{"id":"https://openalex.org/W2088694226","doi":"https://doi.org/10.1017/s0031182097001224","title":"The effects of the peptides AF3 (AVPGVLRFamide) and AF4 (GDVPGVLRFamide) on the somatic muscle of the parasitic nematodes Ascaris suum and Ascaridia galli","display_name":"The effects of the peptides AF3 (AVPGVLRFamide) and AF4 (GDVPGVLRFamide) on the somatic muscle of the parasitic nematodes Ascaris suum and Ascaridia galli","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W2088694226","doi":"https://doi.org/10.1017/s0031182097001224","mag":"2088694226","pmid":"https://pubmed.ncbi.nlm.nih.gov/10190177"},"language":"en","primary_location":{"id":"doi:10.1017/s0031182097001224","doi":"https://doi.org/10.1017/s0031182097001224","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s0031182097001224","pdf_url":null,"source":{"id":"https://openalex.org/S161475033","display_name":"Parasitology","issn_l":"0031-1820","issn":["0031-1820","1469-8161"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2088694226"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052470538","display_name":"Nathan Trim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. TRIM","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Southampton, UK","Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Southampton, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072230113","display_name":"Lindy M. Holden-Dye","orcid":"https://orcid.org/0000-0002-9704-1217","observed_orcids":["https://orcid.org/0000-0002-9704-1217"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. HOLDEN-DYE","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060113846","display_name":"Richard George Ruddell","orcid":"https://orcid.org/0000-0002-7996-4368","observed_orcids":["https://orcid.org/0000-0002-7996-4368"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. RUDDELL","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031692281","display_name":"Robert James Walker","orcid":"https://orcid.org/0000-0003-3366-0956","observed_orcids":["https://orcid.org/0000-0003-3366-0956"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. J. WALKER","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK","institution_ids":["https://openalex.org/I43439940"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I43439940"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.3496,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.47316868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"115","issue":"2","first_page":"213","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.5532000064849854,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.5532000064849854,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.28049999475479126,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.10220000147819519,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ascaris-suum","display_name":"Ascaris suum","score":0.8659999966621399},{"id":"https://openalex.org/keywords/ascaridia-galli","display_name":"Ascaridia galli","score":1.0},{"id":"https://openalex.org/keywords/neuromuscular-junction","display_name":"neuromuscular junction","score":0.7710000276565552},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mecamylamine","display_name":"mecamylamine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cobalt","display_name":"cobalt","score":0.593999981880188},{"id":"https://openalex.org/keywords/sodium-dependence","display_name":"sodium dependence","score":0.5009999871253967},{"id":"https://openalex.org/keywords/muscle-depolarization","display_name":"muscle depolarization","score":0.7670000195503235},{"id":"https://openalex.org/keywords/parasitic-nematodes","display_name":"parasitic nematodes","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2779845534","wikidata":"https://www.wikidata.org/wiki/Q2062253","display_name":"Ascaris suum","level":3,"score":0.9052615761756897},{"id":"https://openalex.org/C2780492224","wikidata":"https://www.wikidata.org/wiki/Q310838","display_name":"Ascaris","level":3,"score":0.6175743341445923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5819523930549622},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.5607563257217407},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.4271409511566162},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3597267270088196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2675260603427887},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.1661364734172821},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15355908870697021}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001197","descriptor_name":"Ascaridia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001197","descriptor_name":"Ascaridia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008464","descriptor_name":"Mecamylamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017165","descriptor_name":"Ascaris