{"id":"https://openalex.org/W2089039697","doi":"https://doi.org/10.1016/s0966-842x(99)01468-7","title":"Bordetella pertussis adenylate cyclase: a toxin with multiple talents","display_name":"Bordetella pertussis adenylate cyclase: a toxin with multiple talents","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2089039697","doi":"https://doi.org/10.1016/s0966-842x(99)01468-7","mag":"2089039697","pmid":"https://pubmed.ncbi.nlm.nih.gov/10217833"},"language":"en","primary_location":{"id":"doi:10.1016/s0966-842x(99)01468-7","doi":"https://doi.org/10.1016/s0966-842x(99)01468-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0966-842x(99)01468-7","pdf_url":null,"source":{"id":"https://openalex.org/S587692","display_name":"Trends in Microbiology","issn_l":"0966-842X","issn":["0966-842X","1878-4380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Microbiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2089039697"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040126899","display_name":"Daniel Ladant","orcid":"https://orcid.org/0000-0003-1955-548X","observed_orcids":["https://orcid.org/0000-0003-1955-548X"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Ladant","raw_affiliation_strings":["Dept of Biochemistry and Molecular Genetics, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Biochemistry and Molecular Genetics, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109967334","display_name":"Agn\u00e8s Ullmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Agnes Ullmann","raw_affiliation_strings":["Dept of Biochemistry and Molecular Genetics, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Biochemistry and Molecular Genetics, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France","institution_ids":["https://openalex.org/I157536573"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109967334"],"corresponding_institution_ids":["https://openalex.org/I157536573"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":1.6101,"has_fulltext":false,"cited_by_count":298,"citation_normalized_percentile":{"value":0.83333333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"7","issue":"4","first_page":"172","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.05460000038146973,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bordetella-pertussis","display_name":"Bordetella pertussis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adenylate-cyclase-toxin","display_name":"adenylate cyclase toxin","score":0.9660000205039978},{"id":"https://openalex.org/keywords/catalytic-domain","display_name":"catalytic domain","score":0.6629999876022339},{"id":"https://openalex.org/keywords/protein-targeting","display_name":"protein targeting","score":0.9629999995231628},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.984000027179718},{"id":"https://openalex.org/keywords/bacterial-virulence-factors","display_name":"bacterial virulence factors","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C2777582894","wikidata":"https://www.wikidata.org/wiki/Q137103","display_name":"Bordetella pertussis","level":3,"score":0.9079396724700928},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.7804604172706604},{"id":"https://openalex.org/C2910325308","wikidata":"https://www.wikidata.org/wiki/Q65920385","display_name":"Adenylate Cyclase Toxin","level":5,"score":0.7737106084823608},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.7508916258811951},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7328560948371887},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.6202449798583984},{"id":"https://openalex.org/C2777824465","wikidata":"https://www.wikidata.org/wiki/Q893440","display_name":"Bordetella","level":4,"score":0.6035284399986267},{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.5504577159881592},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5121166706085205},{"id":"https://openalex.org/C196419574","wikidata":"https://www.wikidata.org/wiki/Q24723791","display_name":"Pertactin","level":5,"score":0.4631836414337158},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4471016824245453},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43946942687034607},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4360222816467285},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3356991410255432},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.3106231093406677},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.23861166834831238},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1970399022102356},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14414650201797485},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08119311928749084},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07602021098136902}],"mesh":[{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001886","descriptor_name":"Bordetella pertussis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001886","descriptor_name":"Bordetella pertussis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001886","descriptor_name":"Bordetella pertussis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010566","descriptor_name":"Virulence Factors, Bordetella","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037361","descriptor_name":"Adenylate Cyclase Toxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0966-842x(99)01468-7","doi":"https://doi.org/10.1016/s0966-842x(99)01468-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0966-842x(99)01468-7","pdf_url":null,"source":{"id":"https://openalex.org/S587692","display_name":"Trends in Microbiology","issn_l":"0966-842X","issn":["0966-842X","1878-4380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Microbiology","raw_type":"journal-article"},{"id":"pmid:10217833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10217833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313928","display_name":"Institut national de la recherche scientifique","ror":"https://ror.org/04td37d32"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1517788279","https://openalex.org/W1526838717","https://openalex.org/W1549383626","https://openalex.org/W1586520658","https://openalex.org/W1899077083","https://openalex.org/W1973454831","https://openalex.org/W1980108836","https://openalex.org/W1980767305","https://openalex.org/W1990299056","https://openalex.org/W1990669291","https://openalex.org/W1993350361","https://openalex.org/W2001600700","https://openalex.org/W2010610091","https://openalex.org/W2011127667","https://openalex.org/W2027983416","https://openalex.org/W2036846779","https://openalex.org/W2047670590","https://openalex.org/W2048895914","https://openalex.org/W2049338606","https://openalex.org/W2064142185","https://openalex.org/W2076288433","https://openalex.org/W2076477984","https://openalex.org/W2081924677","https://openalex.org/W2109351754","https://openalex.org/W2127135538","https://openalex.org/W2136472612","https://openalex.org/W2138859769","https://openalex.org/W2149539126","https://openalex.org/W2320619603"],"related_works":["https://openalex.org/W1484283460","https://openalex.org/W2900688705","https://openalex.org/W1998494984","https://openalex.org/W2046499903","https://openalex.org/W2090951359","https://openalex.org/W1517788279","https://openalex.org/W2883584643","https://openalex.org/W2355078899","https://openalex.org/W2333192259","https://openalex.org/W2913666484"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}