{"id":"https://openalex.org/W2088548720","doi":"https://doi.org/10.1155/2007/45673","title":"Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF- \u03ba B Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF- \u03ba B Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages","display_name":"Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF- \u03ba B Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF- \u03ba B Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2088548720","doi":"https://doi.org/10.1155/2007/45673","mag":"2088548720","pmid":"https://pubmed.ncbi.nlm.nih.gov/18274639","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2220047"},"language":"en","primary_location":{"id":"doi:10.1155/2007/45673","doi":"https://doi.org/10.1155/2007/45673","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2007/45673","pdf_url":"https://downloads.hindawi.com/journals/mi/2007/045673.pdf","source":{"id":"https://openalex.org/S107442880","display_name":"Mediators of Inflammation","issn_l":"0962-9351","issn":["0962-9351","1466-1861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of Inflammation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/mi/2007/045673.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017400543","display_name":"Mari H\u00e4m\u00e4l\u00e4inen","orcid":"https://orcid.org/0000-0002-6409-3758","observed_orcids":["https://orcid.org/0000-0002-6409-3758"]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mari H\u00e4m\u00e4l\u00e4inen","raw_affiliation_strings":["The Immunopharmacology Research Group, University of Tampere, Medical School and Tampere University Hospital, Research Unit, Tampere 33014, Finland","The Immunopharmacology Research Group, University of Tampere, Medical School and Tampere University Hospital, Research Unit, Tampere 33014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Immunopharmacology Research Group, University of Tampere, Medical School and Tampere University Hospital, Research Unit, Tampere 33014, Finland","institution_ids":["https://openalex.org/I4210126318","https://openalex.org/I4387153886"]},{"raw_affiliation_string":"The Immunopharmacology Research Group, University of Tampere, Medical School and Tampere University Hospital, Research Unit, Tampere 33014","institution_ids":["https://openalex.org/I4210126318","https://openalex.org/I4387153886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109426384","display_name":"Riina M. Nieminen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Riina Nieminen","raw_affiliation_strings":["The Immunopharmacology Research Group, University of Tampere, Medical School and Tampere University Hospital, Research Unit, Tampere 33014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Immunopharmacology Research Group, University of Tampere, Medical School and Tampere University Hospital, Research Unit, Tampere 33014","institution_ids":["https://openalex.org/I4210126318","https://openalex.org/I4387153886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111706989","display_name":"Pia Maarit Vuorela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pia Vuorela","raw_affiliation_strings":["Department of Biochemistry and Pharmacy, \u00c5bo Akademi University, Turku 20520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Pharmacy, \u00c5bo Akademi University, Turku 20520","institution_ids":["https://openalex.org/I130217899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107724101","display_name":"Marina Heinonen","orcid":"https://orcid.org/0000-0002-9930-4009","observed_orcids":["https://orcid.org/0000-0002-9930-4009"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Marina Heinonen","raw_affiliation_strings":["Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki 00014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki 00014","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000639183","display_name":"Eeva Moilanen","orcid":"https://orcid.org/0000-0002-8577-0316","observed_orcids":["https://orcid.org/0000-0002-8577-0316"]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Eeva Moilanen","raw_affiliation_strings":["The Immunopharmacology Research Group, University of Tampere, Medical School and Tampere University Hospital, Research Unit, Tampere 33014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Immunopharmacology Research Group, University of Tampere, Medical School and Tampere University Hospital, Research Unit, Tampere 33014","institution_ids":["https://openalex.org/I4210126318","https://openalex.org/I4387153886"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000639183"],"corresponding_institution_ids":["https://openalex.org/I4210126318","https://openalex.org/I4387153886"],"apc_list":{"value":3040,"currency":"USD","value_usd":3040},"apc_paid":{"value":3040,"currency":"USD","value_usd":3040},"fwci":17.7268,"has_fulltext":true,"cited_by_count":971,"citation_normalized_percentile":{"value":0.99669525,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"2007","issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.06970000267028809,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9950000047683716},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8889999985694885},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.8050000071525574},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