suum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017165","descriptor_name":"Ascaris suum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1017/s0031182097001224","doi":"https://doi.org/10.1017/s0031182097001224","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s0031182097001224","pdf_url":null,"source":{"id":"https://openalex.org/S161475033","display_name":"Parasitology","issn_l":"0031-1820","issn":["0031-1820","1469-8161"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology","raw_type":"journal-article"},{"id":"pmid:10190177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10190177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2418466711","https://openalex.org/W2132167213","https://openalex.org/W2039395374","https://openalex.org/W2046151203","https://openalex.org/W2074706860","https://openalex.org/W2040877063","https://openalex.org/W2275113792","https://openalex.org/W2037333830","https://openalex.org/W1973611595","https://openalex.org/W2137668386"],"abstract_inverted_index":{"AF3":[0,47,88,205,218,230,250,263,311],"(AVPGVLRFamide)":[1],"and":[2,31,48,63,98,116,171,206,219,231,251,264,286,321,343],"AF4":[3,49,99,207,220,232,252,265,322],"(GDVPGVLRFamide)":[4],"are":[5],"endogenous":[6],"RFamide-like":[7],"peptides":[8,21,165,337],"isolated":[9],"from":[10,258],"the":[11,17,23,34,39,43,150,161,164,202,217,240,245,333,351],"parasitic":[12,356],"nematode":[13],"Ascaris":[14,27,234,241,254,342],"suum.":[15],"Here":[16],"actions":[18],"of":[19,26,36,54,277,355],"these":[20,336],"on":[22],"somatic":[24,273],"musculature":[25],"have":[28],"been":[29],"investigated":[30],"compared":[32],"to":[33,132,143,163,177,189,204,224,269,335,341],"action":[35,238],"acetylcholine":[37],"(ACh),":[38],"excitatory":[40],"transmitter":[41],"at":[42,135,215,239],"neuromuscular":[44],"junction.":[45],"ACh,":[46,262],"contracted":[50],"muscle":[51,73,133,235,255,274,296],"with":[52,175,275],"EC50S":[53,109,276],"13":[55,278],"+/-":[56,60,65,82,92,103,112,118,169,173,279,283,288,305,315,326],"1":[57],"microM,":[58,281,307,317,328],"24":[59],"6":[61],"nM":[62,114,120,285],"37":[64],"2":[66],"nM,":[67,290],"respectively":[68,291],"(n":[69,292],"=":[70,86,96,107,158,180,293,303,309,313,319,324,330],"6).":[71],"The":[72,141,182,295],"cells":[74,297],"were":[75,110,166,266,298],"depolarized":[76,299],"by":[77,149,185,193,300],"ACh":[78,130,146,186,301],"(3":[79],"microM;":[80,90,101,156],"5.2":[81],"0.4":[83,104],"mV,":[84,94,105],"n":[85,95,106,157,179,308,318,329],"42),":[87],"(1":[89,100],"2.6":[91],"0.3":[93],"19)":[97],"3.3":[102],"19).":[108],"681":[111],"329":[113],"(AF3)":[115],"901":[117],"229":[119],"(AF4),":[121],"but":[122,160],"an":[123,237],"estimate":[124],"could":[125],"not":[126,167,339],"be":[127],"made":[128],"for":[129,260],"due":[131],"contraction":[134],"concentrations":[136],"greater":[137,191],"than":[138,201,222],"10":[139,325],"microM.":[140],"depolarization":[142,183],"3":[144,280,316],"microM":[145],"was":[147,187,212],"abolished":[148],"nicotinic":[151,242],"receptor":[152],"antagonist":[153],"mecamylamine":[154],"(10":[155],"5)":[159],"responses":[162],"(111":[168],"7%":[170],"108":[172],"17%":[174],"respect":[176],"control;":[178],"5).":[181],"elicited":[184],"reduced":[188],"a":[190,194,347],"extent":[192],"50%":[195],"reduction":[196],"in":[197,350],"extracellular":[198],"Na+":[199],"concentration":[200],"response":[203,334],"(P":[208],"<":[209],"0.02).":[210],"Cobalt":[211],"more":[213],"effective":[214],"blocking":[216],"depolarizations":[221],"those":[223],"ACh.":[225,261],"These":[226],"observations":[227],"suggest":[228],"that":[229,259],"contract":[233,270],"without":[236],"receptor.":[243],"Furthermore,":[244],"ionic":[246],"mechanism":[247],"through":[248],"which":[249],"depolarize":[253],"is":[256,338],"different":[257],"also":[267],"found":[268],"Ascaridia":[271],"galli":[272],"721":[282],"236":[284],"371":[287],"177":[289],"7).":[294],"(EC50":[302,312,323],"14":[304],"5":[306,314,327],"5),":[310],"4)":[320],"4).":[331],"Therefore":[332],"unique":[340],"they":[344],"may":[345],"subserve":[346],"functional":[348],"role":[349],"motor":[352],"nervous":[353],"system":[354],"nematodes.":[357]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
