{"id":"https://openalex.org/W2088465409","doi":"https://doi.org/10.1210/jc.2012-2374","title":"Targeting Estrogen Receptor-\u03b1 Reduces Adrenocortical Cancer (ACC) Cell Growthin Vitroandin Vivo: Potential Therapeutic Role of Selective Estrogen Receptor Modulators (SERMs) for ACC Treatment","display_name":"Targeting Estrogen Receptor-\u03b1 Reduces Adrenocortical Cancer (ACC) Cell Growthin Vitroandin Vivo: Potential Therapeutic Role of Selective Estrogen Receptor Modulators (SERMs) for ACC Treatment","publication_year":2012,"publication_date":"2012-10-17","ids":{"openalex":"https://openalex.org/W2088465409","doi":"https://doi.org/10.1210/jc.2012-2374","mag":"2088465409","pmid":"https://pubmed.ncbi.nlm.nih.gov/23074235"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2012-2374","doi":"https://doi.org/10.1210/jc.2012-2374","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2012-2374","pdf_url":"https://academic.oup.com/jcem/article-pdf/97/12/E2238/9044305/jcem2238.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jcem/article-pdf/97/12/E2238/9044305/jcem2238.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049961945","display_name":"Rosa Sirianni","orcid":"https://orcid.org/0000-0002-8966-350X","observed_orcids":["https://orcid.org/0000-0002-8966-350X"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Rosa Sirianni","raw_affiliation_strings":["Department of Pharmaco-Biology (R.S., F.Z., A.C., C.R., V.P.), University of Calabria, 87036 Arcavacata di Rende (CS), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaco-Biology (R.S., F.Z., A.C., C.R., V.P.), University of Calabria, 87036 Arcavacata di Rende (CS), Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023926960","display_name":"Fabiana Zolea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabiana Zolea","raw_affiliation_strings":["Department of Pharmaco-Biology (R.S., F.Z., A.C., C.R., V.P.), University of Calabria, 87036 Arcavacata di Rende (CS), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaco-Biology (R.S., F.Z., A.C., C.R., V.P.), University of Calabria, 87036 Arcavacata di Rende (CS), Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079640436","display_name":"Adele Chimento","orcid":"https://orcid.org/0000-0002-5269-998X","observed_orcids":["https://orcid.org/0000-0002-5269-998X"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Adele Chimento","raw_affiliation_strings":["Department of Pharmaco-Biology (R.S., F.Z., A.C., C.R., V.P.), University of Calabria, 87036 Arcavacata di Rende (CS), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaco-Biology (R.S., F.Z., A.C., C.R., V.P.), University of Calabria, 87036 Arcavacata di Rende (CS), Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003246025","display_name":"Carmen Ruggiero","orcid":"https://orcid.org/0000-0002-9652-2502","observed_orcids":["https://orcid.org/0000-0002-9652-2502"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmen Ruggiero","raw_affiliation_strings":["Department of Pharmaco-Biology (R.S., F.Z., A.C., C.R., V.P.), University of Calabria, 87036 Arcavacata di Rende (CS), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaco-Biology (R.S., F.Z., A.C., C.R., V.P.), University of Calabria, 87036 Arcavacata di Rende (CS), Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070568111","display_name":"Lidia Cerquetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lidia Cerquetti","raw_affiliation_strings":["Department of Clinical and Molecular Medicine (L.C., A.S.), Sant'Andrea Hospital, Sapienza University of Rome, 1035-00189 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine (L.C., A.S.), Sant'Andrea Hospital, Sapienza University of Rome, 1035-00189 Rome, Italy","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072514662","display_name":"Francesco Fallo","orcid":"https://orcid.org/0000-0002-7511-0226","observed_orcids":["https://orcid.org/0000-0002-7511-0226"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Fallo","raw_affiliation_strings":["Department of Medical and Surgical Sciences (F.F., C.P.), University of Padova, 35128 Padova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences (F.F., C.P.), University of Padova, 35128 Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021466692","display_name":"Catia Pilon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Catia Pilon","raw_affiliation_strings":["Department of Medical and Surgical Sciences (F.F., C.P.), University of Padova, 35128 