{"id":"https://openalex.org/W2088198404","doi":"https://doi.org/10.1097/pai.0b013e318284a074","title":"Molecular Analysis of the KIT Gene in Gastrointestinal Stromal Tumors With Novel Mutations","display_name":"Molecular Analysis of the KIT Gene in Gastrointestinal Stromal Tumors With Novel Mutations","publication_year":2013,"publication_date":"2013-07-10","ids":{"openalex":"https://openalex.org/W2088198404","doi":"https://doi.org/10.1097/pai.0b013e318284a074","mag":"2088198404","pmid":"https://pubmed.ncbi.nlm.nih.gov/23455185"},"language":"en","primary_location":{"id":"doi:10.1097/pai.0b013e318284a074","doi":"https://doi.org/10.1097/pai.0b013e318284a074","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pai.0b013e318284a074","pdf_url":null,"source":{"id":"https://openalex.org/S42732013","display_name":"Applied immunohistochemistry & molecular morphology","issn_l":"1533-4058","issn":["1533-4058","1541-2016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Immunohistochemistry & Molecular Morphology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065746423","display_name":"Gizem Calibasi\u2010Kocal","orcid":"https://orcid.org/0000-0002-3201-4752","observed_orcids":["https://orcid.org/0000-0002-3201-4752"]},"institutions":[{"id":"https://openalex.org/I193615760","display_name":"Dokuz Eyl\u00fcl University","ror":"https://ror.org/00dbd8b73","country_code":"TR","type":"education","lineage":["https://openalex.org/I193615760"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Gizem Calibasi","raw_affiliation_strings":["*Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University \u2020Graduate School of Natural and Applied Sciences \u2021Department of Chemistry, Division of Biochemistry, Faculty of Science, Kaynaklar Campus Departments of \u00a7Medical Oncology \u2225Pathology \u00b6Surgery, Faculty of Medicine #Department of Preventive Oncology, Institute of Oncology, Inciralti, Izmir-Turkey","Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University \u2020Graduate School of Natural and Applied Sciences \u2021Department of Chemistry, Division of Biochemistry, Faculty of Science, Kaynaklar Campus Departments of \u00a7Medical Oncology \u2225Pathology \u00b6Surgery, Faculty of Medicine #Department of Preventive Oncology, Institute of Oncology, Inciralti, Izmir-Turkey","institution_ids":["https://openalex.org/I193615760"]},{"raw_affiliation_string":"Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University","institution_ids":["https://openalex.org/I193615760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107981183","display_name":"Yasemin Bask\u0131n","orcid":"https://orcid.org/0000-0002-2661-6925","observed_orcids":["https://orcid.org/0000-0002-2661-6925"]},"institutions":[{"id":"https://openalex.org/I193615760","display_name":"Dokuz Eyl\u00fcl University","ror":"https://ror.org/00dbd8b73","country_code":"TR","type":"education","lineage":["https://openalex.org/I193615760"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Yasemin Baskin","raw_affiliation_strings":["Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University","institution_ids":["https://openalex.org/I193615760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074621139","display_name":"Hakan Aly\u00fcr\u00fck","orcid":"https://orcid.org/0000-0001-8632-4281","observed_orcids":["https://orcid.org/0000-0001-8632-4281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hakan Alyuruk","raw_affiliation_strings":["Graduate School of Natural and Applied Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Natural and Applied Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005593248","display_name":"Levent \u00c7ava\u015f","orcid":"https://orcid.org/0000-0003-2136-6928","observed_orcids":["https://orcid.org/0000-0003-2136-6928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Levent Cavas","raw_affiliation_strings":["Department of Chemistry, Division of Biochemistry, Faculty of Science, Kaynaklar Campus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Division of Biochemistry, Faculty of Science, Kaynaklar Campus","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002448212","display_name":"\u0130lhan \u00d6ztop","orcid":"https://orcid.org/0000-0002-0425-0651","observed_orcids":["https://orcid.org/0000-0002-0425-0651"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilhan Oztop","raw_affiliation_strings":["Medical Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074043755","display_name":"\u00d6zg\u00fcl Sa\u011fol","orcid":"https://orcid.org/0000-0001-9136-5635","observed_orcids":["https://orcid.org/0000-0001-9136-5635"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ozgul Sagol","raw_affiliation_strings":["Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049669117","display_name":"Koray Atila","orcid":"https://orcid.org/0000-0001-9628-5300","observed_orcids":["https://orcid.org/0000-0001-9628-5300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koray Atila","raw_affiliation_strings":["Surgery, Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Faculty of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054834217","display_name":"H\u00fclya Ell\u0131dokuz","orcid":"https://orcid.org/0000-0001-8503-061X","observed_orcids":["https://orcid.org/0000-0001-8503-061X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hulya Ellidokuz","raw_affiliation_strings":["Department of Preventive Oncology, Institute of Oncology, Inciralti, Izmir-Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Oncology, Institute of Oncology, Inciralti, Izmir-Turkey","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Ugur Yilmaz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ugur Yilmaz","raw_affiliation_strings":["Medical Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065746423","https://openalex.org/A5107981183"],"corresponding_institution_ids":["https://openalex.org/I193615760"],"apc_list":null,"apc_paid":null,"fwci":1.1137,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.80411627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"22","issue":"1","first_page":"37","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastrointestinal-stromal-tumor","display_name":"gastrointestinal stromal tumor","score":0.9620000123977661},{"id":"https://openalex.org/keywords/kit-mutations","display_name":"KIT