{"id":"https://openalex.org/W2088693124","doi":"https://doi.org/10.1021/bi991112+","title":"Small Molecular Products of Dealkylation in Soman-Inhibited Electric Eel Acetylcholinesterase","display_name":"Small Molecular Products of Dealkylation in Soman-Inhibited Electric Eel Acetylcholinesterase","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2088693124","doi":"https://doi.org/10.1021/bi991112+","mag":"2088693124","pmid":"https://pubmed.ncbi.nlm.nih.gov/10423232"},"language":"en","primary_location":{"id":"doi:10.1021/bi991112+","doi":"https://doi.org/10.1021/bi991112+","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi991112+","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062705354","display_name":"Carol Viragh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"id":"https://openalex.org/I84470341","display_name":"Catholic University of America","ror":"https://ror.org/047yk3s18","country_code":"US","type":"education","lineage":["https://openalex.org/I84470341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Viragh","raw_affiliation_strings":["Department of Chemistry, The Catholic University of America, Washington, D.C. 20064, and Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0805"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Catholic University of America, Washington, D.C. 20064, and Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0805","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567","https://openalex.org/I84470341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053162331","display_name":"Ildiko M. Kovach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"id":"https://openalex.org/I84470341","display_name":"Catholic University of America","ror":"https://ror.org/047yk3s18","country_code":"US","type":"education","lineage":["https://openalex.org/I84470341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ildiko M. Kovach","raw_affiliation_strings":["Department of Chemistry, The Catholic University of America, Washington, D.C. 20064, and Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0805"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Catholic University of America, Washington, D.C. 20064, and Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0805","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567","https://openalex.org/I84470341"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012634036","display_name":"Lewis K. Pannell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"id":"https://openalex.org/I84470341","display_name":"Catholic University of America","ror":"https://ror.org/047yk3s18","country_code":"US","type":"education","lineage":["https://openalex.org/I84470341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lewis Pannell","raw_affiliation_strings":["Department of Chemistry, The Catholic University of America, Washington, D.C. 20064, and Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0805"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Catholic University of America, Washington, D.C. 20064, and Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0805","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567","https://openalex.org/I84470341"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.5567,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.69208945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"38","issue":"30","first_page":"9557","last_page":"9561"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.6685000061988831,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.6685000061988831,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.31150001287460327,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soman","display_name":"soman","score":0.8100000023841858},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dealkylation","display_name":"dealkylation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/alkene-formation","display_name":"alkene formation","score":0.609000027179718},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.6100000143051147},{"id":"https://openalex.org/keywords/electric-eel","display_name":"electric eel","score":0.6389999985694885},{"id":"https://openalex.org/keywords/reaction-product-analysis","display_name":"reaction product analysis","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C2780266723","wikidata":"https://www.wikidata.org/wiki/Q408044","display_name":"Soman","level":4,"score":0.9135216474533081},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.853533148765564},{"id":"https://openalex.org/C164361826","wikidata":"https://www.wikidata.org/wiki/Q177604","display_name":"Alkylation","level":3,"score":0.5396220088005066},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.5035459399223328},{"id":"https://openalex.org/C2778695967","wikidata":"https://www.wikidata.org/wiki/Q44791900","display_name":"Chloride","level":2,"score":0.44255179166793823},{"id":"https://openalex.org/C2778706303","wikidata":"https://www.wikidata.org/wiki/Q2612896","display_name":"Nerve