Padova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences (F.F., C.P.), University of Padova, 35128 Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029522983","display_name":"Giorgio Arnaldi","orcid":"https://orcid.org/0000-0002-6204-3423","observed_orcids":["https://orcid.org/0000-0002-6204-3423"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgio Arnaldi","raw_affiliation_strings":["Division of Endocrinology (G.A.), University of Ancona, 60020 Ancona, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology (G.A.), University of Ancona, 60020 Ancona, Italy;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055648646","display_name":"Giulia Carpinelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Carpinelli","raw_affiliation_strings":["Department of Cell Biology and Neurosciences (G.C.), Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Neurosciences (G.C.), Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021252493","display_name":"Antonio Stigliano","orcid":"https://orcid.org/0000-0002-7143-0775","observed_orcids":["https://orcid.org/0000-0002-7143-0775"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Stigliano","raw_affiliation_strings":["Department of Clinical and Molecular Medicine (L.C., A.S.), Sant'Andrea Hospital, Sapienza University of Rome, 1035-00189 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine (L.C., A.S.), Sant'Andrea Hospital, Sapienza University of Rome, 1035-00189 Rome, Italy","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076326741","display_name":"Vincenzo Pezzi","orcid":"https://orcid.org/0000-0003-2311-2286","observed_orcids":["https://orcid.org/0000-0003-2311-2286"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Vincenzo Pezzi","raw_affiliation_strings":["Department of Pharmaco-Biology (R.S., F.Z., A.C., C.R., V.P.), University of Calabria, 87036 Arcavacata di Rende (CS), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaco-Biology (R.S., F.Z., A.C., C.R., V.P.), University of Calabria, 87036 Arcavacata di Rende (CS), Italy","institution_ids":["https://openalex.org/I45204951"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5049961945","https://openalex.org/A5076326741"],"corresponding_institution_ids":["https://openalex.org/I45204951"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":5.0032,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.95217214,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"97","issue":"12","first_page":"E2238","last_page":"E2250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.24709999561309814,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenocortical-carcinoma","display_name":"adrenocortical carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9620000123977661},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.9710000157356262},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.8560000061988831},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8830000162124634},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.7730000019073486},{"id":"https://openalex.org/keywords/steroidogenic-factor-1","display_name":"steroidogenic factor 1","score":0.8870000243186951},{"id":"https://openalex.org/keywords/aromatase","display_name":"aromatase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nongenomic-estrogen-signaling","display_name":"non-genomic estrogen signaling","score":0.8820000290870667},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.7990000247955322},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.9670000076293945},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.8799999952316284},{"id":"https://openalex.org/keywords/h295r-cells","display_name":"H295R cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6069999933242798},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5951952338218689},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.5513336062431335},{"id":"https://openalex.org/C144174609","wikidata":"https://www.wikidata.org/wiki/Q14901457","display_name":"Insulin-like growth factor 1 receptor","level":4,"score":0.54632568359375},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5406597852706909},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.501554012298584},{"id":"https://openalex.org/C2781399356","wikidata":"https://www.wikidata.org/wiki/Q918285","display_name":"Adrenocortical