{"id":"https://openalex.org/W2088632809","doi":"https://doi.org/10.1016/j.tins.2008.07.005","title":"Targeting TNF-\u03b1 receptors for neurotherapeutics","display_name":"Targeting TNF-\u03b1 receptors for neurotherapeutics","publication_year":2008,"publication_date":"2008-09-07","ids":{"openalex":"https://openalex.org/W2088632809","doi":"https://doi.org/10.1016/j.tins.2008.07.005","mag":"2088632809","pmid":"https://pubmed.ncbi.nlm.nih.gov/18774186","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2574933"},"language":"en","primary_location":{"id":"doi:10.1016/j.tins.2008.07.005","doi":"https://doi.org/10.1016/j.tins.2008.07.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tins.2008.07.005","pdf_url":null,"source":{"id":"https://openalex.org/S114966740","display_name":"Trends in Neurosciences","issn_l":"0166-2236","issn":["0166-2236","1878-108X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Neurosciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2574933","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091278252","display_name":"Wayne Chadwick","orcid":"https://orcid.org/0000-0003-1465-8180","observed_orcids":["https://orcid.org/0000-0003-1465-8180"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne Chadwick","raw_affiliation_strings":["Receptor Pharmacology Unit, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Pharmacology Unit, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017872286","display_name":"Tim Magnus","orcid":"https://orcid.org/0000-0001-6232-9555","observed_orcids":["https://orcid.org/0000-0001-6232-9555"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tim Magnus","raw_affiliation_strings":["ERSI, Neurologische Universit\u00e4tsklinik, Universit\u00e4t Hamburg, Martinistrasse 52, 20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ERSI, Neurologische Universit\u00e4tsklinik, Universit\u00e4t Hamburg, Martinistrasse 52, 20246 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061101747","display_name":"Bronwen Martin","orcid":"https://orcid.org/0000-0002-9185-6925","observed_orcids":["https://orcid.org/0000-0002-9185-6925"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bronwen Martin","raw_affiliation_strings":["Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA","Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082422559","display_name":"Aleksander M Keselman","orcid":"https://orcid.org/0000-0003-1379-2716","observed_orcids":["https://orcid.org/0000-0003-1379-2716"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleksander Keselman","raw_affiliation_strings":["Receptor Pharmacology Unit, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Pharmacology Unit, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083040475","display_name":"Mark P. Mattson","orcid":"https://orcid.org/0000-0002-9816-4155","observed_orcids":["https://orcid.org/0000-0002-9816-4155","https://orcid.org/0009-0000-5542-5565"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark P. Mattson","raw_affiliation_strings":["Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033862949","display_name":"Stuart R. Maudsley","orcid":"https://orcid.org/0000-0002-1868-184X","observed_orcids":["https://orcid.org/0000-0002-1868-184X"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stuart Maudsley","raw_affiliation_strings":["Receptor Pharmacology Unit, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Pharmacology Unit, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033862949"],"corresponding_institution_ids":["https://openalex.org/I4210136897"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":0.6344,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.46875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"31","issue":"10","first_page":"504","last_page":"511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.09740000218153,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.04520000144839287,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8140000104904175},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-receptor","display_name":"TNF receptor","score":0.8180000185966492},{"id":"https://openalex.org/keywords/neurotherapeutics","display_name":"neurotherapeutics","score":0.9120000004768372},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8209999799728394},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/tnf-alpha-converting-enzyme","display_name":"TNF-alpha converting enzyme","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tnf-alpha-processing","display_name":"TNF-alpha processing","score":0.800000011920929},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7620000243186951},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6448537111282349},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5211067795753479},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.49235427379608154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27651098370552063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15706157684326172}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.tins.2008.07.005","doi":"https://doi.org/10.1016/j.tins.2008.07.