.781000018119812},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8640000224113464},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.902999997138977},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.8809999823570251},{"id":"https://openalex.org/keywords/daidzein","display_name":"daidzein","score":0.8790000081062317},{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":0.9860000014305115},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/isorhamnetin","display_name":"isorhamnetin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/naringenin","display_name":"naringenin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pelargonidin","display_name":"pelargonidin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/flavones","display_name":"flavones","score":0.8809999823570251},{"id":"https://openalex.org/keywords/isoflavones","display_name":"isoflavones","score":0.8029999732971191},{"id":"https://openalex.org/keywords/flavonols","display_name":"flavonols","score":0.8659999966621399},{"id":"https://openalex.org/keywords/flavanones","display_name":"flavanones","score":0.847000002861023},{"id":"https://openalex.org/keywords/anthocyanins","display_name":"anthocyanins","score":0.9929999709129333},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.7491115927696228},{"id":"https://openalex.org/C2779705811","wikidata":"https://www.wikidata.org/wiki/Q412519","display_name":"Isoflavones","level":2,"score":0.6673312783241272},{"id":"https://openalex.org/C2777810353","wikidata":"https://www.wikidata.org/wiki/Q393336","display_name":"Kaempferol","level":4,"score":0.6363881826400757},{"id":"https://openalex.org/C2780955279","wikidata":"https://www.wikidata.org/wiki/Q408732","display_name":"Daidzein","level":3,"score":0.5626444816589355},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.5427736043930054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5199533700942993},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4849555492401123},{"id":"https://openalex.org/C2780450397","wikidata":"https://www.wikidata.org/wiki/Q416138","display_name":"Isorhamnetin","level":5,"score":0.4650631546974182},{"id":"https://openalex.org/C2776848411","wikidata":"https://www.wikidata.org/wiki/Q418374","display_name":"Naringenin","level":4,"score":0.4541657567024231},{"id":"https://openalex.org/C2778821405","wikidata":"https://www.wikidata.org/wiki/Q864222","display_name":"Biochanin A","level":4,"score":0.4403992295265198},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.43273162841796875},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4092784523963928},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3535219430923462},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.27611374855041504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2561134397983551},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12696245312690735},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.12648510932922363},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07624712586402893},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05980604887008667}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007659","descriptor_name":"Ketones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019833","descriptor_name":"Genistein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044948","descriptor_name":"Flavonols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044949","descriptor_name":"Kaempferols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044950","descriptor_name":"Flavanones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047309","descriptor_name":"Flavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1155/2007/45673","doi":"https://doi.org/10.1155/2007/45673","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2007/45673","pdf_url":"https://downloads.hindawi.com/journals/mi/2007/045673.pdf","source":{"id":"https://openalex.org/S107442880","display_name":"Mediators of Inflammation","issn_l":"0962-9351","issn":["0962-9351","1466-1861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of Inflammation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2220047","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2220047","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators Inflamm","raw_type":"Text"},{"id":"pmid:18274639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18274639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of inflammation","raw_type":"Journal Article"},{"id":"pmh:oai:tampub.uta.fi:10024/65974","doi":null,"is_oa":false,"landing_page_url":"http://tampub.uta.fi/handle/10024/65974","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"publishedVersion"},{"id":"pmh:oai:trepo.tuni.fi:10024/65974","doi":null,"is_oa":false,"landing_page_url":"https://trepo.tuni.fi/handle/10024/65974","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"publishedVersion"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.283.2585","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.283.2585","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a1/a5/Mediators_Inflamm_2007_Aug_20_2007_45673.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.472.778","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.472.778","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://downloads.hindawi.com/journals/mi/2007/045673.