{"id":"https://openalex.org/W2088620522","doi":"https://doi.org/10.1517/14656566.3.12.1693","title":"Taxanes for advanced non-small cell lung cancer","display_name":"Taxanes for advanced non-small cell lung cancer","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W2088620522","doi":"https://doi.org/10.1517/14656566.3.12.1693","mag":"2088620522","pmid":"https://pubmed.ncbi.nlm.nih.gov/12472367"},"language":"en","primary_location":{"id":"doi:10.1517/14656566.3.12.1693","doi":"https://doi.org/10.1517/14656566.3.12.1693","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.3.12.1693","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071479221","display_name":"Sakkaraiappan Ramalingam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sakkaraiappan Ramalingam","raw_affiliation_strings":["Division of Hematology-Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015680000","display_name":"Chandra Prakash Belani","orcid":"https://orcid.org/0000-0001-5049-5329","observed_orcids":["https://orcid.org/0000-0001-5049-5329"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandra P Belani","raw_affiliation_strings":["Division of Hematology-Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":0.5203,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.45764463,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"3","issue":"12","first_page":"1693","last_page":"1709"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.09459999948740005,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taxanes","display_name":"taxanes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8880000114440918},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9929999709129333},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":1.0},{"id":"https://openalex.org/keywords/microtubule-stabilizing-agents","display_name":"microtubule-stabilizing agents","score":0.8180000185966492},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.6710000038146973},{"id":"https://openalex.org/keywords/metronomic-dosing","display_name":"metronomic dosing","score":0.8479999899864197},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.8930000066757202},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.7350000143051147},{"id":"https://openalex.org/keywords/recurrent-lung-cancer","display_name":"recurrent lung cancer","score":0.6520000100135803},{"id":"https://openalex.org/keywords/molecularly-targeted-agents","display_name":"molecularly targeted agents","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.9250224232673645},{"id":"https://openalex.org/C2777511904","wikidata":"https://www.wikidata.org/wiki/Q425227","display_name":"Taxane","level":4,"score":0.9162566661834717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.878724217414856},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.727319598197937},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.672545313835144},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.652283787727356},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6290689706802368},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5027060508728027},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4940624535083771},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40183955430984497},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35980117321014404},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.1637870967388153}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1517/14656566.3.12.1693","doi":"https://doi.org/10.1517/14656566.3.12.1693","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.3.12.1693","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:12472367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12472367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on pharmacotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1508617565","https://openalex.org/W1561408641","https://openalex.org/W1749876465","https://openalex.org/W1826360242","https://openalex.org/W1839238860","https://openalex.org/W1842046266","https://openalex.org/W1844362602","https://openalex.org/W1865725105","https://openalex.org/W1868450210","https://openalex.org/W1874925441","https://openalex.org/W1883066466","https://openalex.org/W1903757011","https://openalex.org/W1914960099","https://openalex.org/W1935885922","https://openalex.org/W1941410407","https://openalex.org/W1942454844","https://openalex.org/W1947624718","https://openalex.org/W1971345888","https://openalex.org/W1972010711","https://openalex.org/W1976818021","https://openalex.org/W1983784941","https://openalex.org/W1995582426","https://openalex.org/W2004598625","https://openalex.org/W2004706334","https://openalex.org/W2011447881","https://openalex.org/W2016263166","https://openalex.org/W2016913166","https://openalex.org/W2022907323","https://openalex.org/W2026876189","https://openalex.org/W2029751060","https://openalex.org/W2035890549","https://openalex.org/W2035893503","https://openalex.org/W2037139573","https://openalex.org/W2040211532","https://openalex.org/W2043570236","https://openalex.org/W2057157978","https://openalex.org/W2058978290","https://openalex.org/W2062839616","https://openalex.org/W2065498827","https://openalex.org/W2067898376","https://openalex.org/W2074190059","https://openalex.org/W2075960393","https://openalex.org/W2078530790","https://openalex.org/W2079171343","https://openalex.org/W2084203448","https://openalex.org/W2085527076","https://openalex.org/W2087509992","https://openalex.org/W2091636936","https://openalex.org/W2101100140","https://openalex.org/W2102226853","https://openalex.org/W2125089526","https://openalex.org/W2125367921","https://openalex.org/W2127024723","https://openalex.org/W2130652363","https://openalex.org/W2133635118","https://openalex.org/W2147766528","https://openalex.org/W2149463127","https://openalex.org/W2155236705","https://openalex.org/W2157794621","https://openalex.org/W2162193294","https://openalex.org/W2172229147","https://openalex.org/W2184488763","https://openalex.org/W2213012239","https://openalex.org/W2243915795","https://openalex.org/W2261464614","https://openalex.org/W2262127979","https://openalex.org/W2268793584","https://openalex.org/W2416211740","https://openalex.org/W2461084525","https://openalex.org/W3145077989","https://openalex.org/W4239714259"],"related_works":["https://openalex.org/W2082347539","https://openalex.org/W2133929108","https://openalex.org/W2130858016","https://openalex.org/W2097665152","https://openalex.org/W2118761956","https://openalex.org/W2415570700","https://openalex.org/W2078530790","https://openalex.org/W2104635067","https://openalex.org/W2009529519","https://openalex.org/W2806177456"],"abstract_inverted_index":{"The":[0,33,124],"emergence":[1],"of":[2,30,49,60,76,103,121,126,156,180,191],"novel":[3,39],"chemotherapeutic":[4],"agents":[5,71,108,184],"with":[6,68,114,131,142,185],"promising":[7],"anticancer":[8],"activity":[9],"in":[10,27,54,78,82,112,118,129,152,170],"non-small":[11],"cell":[12,63],"lung":[13,61],"cancer":[14,62],"(NSCLC)":[15],"during":[16],"the":[17,28,58,74,101,104,119,153,161,171,178,189],"1990s":[18],"has":[19,135],"led":[20],"to":[21,149],"an":[22,46,137],"expanded":[23],"role":[24],"for":[25,140,165,188],"chemotherapy":[26,52,70],"management":[29],"this":[31],"disease.":[32],"taxanes":[34],"(paclitaxel":[35],"and":[36,43,72,95,109],"docetaxel)":[37],"are":[38,176],"microtubule":[40],"stabilising":[41],"agents,":[42],"have":[44,88,99],"become":[45,136],"integral":[47],"part":[48],"several":[50],"commonly-used":[51],"regimens":[53,187],"NSCLC.":[55,123,146,193],"Taxanes":[56],"inhibit":[57],"growth":[59],"lines,":[64],"exhibit":[65],"synergistic":[66],"interaction":[67],"other":[69],"enhance":[73],"efficacy":[75,102,151,179],"radiation":[77],"vitro.":[79],"When":[80],"used":[81,111],"low":[83],"doses":[84],"(metronomic":[85],"dosing),":[86],"they":[87],"important":[89],"antiangiogenic":[90],"properties.":[91],"Several":[92,173],"Phase":[93],"II":[94],"III":[96],"clinical":[97],"trials":[98,175],"established":[100],"taxanes,":[105],"as":[106],"single":[107],"when":[110],"combination":[113,130],"a":[115,127,132],"platinum":[116,133],"compound,":[117],"treatment":[120,190],"advanced":[122,143,192],"use":[125],"taxane":[128],"compound":[134],"acceptable":[138],"standard":[139],"patients":[141],"or":[144,167],"metastatic":[145],"In":[147],"addition":[148],"its":[150],"first-line":[154],"therapy":[155],"NSCLC,":[157],"docetaxel":[158],"is":[159],"also":[160],"FDA-approved":[162],"second-line":[163],"agent":[164],"recurrent":[166],"relapsed":[168],"NSCLC":[169],"US.":[172],"ongoing":[174],"comparing":[177],"combining":[181],"molecularly":[182],"targeted":[183],"taxane-based":[186]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}