{"id":"https://openalex.org/W208904596","doi":null,"title":"Dependence-induced changes in opioid-receptor gene expression","display_name":"Dependence-induced changes in opioid-receptor gene expression","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W208904596","mag":"208904596"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:liu-90034","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-90034","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/bachelorThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-90034","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102137902","display_name":"Anna Johansson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anna Johansson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5102137902"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0786999985575676,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.6899999976158142},{"id":"https://openalex.org/keywords/delta-opioid-receptor","display_name":"delta opioid receptor","score":1.0},{"id":"https://openalex.org/keywords/oprm1","display_name":"OPRM1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7039999961853027},{"id":"https://openalex.org/keywords/drug-addiction","display_name":"drug addiction","score":0.5270000100135803},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.6330000162124634},{"id":"https://openalex.org/keywords/sucrose-intake","display_name":"sucrose intake","score":0.7929999828338623},{"id":"https://openalex.org/keywords/voluntary-physical-activity","display_name":"voluntary physical activity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/mesolimbic-dopamine-system","display_name":"mesolimbic dopamine system","score":0.8299999833106995},{"id":"https://openalex.org/keywords/natural-reward","display_name":"natural reward","score":0.6539999842643738},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9020000100135803},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.8870000243186951},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.9819999933242798},{"id":"https://openalex.org/keywords/addiction","display_name":"addiction","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.7712035179138184},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7129803895950317},{"id":"https://openalex.org/C2777650357","wikidata":"https://www.wikidata.org/wiki/Q1569460","display_name":"Mesolimbic pathway","level":5,"score":0.6033116579055786},{"id":"https://openalex.org/C40010229","wikidata":"https://www.wikidata.org/wiki/Q3184856","display_name":"Substance abuse","level":2,"score":0.5590500235557556},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5065921545028687},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4682976305484772},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.4650840163230896},{"id":"https://openalex.org/C143661069","wikidata":"https://www.wikidata.org/wiki/Q670713","display_name":"Reward system","level":2,"score":0.4609867036342621},{"id":"https://openalex.org/C2778799817","wikidata":"https://www.wikidata.org/wiki/Q4681134","display_name":"Addictive behavior","level":3,"score":0.4466802179813385},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4404720962047577},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4269621968269348},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.42291679978370667},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.34875625371932983},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3370179235935211},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32123371958732605},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2180403172969818},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.16650685667991638},{"id":"https://openalex.org/C2780948874","wikidata":"https://www.wikidata.org/wiki/Q640562","display_name":"Ventral tegmental area","level":4,"score":0.11036080121994019}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:liu-90034","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-90034","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/bachelorThesis"},{"id":"mag:208904596","doi":null,"is_oa":false,"landing_page_url":"http://liu.diva-portal.org/smash/get/diva2:611465/FULLTEXT01","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:liu-90034","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-90034","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/bachelorThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W9826222","https://openalex.org/W14337430","https://openalex.org/W203645675","https://openalex.org/W1528330061","https://openalex.org/W1568787506","https://openalex.org/W1578649782","https://openalex.org/W1617955079","https://openalex.org/W1868330658","https://openalex.org/W1938434640","https://openalex.org/W1969551274","https://openalex.org/W1970226919","https://openalex.org/W1972276105","https://openalex.org/W1972349566","https://openalex.org/W1975262853","https://openalex.org/W1975690149","https://openalex.org/W1977573757","https://openalex.org/W1979031324","https://openalex.org/W1982506365","https://openalex.org/W1989201294","https://openalex.org/W1989416066","https://openalex.org/W1989993438","https://openalex.org/W1992787