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:04587ebe5b8e42e3b37f4a7a87656ab0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/04587ebe5b8e42e3b37f4a7a87656ab0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mediators of Inflammation, Vol 2007 (2007)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2007/45673","doi":"https://doi.org/10.1155/2007/45673","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2007/45673","pdf_url":"https://downloads.hindawi.com/journals/mi/2007/045673.pdf","source":{"id":"https://openalex.org/S107442880","display_name":"Mediators of Inflammation","issn_l":"0962-9351","issn":["0962-9351","1466-1861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of Inflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320321855","display_name":"Tekes","ror":"https://ror.org/02ag8cq23"},{"id":"https://openalex.org/F4320326518","display_name":"Tays","ror":"https://ror.org/02hvt5f17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2088548720.pdf","grobid_xml":"https://content.openalex.org/works/W2088548720.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1487371392","https://openalex.org/W1560571961","https://openalex.org/W1591881963","https://openalex.org/W1656644300","https://openalex.org/W1764308599","https://openalex.org/W1972715563","https://openalex.org/W1973435432","https://openalex.org/W1984536165","https://openalex.org/W1988879196","https://openalex.org/W1990802251","https://openalex.org/W1994694127","https://openalex.org/W2004970478","https://openalex.org/W2009878427","https://openalex.org/W2011800250","https://openalex.org/W2012477717","https://openalex.org/W2012992792","https://openalex.org/W2018172478","https://openalex.org/W2024191096","https://openalex.org/W2041848671","https://openalex.org/W2048695976","https://openalex.org/W2054633072","https://openalex.org/W2059436104","https://openalex.org/W2064647661","https://openalex.org/W2072668724","https://openalex.org/W2073972045","https://openalex.org/W2102715783","https://openalex.org/W2104936852","https://openalex.org/W2109581010","https://openalex.org/W2115153703","https://openalex.org/W2116133344","https://openalex.org/W2123063562","https://openalex.org/W2128635872","https://openalex.org/W2136912731","https://openalex.org/W2273704033","https://openalex.org/W4322715279"],"related_works":["https://openalex.org/W7017461181","https://openalex.org/W7097572937","https://openalex.org/W1972715563","https://openalex.org/W2104936852","https://openalex.org/W2054633072","https://openalex.org/W2122390360","https://openalex.org/W2141690002","https://openalex.org/W1980400458","https://openalex.org/W1983121872","https://openalex.org/W2091752888"],"abstract_inverted_index":{"In":[0,32],"inflammation,":[1],"bacterial":[2],"products":[3],"and":[4,23,46,61,75,81,86,93,96,126,136,154,164],"proinflammatory":[5],"cytokines":[6],"induce":[7],"the":[8,33,39,63,68,72,77,83,87,109,130,133,152,174],"formation":[9],"of":[10,13,41,65,67,111,132,138,156,177],"large":[11],"amounts":[12],"nitric":[14,19],"oxide":[15,20],"(NO)":[16],"by":[17],"inducible":[18],"synthase":[21],"(iNOS),":[22],"compounds":[24,48,107,160],"that":[25],"inhibit":[26],"NO":[27,50,98,165],"production":[28,51,99,166],"have":[29],"anti-inflammatory":[30,180],"effects.":[31],"present":[34,149],"study,":[35],"we":[36],"systematically":[37],"investigated":[38],"effects":[40,153],"36":[42],"naturally":[43,157],"occurring":[44,158],"flavonoids":[45,178],"related":[47],"on":[49,161],"in":[52,100,167],"macrophages":[53],"exposed":[54],"to":[55],"an":[56],"inflammatory":[57],"stimulus":[58],"(lipopolysaccharide,":[59],"LPS),":[60],"evaluated":[62],"mechanisms":[64,155],"action":[66],"effective":[69],"compounds.":[70,181],"Flavone,":[71],"isoflavones":[73],"daidzein":[74,127],"genistein,":[76],"flavonols":[78],"isorhamnetin,":[79],"kaempferol":[80],"quercetin,":[82,125],"flavanone":[84],"naringenin,":[85],"anthocyanin":[88],"pelargonidin":[89],"inhibited":[90,108,129],"iNOS":[91,162],"protein":[92],"mRNA":[94],"expression":[95,163],"also":[97,128],"a":[101,117],"dose-dependent":[102],"manner.":[103],"All":[104],"eight":[105],"active":[106],"activation":[110,131],"nuclear":[112],"factor-kappaB":[113],"(NF-kappaB),":[114],"which":[115],"is":[116],"significant":[118],"transcription":[119,139,144],"factor":[120,145],"for":[121,146],"iNOS.":[122,147],"Genistein,":[123],"kaempferol,":[124],"signal":[134],"transducer":[135],"activator":[137],"1":[140],"(STAT-1),":[141],"another":[142],"important":[143],"The":[148,170],"study":[150],"characterises":[151],"phenolic":[159],"activated":[168],"macrophages.":[169],"results":[171],"partially":[172],"explain":[173],"pharmacological":[175],"efficacy":[176],"as":[179]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":40},{"year":2024,"cited_by_count":38},{"year":2023,"cited_by_count":51},{"year":2022,"cited_by_count":63},{"year":2021,"cited_by_count":83},{"year":2020,"cited_by_count":59},{"year":2019,"cited_by_count":55},{"year":2018,"cited_by_count":75},{"year":2017,"cited_by_count":65},{"year":2016,"cited_by_count":60},{"year":2015,"cited_by_count":56},{"year":2014,"cited_by_count":56},{"year":2013,"cited_by_count":53},{"year":2012,"cited_by_count":51}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}