org/W2048066082","https://openalex.org/W2049877855","https://openalex.org/W2053335298","https://openalex.org/W2055354487","https://openalex.org/W2055607178","https://openalex.org/W2056518099","https://openalex.org/W2058005740","https://openalex.org/W2060107244","https://openalex.org/W2061121990","https://openalex.org/W2063619106","https://openalex.org/W2064047482","https://openalex.org/W2067087347","https://openalex.org/W2069518838","https://openalex.org/W2070632817","https://openalex.org/W2074615071","https://openalex.org/W2076314401","https://openalex.org/W2077709632","https://openalex.org/W2079706088","https://openalex.org/W2080602376","https://openalex.org/W2083068695","https://openalex.org/W2089574530","https://openalex.org/W2091624569","https://openalex.org/W2092282016","https://openalex.org/W2092462528","https://openalex.org/W2092799988","https://openalex.org/W2094144878","https://openalex.org/W2100448419","https://openalex.org/W2108992945","https://openalex.org/W2110948748","https://openalex.org/W2111131079","https://openalex.org/W2111772438","https://openalex.org/W2114647652","https://openalex.org/W2120921507","https://openalex.org/W2121399092","https://openalex.org/W2127465687","https://openalex.org/W2127566231","https://openalex.org/W2128739990","https://openalex.org/W2128994729","https://openalex.org/W2130447102","https://openalex.org/W2131833681","https://openalex.org/W2133853290","https://openalex.org/W2134043317","https://openalex.org/W2134230163","https://openalex.org/W2138781054","https://openalex.org/W2144007830","https://openalex.org/W2146387970","https://openalex.org/W2148964728","https://openalex.org/W2149938795","https://openalex.org/W2149954998","https://openalex.org/W2152862467","https://openalex.org/W2153708110","https://openalex.org/W2159040452","https://openalex.org/W2159099751","https://openalex.org/W2163050419","https://openalex.org/W2165907297","https://openalex.org/W2166548889","https://openalex.org/W2170595661","https://openalex.org/W2171050607","https://openalex.org/W2314683555","https://openalex.org/W2340067687","https://openalex.org/W4212962560","https://openalex.org/W6630236164","https://openalex.org/W6637282017","https://openalex.org/W6640193225","https://openalex.org/W6640718618","https://openalex.org/W6679421979","https://openalex.org/W6680823823"],"related_works":["https://openalex.org/W2625718430","https://openalex.org/W1545084887","https://openalex.org/W3150129691","https://openalex.org/W4367293061","https://openalex.org/W2014416796","https://openalex.org/W2115875682","https://openalex.org/W7135491260","https://openalex.org/W2047660841","https://openalex.org/W1480521963","https://openalex.org/W2018388108"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
