{"id":"https://openalex.org/W2088190878","doi":"https://doi.org/10.1016/j.jconrel.2014.07.009","title":"sTRAIL coupled to liposomes improves its pharmacokinetic profile and overcomes neuroblastoma tumour resistance in combination with Bortezomib","display_name":"sTRAIL coupled to liposomes improves its pharmacokinetic profile and overcomes neuroblastoma tumour resistance in combination with Bortezomib","publication_year":2014,"publication_date":"2014-07-17","ids":{"openalex":"https://openalex.org/W2088190878","doi":"https://doi.org/10.1016/j.jconrel.2014.07.009","mag":"2088190878","pmid":"https://pubmed.ncbi.nlm.nih.gov/25041999"},"language":"en","primary_location":{"id":"doi:10.1016/j.jconrel.2014.07.009","doi":"https://doi.org/10.1016/j.jconrel.2014.07.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2014.07.009","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042376678","display_name":"Monica Loi","orcid":"https://orcid.org/0000-0001-8179-8445","observed_orcids":["https://orcid.org/0000-0001-8179-8445"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Loi","raw_affiliation_strings":["Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041377660","display_name":"Pamela Becherini","orcid":"https://orcid.org/0000-0002-8727-0681","observed_orcids":["https://orcid.org/0000-0002-8727-0681","https://orcid.org/0000-0002-0903-8916"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Becherini","raw_affiliation_strings":["Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8727-0681","affiliations":[{"raw_affiliation_string":"Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088779262","display_name":"Laura Emionite","orcid":"https://orcid.org/0000-0002-5199-6384","observed_orcids":["https://orcid.org/0000-0002-5199-6384"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Emionite","raw_affiliation_strings":["Animal Facility, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Facility, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011886571","display_name":"Arianna Giacomini","orcid":"https://orcid.org/0000-0002-9984-9033","observed_orcids":["https://orcid.org/0000-0002-9984-9033"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Giacomini","raw_affiliation_strings":["Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005090241","display_name":"Irene Cossu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"I. Cossu","raw_affiliation_strings":["Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059185764","display_name":"Elisa Destefanis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Destefanis","raw_affiliation_strings":["Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000242295","display_name":"Chiara Brignole","orcid":"https://orcid.org/0000-0002-2563-6991","observed_orcids":["https://orcid.org/0000-0002-2563-6991"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Brignole","raw_affiliation_strings":["Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070686436","display_name":"Daniela Di Paolo","orcid":"https://orcid.org/0000-0001-7264-6888","observed_orcids":["https://orcid.org/0000-0001-7264-6888"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. Di Paolo","raw_affiliation_strings":["Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000217335","display_name":"Francesca Piaggio","orcid":"https://orcid.org/0000-0003-0379-0047","observed_orcids":["https://orcid.org/0000-0003-0379-0047"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Piaggio","raw_affiliation_strings":["Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062757807","display_name":"Patrizia Perri","orcid":"https://orcid.org/0000-0003-2538-8278","observed_orcids":["https://orcid.org/0000-0003-2538-8278"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Perri","raw_affiliation_strings":["Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027704478","display_name":"Michele Cilli","orcid":"https://orcid.org/0000-0003-4083-8986","observed_orcids":["https://orcid.org/0000-0003-4083-8986"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Cilli","raw_affiliation_strings":["Animal Facility, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Facility, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053922930","display_name":"Fabio Pastorino","orcid":"https://orcid.org/0000-0002-8312-808X","observed_orcids":["https://orcid.org/0000-0002-8312-808X"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"F. Pastorino","raw_affiliation_strings":["Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy. Electronic address: fabiopastorino@ospedale-gaslini.ge.it","Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy. Electronic address: fabiopastorino@ospedale-gaslini.ge.it","institution_ids":["https://openalex.org/I2801463291"]},{"raw_affiliation_string":"Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015444918","display_name":"Mirco Ponzoni","orcid":"https://orcid.org/0000-0002-6164-4286","observed_orcids":["https://orcid.org/0000-0002-6164-4286"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"M. Ponzoni","raw_affiliation_strings":["Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy. Electronic address: mircoponzoni@ospedale-gaslini.ge.it","Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy. Electronic address: mircoponzoni@ospedale-gaslini.ge.it","institution_ids":["https://openalex.org/I2801463291"]},{"raw_affiliation_string":"Laboratorio di Oncologia, Istituto Giannina Gaslini, Genova 