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tins.2008.07.005","pdf_url":null,"source":{"id":"https://openalex.org/S114966740","display_name":"Trends in Neurosciences","issn_l":"0166-2236","issn":["0166-2236","1878-108X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Neurosciences","raw_type":"journal-article"},{"id":"pmid:18774186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18774186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in neurosciences","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1661496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2574933","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2574933","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2574933","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1661496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2574933","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G966437622","display_name":"Age and pathology-induced alteration of G protein-coupled receptor signaling","funder_award_id":"Z01AG000318","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W8233037","https://openalex.org/W155107513","https://openalex.org/W1509596990","https://openalex.org/W1530982587","https://openalex.org/W1562902980","https://openalex.org/W1608832731","https://openalex.org/W1915374685","https://openalex.org/W1968295892","https://openalex.org/W1968537977","https://openalex.org/W1969125125","https://openalex.org/W1974069634","https://openalex.org/W1981093904","https://openalex.org/W1981513372","https://openalex.org/W1985720487","https://openalex.org/W1989832126","https://openalex.org/W1995441076","https://openalex.org/W1995505431","https://openalex.org/W1996901446","https://openalex.org/W1997106678","https://openalex.org/W1997192647","https://openalex.org/W1998448144","https://openalex.org/W1998689099","https://openalex.org/W2001751662","https://openalex.org/W2003606001","https://openalex.org/W2007511428","https://openalex.org/W2014111773","https://openalex.org/W2019168768","https://openalex.org/W2024476573","https://openalex.org/W2025392129","https://openalex.org/W2026870832","https://openalex.org/W2027526891","https://openalex.org/W2030148527","https://openalex.org/W2031106660","https://openalex.org/W2033586457","https://openalex.org/W2035104435","https://openalex.org/W2035380500","https://openalex.org/W2037394592","https://openalex.org/W2039047032","https://openalex.org/W2044835905","https://openalex.org/W2052078052","https://openalex.org/W2055697365","https://openalex.org/W2058539601","https://openalex.org/W2058702798","https://openalex.org/W2062098209","https://openalex.org/W2062406681","https://openalex.org/W2063132475","https://openalex.org/W2063504330","https://openalex.org/W2068006559","https://openalex.org/W2072380594","https://openalex.org/W2074466908","https://openalex.org/W2076225570","https://openalex.org/W2076651424","https://openalex.org/W2081371688","https://openalex.org/W2086255604","https://openalex.org/W2086262704","https://openalex.org/W2088335573","https://openalex.org/W2091161875","https://openalex.org/W2094882780","https://openalex.org/W2097672870","https://openalex.org/W2104843745","https://openalex.org/W2107245918","https://openalex.org/W2109577352","https://openalex.org/W2110495699","https://openalex.org/W2111112233","https://openalex.org/W2112041512","https://openalex.org/W2114727688","https://openalex.org/W2123838494","https://openalex.org/W2124091258","https://openalex.org/W2127867087","https://openalex.org/W2130690341","https://openalex.org/W2134461906","https://openalex.org/W2134706781","https://openalex.org/W2135271960","https://openalex.org/W2136509648","https://openalex.org/W2142850882","https://openalex.org/W2145028653","https://openalex.org/W2145327037","https://openalex.org/W2151283331","https://openalex.org/W2152646879","https://openalex.org/W2155850284","https://openalex.org/W2157875164","https://openalex.org/W2162384851","https://openalex.org/W2165655699","https://openalex.org/W2170236911","https://openalex.org/W2177120564","https://openalex.org/W2312313151","https://openalex.org/W2403490611","https://openalex.org/W2409615128","https://openalex.org/W2480036115","https://openalex.org/W3022587572","https://openalex.org/W4299836692","https://openalex.org/W6682913721"],"related_works":["https://openalex.org/W2150320745","https://openalex.org/W2002302995","https://openalex.org/W2911840604","https://openalex.org/W2127867087","https://openalex.org/W2159414274","https://openalex.org/W2104794787","https://openalex.org/W1969046731","https://openalex.org/W2735267462","https://openalex.org/W2400711202","https://openalex.org/W4255370709"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
