{"id":"https://openalex.org/W2088614916","doi":"https://doi.org/10.1016/s0924-9338(11)73772-5","title":"Neurobiological susbtrates in deficit and non deficit schizophrenia","display_name":"Neurobiological susbtrates in deficit and non deficit schizophrenia","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2088614916","doi":"https://doi.org/10.1016/s0924-9338(11)73772-5","mag":"2088614916"},"language":"en","primary_location":{"id":"doi:10.1016/s0924-9338(11)73772-5","doi":"https://doi.org/10.1016/s0924-9338(11)73772-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0924-9338(11)73772-5","pdf_url":null,"source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002872855","display_name":"Celso Arango","orcid":"https://orcid.org/0000-0003-3382-4754","observed_orcids":["https://orcid.org/0000-0003-3382-4754"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"C. Arango","raw_affiliation_strings":["Department of Psychiatry, Hospital Gral. Univ. Gregorio Mara\u00f1\u00f3n, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Hospital Gral. Univ. Gregorio Mara\u00f1\u00f3n, Madrid, Spain","institution_ids":["https://openalex.org/I2960094004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002872855"],"corresponding_institution_ids":["https://openalex.org/I2960094004"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20367039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"S2","first_page":"2069","last_page":"2069"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12308","display_name":"Mental Health and Psychiatry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deficit-syndrome","display_name":"deficit syndrome","score":0.7910000085830688},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/negative-symptoms","display_name":"negative symptoms","score":0.8610000014305115},{"id":"https://openalex.org/keywords/dorsolateral-prefrontal-cortex","display_name":"dorsolateral prefrontal cortex","score":0.925000011920929},{"id":"https://openalex.org/keywords/thalamocortical-circuits","display_name":"thalamocortical circuits","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ventricular-dilation","display_name":"ventriculomegaly","score":0.7590000033378601},{"id":"https://openalex.org/keywords/neurological-soft-signs","display_name":"neurological soft signs","score":0.9670000076293945},{"id":"https://openalex.org/keywords/parietal-lobe","display_name":"parietal lobe","score":0.8899999856948853},{"id":"https://openalex.org/keywords/neural-correlates","display_name":"neural correlates","score":0.7260000109672546},{"id":"https://openalex.org/keywords/positive-symptoms","display_name":"positive symptoms","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7771271467208862},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.647688090801239},{"id":"https://openalex.org/C2993523616","wikidata":"https://www.wikidata.org/wiki/Q17146697","display_name":"Neurological deficit","level":2,"score":0.6167458295822144},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5918190479278564},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5730620622634888},{"id":"https://openalex.org/C2780749935","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive deficit","level":4,"score":0.4937461316585541},{"id":"https://openalex.org/C2779705967","wikidata":"https://www.wikidata.org/wiki/Q2271368","display_name":"Sensory gating","level":3,"score":0.466707706451416},{"id":"https://openalex.org/C3017694942","wikidata":"https://www.wikidata.org/wiki/Q16254243","display_name":"Attention deficit","level":3,"score":0.43988433480262756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3614497184753418},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.34431445598602295},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.28340184688568115},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.221273273229599},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.22100555896759033},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.09697341918945312},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.06815382838249207}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0924-9338(11)73772-5","doi":"https://doi.org/10.1016/s0924-9338(11)73772-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0924-9338(11)73772-5","pdf_url":null,"source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1694864989","https://openalex.org/W2036188695","https://openalex.org/W2037256187","https://openalex.org/W2055001556","https://openalex.org/W2169159524"],"related_works":["https://openalex.org/W201262253","https://openalex.org/W45265562","https://openalex.org/W2141766296","https://openalex.org/W2007298134","https://openalex.org/W2304951053","https://openalex.org/W7097537524","https://openalex.org/W2093867364","https://openalex.org/W7029091179","https://openalex.org/W2068617863","https://openalex.org/W2005342292"],"abstract_inverted_index":{"The":[0],"deficit":[1,56,76,101],"syndrome":[2,33,57],"defines":[3],"a":[4],"subgroup":[5],"of":[6,93],"schizophrenia":[7,79,104],"patients":[8,34,58],"with":[9,50],"prominent":[10],"and":[11,19,77,110,113],"enduring":[12,95],"primary":[13,94],"negative":[14,96],"symptoms":[15,97],"(1).":[16],"Behavioral,":[17],"structural,":[18],"functional":[20],"neuroimaging":[21],"studies":[22,42],"have":[23,37,70,114],"implicated":[24],"mainly":[25],"the":[26,61,91,108],"dorsolateral":[27],"prefrontal":[28,109],"-":[29],"thalamocortical":[30],"circuit.":[31],"Deficit":[32],"seem":[35],"to":[36,106],"larger":[38],"ventricles":[39],"in":[40,55,103],"MRI":[41],"(2).":[43],"Neurological":[44],"soft":[45],"signs":[46],"suggest":[47],"parietal":[48,111],"involvement":[49],"greater":[51],"sensory":[52],"integration":[53],"impairment":[54],"(3).":[59],"On":[60],"contrary,":[62],"some":[63],"biological":[64],"markers":[65],"such":[66],"as":[67],"P50":[68],"gating":[69],"not":[71],"shown":[72],"any":[73],"difference":[74],"between":[75],"non-deficit":[78],"(4).":[80],"Finally,":[81],"no":[82],"pharmacological":[83],"treatment":[84,92],"has":[85],"so":[86],"far":[87],"proven":[88],"effective":[89],"for":[90],"(5).":[98],"In":[99],"conclusion,":[100],"pathology":[102],"seems":[105],"involve":[107],"lobes":[112],"different":[115],"neurobiological":[116],"substrates":[117],"than":[118],"positive":[119],"symptoms.":[120]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}