{"id":"https://openalex.org/W2088087993","doi":"https://doi.org/10.1074/jbc.275.4.2693","title":"Recruitment of Stat4 to the Human Interferon-\u03b1/\u03b2 Receptor Requires Activated Stat2","display_name":"Recruitment of Stat4 to the Human Interferon-\u03b1/\u03b2 Receptor Requires Activated Stat2","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2088087993","doi":"https://doi.org/10.1074/jbc.275.4.2693","mag":"2088087993","pmid":"https://pubmed.ncbi.nlm.nih.gov/10644731"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.275.4.2693","doi":"https://doi.org/10.1074/jbc.275.4.2693","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.275.4.2693","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.275.4.2693","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J.David Farrar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.David Farrar","raw_affiliation_strings":["Department of Pathology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110, USA","Molecular Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I204465549"]},{"raw_affiliation_string":"Molecular Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070145253","display_name":"Janice D. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janice D. Smith","raw_affiliation_strings":["Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109258193","display_name":"Theresa L. Murphy","orcid":"https://orcid.org/0000-0001-6539-8142","observed_orcids":["https://orcid.org/0000-0001-6539-8142"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa L. Murphy","raw_affiliation_strings":["Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040420168","display_name":"KENNETH M. M. MURPHY","orcid":"https://orcid.org/0000-0002-3505-9630","observed_orcids":["https://orcid.org/0000-0002-3505-9630"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth M. Murphy","raw_affiliation_strings":["Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040420168"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I204465549"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.3504,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.94810823,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"275","issue":"4","first_page":"2693","last_page":"2697"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat4","display_name":"STAT4","score":0.9539999961853027},{"id":"https://openalex.org/keywords/stat2","display_name":"STAT2","score":0.828000009059906},{"id":"https://openalex.org/keywords/ifnar","display_name":"IFNAR","score":0.9049999713897705},{"id":"https://openalex.org/keywords/stat4-phosphorylation","display_name":"STAT4 phosphorylation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.5210000276565552},{"id":"https://openalex.org/keywords/il-12-receptor","display_name":"IL-12 receptor","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C2776239193","wikidata":"https://www.wikidata.org/wiki/Q18031750","display_name":"STAT2","level":5,"score":0.8323105573654175},{"id":"https://openalex.org/C65439459","wikidata":"https://www.wikidata.org/wiki/Q14914618","display_name":"STAT4","level":5,"score":0.5720792412757874},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.43062078952789307},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.34856176376342773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33578336238861084},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2083410620689392},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.14833489060401917},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12373027205467224},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017471","descriptor_name":"Receptors, Interferon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017471","descriptor_name":"Receptors, Interferon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050795","descriptor_name":"STAT2 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050797","descriptor_name":"STAT4 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053633","descriptor_name":"Receptor, Interferon alpha-beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.275.4.2693","doi":"https://doi.org/10.1074/jbc.275.4.2693","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.275.4.2693","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10644731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10644731","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.275.4.2693","doi":"https://doi.org/10.1074/jbc.275.4.2693","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.275.4.2693","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3951126598","display_name":null,"funder_award_id":"AI/DK39676","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6735449744","display_name":null,"funder_award_id":"CA09547","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000879652","display_name":"TRAINING IN THE IMMUNOBIOLOGY AND MOLECULAR CELL BIOLOGY OF CANCER","funder_award_id":"T32CA009547","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W131140191","https://openalex.org/W135486017","https://openalex.org/W1497205974","https://openalex.org/W1515848954","https://openalex.org/W1535156928","https://openalex.org/W1604795805","https://openalex.org/W1607019337","https://openalex.org/W1669690603","https://openalex.org/W1747682552","https://openalex.org/W1830966545","https://openalex.org/W1894525365","https://openalex.org/W1958363133","https://openalex.org/W1971892123","https://openalex.org/W1975588465","https://openalex.org/W1986021037","https://openalex.org/W2002726220","https://openalex.org/W2012295450","https://openalex.org/W2012628280","https://openalex.org/W2020467454","https://openalex.org/W2021702586","https://openalex.org/W2038615458","https://openalex.org/W2042511952","https://openalex.org/W2044325609","https://openalex.org/W2045008512","https://openalex.org/W2051705414","https://openalex.org/W2058593261","https://openalex.org/W2070116310","https://openalex.org/W2072482570","https://openalex.org/W2088988430","https://openalex.org/W2091272253","https://openalex.org/W2103565638","https://openalex.org/W2116641130","https://openalex.org/W2135847617","https://openalex.org/W2151712105","https://openalex.org/W2153398168","https://openalex.org/W2155991561","https://openalex.org/W2165588484","https://openalex.org/W4313331188"],"related_works":["https://openalex.org/W1604795805","https://openalex.org/W2109879635","https://openalex.org/W1655394290","https://openalex.org/W2054401680","https://openalex.org/W2034864837","https://openalex.org/W2055836596","https://openalex.org/W1556530772","https://openalex.org/W2151171505","https://openalex.org/W1669690603","https://openalex.org/W1594864284"],"abstract_inverted_index":{"Stat4":[0,14,27,49,79,95,122,136,155,160],"activation":[1,47,82,161],"is":[2,15,28,61],"involved":[3],"in":[4,20,34,45,53,56,123,148],"differentiation":[5],"of":[6,48,66,69,78,89,109,111,114,120,141,154],"type":[7],"1":[8],"helper":[9],"(Th1)":[10],"T":[11,25,40],"cells.":[12,41],"Although":[13],"activated":[16,29,142],"by":[17,30,83,156,162,171],"interleukin":[18],"(IL)-12":[19],"both":[21],"human":[22,85,164],"and":[23,60,81,127],"murine":[24,67,121],"cells,":[26],"interferon":[31],"(IFN)-alpha":[32],"only":[33],"human,":[35],"but":[36,144],"not":[37,97,145],"murine,":[38],"CD4(+)":[39],"This":[42],"species-specific":[43],"difference":[44],"cytokine":[46],"underlies":[50],"critical":[51],"differences":[52],"Th1":[54],"development":[55],"response":[57],"to":[58,63,74,150],"cytokines":[59],"important":[62],"the":[64,76,84,106,112,115,124,128,139,151,157,163],"interpretation":[65],"models":[68],"immunopathogenesis.":[70],"Here,":[71],"we":[72],"sought":[73],"determine":[75],"mechanism":[77],"recruitment":[80,153,170],"IFN-alpha":[86,116,165],"receptor.":[87],"Analysis":[88],"phosphopeptide":[90],"binding":[91],"analysis":[92],"suggests":[93],"that":[94,134],"does":[96],"interact":[98],"directly":[99],"with":[100],"tyrosine-phosphorylated":[101],"amino":[102],"acid":[103],"residues":[104],"within":[105],"cytoplasmic":[107],"domains":[108],"either":[110],"subunits":[113],"receptor":[117,166],"complex.":[118],"Expression":[119],"Stat1-deficient":[125],"U3A":[126],"Stat2-deficient":[129],"U6A":[130],"cell":[131],"lines":[132],"shows":[133],"IFN-alpha-induced":[135],"phosphorylation":[137],"requires":[138],"presence":[140],"Stat2":[143],"Stat1.":[146],"Thus,":[147],"contrast":[149],"direct":[152],"IL-12":[158],"receptor,":[159],"occurs":[167],"through":[168],"indirect":[169],"intermediates":[172],"involving":[173],"Stat2.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}