{"id":"https://openalex.org/W2088330645","doi":"https://doi.org/10.3727/096504009789745584","title":"Expression and Mutation Analysis of TIG1 (Tazarotene-Induced Gene 1) in Human Gastric Cancer","display_name":"Expression and Mutation Analysis of TIG1 (Tazarotene-Induced Gene 1) in Human Gastric Cancer","publication_year":2009,"publication_date":"2009-10-28","ids":{"openalex":"https://openalex.org/W2088330645","doi":"https://doi.org/10.3727/096504009789745584","mag":"2088330645","pmid":"https://pubmed.ncbi.nlm.nih.gov/19806788"},"language":"en","primary_location":{"id":"doi:10.3727/096504009789745584","doi":"https://doi.org/10.3727/096504009789745584","is_oa":true,"landing_page_url":"https://doi.org/10.3727/096504009789745584","pdf_url":null,"source":{"id":"https://openalex.org/S146643948","display_name":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","issn_l":"0965-0407","issn":["0965-0407","1555-3906"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4360969325","host_organization_name":"Cognizant Communication Corporation","host_organization_lineage":["https://openalex.org/P4360969325"],"host_organization_lineage_names":["Cognizant Communication Corporation"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3727/096504009789745584","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Min Soo Son","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Soo Son","raw_affiliation_strings":["Department of Surgery, College of Medicine, Kyung Hee University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, College of Medicine, Kyung Hee University, Seoul, Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073039727","display_name":"Min Ju Kang","orcid":"https://orcid.org/0000-0001-5040-1388","observed_orcids":["https://orcid.org/0000-0001-5040-1388"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min-Ju Kang","raw_affiliation_strings":[", Korea University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Korea University","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111979743","display_name":"Ho Chul Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ho Chul Park","raw_affiliation_strings":["Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyung Hee University","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030626915","display_name":"Sung-Gil Chi","orcid":"https://orcid.org/0000-0003-4643-9003","observed_orcids":["https://orcid.org/0000-0003-4643-9003"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sung-Gil Chi","raw_affiliation_strings":["Department of Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100760941","display_name":"Yong Ho Kim","orcid":"https://orcid.org/0000-0001-7527-0134","observed_orcids":["https://orcid.org/0000-0001-7527-0134"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong Ho Kim","raw_affiliation_strings":["Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyung Hee University","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2805,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.69038775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"17","issue":"11","first_page":"571","last_page":"580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.07980000227689743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.027400000020861626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tig1","display_name":"TIG1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8349999785423279},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.6909999847412109},{"id":"https://openalex.org/keywords/dna-hypermethylation","display_name":"DNA hypermethylation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.9079999923706055},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.7490000128746033},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/malignant-progression","display_name":"malignant progression","score":0.7310000061988831},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6273784041404724},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5383840799331665},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5107060074806213},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5004971027374268},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4138373136520386},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41357916593551636},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.3093158006668091},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17070043087005615}],"mesh":[{"descriptor_ui":"D000077209","descriptor_name":"Decitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002893","descriptor_name":"Chromosomes, Human, Pair 