152","https://openalex.org/W1995651500","https://openalex.org/W1996590225","https://openalex.org/W2010733076","https://openalex.org/W2011132358","https://openalex.org/W2015046028","https://openalex.org/W2016449743","https://openalex.org/W2019763316","https://openalex.org/W2021349110","https://openalex.org/W2024605730","https://openalex.org/W2026747063","https://openalex.org/W2029888262","https://openalex.org/W2033131248","https://openalex.org/W2043486316","https://openalex.org/W2044122225","https://openalex.org/W2044711161","https://openalex.org/W2045112376","https://openalex.org/W2048047690","https://openalex.org/W2050523319","https://openalex.org/W2054764555","https://openalex.org/W2056401590","https://openalex.org/W2056475288","https://openalex.org/W2058339818","https://openalex.org/W2059040634","https://openalex.org/W2059388291","https://openalex.org/W2063357209","https://openalex.org/W2063381382","https://openalex.org/W2063555058","https://openalex.org/W2074378069","https://openalex.org/W2074696277","https://openalex.org/W2079975546","https://openalex.org/W2080133581","https://openalex.org/W2088639396","https://openalex.org/W2092652733","https://openalex.org/W2095830677","https://openalex.org/W2096688894","https://openalex.org/W2106727206","https://openalex.org/W2113650420","https://openalex.org/W2113911243","https://openalex.org/W2123575723","https://openalex.org/W2123661522","https://openalex.org/W2127758256","https://openalex.org/W2128241182","https://openalex.org/W2129143684","https://openalex.org/W2135192074","https://openalex.org/W2138607345","https://openalex.org/W2140795841","https://openalex.org/W2148895573","https://openalex.org/W2157678817","https://openalex.org/W2157765924","https://openalex.org/W2158596485","https://openalex.org/W2162112473","https://openalex.org/W2162992969","https://openalex.org/W2165374000","https://openalex.org/W2167246321","https://openalex.org/W2168748782","https://openalex.org/W2236443413","https://openalex.org/W2460201367","https://openalex.org/W2598791067","https://openalex.org/W3133941431"],"related_works":["https://openalex.org/W2015046028","https://openalex.org/W2081748369","https://openalex.org/W4388109087","https://openalex.org/W1989201294","https://openalex.org/W2974415342","https://openalex.org/W2002911679","https://openalex.org/W2023203746","https://openalex.org/W2785380492","https://openalex.org/W2006614558","https://openalex.org/W4238309752"],"abstract_inverted_index":{"Using":[0],"drugs":[1],"such":[2],"as":[3,258],"alcohol":[4,146,251],"and":[5,15,45,52,64,66,98,123,169,186,209,218,223,232,253],"morphine":[6],"among":[7],"others":[8],"can":[9],"be":[10],"addictive":[11],"in":[12,29,49,76,105,109,131,183,191,196,216,236,249],"some":[13],"individuals,":[14],"progress":[16],"into":[17,82],"a":[18,137,178,193,246],"substance":[19],"abuse":[20],"disorder.":[21],"The":[22,39,111],"mesolimbic":[23],"dopaminergic":[24],"system":[25,129,231],"(MD-system)":[26],"is":[27,41],"involved":[28,74,108],"the":[30,34,70,77,86,91,126,144,150,210,228,237,242,254],"reward":[31,72,230],"process":[32,73],"during":[33],"development":[35],"of":[36,69,79,100,113,121,143,167,174,199,239],"drug":[37,96,145],"addiction.":[38],"MD-system":[40,87],"critical":[42],"for":[43,57,189],"survival":[44],"affects":[46],"different":[47,206],"behaviors":[48],"both":[50,158],"man":[51],"animal.":[53],"Neurochemical":[54],"pathways":[55],"drive":[56],"instance":[58],"physical":[59,135,200],"activity,":[60,136],"food":[61,259],"intake,":[62,97],"love":[63],"reproduction":[65],"are":[67,93,213],"part":[68],"natural":[71,138,151,229,255],"partly":[75],"release":[78],"dopamine":[80],"(DA)":[81],"frontal":[83],"lobes.":[84],"Within":[85],"opioid":[88,128,243],"receptors":[89,102,244],"throughout":[90],"brain":[92,106,172],"affected":[94],"by":[95],"activation":[99],"these":[101,204],"modulate":[103],"DA-release":[104],"regions":[107],"reward-behavior.":[110],"aim":[112],"this":[114],"study":[115],"was":[116,147,161],"to":[117,133,149,163,221],"evaluate":[118],"gene":[119,197,212],"expression":[120,198],"MOR":[122,168],"DOR":[124,170,190],"within":[125],"endogenous":[127],"(EO-system)":[130],"relation":[132],"voluntary":[134,155],"reinforcer.":[139],"Further":[140],"on":[141],"investigations":[142],"compared":[148],"reinforcer":[152],"sucrose":[153],"using":[154],"consumption.":[156],"For":[157],"experiments":[159],"qRT-PCR":[160],"used":[162],"measure":[164],"mRNA":[165],"levels":[166],"from":[171],"areas":[173],"interest.":[175],"We":[176],"found":[177],"small":[179],"significant":[180],"up":[181],"regulation":[182,195],"NAc,":[184],"PFC":[185],"VTA":[187,192,217],"but":[188],"down":[194,214],"exercising":[201],"mice.":[202],"Additionally":[203],"two":[205],"genes":[207],"OPRM1-":[208],"OPRD1-":[211],"regulated":[215],"NAc":[219],"due":[220],"alcohol-":[222],"sugar-intake.":[224],"This":[225],"implicate":[226],"that":[227],"their":[233],"ORs":[234],"point":[235],"direction":[238],"earlier":[240],"findings;":[241],"have":[245],"key":[247],"role":[248],"regulate":[250],"intake":[252],"rewarding":[256],"stimuli":[257],"intake.":[260]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