16148, Italy","institution_ids":["https://openalex.org/I2801463291"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015444918","https://openalex.org/A5053922930"],"corresponding_institution_ids":["https://openalex.org/I2801463291"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":null,"fwci":1.3472,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.74045461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"192","issue":null,"first_page":"157","last_page":"166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.48510000109672546,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.48510000109672546,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.1826000064611435,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.13169999420642853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soluble-trail","display_name":"soluble TRAIL","score":0.8790000081062317},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.7429999709129333},{"id":"https://openalex.org/keywords/pegylated-liposomes","display_name":"PEGylated liposomes","score":0.8629999756813049},{"id":"https://openalex.org/keywords/liposomal-drug-delivery","display_name":"liposomal drug delivery","score":0.7450000047683716},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9620000123977661},{"id":"https://openalex.org/keywords/trail-resistance","display_name":"TRAIL resistance","score":0.7409999966621399},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8500000238418579},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4259999990463257},{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.625},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5640000104904175},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7397756576538086},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.7334128618240356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6161584258079529},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5848798155784607},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4678920805454254},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4510575532913208},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.4312412440776825},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.4272956848144531},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4122006297111511},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3597480356693268},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32466140389442444},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.20394819974899292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14752206206321716},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07501205801963806},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069286","descriptor_name":"Bortezomib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001897","descriptor_name":"Boronic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001897","descriptor_name":"Boronic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jconrel.2014.07.009","doi":"https://doi.org/10.1016/j.jconrel.2014.07.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2014.07.009","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},{"id":"pmid:25041999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25041999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of controlled release : official journal of the Controlled Release Society","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unibs.it:11379/459251","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11379/459251","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1345569834","display_name":null,"funder_award_id":"IG 5505","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320322823","display_name":"Fondazione Umberto Veronesi","ror":"https://ror.org/041g7jm83"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1484817497","https://openalex.org/W1550065416","https://openalex.org/W1969402650","https://openalex.org/W1979914746","https://openalex.org/W1981600616","https://openalex.org/W1991504790","https://openalex.org/W1998422493","https://openalex.org/W2007718868","https://openalex.org/W2012687605","https://openalex.org/W2019276845","https://openalex.org/W2019409985","https://openalex.org/W2020439083","https://openalex.org/W2027250628","https://openalex.org/W2027828682","https://openalex.org/W2034071655","https://openalex.org/W2038118195","https://openalex.org/W2038391190","https://openalex.org/W2041414354","https://openalex.org/W2042502679","https://openalex.org/W2047972729","https://openalex.org/W2054054828","https://openalex.org/W2058879480","https://openalex.org/W2069634792","https://openalex.org/W2078217054","https://openalex.org/W2086393160","https://openalex.org/W2088291142","https://openalex.org/W2090054621","https://openalex.org/W2091574965","https://openalex.org/W2092058648","https://openalex.org/W2095279010","https://openalex.org/W2096913909","https://openalex.org/W2098509343","https://openalex.org/W2101617519","https://openalex.org/W2101657078","https://openalex.org/W2111034566","https://openalex.org/W2120116865","https://openalex.org/W2121580023","https://openalex.org/W2122937570","https://openalex.org/W2123077018","https://openalex.org/W2130465135","https://openalex.org/W2130925781","https://openalex.org/W2130988210","https://openalex.org/W2132485651","https://openalex.org/W2133221875","https://openalex.org/W2144466728","https://openalex.org/W2145700472","https://openalex.org/W2148809263","https://openalex.org/W2160591216","https://openalex.org/W2162653689","https://openalex.org/W2165611334","https://openalex.org/W2167445011","https://openalex.org/W2168093560","https://openalex.org/W2170220752","https://openalex.org/W2326577933","https://openalex.org/W2330709458"],"related_works":["https://openalex.org/W2325848215","https://openalex.org/W4406018882","https://openalex.org/W2035827574","https://openalex.org/W2352719468","https://openalex.org/W2333546933","https://openalex.org/W2034772011","https://openalex.org/W366249503","https://openalex.org/W2335373838","https://openalex.org/W2617815425","https://openalex.org/W2801146707"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