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3727/096504009789745584","doi":"https://doi.org/10.3727/096504009789745584","is_oa":true,"landing_page_url":"https://doi.org/10.3727/096504009789745584","pdf_url":null,"source":{"id":"https://openalex.org/S146643948","display_name":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","issn_l":"0965-0407","issn":["0965-0407","1555-3906"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4360969325","host_organization_name":"Cognizant Communication Corporation","host_organization_lineage":["https://openalex.org/P4360969325"],"host_organization_lineage_names":["Cognizant Communication Corporation"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","raw_type":"journal-article"},{"id":"pmid:19806788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19806788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3727/096504009789745584","doi":"https://doi.org/10.3727/096504009789745584","is_oa":true,"landing_page_url":"https://doi.org/10.3727/096504009789745584","pdf_url":null,"source":{"id":"https://openalex.org/S146643948","display_name":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","issn_l":"0965-0407","issn":["0965-0407","1555-3906"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4360969325","host_organization_name":"Cognizant Communication Corporation","host_organization_lineage":["https://openalex.org/P4360969325"],"host_organization_lineage_names":["Cognizant Communication Corporation"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2068007403","https://openalex.org/W1952661309","https://openalex.org/W1581236691","https://openalex.org/W7098121161","https://openalex.org/W2139885759","https://openalex.org/W3150889307","https://openalex.org/W1993778216","https://openalex.org/W2391323972","https://openalex.org/W2006702023","https://openalex.org/W2529517946"],"abstract_inverted_index":{"Tazarotene-induced":[0],"gene":[1,46],"1":[2],"(TIG1)":[3],"has":[4],"been":[5],"known":[6],"to":[7,16,19,40,108,120,161,186,204,257],"function":[8],"as":[9,47],"a":[10,48,123,166],"cell":[11,18,20,38,74,135,183],"adhesion":[12],"molecule,":[13],"which":[14],"leads":[15],"better":[17],"contact":[21],"and":[22,28,37,65,70,85,137,181,207,264],"reduced":[23],"proliferation.":[24],"We":[25],"investigated":[26],"expression":[27,79,128,148,221,235,267],"mutation":[29],"status":[30],"of":[31,44,53,93,103,126,139,145,149,169,173,188,195,274],"TIG1":[32,78,111,127,150,174,196,220,234,251],"in":[33,131,154,178,200,210,239,261],"primary":[34,60,157,179],"gastric":[35,55,72,262],"tumors":[36,202,206,213],"lines":[39,75,184],"explore":[41],"the":[42,45,91,271],"candidacy":[43],"tumor":[49],"suppressor.":[50],"A":[51],"total":[52],"172":[54],"tissue":[56],"specimes,":[57],"including":[58],"80":[59,66],"adenocarcinomas,":[61],"12":[62],"benign":[63],"tumors,":[64],"adjacent":[67,162],"normal":[68,189],"mucosa,":[69],"15":[71],"cancer":[73,134,182,241],"were":[76,175],"used.":[77],"was":[80,98,106,129,151,197,222,227],"analyzed":[81],"by":[82,243],"semiquantitative":[83],"RT-PCR":[84],"immunoblot":[86],"analysis.":[87],"To":[88],"screen":[89],"for":[90],"presence":[92],"somatic":[94],"mutations,":[95],"RT-PCR-SSCP":[96],"analysis":[97],"carried":[99],"out.":[100],"The":[101],"effect":[102],"5-aza-2'-deoxycytidine":[104,230],"treatment":[105],"examined":[107],"elicit":[109],"whether":[110],"reduction":[112,125,168,194],"is":[113,236,268],"associated":[114,269],"with":[115,270],"abnormal":[116,244],"DNA":[117,245,259],"hypermethylation.":[118,246],"Compared":[119],"noncancerous":[121,163],"tissues,":[122,164],"substantial":[124],"observed":[130],"73.3%":[132],"(11115)":[133],"lines,":[136],"seven":[138],"these":[140,240],"exhibited":[141],"nearly":[142],"undetectable":[143],"levels":[144,172],"expression.":[146],"Decreased":[147],"also":[152],"found":[153],"62":[155],"(77.5%)":[156],"carcinoma":[158],"tissues":[159],"compared":[160,185,203],"indicating":[165,232],"tumor-specific":[167],"TIG1.":[170],"Expression":[171],"significantly":[176,198],"low":[177],"carcinomas":[180],"those":[187],"tissues.":[190],"Moreover,":[191],"loss":[192],"or":[193,216,224],"high":[199],"advanced":[201],"early":[205],"more":[208],"frequent":[209,253],"poorly":[211],"differentiated":[212,218],"than":[214],"well":[215],"moderately":[217],"tumors.":[219,275],"reactivated":[223],"its":[225,265],"level":[226],"elevated":[228],"following":[229],"treatment,":[231],"that":[233,250],"transcriptionally":[237],"silenced":[238],"cells":[242],"These":[247],"data":[248],"indicate":[249],"undergoes":[252],"epigenetic":[254],"inactivation":[255],"due":[256],"aberrant":[258],"hypermethylation":[260],"cancers,":[263],"altered":[266],"malignant":[272],"progression":[273]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}