carcinoma","level":2,"score":0.4869195222854614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4851611256599426},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47561579942703247},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4739665687084198},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4681679904460907},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3534998893737793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3377346992492676},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.31747961044311523},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30266857147216797},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2982661724090576},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12437853217124939},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09652894735336304},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08361169695854187},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.07203710079193115}],"mesh":[{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1210/jc.2012-2374","doi":"https://doi.org/10.1210/jc.2012-2374","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2012-2374","pdf_url":"https://academic.oup.com/jcem/article-pdf/97/12/E2238/9044305/jcem2238.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:23074235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23074235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unical.it:20.500.11770/134500","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11770/134500","pdf_url":null,"source":{"id":"https://openalex.org/S4377196898","display_name":"Archive of Doctoral Theses and Digital Collections (University of Calabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45204951","host_organization_name":"University of Calabria","host_organization_lineage":["https://openalex.org/I45204951"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unipa.it:10447/620703","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10447/620703","pdf_url":null,"source":{"id":"https://openalex.org/S4377196289","display_name":"IRIS UniPA (University of Palermo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I900890020","host_organization_name":"University of Palermo","host_organization_lineage":["https://openalex.org/I900890020"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/673226","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/673226","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.univpm.it:11566/252611","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11566/252611","pdf_url":null,"source":{"id":"https://openalex.org/S4306402571","display_name":"Universit\u00e0 Politecnica delle Marche (Universit\u00e0 Politecnica delle Marche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122534668","host_organization_name":"Marche Polytechnic University","host_organization_lineage":["https://openalex.org/I122534668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.research.unipd.it:11577/2527029","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/2527029","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3022620031","doi":null,"is_oa":false,"landing_page_url":"https://iris.unical.it/handle/20.500.11770/302573","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1210/jc.2012-2374","doi":"https://doi.org/10.1210/jc.2012-2374","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2012-2374","pdf_url":"https://academic.oup.com/jcem/article-pdf/97/12/E2238/9044305/jcem2238.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2088465409.pdf","grobid_xml":"https://content.openalex.org/works/W2088465409.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W8163034","https://openalex.org/W85499927","https://openalex.org/W1533598873","https://openalex.org/W1634064292","https://openalex.org/W1661647511","https://openalex.org/W1834339553","https://openalex.org/W1978795447","https://openalex.org/W1979721685","https://openalex.org/W1980615409","https://openalex.org/W1988079149","https://openalex.org/W1988520880","https://openalex.org/W1992252639","https://openalex.org/W1994359425","https://openalex.org/W1996353650","https://openalex.org/W2011925462","https://openalex.org/W2015524046","https://openalex.org/W2018440486","https://openalex.org/W2020809609","https://openalex.org/W2021559630","https://openalex.org/W2023370041","https://openalex.org/W2025865695","https://openalex.org/W2027583535","https://openalex.org/W2036066109","https://openalex.org/W2038273862","https://openalex.org/W2054666781","https://openalex.org/W2062685114","https://openalex.org/W2065302180","https://openalex.org/W2066923659","https://openalex.org/W2070284356","https://openalex.org/W2072787342","https://openalex.org/W2073763063","https://openalex.org/W2076710019","https://openalex.org/W2086178662","https://openalex.org/W2098762017","https://openalex.org/W2099235053","https://openalex.org/W2106713309","https://openalex.org/W2113893197","https://openalex.org/W2114210346","https://openalex.org/W2121614225","https://openalex.org/W2124556268","https://openalex.org/W2126421673","https://openalex.org/W2127323185","https://openalex.org/W2138551378","https://openalex.org/W2143963955","https://openalex.org/W2144667889","https://openalex.org/W2148788638","https://openalex.org/W2153339609","https://openalex.org/W2153374798","https://openalex.org/W2154500801","https://openalex.org/W2156034409","https://openalex.org/W2162539090","https://openalex.org/W2163679869","https://openalex.org/W2164015349","https://openalex.org/W2165081445","https://openalex.org/W2165626744","https://openalex.org/W2324114402","https://openalex.org/W2462099688","https://openalex.org/W6668967003","https://openalex.org/W6681393296","https://openalex.org/W6684394526"],"related_works":["https://openalex.org/W44028746","https://openalex.org/W3022620031","https://openalex.org/W1955390608","https://openalex.org/W2127323185","https://openalex.org/W3116975807","https://openalex.org/W7217613700","https://openalex.org/W1902738905","https://openalex.org/W2767290046","https://openalex.org/W2018107343","https://openalex.org/W2053494666"],"abstract_inverted_index":{"CONTEXT:":[0],"Adrenocortical":[1],"carcinoma":[2],"(ACC)":[3],"is":[4,18],"a":[5,9,177,195,242,255],"rare":[6],"tumor":[7],"with":[8],"very":[10],"poor":[11],"prognosis":[12],"and":[13,26,49,53,83,120,143,155,172,204,222,225,249,253],"no":[14],"effective":[15,61],"treatment.":[16],"ACC":[17,51,64,251],"characterized":[19],"by":[20,27,44,135,151,190,236],"an":[21,79],"increased":[22,105,198],"production":[23],"of":[24,35,99,131,180,197,216,264],"IGF-II":[25,96,147],"estrogen":[28,57,110,210],"receptor":[29,58,169],"(ER)-\u03b1":[30],"up-regulation.":[31],"OBJECTIVE:":[32],"The":[33,70,209],"objective":[34],"this":[36,188],"study":[37],"was":[38,76,126,233],"to":[39,84,140,206,260],"define":[40],"the":[41,129,181,213,262],"role":[42,244],"played":[43],"ER\u03b1":[45,115,149,161,246,259],"in":[46,62,66,80,88,103,138,176,247],"17\u03b2-estradiol":[47],"(E2)-":[48],"IGF-II-dependent":[50,121,250],"growth":[52,65,232],"evaluate":[54],"whether":[55],"selective":[56],"modulators":[59],"are":[60],"controlling":[63],"vivo.":[67],"EXPERIMENTAL":[68],"DESIGN:":[69],"human":[71],"adrenocortical":[72],"cell":[73,113,122,227],"line":[74],"H295R":[75,94,230],"used":[77],"as":[78,194],"vitro":[81],"model":[82],"generate":[85],"xenograft":[86,231],"tumors":[87],"athymic":[89],"nude":[90],"mice.":[91],"RESULTS:":[92],"In":[93,145,184],"cells":[95],"controlled":[97],"expression":[98,134,193],"steroidogenic":[100],"factor-1":[101],"that,":[102],"turn,":[104],"aromatase":[106],"transcription":[107],"and,":[108],"consequently,":[109],"production,":[111],"inducing":[112],"proliferation.":[114,123,228],"silencing":[116],"significantly":[117],"blocked":[118],"E2-":[119,224,248],"This":[124],"effect":[125],"dependent":[127],"on":[128],"regulation":[130],"cyclin":[132],"D1":[133],"ER\u03b1,":[136],"activated":[137],"response":[139],"both":[141,223],"E2":[142,186],"IGF-II.":[144],"fact,":[146],"induced":[148],"activation":[150,179,203],"phosphorylating":[152],"serine":[153],"118":[154],"167.":[156],"Furthermore,":[157],"we":[158],"demonstrated":[159],"that":[160,166],"mediated":[162],"E2-induced":[163],"nongenomic":[164],"signaling":[165],"stimulated":[167],"IGF-I":[168],"(IGF1R),":[170],"ERK1/2,":[171],"AKT":[173],"phosphorylation,":[174],"resulting":[175],"ligand-independent":[178],"IGF1R-induced":[182],"pathway.":[183],"addition,":[185],"potentiated":[187],"pathway":[189],"up-regulating":[191],"IGF1R":[192,207,219],"consequence":[196],"cAMP-responsive":[199],"element":[200],"binding":[201,205],"protein":[202,220],"promoter.":[208],"antagonist,":[211],"hydroxytamoxifen,":[212],"active":[214],"metabolite":[215],"tamoxifen,":[217],"reduced":[218,235],"levels":[221],"IGF-II-induced":[226],"Moreover,":[229],"strongly":[234],"tamoxifen.":[237],"CONCLUSION:":[238],"These":[239],"findings":[240],"establish":[241],"critical":[243],"for":[245,257],"proliferation":[252,263],"provide":[254],"rationale":[256],"targeting":[258],"control":[261],"ACC.":[265]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}