agent","level":4,"score":0.41053032875061035},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3656069040298462},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.27963942289352417},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10416674613952637},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000441","descriptor_name":"Hexanols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002849","descriptor_name":"Chromatography, Gas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003640","descriptor_name":"Dealkylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004593","descriptor_name":"Electrophorus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006586","descriptor_name":"Hexanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012999","descriptor_name":"Soman","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi991112+","doi":"https://doi.org/10.1021/bi991112+","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi991112+","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:10423232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10423232","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W578736495","https://openalex.org/W1542038626","https://openalex.org/W1778515962","https://openalex.org/W1964939090","https://openalex.org/W1965549661","https://openalex.org/W1968662992","https://openalex.org/W1971048984","https://openalex.org/W1989146628","https://openalex.org/W1995608522","https://openalex.org/W1997184864","https://openalex.org/W1998312296","https://openalex.org/W1999972896","https://openalex.org/W2000804136","https://openalex.org/W2002419954","https://openalex.org/W2005833473","https://openalex.org/W2015614837","https://openalex.org/W2017993238","https://openalex.org/W2024481680","https://openalex.org/W2027363543","https://openalex.org/W2036200632","https://openalex.org/W2037970345","https://openalex.org/W2044795328","https://openalex.org/W2045763735","https://openalex.org/W2051593446","https://openalex.org/W2051679721","https://openalex.org/W2053972543","https://openalex.org/W2056941024","https://openalex.org/W2062448952","https://openalex.org/W2068098955","https://openalex.org/W2071370689","https://openalex.org/W2078417329","https://openalex.org/W2087762757","https://openalex.org/W2088636647","https://openalex.org/W2109507519","https://openalex.org/W2136442032","https://openalex.org/W2270309244","https://openalex.org/W2282697960","https://openalex.org/W2324425905","https://openalex.org/W2327472417","https://openalex.org/W2395525578","https://openalex.org/W2584023400","https://openalex.org/W4229488389","https://openalex.org/W4239393784","https://openalex.org/W4250761900"],"related_works":["https://openalex.org/W1968662992","https://openalex.org/W2005833473","https://openalex.org/W2270309244","https://openalex.org/W2017993238","https://openalex.org/W2088395036","https://openalex.org/W2587757926","https://openalex.org/W2089264334","https://openalex.org/W2028297933","https://openalex.org/W2327681615","https://openalex.org/W2017108174"],"abstract_inverted_index":{"Product":[0],"analysis":[1],"of":[2,29,42,82,85,97,115,131,148],"dealkylation":[3,51],"in":[4,34,52,90,109,157],"P(S)C(S)-soman-inhibited":[5],"electric":[6],"eel":[7],"acetylcholinesterase":[8],"(AChE)":[9],"by":[10,128,137],"GC-MS":[11],"using":[12],"the":[13,35,47,83,91,95,98,113,146,149],"selected":[14],"ion":[15,89],"monitoring":[16],"mode":[17],"has":[18],"been":[19],"carried":[20],"out.":[21],"The":[22,50,140],"instrument":[23],"was":[24],"calibrated":[25],"with":[26,112,145,155],"pure":[27],"standards":[28],"2,3-dimethyl-1-butene":[30],"and":[31,38,44,60,69,134],"2,":[32,71],"3-dimethyl-2-butene":[33],"gas":[36],"phase":[37],"methylene":[39],"chloride":[40],"extracts":[41],"2,3-dimethyl-2-butanol":[43],"3,3-dimethyl-2-butanol":[45,74],"from":[46,101],"aqueous":[48],"phase.":[49],"soman-inhibited":[53],"AChE":[54],"at":[55],"pH":[56],"5.0":[57],"+/-":[58],"0.2":[59],"25":[61],"degrees":[62],"C":[63],"produces":[64],"close":[65],"to":[66,78],"40%":[67],"alkenes":[68],"50-60%":[70],"3-dimethyl-2-butanol.":[72],"No":[73],"could":[75],"be":[76],"detected":[77],"provide":[79],"direct":[80],"evidence":[81],"intervention":[84],"a":[86,102],"secondary":[87],"carbenium":[88,104],"reaction":[92,99],"path.":[93],"All":[94],"products":[96,133],"originate":[100],"tertiary":[103],"ion.":[105],"These":[106],"findings":[107],"are":[108],"good":[110],"agreement":[111],"results":[114],"Michel":[116],"et":[117],"al.":[118],"[(1967)":[119],"Arch.":[120],"Biochem.":[121],"Biophys.":[122],"121,":[123],"29],":[124],"which":[125],"were":[126,143],"obtained":[127],"countercurrent":[129],"distribution":[130],"tritium-labeled":[132],"their":[135],"identification":[136],"scintillation":[138],"counting.":[139],"early":[141],"experiments":[142],"performed":[144],"mixture":[147],"four":[150],"soman":[151],"diastereomers,":[152],"all":[153],"labeled":[154],"tritium":[156],"Calpha.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