mutations","score":0.9160000085830688},{"id":"https://openalex.org/keywords/novel-mutations","display_name":"novel mutations","score":0.7570000290870667},{"id":"https://openalex.org/keywords/exon-11-mutations","display_name":"exon 11 mutations","score":0.8619999885559082},{"id":"https://openalex.org/keywords/turkish-population","display_name":"Turkish population","score":0.656000018119812},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.9449999928474426},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.8375256061553955},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.5996188521385193},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.560478687286377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5158737897872925},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49618133902549744},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4916861653327942},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.48852622509002686},{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.4856237471103668},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45745623111724854},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38626009225845337},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24103793501853943},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.23270955681800842},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046152","descriptor_name":"Gastrointestinal Stromal Tumors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046152","descriptor_name":"Gastrointestinal Stromal Tumors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046152","descriptor_name":"Gastrointestinal Stromal Tumors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/pai.0b013e318284a074","doi":"https://doi.org/10.1097/pai.0b013e318284a074","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pai.0b013e318284a074","pdf_url":null,"source":{"id":"https://openalex.org/S42732013","display_name":"Applied immunohistochemistry & molecular morphology","issn_l":"1533-4058","issn":["1533-4058","1541-2016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Immunohistochemistry & Molecular Morphology","raw_type":"journal-article"},{"id":"pmid:23455185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23455185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied immunohistochemistry & molecular morphology : AIMM","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7300000190734863,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1583312822","https://openalex.org/W1933891757","https://openalex.org/W1968478357","https://openalex.org/W1973125946","https://openalex.org/W1979895715","https://openalex.org/W1989773675","https://openalex.org/W1991891583","https://openalex.org/W1991928855","https://openalex.org/W2000998080","https://openalex.org/W2004579259","https://openalex.org/W2005081096","https://openalex.org/W2008920989","https://openalex.org/W2019607817","https://openalex.org/W2023194647","https://openalex.org/W2041415161","https://openalex.org/W2068079378","https://openalex.org/W2070263675","https://openalex.org/W2092105161","https://openalex.org/W2095724872","https://openalex.org/W2095974037","https://openalex.org/W2097071478","https://openalex.org/W2101214437","https://openalex.org/W2108401821","https://openalex.org/W2109508638","https://openalex.org/W2113846802","https://openalex.org/W2117946715","https://openalex.org/W2118897332","https://openalex.org/W2119854239","https://openalex.org/W2130500186","https://openalex.org/W2150475380","https://openalex.org/W2150501295","https://openalex.org/W2155503879","https://openalex.org/W2161599196","https://openalex.org/W2161733130","https://openalex.org/W2165902939","https://openalex.org/W2166485548","https://openalex.org/W2171620774","https://openalex.org/W2263807834","https://openalex.org/W2321213005"],"related_works":["https://openalex.org/W2417766600","https://openalex.org/W2060169551","https://openalex.org/W2362849034","https://openalex.org/W2068932327","https://openalex.org/W2168467210","https://openalex.org/W2015388398","https://openalex.org/W2039352533","https://openalex.org/W2025851750","https://openalex.org/W3092216457","https://openalex.org/W2362650105"],"abstract_inverted_index":{"Gastrointestinal":[0],"stromal":[1],"tumors":[2,9],"(GISTs)":[3],"are":[4],"the":[5,11,25,74,79,105,128,172,182,188],"most":[6],"common":[7],"mesenchymal":[8],"of":[10,78,104,130,148,174,184],"gastrointestinal":[12],"tract.":[13],"KIT":[14,28,54,80,131],"gene":[15,55,81],"mutations":[16,29,132,137,165],"have":[17],"great":[18],"importance":[19,173],"for":[20,53,109,113,117],"GISTs.":[21],"This":[22,71],"study":[23,72],"evaluated":[24],"relationship":[26],"between":[27,124],"and":[30,37,47,60,88,127,191],"GIST":[31],"clinicopathologic":[32],"features":[33],"to":[34],"define":[35],"region-specific":[36],"population-specific":[38],"differences.":[39],"Genomic":[40],"DNA":[41],"was":[42,51,99,121],"extracted":[43],"from":[44,84],"60":[45],"GISTs,":[46],"polymerase":[48],"chain":[49,63],"reaction":[50,64],"performed":[52],"exons":[56,107],"9,":[57],"11,":[58],"13,":[59],"17.":[61],"Polymerase":[62],"amplicons":[65],"were":[66],"sequenced":[67],"in":[68,82,95,138,141,157,187],"both":[69],"directions.":[70],"represents":[73],"first":[75],"mutation":[76,93,156],"data":[77],"GISTs":[83],"a":[85,155],"Turkish":[86],"population":[87],"reports":[89],"novel":[90],"mutations.":[91],"The":[92],"rate":[94],"exon":[96,110,114,118,142,159],"11":[97,143],"(46.7%)":[98],"remarkably":[100],"higher":[101],"than":[102,166],"those":[103,153,167],"other":[106],"(8.3%":[108],"9;":[111],"11.7%":[112],"13;":[115],"1.7%":[116],"17).":[119],"There":[120],"an":[122],"association":[123],"malignancy":[125,149],"potential":[126],"presence":[129],"(odds":[133,160],"ratio=3.18).":[134],"Cases":[135],"with":[136,152],"codons":[139],"W557-K558":[140],"had":[144],"11-fold":[145],"greater":[146],"risk":[147],"when":[150],"compared":[151],"without":[154],"this":[158],"ratio=11).":[161],"We":[162],"report":[163],"different":[164],"previously":[168],"reported,":[169],"which":[170],"emphasizes":[171],"personalized":[175],"medicine":[176],"that":[177],"could":[178],"be":[179],"empowered":[180],"by":[181],"use":[183],"bioinformatics":[185],"tools":[186],"diagnostic":[189],"process":[190],"therapeutic":[192],"approaches.":[193]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}